A versatile gene-based test for genome-wide association studies.
paper
Cited
Public
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- Authors
- Liu, Jimmy Z; McRae, Allan F; Nyholt, Dale R; Medland, Sarah E; Wray, Naomi R; Brown, Kevin M; AMFS Investigators; Hayward, Nicholas K; Montgomery, Grant W; Visscher, Peter M; Martin, Nicholas G; Macgregor, Stuart
- Year
- 2010
- Journal
- American journal of human genetics
- PMID
- 20598278
- DOI
- 10.1016/j.ajhg.2010.06.009
- PMCID
- PMC2896770
We have derived a versatile gene-based test for genome-wide association studies (GWAS). Our approach, called VEGAS (versatile gene-based association study), is applicable to all GWAS designs, including family-based GWAS, meta-analyses of GWAS on the basis of summary data, and DNA-pooling-based GWAS, where existing approaches based on permutation are not possible, as well as singleton data, where they are. The test incorporates information from a full set of markers (or a defined subset) within a gene and accounts for linkage disequilibrium between markers by using simulations from the multivariate normal distribution. We show that for an association study using singletons, our approach produces results equivalent to those obtained via permutation in a fraction of the computation time. We demonstrate proof-of-principle by using the gene-based test to replicate several genes known to be associated on the basis of results from a family-based GWAS for height in 11,536 individuals and a DNA-pooling-based GWAS for melanoma in approximately 1300 cases and controls. Our method has the potential to identify novel associated genes; provide a basis for selecting SNPs for replication; and be directly used in network (pathway) approaches that require per-gene association test statistics. We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application.
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| Recent Advances in the Systems Biology of Aging. | McCormick MA et al. | β | 2018 | β |
| Regional enrichment analyses on genetic profiles for schizophrenia and bipolar disorder. | Liu J et al. | β | 2018 | β |
| Shared Biological Pathways Between Alzheimer's Disease and Ischemic Stroke. | Cui P et al. | β | 2018 | β |
| Socio-demographic, Clinical, and Genetic Determinants of Quality of Life in Lung Cancer Patients. | Pierzynski JA et al. | β | 2018 | β |
| Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. | Davies G et al. | β | 2018 | β |
| The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease. | Ni H et al. | β | 2018 | β |
| Using Genomic Data to Find Disease-Modifying Loci in Huntington's Disease (HD). | Holmans P et al. | β | 2018 | β |
| V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis. | Duan X et al. | β | 2018 | β |
| 10 Years of GWAS Discovery: Biology, Function, and Translation. | Visscher PM et al. | β | 2017 | β |
| Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization. | Haitjema S et al. | β | 2017 | β |
| Adjusting for Familial Relatedness in the Analysis of GWAS Data. | Thomson R et al. | β | 2017 | β |
| A Gene-Based Analysis of Acoustic Startle Latency. | Smith AK et al. | β | 2017 | β |
| A method for integrating neuroimaging into genetic models of learning performance. | Mehta CM et al. | β | 2017 | β |
| A Novel Approach for Pathway Analysis of GWAS Data Highlights Role of BMP Signaling and Muscle Cell Differentiation in Colorectal Cancer Susceptibility. | Mishra A et al. | β | 2017 | β |
| A pathway analysis of genome-wide association study highlights novel type 2 diabetes risk pathways. | Liu Y et al. | β | 2017 | β |
| Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence. | FernΓ‘ndez E et al. | β | 2017 | β |
| Association of atrial fibrillation susceptibility genes, atrial fibrillation phenotypes and response to catheter ablation: a gene-based analysis of GWAS data. | Husser D et al. | β | 2017 | β |
| Associations Between Genetic Variants of NADPH Oxidase-Related Genes and Blood Pressure Responses to Dietary Sodium Intervention: The GenSalt Study. | Han X et al. | β | 2017 | β |
| Bayesian genome- and epigenome-wide association studies with gene level dependence. | Lock EF et al. | β | 2017 | β |
| BAYESIAN LARGE-SCALE MULTIPLE REGRESSION WITH SUMMARY STATISTICS FROM GENOME-WIDE ASSOCIATION STUDIES. | Zhu X et al. | β | 2017 | β |
| Chromosome contacts in activated T cells identify autoimmune disease candidate genes. | Burren OS et al. | β | 2017 | β |
