The three mapping strategies (positional, eQTL and chromatin interaction mapping) result in a set of prioritized genes, based on the GWAS input and specific user-defined filter settings. Both eQTL and chromatin interaction mapping may lead to prioritized genes that are not necessarily themselves located inside a genomic risk locus, although they are linked to SNPs within a genomic risk locus. The combination of positional mapping of deleterious coding SNPs, eQTL mapping, and chromatin interaction mapping across (relevant) tissue types may reveal multiple lines of evidence pointing towards the same genes and enables to prioritize genes that are highly likely involved in the trait of interest.
