Functional mapping and annotation of genetic associations with FUMA.

paper Cited Public

Authors: Watanabe, Kyoko; Taskesen, Erdogan; van Bochoven, Arjen; Posthuma, Danielle
Year: 2017
Journal: Nature communications
PMID: 29184056
DOI: 10.1038/s41467-017-01261-5
PMCID: PMC5705698

Fig. 1

Overview of FUMA. FUMA includes two core processes, SNP2GENE and GENE2FUNC. The input is GWAS summary statistics. SNP2GENE prioritizes functional SNPs and genes, outputs tables (blue boxes), and creates Manhattan, quantile–quantile (QQ) and interactive regional plots (box at right bottom). GENE2FUNC provides four outputs; a gene expression heatmap, enrichment of differentially expressed gene (DEG) sets in a certain tissue compared to all other tissue types, overrepresentation of gene sets, and links to external biological information of input genes. All results are downloadable as text files or high-resolution images

LLM interpretation

This figure is a workflow diagram illustrating the architecture of FUMA, which processes GWAS summary statistics through two core modules: SNP2GENE and GENE2FUNC. The SNP2GENE process involves a three-step characterization of significant hits (genomic loci, annotation, and functional mapping) and genome-wide analyses using MAGMA, resulting in various data tables and interactive visualizations. The GENE2FUNC module generates outputs including a gene expression heatmap, tissue specificity (DEG) bar charts, gene set overrepresentation plots, and links to external biological databases.

Fig. 2

Overview of prioritized genes from BMI GWAS by FUMA. Starting from the BMI GWAS summary statistics, boxes represent results of the SNP2GENE process. The annotated SNPs include all independent lead SNPs and SNPs which are in LD with these lead SNPs. Prioritized genes are divided into three categories; genes that are implicated by deleterious coding SNPs (colored pink), by eQTLs for these genes (colored blue), or by chromatin interactions (colored green). The prioritized genes are further categorized into previously reported genes (blue) and novel genes (red) prioritized genes by FUMA. *These genes were not prioritized by FUMA since they do not have either deleterious coding SNPs, eQTLs or chromatin interactions, although they are located within GWAS risk loci

LLM interpretation

This figure is a flow diagram illustrating the prioritization of genes from a BMI GWAS using the FUMA pipeline. It details the progression from 77 genomic loci and 10,367 SNPs to 400 prioritized genes, categorized by mapping method: deleterious coding SNPs (pink), eQTLs (blue), and chromatin interactions (green). A Venn diagram at the bottom compares these prioritized genes against 116 previously reported genes, identifying 70 known candidates and 330 novel candidates.

Fig. 3

Regional plot of the locus 16q.12.2 of BMI GWAS. a Extended region of the FTO locus, which includes prioritized genes RBL2 and IRX3. Genes prioritized by FUMA are highlighted in red. b Zoomed in regional plot of FTO locus with, from the top, GWAS P-value (SNPs are colored based on r 2), CADD score, RequlomeDB score and eQTL P-value. Non-GWAS-tagged SNPs are shown at the top of the plot as rectangles since they do not have a P-value from the GWAS, but they are in LD with the lead SNP. eQTLs are plotted per gene and colored based on tissue types. In the plots of CADD score, RegulomeDB score and eQTLs, SNPs which are not mapped to any gene are colored gray

LLM interpretation

This figure presents regional plots of the 16q.12.2 locus associated with BMI. Panel **a** shows two Manhattan plots (extended and zoomed) mapping GWAS P-values against chromosome 16 coordinates, with SNPs colored by linkage disequilibrium ($r^2$) to the lead SNP and prioritized genes (e.g., *FTO*, *IRX3*, *RBL2*) highlighted. Panel **b** provides a zoomed-in multi-track visualization showing CADD scores, RegulomeDB scores, and eQTL P-values across various GTEx tissues for the same genomic region.

Fig. 4

Chromatin interactions and eQTLs of BMI risk loci on chr. 16. The most outer layer is the Manhattan plot displaying SNPs with P-value < 0.05. Candidate SNPs are colored based on the highest r 2 to one of the independent significant loci (red: r 2 > 0.8, orange: r 2 > 0.6). Other SNPs are colored in gray. rsID of top SNPs per locus are labeled. The outer circle is the chromosome coordinate and genomic risk loci are highlighted in blue. Genes mapped by either Hi-C or eQTLs are shown on the inner circle. Genes mapped by Hi-C, eQTLs are colored orange and green, respectively. Genes mapped by both are colored red. Chromatin interaction and eQTLs are shown as links colored orange and green respectively

LLM interpretation

This is a Circos plot illustrating chromatin interactions and eQTLs for BMI risk loci on chromosome 16. The outermost ring is a Manhattan plot showing significant SNPs, with top SNPs labeled by rsID and genomic risk loci highlighted in blue on the coordinate circle. The inner circle displays target genes, with links colored orange for Hi-C interactions and green for eQTLs, while genes mapped by both methods are colored red.

#	Section	Preview
0	Introduction	In the past decade, more than 2500 genome-wide association studies (GWAS) have identified thousands…
1	Introduction	by multiple correlated SNPs, and may cover multiple closely located genes. Some of these genes may…
2	Introduction	If none of these tested SNPs and none of the other (not tested but known) SNPs in LD with the lead…
3	Introduction	In practice, the extraction and interpretation of the relevant biological information from available…
4	Introduction	and figures containing extensive information on, e.g., functionality of SNPs in genomic risk loci,…
5	Results — Overview of FUMA web application	FUMA incorporates 18 biological data repositories and tools to process GWAS summary statistics and…
6	Results — Overview of FUMA web application	The core function of FUMA is the SNP2GENE process (Fig.1) in which SNPs are annotated with their…
7	Results — Overview of FUMA web application	Functionally annotated SNPs are subsequently mapped to genes based on functional consequences on…
8	Results — Overview of FUMA web application	SNPs in LD of independent significant SNPs will not be prioritized by FUMA. eQTL mapping is used to…
9	Results — Overview of FUMA web application	contains Hi-C data of 14 tissue types and seven cell lines from the study of Schmitt et al.11, yet…
10	Results — Overview of FUMA web application	For each of these three mapping strategies, additional filtering of SNPs based on functional…
11	Results — Overview of FUMA web application	The three mapping strategies (positional, eQTL and chromatin interaction mapping) result in a set of…
12	Results — Overview of FUMA web application	To obtain insight into putative biological mechanisms of prioritized genes, the GENE2FUNC process…
13	Results — Overview of FUMA web application	The results of SNP2GENE and GENE2FUNC processes are displayed as either interactive tables or plots…
14	Results — FUMA covers various features of existing tools	As a variety of bioinformatics tools have been developed to obtain insights in GWAS results23–25,…
15	Results — FUMA covers various features of existing tools	LD calculation is the first step to characterize risk loci of GWAS by computing population specific…
16	Results — FUMA covers various features of existing tools	Variant Annotation is required to obtain information on biological consequences of SNPs in the risk…
17	Results — FUMA covers various features of existing tools	Gene-based test/gene-set analyses are methods that enable to summarize SNP associations at the gene…
18	Results — FUMA covers various features of existing tools	Visualization is one of the essential features that allows (quick) insights into the GWAS results,…
19	Results — FUMA covers various features of existing tools	The current lack of a single platform that integrates all possible resources for post-GWAS…

