In summary, we have constructed and evaluated a trans-ancestry T2D PRS in multiple populations. Future work is needed to expand the scale of non-European genomic resources and conduct larger GWAS in underrepresented populations to further increase the transferability of PRS, assess the predictive performance of the PRS in more diverse samples and real-world settings, refine risk communications, and monitor the impact of returning risk estimates on related clinical outcomes, in order to ensure equitable and effective deployment of PRS to clinical care.
