Associations of genotypes with LDL cholesterol concentrations are detailed in Table 2. The association between rs646776 (at 1p13 near CELSR2/PSRC1/SORT1) and LDL cholesterol was highly significant in all three ethnic groups (P = 0.0005 in non-Hispanic blacks, P = 1.8 × 10−6 in Mexican Americans, and P = 0.002 in non-Hispanic whites). The effects of rs646776 on LDL cholesterol are summarized in the Figure. In each ethnic group, individuals with at least one copy of the minor G allele had lower LDL cholesterol. Each copy of the minor allele lowered LDL cholesterol by ~5mg/dL in non-Hispanic blacks, ~11 mg/dL in Mexican Americans, and ~4 mg/dL in non-Hispanic whites.