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Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies.	Koch E et al.	—	2026	→
Genome-wide meta-analysis identifies genetic risk loci for mono- and polyneuropathies in 983 477 individuals.	Broberg M et al.	—	2026	→
Genome-wide meta-analysis with 2,206,440 individuals identifies 322 novel risk loci for obesity.	Gao R et al.	—	2026	→
Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome.	Moolhuijsen LME et al.	—	2026	→
Genomic and proteomic insights into hidradenitis suppurativa.	Argyropoulou M et al.	—	2026	→
Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block.	Wang T et al.	—	2026	→
Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture.	Lu C et al.	—	2026	→
Genomic structural equation modeling reveals shared genetic structure of cardiac function and structure-function association studies of CLCNKA mutations.	Li X et al.	—	2026	→
Genomic Study of Resilience to Posttraumatic Stress Disorder in the Million Veteran Program.	Overstreet C et al.	—	2026	→
GWASs of the Nasolabial Fold Identified Variants Related to Genes that Also Affect Facial Morphology.	Wang F et al.	—	2026	→
GxE in psychiatry - challenges and opportunities.	Berkers S et al.	—	2026	→
Hemispheric Asymmetry in the Genetic Overlap between Schizophrenia and White Matter Microstructure.	Zhang Y et al.	—	2026	→
Host control of persistent Epstein-Barr virus infection.	Schmidt A et al.	—	2026	→
Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and Mendelian randomization.	Rout M et al.	—	2026	→
Identification of overlapping genetic loci between inflammatory bowel disease and major depressive disorder.	Chang S et al.	—	2026	→
Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study.	Zhao G et al.	—	2026	→
Impacts of host genetics on gut microbiome composition in Alzheimer's disease.	Liu J et al.	—	2026	→
Independent association of leg-height ratio with 15 cardiometabolic diseases.	Zhao R et al.	—	2026	→
Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis.	Zhou J et al.	—	2026	→
Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases.	Ma Y et al.	—	2026	→
Integrative Analysis of Placental Methylomes Identifies Epigenetically Regulated Genes Implicated in Fetal Growth Restriction.	Bednarek-Jędrzejek M et al.	—	2026	→
Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications.	Wang S et al.	—	2026	→
Integrative genomics reveal genetic links of chronic cough with risk factors and brain regional volumes.	Lin Z et al.	—	2026	→
In Vivo Screen of Parkinson's Disease GWAS Risk Genes Identifies <i>ARIH2</i> as a Novel Regulator of α-Synuclein Toxicity in Dopaminergic Neurons.	Armakola M et al.	—	2026	→
KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.	Kamiza AB et al.	—	2026	→
Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations.	Lee S et al.	—	2026	→
Large-Scaled Proteomics Analysis for Glaucoma: Integrated Genetics, Multi-Omics, UK Biobank and Therapeutic Analysis.	Xu J et al.	—	2026	→
Large-Scale Facial Image Analysis and GWAS Unravel the Genetic Architecture of Facial Morphological Aging.	Shin JG et al.	—	2026	→
Large-scale genetic study identifies shared genetic regions between cerebrovascular and neurodegenerative diseases.	Khamkar AS et al.	—	2026	→
Leveraging ancestral recombination graphs for scalable mixed-model analysis of complex traits.	Zhu J et al.	—	2026	→
Longitudinal study on the association between salty food preference and obesity prevalence.	Bae JH et al.	—	2026	→
Mapping the genetically predicted associations of plasma metabolites with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization and transcriptome analysis.	Wang Q et al.	—	2026	→
Mapping the genetic landscape of suicide risk: Insights from genomic SEM.	Yao K et al.	—	2026	→
Mendelian randomization study of GLP-1R effects on ovarian cancer subtypes mediated by metabolic factors.	Liu J et al.	—	2026	→
Meta-analysis of genome-wide association studies of food allergy and IgE sensitization.	Maier L et al.	—	2026	→
Metabolomic aging clock predicts risk of different cardiovascular diseases in the UK Biobank.	You G et al.	—	2026	→
Molecular systems, human noncoding sequence variants, and blood pressure.	Qiu Q et al.	—	2026	→
MRI-based multi-organ clocks for healthy aging and disease assessment.	MULTI Consortium et al.	—	2026	→
Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.	Koller D et al.	—	2026	→
Multi-ancestry genome-wide association study and meta-analysis of lung function decline.	Patchen BK et al.	—	2026	→
Multi-omics integration reveals shared genetic architecture between metabolic markers and gray matter atrophy in Alzheimer's Disease.	Wang P et al.	—	2026	→
Multi-organ network of cardiometabolic disease-depression multimorbidity revealed by phenotypic and genetic analyses of MR images.	Wang J et al.	—	2026	→
Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis.	Liu M et al.	—	2026	→
Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients.	Goleva SB et al.	—	2026	→
Multi-trait genome-wide analysis identified risk loci and candidate drugs for heart failure.	Yu Z et al.	—	2026	→
Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk.	Poore HE et al.	—	2026	→
Multivariate genomic analysis elucidates the genetic architecture of shared components of burning mouth syndrome.	Lian Q et al.	—	2026	→
No Evidence that Genetically Predicted Circulating Retinol Is Protective for Skin Cancer.	Helder M et al.	—	2026	→
Optimizing colorectal cancer screening through polygenic risk score-based risk stratification: evidence from a population-based cohort and screening trial.	Chen H et al.	—	2026	→
Pharmacogenomics of antiepileptic drug mood stabilizer treatment response in bipolar disorder: A MoStGen Consortium study.	Ho AM et al.	—	2026	→
PheCode-guided multi-modal topic modeling of electronic health records improves disease incidence prediction and GWAS discovery from UK Biobank.	Yang Z et al.	—	2026	→
Placental gene expression signatures based on maternal parity.	Haizler-Cohen L et al.	—	2026	→
Pleiotropic gene mapping reveals shared immune regulatory hubs across 15 autoimmune diseases.	Jin Y et al.	—	2026	→
Polygenic Contribution to Sensorineural Hearing Loss Implicates Novel Risk Loci and Convergence with Congenital Hearing Loss Genes.	Clifford RE et al.	—	2026	→
Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders.	Antonyan L et al.	—	2026	→
Population- and haplotype-dependent variation around <i>TYR</i> rs1126809: An in silico study for melanoma risk research.	Balogh ÁÁ et al.	—	2026	→
Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.	Xue H et al.	—	2026	→
Precision Medicine Targets in Glymphatic System Dysfunction: A Genomic and Molecular Perspective.	Wang Q et al.	—	2026	→
Prediction and characterization of genetically regulated expression of asthma tissues from African-ancestry populations.	Slack SD et al.	—	2026	→
Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance.	Anastasi F et al.	—	2026	→
PYRAMA: an open-source tool for advanced meta-analysis of genome wide association studies.	Manios GA et al.	—	2026	→
Right and Left Atrial Dysfunction as Independent Cardiovascular Risk Factors: A UK Biobank Study.	Yogeswaran V et al.	—	2026	→
Shared genetic architecture and potential comorbid mechanisms between rheumatoid arthritis and idiopathic pulmonary fibrosis.	Yuan M et al.	—	2026	→
Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.	Hope S et al.	—	2026	→
Shared genetic architecture of obesity and gastroesophageal reflux disease.	Xiao L et al.	—	2026	→
Shared genetic architecture of psychiatric disorders and ocular diseases: Evidence from genome-wide analyses.	Zhang ZY et al.	—	2026	→
Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis.	Song J et al.	—	2026	→
Shared Genetic Basis Between Systemic Lupus Erythematosus and Inflammatory Bowel Disease in East Asian Ancestry: A Genome-Wide Cross-trait Analysis.	Mo X et al.	—	2026	→
Shared genetic etiology between specific phobia and other psychiatric disorders.	Ueda K et al.	—	2026	→
Shared Genetic Liability across Systems of Psychiatric and Physical Illness.	Lawrence JM et al.	—	2026	→
Shared genetic structure between COVID-19 and migraine: insights from large-scale genome-wide cross-trait analysis.	Wang X et al.	—	2026	→
Shared genetic underpinnings of gray matter volume alterations and metabolic traits in major depressive disorder.	Wu X et al.	—	2026	→
Shared latent genetic liability across fibromyalgia and psychiatric traits: Novel insights from genomic structural equation modeling.	Lin L et al.	—	2026	→
Sleep chart of biological ageing clocks in middle and late life.	MULTI Consortium et al.	—	2026	→
Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling.	Watson CJ et al.	—	2026	→
The anti-NMDAR1 antibodies and IL-17 signaling pathway shape NMDAR encephalitis.	Xu Z et al.	—	2026	→
The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.	Moberget T et al.	—	2026	→
The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study.	Armstrong RA et al.	—	2026	→
The genetic architecture of reproductive subtypes of depression in females.	Crestol A et al.	—	2026	→
The genetic landscape of human functional brain connectivity.	Maciel BA et al.	—	2026	→
The genetic relationships between post-traumatic stress disorder and its corresponding neural circuit structures.	Gong Q et al.	—	2026	→
The genetics of cannabis lifetime use.	Bright U et al.	—	2026	→
The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians.	Harris M et al.	—	2026	→
The power of genetics in decoding Sjögren's disease: current status and future development.	Radziszewski M et al.	—	2026	→
The shared genetic architecture underlying the autoimmune and cardiovascular disease: a multivariate genome-wide analysis.	Zhang J et al.	—	2026	→
Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.	Zhang CY et al.	—	2026	→
Trans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders.	Werwath KE et al.	—	2026	→
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.	Fernandez Garcia M et al.	—	2026	→
Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.	Khan Y et al.	—	2026	→
Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease.	Ma J et al.	—	2026	→
Turning heterogeneity of statistical epistasis networks to an advantage.	Duroux D et al.	—	2026	→
Uncovering novel biomarkers and drug targets for androgenetic alopecia via metabolite regulation and multi-tissue validation.	Yi S et al.	—	2026	→
Uncovering pleiotropic loci linking keratoconus and allergic diseases through integrative genomic analyses.	Li G et al.	—	2026	→
Uncovering polygenic and local genetic overlap between sarcopenia and Alzheimer's disease.	Ding K et al.	—	2026	→
Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses.	Han Y et al.	—	2026	→
Unraveling the genetic interplay and therapeutic potentials between major depressive disorder and metabolic syndrome: multi-ancestry and multi-trait genome-wide association analyses.	Feng Y et al.	—	2026	→
Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study.	Lin YJ et al.	—	2026	→
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.	Bocher O et al.	—	2026	→
Unveiling the glymphatic system's role in brain aging: A comprehensive biomarker and modifiable intervention target.	Fang Y et al.	—	2026	→
Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance.	Qiu S et al.	—	2026	→
Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders.	Qiu S et al.	—	2026	→
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma.	Saarentaus EC et al.	—	2025	→
A blood- and brain-based EWAS of smoking.	Chybowska AD et al.	—	2025	→
A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.	Sproviero D et al.	—	2025	→
A comparison of genome-wide association analyses of persistent symptoms after Lyme disease, fibromyalgia, and myalgic encephalomyelitis - chronic fatigue syndrome.	Hirsch AG et al.	—	2025	→
A comprehensive water buffalo pangenome reveals extensive structural variation linked to population-specific signatures of selection.	Arshad F et al.	—	2025	→
A computational reference for human genomics analysis in (poly)phenol research.	Treccani M et al.	—	2025	→
A contextual genomic perspective on physical activity and its relationship to health, well being and illness.	Galimberti M et al.	—	2025	→
A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration.	Yang H et al.	—	2025	→
Adaptive introgression in modern human circadian rhythm genes.	Kendall C et al.	—	2025	→
A genetically informed brain atlas for enhancing brain imaging genomics.	Bao J et al.	—	2025	→
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.	Smeland OB et al.	—	2025	→
A genome-wide association study for lifetime estrogen exposure identifies novel loci and polygenic signals in East Asian postmenopausal women.	Yuk M et al.	—	2025	→
A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.	Beyene MB et al.	—	2025	→
A genome-wide association study identifies a novel East Asian-specific locus for dementia with Lewy bodies in Japanese subjects.	Mitsumori R et al.	—	2025	→
A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration.	Oh K et al.	—	2025	→
A genome-wide association study identifies genetic variants associated with hip pain in the UK Biobank cohort (N = 221,127).	Pan Q et al.	—	2025	→
A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers.	Cabrera-Serrano AJ et al.	—	2025	→
A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women.	Erdogan-Yildirim Z et al.	—	2025	→
