The WT or Mut luciferase expression vector of the putative binding site in MTF1 and YY2 mRNA 3′ UTR was constructed and co-transfected into HEK293T cells with LINC00665 and its NC plasmid, respectively, and luciferase reporter gene system analysis was performed. These cells were divided into five groups, respectively: control, MTF1-3′ UTR-WT + LINC00665-NC, MTF1-3′ UTR-WT + LINC00665, MTF1-3′ UTR-Mut + LINC00665-NC, and MTF1-3′ UTR-Mut + LINC00665 groups; and control, YY2-3′ UTR-WT + LINC00665-NC, YY21-3′ UTR-WT + LINC00665, YY2-3′ UTR-Mut + LINC00665-NC, and YY2-3′ UTR-Mut + LINC00665 groups.