| Cognitive genomics: Searching for the genetic roots of neuropsychological functioning. | Bearden CE et al. | β | 2017 | β |
| COMBAT: A Combined Association Test for Genes Using Summary Statistics. | Wang M et al. | β | 2017 | β |
| Copy number variation meta-analysis reveals a novel duplication at 9p24 associated with multiple neurodevelopmental disorders. | Glessner JT et al. | β | 2017 | β |
| Dissecting the genetics of complex traits using summary association statistics. | Pasaniuc B et al. | β | 2017 | β |
| Exome Sequencing of Extended Families with Alzheimer's Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function. | Cukier HN et al. | β | 2017 | β |
| Fine mapping genetic associations between the HLA region and extremely high intelligence. | Zabaneh D et al. | β | 2017 | β |
| Functional mapping and annotation of genetic associations with FUMA. | Watanabe K et al. | β | 2017 | β |
| Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling. | Ferreira MA et al. | β | 2017 | β |
| Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia. | Mishra A et al. | β | 2017 | β |
| Gene-based genome-wide association study identified 19p13.3 for lean body mass. | Ran S et al. | β | 2017 | β |
| Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies. | Rava M et al. | β | 2017 | β |
| Genetic architecture of age-related cognitive decline in African Americans. | Raj T et al. | β | 2017 | β |
| Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. | Mandage R et al. | β | 2017 | β |
| Genetic susceptibility to cardiovascular disease and risk of dementia. | Karlsson IK et al. | β | 2017 | β |
| Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders. | Lester KJ et al. | β | 2017 | β |
| Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a Novel Susceptibility Gene for Attention Deficit Hyperactivity Disorder. | Garcia-MartΓnez I et al. | β | 2017 | β |
| Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide. | Salvi E et al. | β | 2017 | β |
| Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma. | Lin YY et al. | β | 2017 | β |
| Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy. | Kim SK et al. | β | 2017 | β |
| Genome-wide association study of body mass index in subjects with alcohol dependence. | Polimanti R et al. | β | 2017 | β |
| Genome-Wide Association Study of Psychosis Proneness in the Finnish Population. | Ortega-Alonso A et al. | β | 2017 | β |
| Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. | Boueiz A et al. | β | 2017 | β |
| Genome-Wide Gene-Potassium Interaction Analyses on Blood Pressure: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity). | Li C et al. | β | 2017 | β |
| Genome-wide network-based pathway analysis of CSF t-tau/AΞ²1-42 ratio in the ADNI cohort. | Cong W et al. | β | 2017 | β |
| Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities. | Beecham A et al. | β | 2017 | β |
| Genotype-Phenotype Study of the Middle Gangetic Plain in India Shows Association of rs2470102 with Skin Pigmentation. | Mishra A et al. | β | 2017 | β |
| Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1. | McCaffrey JC et al. | β | 2017 | β |
| GWAB: a web server for the network-based boosting of human genome-wide association data. | Shim JE et al. | β | 2017 | β |
| GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians. | Nongmaithem SS et al. | β | 2017 | β |
| Heritability and GWAS Analyses of Acne in Australian Adolescent Twins. | Mina-Vargas A et al. | β | 2017 | β |
| IGESS: a statistical approach to integrating individual-level genotype data and summary statistics in genome-wide association studies. | Dai M et al. | β | 2017 | β |
| Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. | Bogdan R et al. | β | 2017 | β |
| Improving the detection of pathways in genome-wide association studies by combined effects of SNPs from Linkage Disequilibrium blocks. | Zhao H et al. | β | 2017 | β |
| Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression. | Calderon D et al. | β | 2017 | β |
| Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation. | Lonjou C et al. | β | 2017 | β |
| Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. | Willems SM et al. | β | 2017 | β |
| Melanoma Expression Genes Identified through Genome-Wide Association Study ofΒ Breslow Tumor Thickness. | Fang S et al. | β | 2017 | β |
| Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. | Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium | β | 2017 | β |
| No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival. | Sucheston-Campbell LE et al. | β | 2017 | β |
| Pathway analysis of complex diseases for GWAS, extending to consider rare variants, multi-omics and interactions. | Kao PY et al. | β | 2017 | β |
| Pharmacogenetic study of long-term response to interferon-Ξ² treatment in multiple sclerosis. | Clarelli F et al. | β | 2017 | β |
| PR Interval Associated Genes, Atrial Remodeling and Rhythm Outcome of Catheter Ablation of Atrial Fibrillation-A Gene-Based Analysis of GWAS Data. | Husser D et al. | β | 2017 | β |
| Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. | Yang Z et al. | β | 2017 | β |
| Reporting Correct p Values in VEGAS Analyses. | Hecker J et al. | β | 2017 | β |
| Rethinking ovarian cancer genomics: where genome-wide association studies stand? | Pinto R et al. | β | 2017 | β |
| Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians. | Fan Q et al. | β | 2017 | β |
| Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children. | Marques CR et al. | β | 2017 | β |
| Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis. | Hayden LP et al. | β | 2017 | β |
| Systematical analyses of variants in DNase I hypersensitive sites to identify hepatocellular carcinoma susceptibility loci in a Chinese population. | Jiang T et al. | β | 2017 | β |
| Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments. | Mukherjee S et al. | β | 2017 | β |
| The SNP-set based association study identifies ITGA1 as a susceptibility gene of attention-deficit/hyperactivity disorder in Han Chinese. | Liu L et al. | β | 2017 | β |
| The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesity-related traits and mediates by interacting with Apo-A1. | Hebbar P et al. | β | 2017 | β |
| Two-dimensional enrichment analysis for mining high-level imaging genetic associations. | Yao X et al. | β | 2017 | β |
| Weighted Protein Interaction Network Analysis of Frontotemporal Dementia. | Ferrari R et al. | β | 2017 | β |
| What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude? | Malone SM et al. | β | 2017 | β |
| Adaptive gene- and pathway-trait association testing with GWAS summary statistics. | Kwak IY et al. | β | 2016 | β |
| A genome-wide analysis of the response to inhaled Ξ²2-agonists in chronic obstructive pulmonary disease. | Hardin M et al. | β | 2016 | β |
| A genome-wide approach to children's aggressive behavior: The EAGLE consortium. | Pappa I et al. | β | 2016 | β |
| A Genome-wide Association Analysis in Four Populations Reveals Strong Genetic Heterogeneity For Birth Weight. | Luo T et al. | β | 2016 | β |
| A genome-wide investigation of food addiction. | Cornelis MC et al. | β | 2016 | β |
| Analysis of Common Single Nucleotide Polymorphisms in Complex Regional Pain Syndrome: Genome Wide Association Study Approach and Pooled DNA Strategy. | Janicki PK et al. | β | 2016 | β |
| ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations. | Chimusa ER et al. | β | 2016 | β |
| A Nonlinear Model for Gene-Based Gene-Environment Interaction. | Sa J et al. | β | 2016 | β |
| A Powerful Procedure for Pathway-Based Meta-analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations. | Zhang H et al. | β | 2016 | β |
| A Simple Test of Class-Level Genetic Association Can Reveal Novel Cardiometabolic Trait Loci. | Qian J et al. | β | 2016 | β |
| Association between Genetic Variants in DNA Double-Strand Break Repair Pathways and Risk of Radiation Therapy-Induced Pneumonitis and Esophagitis in Non-Small Cell Lung Cancer. | Zhao L et al. | β | 2016 | β |
| Associations of polymorphisms in TXNIP and gene-environment interactions with the risk of coronary artery disease in a Chinese Han population. | Wang XB et al. | β | 2016 | β |
| Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population. | Yin X et al. | β | 2016 | β |
| Common variants in DRD2 are associated with sleep duration: the CARe consortium. | Cade BE et al. | β | 2016 | β |
| Dissecting the genetics of complex traits using summary association statistics | Pasaniuc B et al. | β | 2016 | β |
| Enrichment of SNPs in Functional Categories Reveals Genes Affecting Complex Traits. | Zhao H et al. | β | 2016 | β |
| EPS: an empirical Bayes approach to integrating pleiotropy and tissue-specific information for prioritizing risk genes. | Liu J et al. | β | 2016 | β |
| Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits. | Polimanti R et al. | β | 2016 | β |
| Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences. | Hill WD et al. | β | 2016 | β |
| Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics. | Lamparter D et al. | β | 2016 | β |
| Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits. | Bakshi A et al. | β | 2016 | β |
| FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics. | Huang J et al. | β | 2016 | β |
| Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases. | Nakka P et al. | β | 2016 | β |
| Gene-based analysis identified the gene ZNF248 is associated with late-onset asthma in African Americans. | Wang L et al. | β | 2016 | β |
| Gene-Based Genome-Wide Association Analysis in European and Asian Populations Identified Novel Genes for Rheumatoid Arthritis. | Zhu H et al. | β | 2016 | β |
| Gene expression in major depressive disorder. | Jansen R et al. | β | 2016 | β |
| Genetic Association-Guided Analysis of Gene Networks for the Study of Complex Traits. | Greene CS et al. | β | 2016 | β |
| Genetic Moderation of Stress Effects on Corticolimbic Circuitry. | Bogdan R et al. | β | 2016 | β |
| Genome-wide analysis identifies 12 loci influencing human reproductive behavior. | Barban N et al. | β | 2016 | β |
| Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster. | Vonesch SC et al. | β | 2016 | β |
| Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. | Lane JM et al. | β | 2016 | β |
| Genome-Wide Association of Heroin Dependence in Han Chinese. | Kalsi G et al. | β | 2016 | β |
| Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis. | Gharahkhani P et al. | β | 2016 | β |
| Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior. | Cornelis MC et al. | β | 2016 | β |
| Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder. | Kilaru V et al. | β | 2016 | β |
| Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study. | Li C et al. | β | 2016 | β |
| Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits. | Ballantyne RL et al. | β | 2016 | β |
| Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. | Teumer A et al. | β | 2016 | β |
| Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults. | Mather KA et al. | β | 2016 | β |
| Germline Genetic Variants in the Wnt/Ξ²-Catenin Pathway as Predictors of Colorectal Cancer Risk. | Hildebrandt MA et al. | β | 2016 | β |
| High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences. | Rivera NV et al. | β | 2016 | β |
| Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype. | Pasterkamp G et al. | β | 2016 | β |
| Identification of Susceptible Loci and Enriched Pathways for Bipolar II Disorder Using Genome-Wide Association Studies. | Kao CF et al. | β | 2016 | β |
| Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin. | Galesloot TE et al. | β | 2016 | β |
| MetaNetVar: Pipeline for applying network analysis tools for genomic variants analysis. | Moyer E et al. | β | 2016 | β |
| MiRNA-Related Genetic Variations Associated with Radiotherapy-Induced Toxicities in Patients with Locally Advanced Non-Small Cell Lung Cancer. | Li R et al. | β | 2016 | β |
| Multi-strategy genome-wide association studies identify the DCAF16-NCAPG region as a susceptibility locus for average daily gain in cattle. | Zhang W et al. | β | 2016 | β |
| Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder. | Khadka S et al. | β | 2016 | β |
| Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer's disease: a study of ADNI cohorts. | Song A et al. | β | 2016 | β |
| Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. | Jaeger PA et al. | β | 2016 | β |
| Oxidative phosphorylation and lacunar stroke: Genome-wide enrichment analysis of common variants. | Traylor M et al. | β | 2016 | β |
| Pathway-based Genome-wide Association Studies Reveal the Association Between Growth Factor Activity and Inflammatory Bowel Disease. | Li J et al. | β | 2016 | β |
| PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses. | Zhang DF et al. | β | 2016 | β |
| Pleiotropic Genes Affecting Carcass Traits in Bos indicus (Nellore) Cattle Are Modulators of Growth. | G T Pereira A et al. | β | 2016 | β |
| Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. | Ek WE et al. | β | 2016 | β |
| Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations. | Shirali M et al. | β | 2016 | β |