A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions.	Mhatre S et al.	—	2025	→
A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort.	Treccani M et al.	—	2025	→
A genome-wide association study of high-sensitivity C-reactive protein in a large Korean population highlights its genetic relationship with cholesterol metabolism.	Oh K et al.	—	2025	→
A genome-wide association study of imaging-defined atherosclerosis.	Gummesson A et al.	—	2025	→
A genome-wide meta-analysis reveals shared and population-specific variants for allergic sensitization.	Noguchi E et al.	—	2025	→
A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders.	Antonatos C et al.	—	2025	→
A GWAS of angiotensin-converting enzyme inhibitor-induced angioedema in a South African population.	Mugo JW et al.	—	2025	→
A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth.	Pathare ADS et al.	—	2025	→
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.	Nagarajan P et al.	—	2025	→
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.	Malone SG et al.	—	2025	→
A meta-analysis of genome-wide studies of resilience in the German population.	Herrera-Rivero M et al.	—	2025	→
A multi-ancestry genome-wide association study identifies novel candidate loci in the RARB gene associated with hypertensive disorders of pregnancy.	Mack JA et al.	—	2025	→
A multilayered genetic structure analysis between inflammatory bowel disease and bone density/osteoporosis.	Qin M et al.	—	2025	→
A multi-level exploration of the genetic basis between lung cancer and schizophrenia.	Wu L et al.	—	2025	→
A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GPR12 loci.	Ihejirika SA et al.	—	2025	→
A multilevel study on the genetic relationship between schizophrenia and inflammatory bowel disease.	Li C et al.	—	2025	→
Analysis of Genome-Wide Association Studies.	Gampawar P et al.	—	2025	→
Analysis of Genomic and Transcriptomic Data Revealed Key Genes and Processes in the Development of Major Depressive Disorder.	Ivanov SM et al.	—	2025	→
An evolutionary perspective on the genetics of anorexia nervosa.	Breton É et al.	—	2025	→
A one-shot, lossless algorithm for cross-cohort learning in mixed-outcomes analysis.	Li R et al.	—	2025	→
Archaic adaptive introgression in modern human reproductive genes.	Kendall C et al.	—	2025	→
A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex.	Dufournet A et al.	—	2025	→
Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes.	Kim S et al.	—	2025	→
Association of genetically predicted levels of circulating blood lipids with coronary artery disease incidence.	Manikpurage HD et al.	—	2025	→
Association of SULT2A1 Locus With Abiraterone Clearance in the Alliance A031201: Randomized Phase III Study of Enzalutamide Compared With Enzalutamide Plus Abiraterone for Metastatic Castration-Resistant Prostate Cancer.	Norton N et al.	—	2025	→
Associations between common genetic variants and income provide insights about the socio-economic health gradient.	Kweon H et al.	—	2025	→
Associations of plasma sex-related hormone and protein levels and alcohol dependence.	Ho AM et al.	—	2025	→
Associations of schizophrenia with arrhythmic disorders and electrocardiogram traits: genetic exploration of population samples.	Treur JL et al.	—	2025	→
A Systematic Investigation of the Common Genetic Architecture of Substance Use Traits and the Relationship with Mental Health.	Pasman JA et al.	—	2025	→
A systematic review of GWAS on CMR imaging traits: genetic insights into cardiovascular structure, function, and diseases.	Lakda S et al.	—	2025	→
Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.	Pujol Gualdo N et al.	—	2025	→
Atlas of Proteomic signatures of brain structure and its links to brain disorders.	Ren P et al.	—	2025	→
Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project.	Le H et al.	—	2025	→
Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project.	Le H et al.	—	2025	→
Autoimmune diseases and the risk and prognosis of latent autoimmune diabetes in adults.	Santoso C et al.	—	2025	→
A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population.	Ohyama N et al.	—	2025	→
Barrier genes are associated with preterm birth.	Chen KR et al.	—	2025	→
BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis.	Anterasian C et al.	—	2025	→
Beyond volume: Unraveling the genetics of human brain geometry.	Primus SA et al.	—	2025	→
Bidirectional genetic links between chronic obstructive pulmonary disease and frailty: Genome-wide association study insights.	Yan F et al.	—	2025	→
Bidirectional genetic overlap between psychiatric disorders and high-density lipoprotein cholesterol levels.	Li X et al.	—	2025	→
Blood Pressure Genetics in Han Taiwanese With Cross-Trait Analysis in East Asians: Insights Into Comorbidities, All-Cause Mortality, and Cardiovascular Mortality.	Lin YJ et al.	—	2025	→
Blunted cortisol as a biomarker of depression based on the attenuation hypothesis: A Mendelian randomization analysis using depression as exposure.	Chan II	—	2025	→
Brain-based gene expression and corresponding behavioural relevance of risk genes for broad antisocial behaviour.	Rokicki J et al.	—	2025	→
Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics.	MULTI Consortium et al.	—	2025	→
Brain insulin receptor gene network shapes risk for metabolic disease after early-life stress in women.	Jaramillo-Ospina AM et al.	—	2025	→
Brain morphology mediating the effects of common genetic risk variants on Alzheimer's disease.	Breddels EM et al.	—	2025	→
BreastSubtypeR: a unified R/Bioconductor package for intrinsic molecular subtyping in breast cancer research.	Yang Q et al.	—	2025	→
Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.	Guo H et al.	—	2025	→
BTS: a scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across >1000s of omics datasets.	Kuksa PP et al.	—	2025	→
Causal association between blood metabolites and head and neck cancer: butyrylcarnitine identified as an associated trait for cancer risk and progression.	Li Y et al.	—	2025	→
Causal association of immune-related genes with mouth ulcers: findings from summary-based Mendelian randomization and transcriptome-wide association analysis.	Shi M et al.	—	2025	→
Causal associations between gut microbiota and rheumatoid arthritis: A two-sample Mendelian randomization study.	Wei F et al.	—	2025	→
Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization.	Chen L et al.	—	2025	→
Causal Associations Between Remnant Cholesterol Levels and Atherosclerosis-Related Cardiometabolic Risk Factors: A Bidirectional Mendelian Randomization Analysis.	Ko YS et al.	—	2025	→
Causal correlation between gut microbiota and stable angina pectoris: a two-sample Mendelian randomisation study.	Zhou C et al.	—	2025	→
Causal Effects of Inflammatory Cytokines and Immune Cell Phenotypes on Spontaneous Abortion: Evidence From Mendelian Randomization.	Lin S et al.	—	2025	→
Causal relationship and shared genetic pathways between diabetic kidney disease and cognitive impairment: a Mendelian randomization study.	Yu K et al.	—	2025	→
Causal relationship between hippocampal subfield volume and alzheimer's disease: a mendelian randomization study.	Wan S et al.	—	2025	→
Causal relationship between tinnitus and 8 psychiatric phenotypes: a Mendelian randomization study.	Guo T et al.	—	2025	→
Cell-weighted polygenic risk scores are associated with β-amyloid and tau biomarkers in Alzheimer's disease.	Kumar A et al.	—	2025	→
Characterizing pleiotropy among bipolar disorder, schizophrenia, and major depression: a genome-wide cross-disorder meta-analysis.	Friligkou E et al.	—	2025	→
Childhood obesity influences mid-to-late life bone health through shared genetic architecture.	Xia M et al.	—	2025	→
Chromatin state origins of uterine leiomyoma.	Räisänen M et al.	—	2025	→
Chromosome X-wide common variant association study in autism spectrum disorder.	Mendes M et al.	—	2025	→
Chronic overlapping pain conditions and nociplastic pain.	Johnston KJA et al.	—	2025	→
Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis.	Tang L et al.	—	2025	→
Clinical Utility of Plasma GFAP and NEFL as Biomarkers for Dementia in the Community.	Li HY et al.	—	2025	→
Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study.	Güler M et al.	—	2025	→
Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction.	Xiong Z et al.	—	2025	→
Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD.	Zhong Y et al.	—	2025	→
Common genetic variation influencing the human lung imaging phenotypes.	Zhu M et al.	—	2025	→
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.	Lee DSM et al.	—	2025	→
Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex.	Schwaba T et al.	—	2025	→
Comprehensive and Site-Specific Characterization of Protein N-Glycosylation in AD Samples Reveals Its Potential Roles in Protein Aggregation and Synaptic Dysfunction.	Xu X et al.	—	2025	→
Comprehensive genome-wide analysis of retinal vessel caliber reveals microvascular-blood pressure pathways: advancing predictive, preventive, and personalized medicine.	Niu Y et al.	—	2025	→
Comprehensive Genome-Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases.	Jiang Y et al.	—	2025	→
Comprehensive Profiling of Genetic and Nongenetic Factors that Influence Skin Traits in Asian Women from 4 Countries.	Moon H et al.	—	2025	→
Contribution of copy number variations to education, socioeconomic status and cognition from a genome-wide study of 305,401 subjects.	Wu XR et al.	—	2025	→
Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis.	Qiao J et al.	—	2025	→
COPD-associated proteins as biomarkers and drug targets: Insights from genetic and proteomic analyses.	Lin X et al.	—	2025	→
Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals.	Husami SF et al.	—	2025	→
Correcting for volunteer bias in GWAS increases SNP effect sizes and heritability estimates.	van Alten S et al.	—	2025	→
COVID-19 infection and longevity: an observational and mendelian randomization study.	Qiu S et al.	—	2025	→
Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression.	Li Y et al.	—	2025	→
Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.	Luo Y et al.	—	2025	→
Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates.	Liu Y et al.	—	2025	→
Cross-Trait Genome-Wide Association Study Identifies Shared Genetic Risk Loci Between COPD and Five Autoimmune Diseases.	Wen H et al.	—	2025	→
Cross-trait multivariate GWAS confirms health implications of pubertal timing.	Zhou S et al.	—	2025	→
CXCL12 drives natural variation in coronary artery anatomy across diverse populations.	Rios Coronado PE et al.	—	2025	→
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.	Pottier C et al.	—	2025	→
Deciphering genetic adaptations of Old World camels through comparative genomic analyses across all camelid species.	Guo X et al.	—	2025	→
Deciphering the influence of socioeconomic status on brain structure: insights from Mendelian randomization.	Xia C et al.	—	2025	→
Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density.	Zhou J et al.	—	2025	→
Decoding the genetic architecture of women reproductive aging: multi-omic integration identifies novel loci and mechanistic pathways for precision intervention.	Kang YF et al.	—	2025	→
Decomposing the genetic background of chronic back pain.	Elgaeva EE et al.	—	2025	→
Deep adversarial learning identifies ADHD-specific associations between apoptotic genes and white matter microstructure in frontal-striatum-cerebellum circuit.	Zhao Y et al.	—	2025	→
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank.	Xu W et al.	—	2025	→
Deleterious variants in LTBP4 are associated with severe pediatric sepsis.	Qin Y et al.	—	2025	→
Detecting genetic interactions with visible neural networks.	van Hilten A et al.	—	2025	→
Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence.	Wu X et al.	—	2025	→
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations.	Liu JJ et al.	—	2025	→
Disentangling associations between complex traits and cell types with seismic.	Lai Q et al.	—	2025	→
Disentangling nature and nurture: Exploring the genetic background of depressive symptoms in the absence of recent stress exposure using a GWAS approach.	Erdelyi-Hamza B et al.	—	2025	→
Dissecting metabolic dysfunction- and alcohol-associated liver disease (MetALD) using proteomic and metabolomic profiles.	Liu J et al.	—	2025	→
Dissecting the causal association of periodontitis with biological aging and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis.	Cao Y et al.	—	2025	→
Dissecting the Genetic Architecture of Intracranial Aneurysms.	Adkar SS et al.	—	2025	→
Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.	Shao H et al.	—	2025	→
Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease.	Trenkwalder T et al.	—	2025	→
DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases.	Carbonneau M et al.	—	2025	→
Early lipid genetics: identification of common and rare genetic variants for lipid traits in Indian adolescents.	Nair JM et al.	—	2025	→
Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.	Beeche C et al.	—	2025	→
Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients.	Kang L et al.	—	2025	→
Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour.	Rocks D et al.	—	2025	→
Elucidating Regulatory Mechanisms of Genes Involved in Pathobiology of Sjögren's Disease: Immunostimulation Using a Cell Culture Model.	Kepple DD et al.	—	2025	→
Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study.	Sun F et al.	—	2025	→
Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS.	Goovaerts S et al.	—	2025	→
