There were no genome-wide significant findings. Three of the top regions in the primary analysis also produced P-values less than 10−5 in the meta-analyses that are presented in a companion article.36 (Low meta-analytic P-values required a consistent allelic direction of association across samples.) In the primary meta-analysis (Broad phenotype) that included all MDD cases from GenRED, STAR*D and GAIN-MDD, SNP rs17144465 in SP4 (7p14.3) had P= 8.38 × 10−7, lower than that for GenRED alone (P=5.97 × 10−6). Another two of top GenRED regions (18q22.1 and 5p13.2) yielded P<10−5 In the Narrow meta-analysis (recurrent early-onset MDD in all samples). For 18q22.1 (rs17077540), the meta-analysis (P=7.55 × 10−7) did not provide stronger support than GenRED alone (1.83 × 10−7). For 5p13.2, the meta-analysis P-value (1.68 × 10−6) was slightly smaller than for GenRED alone (P=2.49 × 10−6). Please see the companion article for further details.