| Resequencing of the CETP gene in American whites and African blacks: Association of rare and common variants with HDL-cholesterol levels. | Pirim D et al. | β | 2016 | β |
| Rigorous tests of gene-environment interactions in a lab study of the oxytocin receptor gene (OXTR), alcohol exposure, and aggression. | LoParo D et al. | β | 2016 | β |
| Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease. | Traylor M et al. | β | 2016 | β |
| STAMS: STRING-assisted module search for genome wide association studies and application to autism. | Hillenmeyer S et al. | β | 2016 | β |
| Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. | Johnson MR et al. | β | 2016 | β |
| The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants. | Hollman AL et al. | β | 2016 | β |
| Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases. | Marbach D et al. | β | 2016 | β |
| A Bayesian Partitioning Model for the Detection of Multilocus Effects in Case-Control Studies. | Ray D et al. | β | 2015 | β |
| Adapt-Mix: learning local genetic correlation structure improves summary statistics-based analyses. | Park DS et al. | β | 2015 | β |
| A gene-based association method for mapping traits using reference transcriptome data. | Gamazon ER et al. | β | 2015 | β |
| A guide to genome-wide association analysis and post-analytic interrogation. | Reed E et al. | β | 2015 | β |
| Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. | Hart AB et al. | β | 2015 | β |
| A Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer's Disease. | Wang W et al. | β | 2015 | β |
| A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families. | Wang YT et al. | β | 2015 | β |
| Analysis of genes, pathways and networks involved in disease severity and age at onset in primary-progressive multiple sclerosis. | Giacalone G et al. | β | 2015 | β |
| A regularized multivariate regression approach for eQTL analysis. | Wang X et al. | β | 2015 | β |
| A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model. | Yan Q et al. | β | 2015 | β |
| Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study. | Hansen JG et al. | β | 2015 | β |
| Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. | Chauhan G et al. | β | 2015 | β |
| Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes. | Fang S et al. | β | 2015 | β |
| A twin study of breastfeeding with a preliminary genome-wide association scan. | Colodro-Conde L et al. | β | 2015 | β |
| Beyond the usual suspects: a multidimensional genetic exploration of infant attachment disorganization and security. | Pappa I et al. | β | 2015 | β |
| Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder. | SΓ‘nchez-Mora C et al. | β | 2015 | β |
| Clique-Based Clustering of Correlated SNPs in a Gene Can Improve Performance of Gene-Based Multi-Bin Linear Combination Test. | Yoo YJ et al. | β | 2015 | β |
| Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. | Esplin MS et al. | β | 2015 | β |
| Converging evidence does not support GIT1 as an ADHD risk gene. | Klein M et al. | β | 2015 | β |
| Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. | Ma J et al. | β | 2015 | β |
| Effect of occupational exposures on lung cancer susceptibility: a study of gene-environment interaction analysis. | Malhotra J et al. | β | 2015 | β |
| EW_dmGWAS: edge-weighted dense module search for genome-wide association studies and gene expression profiles. | Wang Q et al. | β | 2015 | β |
| Gene-based mapping and pathway analysis of metabolic traits in dairy cows. | Ha NT et al. | β | 2015 | β |
| Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity. | HΓ€gg S et al. | β | 2015 | β |
| Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. | Lopez LM et al. | β | 2015 | β |
| Genetic and environmental factors in conjunctival UV autofluorescence. | Yazar S et al. | β | 2015 | β |
| Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study. | Li C et al. | β | 2015 | β |
| Genetic associations with brain cortical thickness in multiple sclerosis. | Matsushita T et al. | β | 2015 | β |
| Genetic basis of a cognitive complexity metric. | Hansell NK et al. | β | 2015 | β |
| Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study. | Niemsiri V et al. | β | 2015 | β |
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| Genetic determinants of disease progression in Alzheimer's disease. | Wang X et al. | β | 2015 | β |
| Genetic Determinants of Survival in Patientswith Alzheimerβs Disease. | Wang X et al. | β | 2015 | β |