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis.	Wang L et al.	—	2025	→
Epigenome-wide DNA methylation profiling reveals risk genes for migraine and its subtypes.	Liu M et al.	—	2025	→
Epistasis regulates genetic control of cardiac hypertrophy.	Wang Q et al.	—	2025	→
Establishing a robust triangulation framework to explore the relationship between hearing loss and Parkinson's disease.	Zhang H et al.	—	2025	→
Examining the genetic relationship between Alzheimer's disease, schizophrenia and their shared risk factors using genomic structural equation modelling.	Almeida E Sousa I et al.	—	2025	→
Exome sequencing identifies genes for socioeconomic status in 350,770 individuals.	Wu XR et al.	—	2025	→
Exome sequencing identifies protein-coding variants associated with loneliness and social isolation.	Wang YX et al.	—	2025	→
Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons.	Worf K et al.	—	2025	→
Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights.	Wu X et al.	—	2025	→
Exploring bidirectional causal relationships between antibody-mediated immune responses to infectious agents and systemic lupus erythematosus through Mendelian randomization and meta-analyses.	Dai Z et al.	—	2025	→
Exploring genetic structures and shared sites between alcohol, cheese intake, and inflammatory bowel disease.	Huang Z et al.	—	2025	→
Exploring the association between systemic lupus erythematosus and osteonecrosis by Mendelian randomization analysis.	Qi B et al.	—	2025	→
Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses.	Yin Y et al.	—	2025	→
Exploring the early drivers of pain in Parkinson's disease.	Liu S et al.	—	2025	→
Exploring the genetic architecture of multiple long-term conditions using a genome-wide association study in the UK Biobank population.	Nair ATN et al.	—	2025	→
Exploring the genetic basis between inflammatory bowel disease and venous thromboembolism.	Wu Y et al.	—	2025	→
Exploring the genetic components and multi-omics sources of inflammatory bowel disease from the perspective of autoimmune disorders.	Wang Z et al.	—	2025	→
Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization.	Ding L et al.	—	2025	→
Exploring the genetic intersection of dried fruit intake and breast cancer risk: a multi-trait genomic analysis with epidemiological context.	Zou K et al.	—	2025	→
Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders.	Song Q et al.	—	2025	→
Exploring the Genetic Underpinnings of Diffusion Tensor Image Analysis Along the Perivascular Space: A Genome-Wide Correlation Study and Implications for Brain Health.	Wu J et al.	—	2025	→
Exploring the link between Di-2-ethylhexyl phthalate (DEHP) exposure and muscle mass: A systematic investigation utilizing NHANES data analysis, network toxicology and molecular docking approaches.	Hao JQ et al.	—	2025	→
Exploring the omnigenic architecture of selected complex traits.	Ratajczak F et al.	—	2025	→
Exploring the Role of Glycine Metabolism in Coronary Artery Disease: Insights from Human Genetics and Mouse Models.	Biswas S et al.	—	2025	→
Exploring the shared genetic architecture between testosterone traits and major depressive disorder.	Lu W et al.	—	2025	→
Exploring the shared genetic basis of attention-deficit/hyperactivity disorder and obstructive sleep apnea: A multi-omics analysis.	Huang Y et al.	—	2025	→
Exploring the toxicological mechanisms of atrazine in prostate cancer by network toxicology and molecular docking.	Mi J et al.	—	2025	→
Father's adolescent body silhouette is associated with offspring asthma, lung function and BMI through DNA methylation.	Kitaba NT et al.	—	2025	→
Fine-Mapping the Results From Genome-Wide Association Studies of Primary Biliary Cholangitis Using SuSiE and h2-D2.	Gjoka A et al.	—	2025	→
FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries.	Wonkam A et al.	—	2025	→
From Genome-Wide SNPs to Neuroimmune Crosstalk: Mapping the Genetic Landscape of IBD and Its Brain Overlap.	Tripathi U et al.	—	2025	→
From single nucleotide variations to genes: identifying the genetic links between sleep and psychiatric disorders.	Jia N et al.	—	2025	→
Functional Annotation of Bipolar Disorder 2 Risk Location Implicates Novel Susceptibility Genes.	Can GŞ et al.	—	2025	→
Functional impairment in COPD can be predicted using genomic-derived data.	Marçalo R et al.	—	2025	→
Functional variant at 19q13.3 confers nonsyndromic cleft palate susceptibility by regulating <i>HIF3A</i>.	Lou S et al.	—	2025	→
Gastroesophageal reflux disease increases predisposition to severe COVID-19: Insights from integrated Mendelian randomization and genetic analysis.	Pan J et al.	—	2025	→
Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.	Dang X et al.	—	2025	→
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study.	Reitz J et al.	—	2025	→
Genetically supported targets and drug repurposing for brain aging: A systematic study in the UK Biobank.	Yi F et al.	—	2025	→
Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.	Jordà P et al.	—	2025	→
Genetic Analysis of the X Chromosome Associates Loci with Progression of Parkinson's Disease.	Liao Y et al.	—	2025	→
Genetic and neural mechanisms shared by schizophrenia and depression.	Xie Y et al.	—	2025	→
Genetic approach uncovering the pathways between childhood maltreatment and suicide attempt.	Qu D et al.	—	2025	→
Genetic architecture and mechanisms shared between kidney and ureteral stones, cardiovascular diseases, and metabolic syndrome: A comprehensive GWAS analysis.	Hua Y et al.	—	2025	→
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.	Wu Z et al.	—	2025	→
Genetic architecture of gastric adenocarcinoma in West Asia.	Latifi-Navid S et al.	—	2025	→
Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci.	Zhang M et al.	—	2025	→
Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.	Chen TT et al.	—	2025	→
Genetic association of attention-deficit/hyperactivity disorder with thirteen ocular disorders.	Chen XN et al.	—	2025	→
Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use.	Aliev F et al.	—	2025	→
Genetic associations of cholelithiasis and biliary tract cancer.	Jiang Y et al.	—	2025	→
Genetic Associations of Clonal Hematopoiesis With Cardioembolic Stroke: Insights From Genome-Wide Mendelian Randomization, Bulk RNA, Single-Cell RNA Sequencing.	Tan H et al.	—	2025	→
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort.	Åkerlund M et al.	—	2025	→
Genetic associations with educational fields.	Cheesman R et al.	—	2025	→
Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts.	Bolier M et al.	—	2025	→
Genetic correlation and causation of craniofacial microsomia with 33 diseases in Asian populations: insights from large-scale genome-wide cross-trait analysis.	Luo P et al.	—	2025	→
Genetic Crosstalk Between Type 1 Diabetes and Sjögren's Syndrome: A Systematic Exploration of Risk Genes and Common Pathways.	Fahira A et al.	—	2025	→
Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue.	Ahmed A et al.	—	2025	→
Genetic determinants of monocyte splicing are enriched for disease susceptibility loci.	Nassiri I et al.	—	2025	→
Genetic differences in the HLA region contribute to the variability in SARS-CoV-2 vaccine responsiveness of older persons: the Doetinchem Cohort Study.	Kuijpers Y et al.	—	2025	→
Genetic Distinctions Between Reticular Pseudodrusen and Drusen: A Genome-Wide Association Study.	Schwartz R et al.	—	2025	→
Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective.	Dack K et al.	—	2025	→
Genetic imputation of transcriptome and proteome illuminates novel therapeutic targets of cutaneous melanoma.	Xu Y et al.	—	2025	→
Genetic insights into CRP levels in Indian adolescents: confirming adult genetic associations.	Nair JM et al.	—	2025	→
Genetic insights into modifiable risk factors of stroke and their joint effects: A genome-wide pleiotropic analysis.	Yang Z et al.	—	2025	→
Genetic Insights Into the Interplay Between Aging and Kidney Health.	Wang Y et al.	—	2025	→
Genetic Insights of Image-Based Traits: Analysis Pipeline for AI-based Phenotyping, Combined-GWAS, and Federated Learning with Application to the Human Face	Liu X et al.	—	2025	—
Genetic Links between Gastrointestinal Disorders and Kidney Stone Disease: Insights from a Genome-Wide Cross-Trait Analysis.	Wang Y et al.	—	2025	→
Genetic links between multimorbidity and human aging.	Dinh PA et al.	—	2025	→
Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults.	Ceja Z et al.	—	2025	→
Genetic Markers of Postmortem Brain Iron.	Cornelis MC et al.	—	2025	→
Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design.	Li X et al.	—	2025	→
Genetic overlap between household income and psychiatric disorders.	Zhang J et al.	—	2025	→
Genetic overlap between schizophrenia and constipation: insights from a genome-wide association study in a European population.	Luo Q et al.	—	2025	→
Genetic Pleiotropy and Causal Pathways Linking Glycemic Traits to Asthma: An Integrated Proteogenomic Investigation.	Chen L et al.	—	2025	→
Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations.	Jiang X et al.	—	2025	→
Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism.	Tan H et al.	—	2025	→
Genetic proxies for clinical traits are associated with increased risk of severe COVID-19.	Chaddock NJM et al.	—	2025	→
Genetic relationship between epilepsy and mental disorders: A comprehensive GWAS analysis.	Abudusalamu R et al.	—	2025	→
Genetic relationship between Sjögren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis.	Zhou Y et al.	—	2025	→
Genetic risk and polygenic risk score assessment of prediabetes and progression to type 2 diabetes.	Aliyu U et al.	—	2025	→
Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data.	Gao C et al.	—	2025	→
Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.	Petrican R et al.	—	2025	→
Genetics of constant and severe pain in the NAPS2 cohort of recurrent acute and chronic pancreatitis patients.	Dunbar EK et al.	—	2025	→
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes.	Assary E et al.	—	2025	→
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.	Chami N et al.	—	2025	→
Genetic susceptibility and environmental risk factors in bladder cancer: Evidence from the UK biobank.	Bukavina L et al.	—	2025	→
Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population.	Cui Q et al.	—	2025	→
Genetic susceptibility to recurrent vulvovaginal candidiasis in an African population from Nairobi, Kenya.	Omosa-Manyonyi GS et al.	—	2025	→
Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity.	Wang X et al.	—	2025	→
Genetic variants associated with chronic postsurgical pain: evidence from the China Surgery and Anaesthesia Cohort study.	Song J et al.	—	2025	→
Genetic variants associated with gout identified through a genome-wide study in the UK biobank (N = 150 542).	Tao Y et al.	—	2025	→
Genetic variants associated with metabolic dysfunction-associated fatty liver diseases in a Korean population.	Park JH et al.	—	2025	→
Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis.	Inman K et al.	—	2025	→
Genome- and Exome-Wide Identification of Common-to-Rare Variants Associated with Middle Ear Cholesteatoma.	Qiu K et al.	—	2025	→
Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder.	Zhao Y et al.	—	2025	→
Genome topology analysis and transcriptomics of human osteoclasts reveals enhancer-promoter interactions at loci for bone traits and diseases.	Wilson SG et al.	—	2025	→
Genome-Wide 5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Analysis of Plasma Cell-Free DNA in Schizophrenia.	Xue G et al.	—	2025	→
Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.	Xiang R et al.	—	2025	→
Genome-wide analysis identifies novel shared loci between depression and white matter microstructure.	Zhao Q et al.	—	2025	→
Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health.	Jawinski P et al.	—	2025	→
Genome-wide analysis of screen behaviors among adolescents identifies novel loci and overlap with educational attainment and mental disorders.	Frei E et al.	—	2025	→
Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.	Ran L et al.	—	2025	→
Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome.	Aslam MM et al.	—	2025	→
Genome-Wide Association Analyses of HPV16 and HPV18 Seropositivity Identify Susceptibility Loci for Cervical Cancer.	Beckhaus T et al.	—	2025	→
Genome-wide association analysis of composite sleep health scores in 413,904 individuals.	Goodman MO et al.	—	2025	→
Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy.	Mori Y et al.	—	2025	→
Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets.	Ricci A et al.	—	2025	→
Genome-wide association meta-analyses of drug-resistant epilepsy.	Leu C et al.	—	2025	→
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry.	Gui A et al.	—	2025	→
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes.	van der Laan CM et al.	—	2025	→
Genome-wide association, single-cell, and spatial transcriptomics analyses reveal the role of the STK24-expressing positive cells in LUAD progression and the tumor microenvironment, identifying STK24 as a potential therapeutic target.	Liu J et al.	—	2025	→
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.	Jee YH et al.	—	2025	→
Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.	Sherva R et al.	—	2025	→
Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B.	Godrich D et al.	—	2025	→
Genome-wide association study and candidate gene identification for fall armyworm resistance in maize (Zea mays L.).	Wang T et al.	—	2025	→
