contains Hi-C data of 14 tissue types and seven cell lines from the study of Schmitt et al.11, yet new chromatin interaction data will be added when it becomes available and FUMA also allows users to upload their own chromatin interaction matrices, which is not limited to Hi-C, but also accommodates ChIA-PET, 5C or Capture Hi-C data (Methods and Supplementary Note 3). Since chromatin interactions are often defined in a certain resolution (as a genomic region), such as 40 kb, an interacting region may span multiple genes. To further prioritize candidate genes from chromatin interaction mapping, information on tissue/cell type specific enhancer and promoter regions from the Roadmap Epigenomics Project10 can be optionally integrated with interacting regions to filters SNPs and target genes (see Methods for details).
