Three independent signals (four SNPs) that were associated with time to AIDS in our cohort had a P-value below 0.05 and a similar polarity in the GRIV cohort (Table 1). SNP rs1523635, which had the strongest association with a more rapid progression to AIDS in our cohort was also associated with rapid progression in the GRIV (P = 2.42×10−2). SNPs rs6845554 and rs6827754, which are in complete LD (r2 = 1) were both associated with rapid progression in the GRIV cohort as well (P = 2.75×10−2). Finally, SNP rs6018199 was associated with non-progression in the ACS cohort as well as in the GRIV cohort (P = 4.22×10−3).