Genome-wide association study and Mendelian randomization analyses reveal insights into bladder cancer etiology.	Larsson SC et al.	—	2025	→
Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.	Byun J et al.	—	2025	→
Genome-Wide Association Study for Resting Electrocardiogram in the Qatari Population Identifies 6 Novel Genes and Validates Novel Polygenic Risk Scores.	Khan N et al.	—	2025	→
Genome Wide Association Study (GWAS) Identifies Novel Genetic Loci for Second-Generation Antipsychotics (SGA)-Induced Metabolic Syndrome (MetS).	El Rouby N et al.	—	2025	→
Genome-wide association study identifies common variants associated with breast cancer in South African Black women.	Hayat M et al.	—	2025	→
Genome-wide association study identifies <i>ABCG1</i> as a susceptibility locus for tick-borne encephalitis.	Gampawar PG et al.	—	2025	→
Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank (<i>N</i> = 172,230).	Pan Q et al.	—	2025	→
Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.	Chebii VJ et al.	—	2025	→
Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders.	Strom NI et al.	—	2025	→
Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction.	Imtiaz MA et al.	—	2025	→
Genome-wide association study of chlamydia reinfection in African American women.	Tiwari HK et al.	—	2025	→
Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study.	Shinoda G et al.	—	2025	→
Genome-wide association study of common side effects following COVID-19 booster vaccination in a cohort of corporate employees in Japan.	Omae Y et al.	—	2025	→
Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program.	Raghavan S et al.	—	2025	→
Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits.	Toki R et al.	—	2025	→
Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics.	Andersson NW et al.	—	2025	→
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.	Hoffmann TJ et al.	—	2025	→
Genome-wide association study provides insights into the genetic basis of Lewy body dementia.	Zhu P et al.	—	2025	→
Genome-wide association study provides novel insight into the genetic architecture of severe obesity.	Krishnan M et al.	—	2025	→
Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy.	Gurung RL et al.	—	2025	→
Genome-wide association study unravels mechanisms of brain glymphatic activity.	Huang SY et al.	—	2025	→
Genome-wide associations with metabolic syndrome among UK Biobank participants reporting use of second-generation antipsychotics.	Rouby NE et al.	—	2025	→
Genome-wide by trait interaction analyses with neuroticism reveal chronic pain-associated depression as a distinct genetic subtype.	Krause S et al.	—	2025	→
Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.	Valo E et al.	—	2025	→
Genome-Wide Cross-Trait Analysis in European Populations Reveals Shared Genetic Architecture of Chronic Obstructive Pulmonary Disease and the Allergy Spectrum.	Bu L et al.	—	2025	→
Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources.	Pilalis E et al.	—	2025	→
Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure.	Shraim R et al.	—	2025	→
Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density.	Lei B et al.	—	2025	→
Genome-wide interaction association analysis identifies interactive effects of childhood maltreatment and kynurenine pathway on depression.	Sun Y et al.	—	2025	→
Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.	Kim J et al.	—	2025	→
Genome-Wide Pleiotropy Analysis Identifies Shared and Opposing Pathways Influencing Coronary Artery Disease and Cancer.	Yarmolinsky J et al.	—	2025	→
Genome-wide Pleiotropy Analysis Reveals Shared Genetic Associations between Type 2 Diabetes Mellitus and Subcortical Brain Volumes.	Zhao Q et al.	—	2025	→
Genome-wide study links cardiometabolic factors to cognition via APOA4-APOA5-ZPR1-BUD13 and other loci in rural Indians.	Chakraborty S et al.	—	2025	→
Genomic correlation, shared loci, and causal association between obesity, periodontitis and tooth loss.	Chen L et al.	—	2025	→
Genomic correlation, shared loci, and causal link between obesity and diabetic microvascular complications: A genome-wide pleiotropic analysis.	Zhang W et al.	—	2025	→
Genomic Correlations, Shared Loci, and Drug Targets Between Polycystic Ovary Syndrome and Asthma: Insights From Genome-wide Association Analysis.	Ji E et al.	—	2025	→
Genomic data-driven framework for drug target discovery in atrial fibrillation.	Tao Y et al.	—	2025	→
Genomic determinants of biological age estimated by deep learning applied to retinal images.	Huang Y et al.	—	2025	→
GenomicSEM Modelling of Diverse Executive Function GWAS Improves Gene Discovery.	Perry LC et al.	—	2025	→
Genomic structural equation Modeling analysis of glaucoma Endophenotypes: investigating genetic architecture and non-intraocular pressure mechanisms.	Marzban M et al.	—	2025	→
Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk.	Zhou Y et al.	—	2025	→
Genomic structural equation modeling uncovers novel risk loci for bone metabolic disorders: cross-tissue genetic mechanisms and bone-brain axis regulation.	Zhou Y et al.	—	2025	→
Global and Sex-Stratified Genome-Wide Association Study of Long COVID Based on Patient-Driven Symptom Recall.	Polo-Alonso S et al.	—	2025	→
Gut Microbiota and White Matter Integrity: A Two-Sample Mendelian Randomization Analysis.	Zhang L et al.	—	2025	→
GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.	Sun Y et al.	—	2025	→
GWAS by Subtraction to Disentangle RBD Genetic Background from α-Synucleinopathies.	Gaudio A et al.	—	2025	→
GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis.	Yuan S et al.	—	2025	→
GWAS Meta-Analysis Identifies Susceptibility Loci for Keloids and Hypertrophic Scarring in Europeans.	Dand N et al.	—	2025	→
GWAS study of myelosuppression among NSCLC patients receiving platinum-based combination chemotherapy.	Huang H et al.	—	2025	→
HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement.	Farashi S et al.	—	2025	→
Identification of Alzheimer's disease susceptibility genes by integrating eight human brain single-cell transcriptomes with genome-wide association studies.	He Y et al.	—	2025	→
Identification of biomarkers for endometriosis based on summary-data-based Mendelian randomization and machine learning.	Xie Z et al.	—	2025	→
Identification of blood eQTLs in older adults.	Toyin A et al.	—	2025	→
Identification of causal plasma proteins and targeted therapy for primary hepatic carcinoma via proteome-wide Mendelian randomization.	Wang H et al.	—	2025	→
Identification of clinically meaningful, overlapping obstructive respiratory disease subtypes via data-driven approaches in a primary care population.	Pikoula M et al.	—	2025	→
Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women.	Dabbs-Brown A et al.	—	2025	→
Identification of genetic architecture shared between schizophrenia and Alzheimer's disease.	Liu H et al.	—	2025	→
Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity.	Kwon SA et al.	—	2025	→
Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study.	Yun D et al.	—	2025	→
Identification of potential drug targets for pelvic organ prolapse using a proteome-wide Mendelian randomization approach.	Xie Z et al.	—	2025	→
Identification of potential therapeutic targets for problematic alcohol use using multi-omics data.	Lee DJ et al.	—	2025	→
Identification of therapeutic targets for psoriatic arthritis through proteomics.	Zhang F et al.	—	2025	→
Identifying common genetic etiologies between iridocyclitis and related immune-mediated diseases.	Liu Z et al.	—	2025	→
Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues.	Peng S et al.	—	2025	→
Identifying Four Obesity Axes Through Integrative Multiomics and Imaging Analysis.	Odoemelam CS et al.	—	2025	→
[Identifying genetic etiology of ischemic stroke based on pleiotropy of obesity related genes: A sibling study].	Wang K et al.	—	2025	→
Identifying genetic variants associated with sugar intake and appraising the genetic correlations with cardiovascular outcomes.	Janzi S et al.	—	2025	→
Identifying Therapeutic Targets for Amyotrophic Lateral Sclerosis Through Modeling of Multi-Omics Data.	Blaudin de Thé FX et al.	—	2025	→
Immune-Developmental Processes Contribute to Schizophrenia Risk: Insights From a Genetic Overlap Study With Height.	Romero C et al.	—	2025	→
Immune DNA methylation in depression: cross-sectional and longitudinal study.	Herrera-Rivero M et al.	—	2025	→
Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk.	Liang Q et al.	—	2025	→
Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study.	Ota VK et al.	—	2025	→
Improving genetic variant identification for quantitative traits using ensemble learning-based approaches.	Sharma J et al.	—	2025	→
Insights from a methylome-wide association study of antidepressant exposure.	Davyson E et al.	—	2025	→
Insights Into Chronic Low Back Pain Etiology: Population-Based Genome-Wide Association Study Identifies 18 Risk Loci.	Martinsen AE et al.	—	2025	→
Integrated Genomic Approaches to Elucidate the Genetic Basis of Brugada Syndrome in Taiwanese Patients.	Goswami C et al.	—	2025	→
Integrated Multi-Omics Analysis and Cross-Model Validation Reveal Mitochondrial Signatures in Alzheimer's Disease.	Xu X et al.	—	2025	→
Integrating a multi-omics strategy framework to screen potential targets in cognitive impairment-related epilepsy.	Xu C et al.	—	2025	→
Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects.	Yao K et al.	—	2025	→
Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS meta-analysis, biological network construction, and structural modeling.	Sagulkoo P et al.	—	2025	→
Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk.	Ketkar S et al.	—	2025	→
Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential.	Chen H et al.	—	2025	→
Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes.	Du Y et al.	—	2025	→
Integrative genome-wide association studies, proteome-wide Mendelian randomization, and single-cell RNA sequencing identify interleukin-6 receptor protein as a therapeutic target in aortic aneurysm.	Bai Z et al.	—	2025	→
Integrative Genomics Refines Tissues, Candidate Genes and Putative Regulatory Links Involved in the Humic Adaptation of Keystone Freshwater Fish.	Ozerov MY et al.	—	2025	→
Integrative GWAS and Mendelian randomization study of rheumatoid arthritis based on the 2019 UK Biobank questionnaire.	Cai T et al.	—	2025	→
Integrative neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder.	Dias HD et al.	—	2025	→
Integrative proteo-metabolomic analysis in rheumatoid arthritis reveals potential therapeutic targets: Harnessing Mendelian randomization.	Almars AI et al.	—	2025	→
Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression.	Torok D et al.	—	2025	→
Intricate interactions between fine-scale genetic structure, lifestyle, and dietary habits in the Japanese population.	Chen Y et al.	—	2025	→
Investigating associations between JAK inhibition and venous thromboembolism by systematic mining of large-scale datasets.	Haysen SR et al.	—	2025	→
Investigating shared risk variants and genetic etiology between Alzheimer's disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis.	Dang W et al.	—	2025	→
Investigating the causal and genetic relationship between migraine and Parkinson's disease.	Deng MG et al.	—	2025	→
Investigating the common genetic architecture and causality of metabolic disorders with neurodegenerative diseases.	Hong H et al.	—	2025	→
Investigating the common genetic basis between inflammatory bowel disease and metabolic syndrome through genomic structural equation modeling.	Shen P et al.	—	2025	→
Investigating the Relationships Between Neurodegenerative Diseases and Cancer Types: A Computational Approach.	Cava C et al.	—	2025	→
Investigating the shared genetic architecture between anxiety and stroke.	Zhang Y et al.	—	2025	→
Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis.	Yuan L et al.	—	2025	→
Investigating the shared genetic architecture between post-traumatic stress disorder and neurodegenerative diseases: a large-scale genomewide cross-trait analysis.	Shi Y et al.	—	2025	→
Investigating the shared genetic architecture between schizophrenia and sex hormone traits.	He X et al.	—	2025	→
Investigating the shared genetic structure between rheumatoid arthritis and stroke.	Qin Q et al.	—	2025	→
Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics.	Liu J et al.	—	2025	→
Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.	Zhu Z et al.	—	2025	→
Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.	Gurholt TP et al.	—	2025	→
Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals.	Wu XR et al.	—	2025	→
Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.	Tadros R et al.	—	2025	→
Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors.	Ao L et al.	—	2025	→
Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.	Zhu Z et al.	—	2025	→
Large-Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain.	Li ZY et al.	—	2025	→
Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer.	Hoppe R et al.	—	2025	→
Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA.	Abdellaoui A et al.	—	2025	→
Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort.	Mihov M et al.	—	2025	→
Linking genomic and proteomic signatures to brain amyloid burden: insights from GR@ACE/DEGESCO.	Puerta R et al.	—	2025	→
Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.	Sorlí JV et al.	—	2025	→
Liver Enzyme Genetics and Health Conditions in East Asians: Genetic Architecture and Causal Insights.	Lin YJ et al.	—	2025	→
