these clinical trials may be partly explained by the many factors that influence the effectiveness of returning PRS to patients, including the understanding of the implications of polygenic risk by patients and HCPs, the change of healthcare services based on personalized risk estimates (e.g., surveillance of patients, ordering screening tests, prescribing preventive medications, or providing lifestyle advice), communication of risk to patients, the availability of risk management protocols, and uptake of and adherence to risk-reduction recommendations. Expanded research on the best practice of returning genetic testing results in clinical settings will clarify the benefits of adding polygenic risk estimates to clinical risk factors and family history to create an integrated risk assessment.