Local ancestry-informed GWAS of warfarin dose requirement in African Americans identifies a CYP2C19 splicing QTL.	Singh A et al.	—	2025	→
Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease.	Ray NR et al.	—	2025	→
Local genetic sex differences in quantitative traits.	Uffelmann E et al.	—	2025	→
Local patterns of genetic sharing between neuropsychiatric and insulin resistance-related conditions.	Fanelli G et al.	—	2025	→
Lower expression of <i>BIN1's</i> neuronal isoform in vulnerable excitatory neurons increases risk in Alzheimer's disease.	Ranganathan R et al.	—	2025	→
<i>APOE</i> Genotype-Stratified Meta-Analysis of Cognitive Decline Reveals Novel Loci for Language and Global Cognitive Function in Older Adults.	Acharya V et al.	—	2025	→
<i>CARINH</i>, an Interferon-Induced LncRNA in Cancer and Inflammation.	Gourvest M et al.	—	2025	→
M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits.	Ochoa S et al.	—	2025	→
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology.	Rajesh AE et al.	—	2025	→
Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain health.	Yi F et al.	—	2025	→
Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development.	Zhu JD et al.	—	2025	→
Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune Response.	Chen J et al.	—	2025	→
Mapping rare protein-coding variants on multi-organ imaging traits.	Fan Y et al.	—	2025	→
Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies.	Fominykh V et al.	—	2025	→
Mapping the landscape of childhood obesity: genomic insights and socioeconomic status in Indian school-going children.	Nair JM et al.	—	2025	→
Maternal Smoking During Pregnancy Interacts With Genetic Factors to Increase Risk for Low Birth Weight but Not Harmful Offspring Smoking Behaviors in Europeans.	Romero Villela PN et al.	—	2025	→
Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI.	Fürtjes AE et al.	—	2025	→
Mechanistic Insights into Drug-Induced Guillain-Barré Syndrome: A Large-Cohort Analysis of the FAERS Database.	Gui J et al.	—	2025	→
Mendelian randomization analysis of gut microbiota and chronic kidney disease: Implications for herbal interventions.	Hu X et al.	—	2025	→
Mendelian randomization and genetic pleiotropy analysis for the connection between inflammatory bowel disease and Alzheimer's disease.	Wu Y et al.	—	2025	→
Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity.	Villaplana-Velasco A et al.	—	2025	→
Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.	Sadhu N et al.	—	2025	→
Missing Regulation Between Genetic Association and Transcriptional Abundance for Hypercholesterolemia Genes.	Hakim A et al.	—	2025	→
Molecular Signatures of Early-Onset Bipolar Disorder and Schizophrenia: Transcriptomic and Machine-Learning Insights into Calcium and cAMP Signaling, Including Sex-Specific Patterns.	Afjeh SS et al.	—	2025	→
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.	Johnson EC et al.	—	2025	→
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.	Bentley AR et al.	—	2025	→
Multi-ancestry genome-wide association meta-analysis identifies novel associations and informs genetic risk prediction for Hirschsprung disease.	Zhong Y et al.	—	2025	→
Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response.	Davis CN et al.	—	2025	→
Multiancestry Genome-Wide Association Study of Early Childhood Caries.	Shrestha P et al.	—	2025	→
Multi-ancestry genome-wide association study of topiramate's effects on heavy alcohol use.	Davis CN et al.	—	2025	→
Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.	Zhang M et al.	—	2025	→
Multi-ancestry investigation of the genomics of erectile dysfunction.	Bright U et al.	—	2025	→
Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain.	Stanaway IB et al.	—	2025	→
Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.	Greene CA et al.	—	2025	→
Multi-omic dissection of clinically diagnosed and self-reported major depressive disorder reveals phenotype-specific genetic and proteomic architecture in East Asian populations.	Wang W et al.	—	2025	→
Multiomics analysis demonstrated a strong correlation between lipid-mediated chronic kidney disease and stroke: Potential benefits of affected patient cohorts.	Liu YS et al.	—	2025	→
Multi-omics Analysis of Energy Metabolism Pathways Across Major Psychiatric Disorders.	Zou S et al.	—	2025	→
Multiomics Analysis of the Molecular Response to Glucocorticoids: Insights Into Shared Genetic Risk From Psychiatric to Medical Disorders.	Knauer-Arloth J et al.	—	2025	→
Multi-omics and comprehensive multi-trait analysis identify shared genetic etiology of heart failure and related cancers.	Shui W et al.	—	2025	→
Multi-omic spatial effects on high-resolution AI-derived retinal thickness.	Jackson VE et al.	—	2025	→
Multi-omics profiling uncovers paradoxical Epstein-Barr virus involvement in autoimmune liver disease pathogenesis.	Zheng L et al.	—	2025	→
Multi-omic underpinnings of heterogeneous aging across multiple organ systems.	Xiong J et al.	—	2025	→
Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk.	MULTI consortium et al.	—	2025	→
Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer's disease.	Fu M et al.	—	2025	→
Multitrait GWAS of non-suicidal self-injury and the polygenetic effects on child psychopathology and brain structures.	Sun Y et al.	—	2025	→
Multivariate genetic architecture of poor sleep quality.	Wang Q et al.	—	2025	→
Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health.	Ye C et al.	—	2025	→
Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities.	Chen H et al.	—	2025	→
Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery.	Mountford HS et al.	—	2025	→
Neural-genetic-environmental evidence for a disease factor in mental and physical health multimorbidity.	Chen J et al.	—	2025	→
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders.	Wen J et al.	—	2025	→
Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle.	Jin Y et al.	—	2025	→
New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping.	Lu C et al.	—	2025	→
New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma.	Wang Y et al.	—	2025	→
No causal links between estradiol and female's brain and mental health using Mendelian randomization.	Oppenheimer H et al.	—	2025	→
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.	Bradley J et al.	—	2025	→
Novel Genes Associated With Working Memory Are Identified by Combining Connectome, Transcriptome, and Genome.	Zhao X et al.	—	2025	→
Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index.	Park K et al.	—	2025	→
Novel Insights Into the Genetic Basis Between Cholelithiasis and Four Dietary Patterns.	Zheng E et al.	—	2025	→
Novel polygenic risk score associates with diverticulitis in a multi-institutional, ancestrally diverse cohort.	Neylan CJ et al.	—	2025	→
Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD.	Wilson AC et al.	—	2025	→
O-GalNAc glycans are enriched in neuronal tracts and regulate nodes of Ranvier.	Noel M et al.	—	2025	→
Pharmacogenomics and Pharmacokinetics of Aspirin in Preeclampsia Prevention.	Tlaye KG et al.	—	2025	→
Pharmacologic and genetic evidence converge on mechanisms of psychotic illness.	Fennessy B et al.	—	2025	→
Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations.	Soremekun C et al.	—	2025	→
Plasma circulating microRNAs and symptoms of depression: Results from a population-based study.	Kuilman MM et al.	—	2025	→
Plasma Protein Biomarkers of Spirometry Measures of Impaired Lung Function.	Aggarwal M et al.	—	2025	→
Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers.	van der Meer D et al.	—	2025	→
Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis.	Koch E et al.	—	2025	→
Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank.	Akimova ET et al.	—	2025	→
Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis.	Antonatos C et al.	—	2025	→
Population screening of adults identifies novel genetic variants associated with celiac disease.	Alam MS et al.	—	2025	→
Possible linking and treatment between Parkinson's disease and inflammatory bowel disease: a study of Mendelian randomization based on gut-brain axis.	Wang B et al.	—	2025	→
Post-genome-wide association study dissects genetic vulnerability and risk gene expression of Sjögren's disease for cardiovascular disease.	Yi X et al.	—	2025	→
Prioritizing effector genes at trait-associated loci using multimodal evidence.	Schipper M et al.	—	2025	→
Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer.	Mahmud AKMF et al.	—	2025	→
Proteogenomic signature of Alzheimer's disease and related dementia risk in individuals with major depressive disorder.	Diniz BS et al.	—	2025	→
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.	Caro I et al.	—	2025	→
Proteome-Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy.	Gui J et al.	—	2025	→
Proteome-wide mendelian randomization identifies FCRL3 and LY9 as potential therapeutic targets for lymphoma.	Guo Q et al.	—	2025	→
Proteome-wide mendelian randomization reveals circulating proteins causally associated with childhood body mass index.	Avocegamou R et al.	—	2025	→
Proteomic insights into chronic pancreatitis: Proteome-wide mendelian randomization to identify potential therapeutic targets.	Li Q et al.	—	2025	→
Proteomic landscape of multidimensional aging phenotypes.	Cao Z et al.	—	2025	→
PTPRD pleiotropy, genetically driven childbirth timing, and corpus callosum microstructure as potential mechanisms underlying ADHD-RLS comorbidity.	Li FJ et al.	—	2025	→
Realizing the promise of genome-wide association studies for effector gene prediction.	Costanzo MC et al.	—	2025	→
Recent Advances in Experimental Functional Characterization of GWAS Candidate Genes in Osteoporosis.	Malavašič P et al.	—	2025	→
Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks.	Wen J	—	2025	→
Regulatory polymorphisms of <i>MSH6</i>, <i>MSH2</i>, <i>FBXO11,</i> and <i>PPP1R21</i> genes affect survival of patients with immunotherapy-treated lung cancer.	Esposito M et al.	—	2025	→
Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location.	Wills C et al.	—	2025	→
Revealing the genetic and immunological crosstalk between SLE and ccRCC: An integrative genomic analysis approach.	Lin F et al.	—	2025	→
Role of ferroptosis-related IREB2 in the shared genetic etiology between smoking and facial aging: Insights from large-scale genome-wide cross-trait analysis.	Cai X et al.	—	2025	→
rs762855 single nucleotide polymorphism modulates the risk for diffuse-type gastric cancer in females: a genome-wide association study in the Korean population.	Park K et al.	—	2025	→
Sarcopenia and cognitive impairment: a multidimensional study of clinical associations, shared genetics, and causal links.	Zhang K et al.	—	2025	→
Several Common Genetic Variations Associate With Functional or Anatomic Effects of Anti-VEGF Treatment in Conditions With Macular Edema.	Klaassen I et al.	—	2025	→
Sex dependent genetic architecture of biochemically verified tobacco use.	Chenoweth MJ et al.	—	2025	→
Sex-differentiated placental methylation and gene expression regulation has implications for neonatal traits and adult diseases.	Tekola-Ayele F et al.	—	2025	→
Sex-stratified genome-wide association meta-analysis of major depressive disorder.	Thomas JT et al.	—	2025	→
Sex-stratified genome-wide meta-analysis identifies novel loci for cognitive decline in older adults.	Acharya V et al.	—	2025	→
Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus.	Guo X et al.	—	2025	→
Shared genetic architecture and causal relationship between frailty and schizophrenia.	Deng MG et al.	—	2025	→
Shared genetic architecture between anxiety, depression and erectile dysfunction: a genome-wide cross-trait analysis.	Xie L et al.	—	2025	→
Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases.	Lazanas P et al.	—	2025	→
Shared genetic architecture between grip strength and cognitive function: insights from large-scale genome-wide cross-trait analysis.	Liu H et al.	—	2025	→
Shared genetic architecture between leukocyte telomere length and Alzheimer's disease.	Cao Z et al.	—	2025	→
Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis.	Li G et al.	—	2025	→
Shared genetic architecture between stroke and blood lipids: a large-scale genome-wide cross-trait analysis.	Bai W et al.	—	2025	→
Shared genetic architecture contributes to risk of major cardiovascular diseases.	Qiao J et al.	—	2025	→
Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes.	Liu W et al.	—	2025	→
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.	Shen J et al.	—	2025	→
Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.	Dou C et al.	—	2025	→
Shared Genetic Links Between Birth Weight and Developmental-Behavioral Disorders.	Sun R et al.	—	2025	→
Shared genetics and causal relationship between sociability and the brain's default mode network.	Fanelli G et al.	—	2025	→
Shared genetics between metabolic traits and sensorineural hearing loss: a large-scale genome-wide cross-trait analysis.	Wang X et al.	—	2025	→
Shared genetics of lung cancer and type 2 diabetes: a large-scale genome-wide cross-trait analysis.	Wang Z et al.	—	2025	→
Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region.	Che WI et al.	—	2025	→
Shared neuroimaging and molecular profiles in type 2 diabetes mellitus and major depressive disorder: an integrative analysis of genetic, transcriptomic, and neuroimaging data.	Xu J et al.	—	2025	→
Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination.	Li W et al.	—	2025	→
Single-Cell Sequencing of Human Neural Organoids in a Model of Intracerebral Hemorrhage Reveals Temporally Dynamic Responses to Blood.	Seah C et al.	—	2025	→
SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection.	Crist RC et al.	—	2025	→
SLC45A4 is a pain gene encoding a neuronal polyamine transporter.	Middleton SJ et al.	—	2025	→
Sparse multitask group Lasso for genome-wide association studies.	Nouira A et al.	—	2025	→
Spatiotemporal dynamics of RERE in schizophrenia pathogenesis: insights from multi-omics and single-cell sequencing.	Shen J et al.	—	2025	→
SSL-VQ: vector-quantized variational autoencoders for semi-supervised prediction of therapeutic targets across diverse diseases.	Namba S et al.	—	2025	→
Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity.	Jia Y et al.	—	2025	→
Structural framework to address variant-gene relationship in primary open-angle glaucoma.	Singh N et al.	—	2025	→
Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia.	Lu Z et al.	—	2025	→
Susceptibility genes for allergic conjunctivitis revealed by cross-tissue transcriptome-wide association study.	Xu Q et al.	—	2025	→
Synergic effect of arsenic exposure related methylation changes in three cohorts exposed to levels of this toxicant.	Sokolowska KE et al.	—	2025	→
Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases.	Ma Y et al.	—	2025	→
Systematic review and independent validation of genetic factors of radiographic outcome in rheumatoid arthritis identifies a genome-wide association with CARD9.	Sharma SD et al.	—	2025	→
Systematic Review of Mendelian Randomization Studies on <i>Helicobacter pylori</i>-Associated Health Outcomes.	Kato I et al.	—	2025	→
The ADCY1-mediated cAMP signaling pathway mediates functional effects of montelukast treatment in brain organoids.	Xu Z et al.	—	2025	→
The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia.	Wang Z et al.	—	2025	→
The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study.	Chen W et al.	—	2025	→
The brief resilience scale: a genome-wide association study in the UK Biobank.	Cornelis MC et al.	—	2025	→
The Causal Relationship Between Gut Microbiomes, Inflammatory Mediators, and Traumatic Brain Injury in Europeans: Evidence from Genetic Correlation and Functional Mapping Annotation Analyses.	Song B et al.	—	2025	→
The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia.	Toikumo S et al.	—	2025	→
The crucial role of immune factors in susceptibility to SARS-CoV-2 infection and severity of COVID-19.	Yu XH et al.	—	2025	→
The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol.	Berthold N et al.	—	2025	→
The emergence of genetic variants linked to brain and cognitive traits in human evolution.	Libedinsky I et al.	—	2025	→
The genetic architecture of brainstem structures.	Xue H et al.	—	2025	→
The genetic architecture of cervical length is shared with spontaneous preterm birth risk.	Wolf HM et al.	—	2025	→
The Genetic Architecture of the Human Corpus Callosum and its Subregions.	Bhatt RR et al.	—	2025	→
The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis.	Tong Y et al.	—	2025	→
The genetic overlap between major depressive disorder, white blood cell counts and interleukin 6.	Wiström ED et al.	—	2025	→
The genetics of low and high birthweight and their relationship with cardiometabolic disease.	Moen GH et al.	—	2025	→
The Genetic Specificity of Cognitive Tests After Controlling for General Cognitive Ability.	Procopio F et al.	—	2025	→
The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases.	Konieczny MJ et al.	—	2025	→
The health impacts and genetic architecture of food liking in cardio-metabolic diseases.	Jiang W et al.	—	2025	→
The impact of chronic pain on brain gene expression.	Collier L et al.	—	2025	→
The phenotypic and genetic association between endometriosis and immunological diseases.	Shigesi N et al.	—	2025	→
The relationship between vitamin D levels and depression: a genetically informed study.	Lyu H et al.	—	2025	→
The Role of Energy Homeostasis in Depression Pathophysiology and Its Heterogeneity.	Pistis G et al.	—	2025	→
The role of inflammation in the development of tic symptoms in subjects with ADHD.	Takahashi N et al.	—	2025	→
The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study.	Wang X et al.	—	2025	→
The shared genetic architecture between schizophrenia and common peripheral organ imaging phenotypes.	Xie Y et al.	—	2025	→
The shared genetic etiology of autoimmune disorders and interstitial lung disease: insights from large-scale genome-wide cross-trait analysis.	Zhou F et al.	—	2025	→
Toxic effects of enrofloxacin on grass carp (Ctenopharyngodon idellus): an ecological risk assessment based on cross-system regulatory mechanisms and network toxicology.	Li P et al.	—	2025	→
Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects.	Downie CG et al.	—	2025	→
Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease.	Cao X et al.	—	2025	→
Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer.	Wang L et al.	—	2025	→
Transcriptomic divergence of network hubs in the prenatal human brain.	Oldham S et al.	—	2025	→
Trans-ethnic GWAS meta-analysis of idiopathic spermatogenic failure highlights the immune-mediated nature of Sertoli cell-only syndrome.	González-Muñoz S et al.	—	2025	→
TRIAGE: an R package for regulatory gene analysis.	Zhao Q et al.	—	2025	→
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling.	Foote IF et al.	—	2025	→
Unraveling the genetic link: causal effects and PRS predictions of adiposity-related health conditions in East Asian individuals.	Lin YJ et al.	—	2025	→
Unraveling the genetic links between depression and type 2 diabetes.	Baranova A et al.	—	2025	→
Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program.	Pathak GA et al.	—	2025	→
Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study.	Huang W et al.	—	2025	→
Unraveling the Shared Genetic Architecture and Polygenic Overlap Between Loneliness, Major Depressive Disorder, and Sleep-Related Traits.	Rehman Z et al.	—	2025	→
Unraveling the shared genetic foundations of neurodevelopmental and psychiatric disorders: Insights from comprehensive genome-wide analyses.	Maimaiti A et al.	—	2025	→
Unravelling the causal link between gut microbiota and acne risk using a genetic approach.	Cao F et al.	—	2025	→
Unsupervised feature extraction using deep learning empowers discovery of genetic determinants of the electrocardiogram.	Sieliwonczyk E et al.	—	2025	→
Unsupervised Learning-Derived Complex Metabolic Signatures Refine Cardiometabolic Risk.	Zhou Y et al.	—	2025	→
Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders.	Liwayiding A et al.	—	2025	→
Unveiling the Causal Relationship between Thyroid and Kidney Function: A Multivariable Mendelian Randomization.	Tsao HM et al.	—	2025	→
Unveiling the genetic pleiotropy between anxiety disorders and autoimmune diseases: insights from large-scale genome-wide cross-trait analysis.	Lin H et al.	—	2025	→
Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study.	Xu J et al.	—	2025	→
Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity from a common risk factor.	Liang X et al.	—	2025	→
Uterine fibroids show evidence of shared genetic architecture with blood pressure traits.	Akerele AT et al.	—	2025	→
Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk.	Carlson JC et al.	—	2025	→
Whole exome sequencing identified six novel genes for depressive symptoms.	Li ZY et al.	—	2025	→
Whole-exome sequencing identifies 5 novel genes associated with carpal tunnel syndrome.	Wang ZY et al.	—	2025	→
Whole-exome sequencing in children with dyslexia implicates rare variants in CLDN3 and ion channel genes.	Marianski K et al.	—	2025	→
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.	Selvaraj MS et al.	—	2025	→
Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders.	Xu H et al.	—	2025	→
X-chromosome association study reveals genetic susceptibility loci of hypospadias in southern Chinese population.	Liu Y et al.	—	2025	→
Accurate identification of genes associated with brain disorders by integrating heterogeneous genomic data into a Bayesian framework.	He D et al.	—	2024	→
A comprehensive study of genetic regulation and disease associations of plasma circulatory microRNAs using population-level data.	Mustafa R et al.	—	2024	→
Advancing crop improvement through GWAS and beyond in mung bean.	Ahmed SR et al.	—	2024	→
A genetic study to identify pathogenic mechanisms and drug targets for benign prostatic hyperplasia: a multi-omics Mendelian randomization study.	Liu B et al.	—	2024	→
A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.	Chen SP et al.	—	2024	→
A genome-wide Association study of the Count of Codeine prescriptions.	Song W et al.	—	2024	→
A Genome-Wide Association Study Reveals a Novel Susceptibility Locus for Pancreas Divisum at 3q29.	Gaitanidis A et al.	—	2024	→
A genome-wide cross-trait analysis identifying shared genetic basis and causal relationships between Hunner-type interstitial cystitis and autoimmune diseases in East Asian populations.	Lyu X et al.	—	2024	→
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.	Gupta P et al.	—	2024	→
A meta-analysis and polygenic score study identifies novel genetic markers for waist-hip ratio in African populations.	Zhong M et al.	—	2024	→
A Multivariable Mendelian Randomization Study of Systolic and Diastolic Blood Pressure, Lipid Profile, and Heart Failure Subtypes.	Liu C et al.	—	2024	→
Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline.	Wiegrebe S et al.	—	2024	→
An emerging multi-omic understanding of the genetics of opioid addiction.	Johnson EO et al.	—	2024	→
A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors.	Jia X et al.	—	2024	→
A sex-stratified analysis of the genetic architecture of human brain anatomy.	Shafee R et al.	—	2024	→
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens.	Reiner BC et al.	—	2024	→
Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.	Teixeira SK et al.	—	2024	→
Association between 25(OH) vitamin D and multiple sclerosis: cohort, shared genetics, and Causality.	Yu XH et al.	—	2024	→
Association between 25(OH) vitamin D and schizophrenia: shared genetic correlation, pleiotropy, and causality.	Rong GW et al.	—	2024	→
Association of a composite trait for anthropometrics, adiposity and energy expenditure with cardiometabolic diseases: An age-stratified cohort and genetic risk score analysis.	Meulmeester FL et al.	—	2024	→
Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.	Federmann LM et al.	—	2024	→
Associations Between Gut Microbiota and Alcohol Abuse: A Mendelian Randomisation and Bioinformatics Study.	Wang X et al.	—	2024	→
Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels.	Hahn J et al.	—	2024	→
Blood-derived microRNAs are related to cognitive domains in the general population.	Melas K et al.	—	2024	→
Brain aging patterns in a large and diverse cohort of 49,482 individuals.	Yang Z et al.	—	2024	→
Cannabis use disorder increases risk of large-artery atherosclerotic stroke and migraine with aura through mendelian randomization study.	Dong L et al.	—	2024	→
Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer.	Sun X et al.	—	2024	→
Causal associations and shared genetic etiology of neurodegenerative diseases with epigenetic aging and human longevity.	Guo Y et al.	—	2024	→
Causal relationship between beta-2 microglobulin and B-cell malignancies: genome-wide meta-analysis and a bidirectional two-sample Mendelian randomization study.	Li J et al.	—	2024	→
Characterizing Common and Rare Variations in Nontraditional Glycemic Biomarkers Using Multivariate Approaches on Multiancestry ARIC Study.	Ray D et al.	—	2024	→
Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.	Jaholkowski P et al.	—	2024	→
Clinical and genetic associations of asymmetric apical and septal left ventricular hypertrophy.	Yuan V et al.	—	2024	→
Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes.	Li M et al.	—	2024	→
Comprehensive Evaluation of the Genetic Basis of Keratoconus: New Perspectives for Clinical Translation.	Cerván-Martín M et al.	—	2024	→
Critical genes in genitourinary embryogenesis are related to the development of adult hydrocele.	Roberson JL et al.	—	2024	→
Deciphering the alteration of MAP2 interactome caused by a schizophrenia-associated phosphorylation.	Lyu J et al.	—	2024	→
DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits.	Hwang LD et al.	—	2024	→
Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.	Chen HL et al.	—	2024	→
Disease Modules Associated with Unfavorable Sleep Patterns and Their Genetic Determinants: A Prospective Cohort Study of the UK Biobank.	Yang H et al.	—	2024	→
Disentangling the genetic overlap between ischemic stroke and obesity.	Yang R et al.	—	2024	→
Dissecting shared genetic architecture between depression and body mass index.	Zhang H et al.	—	2024	→
Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging.	Lelievre R et al.	—	2024	→
Effect of the Intake of Solid Block Dairy Products Like Cheese on Serum Uric Acid in Children: A Preliminary Mechanistic Investigation.	Lu Z et al.	—	2024	→
Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity.	Townsend HA et al.	—	2024	→
Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study.	Breinbjerg A et al.	—	2024	→
Extracellular vesicle-mediated trafficking of molecular cues during human brain development.	Forero A et al.	—	2024	→
FAVOR-GPT: a generative natural language interface to whole genome variant functional annotations.	Li TC et al.	—	2024	→
Fine mapping-based multi-omics analysis interprets the gut-lung axis function of SGLT2 inhibitors.	Yuan F et al.	—	2024	→
From Genome-wide Association Studies to Functional Variants: ARL14 Cis-regulatory Variants Are Associated With Severe Malaria.	Adjemout M et al.	—	2024	→
From Phenotype to Molecules: Unveiling the Genetic and Immunological Bridges Between Autoimmune Diseases and Vitiligo.	Hu Y et al.	—	2024	→
Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study.	Shi R et al.	—	2024	→
Genetically predicted dietary intake and risks of colorectal cancer: a Mendelian randomisation study.	Hoang T et al.	—	2024	→
Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum.	Wen J et al.	—	2024	→
Genetic and Modifiable Risk Factors for Postoperative Complications of Total Joint Arthroplasty: A Genome-Wide Association and Mendelian Randomization Study.	Guo S et al.	—	2024	→
Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in <i>CD46</i> and other loci.	Grodstein F et al.	—	2024	→
Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.	Ning C et al.	—	2024	→
Genetic basis of right and left ventricular heart shape.	Burns R et al.	—	2024	→
Genetic-by-age interaction analyses on complex traits in UK Biobank and their potential to identify effects on longitudinal trait change.	Winkler TW et al.	—	2024	→
Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors.	Savage JE et al.	—	2024	→
Genetic interactions and pleiotropy in metabolic diseases: Insights from a comprehensive GWAS analysis.	Shen J et al.	—	2024	→
Genetic overlap and Mendelian randomization analysis highlighted the causal relationship between psoriatic disease and migraine.	Tan Y et al.	—	2024	→
Genetic overlap between major depressive disorder and obstructive sleep apnea.	Lin F et al.	—	2024	→
Genetic predisposition to bone mineral density and their health conditions in East Asians.	Lin YJ et al.	—	2024	→
Genetic variants associated with sepsis-associated acute kidney injury.	Douville NJ et al.	—	2024	→
Genetic variants for Alzheimer's disease and comorbid conditions.	Pan M et al.	—	2024	→
Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.	Ni Z et al.	—	2024	→
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.	Gorman BR et al.	—	2024	→
Genome-wide association analysis and admixture mapping in a Puerto Rican cohort supports an Alzheimer disease risk locus on chromosome 12.	Akgun B et al.	—	2024	→
Genome-wide association analysis of cystatin c and creatinine kidney function in Chinese women.	Cai Y et al.	—	2024	→
Genome-wide association analysis of hypertension and epigenetic aging reveals shared genetic architecture and identifies novel risk loci.	Li X et al.	—	2024	→
Genome-wide association studies for pelvic organ prolapse in the Japanese population.	Matsunami M et al.	—	2024	→
Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank.	Alcalde-Herraiz M et al.	—	2024	→
Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration.	Ahmad S et al.	—	2024	→
Genome-wide Association Study of Susceptibility to Respiratory Syncytial Virus Hospitalization in Young Children <5 Years of age.	Egeskov-Cavling AM et al.	—	2024	→
Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.	Jurgens SJ et al.	—	2024	→
Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.	DeForest N et al.	—	2024	→
Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome.	Long P et al.	—	2024	→
Genome-Wide European Ancestry Study Identifies Coronary Artery Disease-Associated Loci Through Gene-Sex Hormone Interaction.	Jain V et al.	—	2024	→
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations.	Salo V et al.	—	2024	→
Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.	Braun A et al.	—	2024	→
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.	García-Marín LM et al.	—	2024	→
Genomic insights into gestational weight gain uncover tissue-specific mechanisms and pathways.	Jasper EA et al.	—	2024	→
Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.	Morey RA et al.	—	2024	→
Genomic variations associated with risk and protection against vincristine-induced peripheral neuropathy in pediatric cancer patients.	Mufti K et al.	—	2024	→
Germline copy number variants and endometrial cancer risk.	Stylianou CE et al.	—	2024	→
Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing.	Fu C et al.	—	2024	→
GWAS breakthroughs: mapping the journey from one locus to 393 significant coronary artery disease associations.	Aherrahrou R et al.	—	2024	→
GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma.	Huang Y et al.	—	2024	→
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.	Shade LMP et al.	—	2024	→
Hemochromatosis neural archetype reveals iron disruption in motor circuits.	Loughnan R et al.	—	2024	→
Heritability and genetic contribution analysis of structural-functional coupling in human brain.	Dai W et al.	—	2024	→
hsa-miR-582-3p in umbilical cord blood is negatively associated with maternal exposure to childhood maltreatment.	Micali D et al.	—	2024	→
Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.	Ambalavanan A et al.	—	2024	→
Identification of genetic basis of brain imaging by group sparse multi-task learning leveraging summary statistics.	Xi D et al.	—	2024	→
Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders.	Tesfaye M et al.	—	2024	→
Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.	Ding K et al.	—	2024	→
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis.	Li M et al.	—	2024	→
Identifying Common Genetic Etiologies Between Inflammatory Bowel Disease and Related Immune-Mediated Diseases.	Liu X et al.	—	2024	→
Identifying key genes in COPD risk via multiple population data integration and gene prioritization.	Zainab A et al.	—	2024	→
Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness.	Amelink JS et al.	—	2024	→
Impact of the near-physiological temperature on the in vitro maturation of bovine oocytes: A comparative proteomic approach.	Tavares WCM et al.	—	2024	→
Improved polygenic risk prediction in migraine-first patients.	Torok D et al.	—	2024	→
Improving genetic risk modeling of dementia from real-world data in underrepresented populations.	Fu M et al.	—	2024	→
Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth.	Gan Y et al.	—	2024	→
Investigating Genetic Overlap between Alzheimer's Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis.	Kirby A et al.	—	2024	→
Investigating the causal relationship between inflammation and multiple types of hearing loss: a multi-omics approach combining Mendelian randomization and molecular docking.	Zhang J et al.	—	2024	→
Investigating the genetic relationship of intracranial and subcortical brain volumes with depression and other psychiatric disorders.	García-Marín LM et al.	—	2024	→
Investigating the shared genetic architecture between depression and subcortical volumes.	Liu M et al.	—	2024	→
Investigating the Shared Genetic Architecture Between Psychiatric Disorders and Executive Function.	Zhang S et al.	—	2024	→
Investigating the shared genetic architecture of osteoarthritis and frailty: a genome-wide cross-trait analysis.	Guo H et al.	—	2024	→
Investigating the shared genetic basis of inflammatory bowel disease and systemic lupus erythematosus using genetic overlap analysis.	Yuan W et al.	—	2024	→
Leveraging ancient DNA to uncover signals of natural selection in Europe lost due to admixture or drift.	Pandey D et al.	—	2024	→
Meta-analysis of genome-wide association studies for cancer therapy-related cardiovascular dysfunction and functional mapping highlight an intergenic region close to TP63.	Martínez-Campelo L et al.	—	2024	→
Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry.	Asiimwe IG et al.	—	2024	→
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity.	Taryma-Leśniak O et al.	—	2024	→
Mitochondrial related variants associated with cardiovascular traits.	Cañadas-Garre M et al.	—	2024	→
Molecular landscape of the overlap between Alzheimer's disease and somatic insulin-related diseases.	Ruisch IH et al.	—	2024	→
Morphometric Similarity Patterning of Amyloid-<i>β</i> and Tau Proteins Correlates with Transcriptomics in the Alzheimer's Disease Continuum.	Brusini L et al.	—	2024	→
Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.	Gorman BR et al.	—	2024	→
Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.	Carreras-Torres R et al.	—	2024	→
Multi-trait analysis reveals risk loci for heart failure and the shared genetic etiology with blood lipids, blood pressure, and blood glucose.	Zhu Y et al.	—	2024	→
Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.	Koskeridis F et al.	—	2024	→
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome.	Park S et al.	—	2024	→
NeuroimaGene: an R package for assessing the neurological correlates of genetically regulated gene expression.	Bledsoe X et al.	—	2024	→
New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans.	Gal Z et al.	—	2024	→
Novel Insights Into the Causal Effects and Shared Genetics Between Body Fat and Parkinson Disease.	Zhao Q et al.	—	2024	→
Novel risk loci for COVID-19 hospitalization among admixed American populations.	Diz-de Almeida S et al.	—	2024	→
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease.	Jamialahmadi O et al.	—	2024	→
Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.	Jabalameli MR et al.	—	2024	→
Population clustering of structural brain aging and its association with brain development.	Duan H et al.	—	2024	→
Probabilistic inference of epigenetic age acceleration from cellular dynamics.	Dabrowski JK et al.	—	2024	→
PWAS Hub for exploring gene-based associations of common complex diseases.	Kelman G et al.	—	2024	→
Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction.	Savage JE et al.	—	2024	→
Revealing genetic causality between blood-based biomarkers and major depression in east Asian ancestry.	Mo X et al.	—	2024	→
Rintatolimod in Advanced Pancreatic Cancer Enhances Antitumor Immunity through Dendritic Cell-Mediated T-Cell Responses.	van Eijck CWF et al.	—	2024	→
Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort.	Räsänen J et al.	—	2024	→
Serum liver enzymes and risk of stroke: Systematic review with meta-analyses and Mendelian randomization studies.	Li C et al.	—	2024	→
Sex differences in shared genetic determinants between severe mental disorders and metabolic traits.	Pisanu C et al.	—	2024	→
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.	Nordeidet AN et al.	—	2024	→
Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke.	Cárcel-Márquez J et al.	—	2024	→
Shared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes.	Xie Y et al.	—	2024	→
Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue.	Li Y et al.	—	2024	→
Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis.	Liu X et al.	—	2024	→
Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases.	Gong T et al.	—	2024	→
Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis.	Lu ZA et al.	—	2024	→
Shared genetic architecture of cortical thickness alterations in major depressive disorder and schizophrenia.	Wang H et al.	—	2024	→
Shared genetic architecture of psychiatric disorders and hemorrhoidal disease: a large-scale genome-wide cross-trait analysis.	Chen Z et al.	—	2024	→
Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis.	Qin C et al.	—	2024	→
Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants.	Chen Y et al.	—	2024	→
Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease.	Di H et al.	—	2024	→
Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates.	Lalagkas PN et al.	—	2024	→
Skin Microbiota, Circulating Metabolic Biomarker, Epilepsy: A Mendelian Randomization Analysis.	Wang Y et al.	—	2024	→
The association between patterns of exposure to adverse life events and the risk of chronic kidney disease: a prospective cohort study of 140,997 individuals.	Li C et al.	—	2024	→
The Causal Effect of Adult Height on Late-Life Handgrip Strength: The Singapore Chinese Health Study.	Chang X et al.	—	2024	→
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.	Gong T et al.	—	2024	→
The genetic architecture of substance use and its diverse correlations with mental health traits.	Wormington B et al.	—	2024	→
The genetic landscape of basal ganglia and implications for common brain disorders.	Bahrami S et al.	—	2024	→
The genetic landscape of neuro-related proteins in human plasma.	Repetto L et al.	—	2024	→
The goldmine of GWAS summary statistics: a systematic review of methods and tools.	Kontou PI et al.	—	2024	→
The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits.	Belbellaj W et al.	—	2024	→
The shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ER + breast cancer but not ER- breast cancer.	Bi K et al.	—	2024	→
Uncovering genetic loci and biological pathways associated with age-related cataracts through GWAS meta-analysis.	Diaz-Torres S et al.	—	2024	→
Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and Schizophrenia.	Shen J et al.	—	2024	→
Unraveling the shared genetics of common epilepsies and general cognitive ability.	Karadag N et al.	—	2024	→
Unveiling the shared genetic architecture between testosterone and polycystic ovary syndrome.	Sun S et al.	—	2024	→
Valid inference for machine learning-assisted genome-wide association studies.	Miao J et al.	—	2024	→
Whole-genome sequencing identifies novel genes for autism in Chinese trios.	Chang S et al.	—	2024	→
Widespread transposable element dysregulation in human aging brains with Alzheimer's disease.	Feng Y et al.	—	2024	→