| Genetic determinants of swallowing impairments among community dwelling older population. | Raginis-Zborowska A et al. | β | 2015 | β |
| Genetics of hand grip strength in mid to late life. | Chan JP et al. | β | 2015 | β |
| Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia. | Wolthusen RP et al. | β | 2015 | β |
| Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients. | Hildebrandt MA et al. | β | 2015 | β |
| Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder. | Forstner AJ et al. | β | 2015 | β |
| Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. | Wolf ZT et al. | β | 2015 | β |
| Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population. | Kuo PH et al. | β | 2015 | β |
| Genome-wide association study identifies SNPs in the MHC class II loci that are associated with self-reported history of whooping cough. | McMahon G et al. | β | 2015 | β |
| Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. | Derringer J et al. | β | 2015 | β |
| Genome-wide association study of blood lead shows multiple associations near ALAD. | Warrington NM et al. | β | 2015 | β |
| Genome-wide association study of selenium concentrations. | Cornelis MC et al. | β | 2015 | β |
| Genome-wide association study of serum minerals levels in children of different ethnic background. | Chang X et al. | β | 2015 | β |
| Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults. | Dong J et al. | β | 2015 | β |
| Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. | Debette S et al. | β | 2015 | β |
| Heterogeneous Network Edge Prediction: A Data Integration Approach to Prioritize Disease-Associated Genes. | Himmelstein DS et al. | β | 2015 | β |
| Hierarchical Classes Analysis (HICLAS): A novel data reduction method to examine associations between biallelic SNPs and perceptual organization phenotypes in schizophrenia. | Joseph J et al. | β | 2015 | β |
| Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease. | Yan J et al. | β | 2015 | β |
| Identification and functional characterization of rare SHANK2 variants in schizophrenia. | Peykov S et al. | β | 2015 | β |
| Immune-related pathways including HLA-DRB1(β)13:02 are associated with panic disorder. | Shimada-Sugimoto M et al. | β | 2015 | β |
| Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes. | Ning K et al. | β | 2015 | β |
| In Search for the Genetic Basis of Quality of Life in Healthy Swedish Women--A GWAS Study Using the iCOGS Custom Genotyping Array. | Schoormans D et al. | β | 2015 | β |
| Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait. | FraniΔ S et al. | β | 2015 | β |
| JAG: A Computational Tool to Evaluate the Role of Gene-Sets in Complex Traits. | Lips ES et al. | β | 2015 | β |
| JEPEG: a summary statistics based tool for gene-level joint testing of functional variants. | Lee D et al. | β | 2015 | β |
| MAGMA: generalized gene-set analysis of GWAS data. | de Leeuw CA et al. | β | 2015 | β |
| Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. | Genetics of Personality Consortium et al. | β | 2015 | β |
| Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology. | Springelkamp H et al. | β | 2015 | β |
| Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. | Li YR et al. | β | 2015 | β |
| MGAS: a powerful tool for multivariate gene-based genome-wide association analysis. | Van der Sluis S et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| MUGBAS: a species free gene-based programme suite for post-GWAS analysis. | Capomaccio S et al. | β | 2015 | β |
| Multilevel-analysis identify a cis-expression quantitative trait locus associated with risk of renal cell carcinoma. | Shu X et al. | β | 2015 | β |
| Network-assisted analysis of primary SjΓΆgren's syndrome GWAS data in Han Chinese. | Fang K et al. | β | 2015 | β |
| NETWORK ASSISTED ANALYSIS TO REVEAL THE GENETIC BASIS OF AUTISM. | Liu L et al. | β | 2015 | β |
| Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals. | Chang S et al. | β | 2015 | β |
| Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans. | Repunte-Canonigo V et al. | β | 2015 | β |
| PINBPA: cytoscape app for network analysis of GWAS data. | Wang L et al. | β | 2015 | β |
| Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium. | Lagergren K et al. | β | 2015 | β |
| Powerful Tests for Multi-Marker Association Analysis Using Ensemble Learning. | Padhukasahasram B et al. | β | 2015 | β |
| Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia. | FΓΆcking M et al. | β | 2015 | β |
| Reduced protein synthesis in schizophrenia patient-derived olfactory cells. | English JA et al. | β | 2015 | β |
| Relative performance of gene- and pathway-level methods as secondary analyses for genome-wide association studies. | Wojcik GL et al. | β | 2015 | β |
| Searching new signals for production traits through gene-based association analysis in three Italian cattle breeds. | Capomaccio S et al. | β | 2015 | β |
| Selecting causal genes from genome-wide association studies via functionally coherent subnetworks. | TaΕan M et al. | β | 2015 | β |
| Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia. | Banerjee A et al. | β | 2015 | β |
| Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study. | Lin X et al. | β | 2015 | β |
| The genetic basis of quality of life in healthy Swedish women: a candidate gene approach. | Schoormans D et al. | β | 2015 | β |
| Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. | Zhao Z et al. | β | 2015 | β |
| Understanding multicellular function and disease with human tissue-specific networks. | Greene CS et al. | β | 2015 | β |
| VEGAS2: Software for More Flexible Gene-Based Testing. | Mishra A et al. | β | 2015 | β |
| XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome. | Gao F et al. | β | 2015 | β |
| Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases. | Chang D et al. | β | 2014 | β |
| A fast multilocus test with adaptive SNP selection for large-scale genetic-association studies. | Zhang H et al. | β | 2014 | β |
| A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility. | Damotte V et al. | β | 2014 | β |
| A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. | Davies G et al. | β | 2014 | β |
| A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations. | Evangelou M et al. | β | 2014 | β |
| A Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese. | Wang B et al. | β | 2014 | β |
| A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism. | Wittkowski KM et al. | β | 2014 | β |
| Applying genome-wide gene-based expression quantitative trait locus mapping to study population ancestry and pharmacogenetics. | Yang HC et al. | β | 2014 | β |
| Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts. | Chang SC et al. | β | 2014 | β |
| A review of multivariate analyses in imaging genetics. | Liu J et al. | β | 2014 | β |
| A robust method for genome-wide association meta-analysis with the application to circulating insulin-like growth factor I concentrations. | Wang T et al. | β | 2014 | β |
| Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders. | Stein CM et al. | β | 2014 | β |
| Boosting signals in gene-based association studies via efficient SNP selection. | Wu C et al. | β | 2014 | β |
| Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. | Benyamin B et al. | β | 2014 | β |
| Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. | McDonald ML et al. | β | 2014 | β |
| Common genetic variations in the vitamin D pathway in relation to blood pressure. | Wang L et al. | β | 2014 | β |
| Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis. | Olden M et al. | β | 2014 | β |
| Comprehensive evaluation of the association of APOE genetic variation with plasma lipoprotein traits in U.S. whites and African blacks. | Radwan ZH et al. | β | 2014 | β |
| DSM-5 cannabis use disorder: a phenotypic and genomic perspective. | Agrawal A et al. | β | 2014 | β |
| Functional and genomic context in pathway analysis of GWAS data. | Mooney MA et al. | β | 2014 | β |
| Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability. | Hill WD et al. | β | 2014 | β |
| Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample. | Irons DE et al. | β | 2014 | β |
| Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups. | Padhukasahasram B et al. | β | 2014 | β |
| Genetic association of impulsivity in young adults: a multivariate study. | Khadka S et al. | β | 2014 | β |
| Genetic associations with micronutrient levels identified in immune and gastrointestinal networks. | Morine MJ et al. | β | 2014 | β |
| Genetic distance as an alternative to physical distance for definition of gene units in association studies. | Rodriguez-Fontenla C et al. | β | 2014 | β |
| Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. | Hysi PG et al. | β | 2014 | β |
| Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. | Otowa T et al. | β | 2014 | β |
| Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. | Bolton JL et al. | β | 2014 | β |
| Genome-wide association study of smoking behaviours among Bangladeshi adults. | Argos M et al. | β | 2014 | β |
| Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections. | Ye Z et al. | β | 2014 | β |
| Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. | Loukola A et al. | β | 2014 | β |
| Genome-wide linkage and regional association study of blood pressure response to the cold pressor test in Han Chinese: the genetic epidemiology network of salt sensitivity study. | Yang X et al. | β | 2014 | β |
| Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. | Simpson CL et al. | β | 2014 | β |
| Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview. | Iacono WG et al. | β | 2014 | β |
| Genome-wide screening for DNA variants associated with reading and language traits. | Gialluisi A et al. | β | 2014 | β |
| GWAS-based pathway analysis differentiates between fluid and crystallized intelligence. | Christoforou A et al. | β | 2014 | β |
| Heritability and molecular genetic basis of acoustic startle eye blink and affectively modulated startle response: a genome-wide association study. | Vaidyanathan U et al. | β | 2014 | β |
| Heritability and molecular genetic basis of antisaccade eye tracking error rate: a genome-wide association study. | Vaidyanathan U et al. | β | 2014 | β |
| Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study. | Vaidyanathan U et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. | Hill WD et al. | β | 2014 | β |
| Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. | Bailey JN et al. | β | 2014 | β |
| Identification of novel risk genes associated with typeΒ 1 diabetes mellitus using a genome-wide gene-based association analysis. | Qiu YH et al. | β | 2014 | β |
| Impact of genetic variants in human scavenger receptor class B type I (SCARB1) on plasma lipid traits. | Niemsiri V et al. | β | 2014 | β |
| Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies. | Zhang X et al. | β | 2014 | β |
| Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder. | Witt SH et al. | β | 2014 | β |
| Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease. | Ashbrook DG et al. | β | 2014 | β |
| Lipoprotein lipase gene sequencing and plasma lipid profile. | Pirim D et al. | β | 2014 | β |
| Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese. | Zhang DF et al. | β | 2014 | β |
| Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. | Pei YF et al. | β | 2014 | β |
| Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. | Springelkamp H et al. | β | 2014 | β |
| Network.assisted analysis to prioritize GWAS results: principles, methods and perspectives. | Jia P et al. | β | 2014 | β |
| Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. | Benyamin B et al. | β | 2014 | β |
| On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. | Qiao D et al. | β | 2014 | β |
| PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. | Jun G et al. | β | 2014 | β |
| Premorbid risk factors for major depressive disorder: are they associated with early onset and recurrent course? | Wilson S et al. | β | 2014 | β |
| Promoter variant rs2301228 on the neural cell adhesion molecule 1 gene confers risk of schizophrenia in Han Chinese. | Zhang W et al. | β | 2014 | β |
| Results of a "GWAS plus:" general cognitive ability is substantially heritable and massively polygenic. | Kirkpatrick RM et al. | β | 2014 | β |
| Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. | Cho MH et al. | β | 2014 | β |
| Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans. | Kim YD et al. | β | 2014 | β |
| Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways. | Logue MW et al. | β | 2014 | β |
| Set-based joint test of interaction between SNPs in the VEGF pathway and exogenous estrogen finds association with age-related macular degeneration. | Courtenay MD et al. | β | 2014 | β |
| Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes. | Luo X et al. | β | 2014 | β |
| Testing the role of circadian genes in conferring risk for psychiatric disorders. | Byrne EM et al. | β | 2014 | β |
| Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations. | Li YR et al. | β | 2014 | β |
| VSEAMS: a pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes. | Burren OS et al. | β | 2014 | β |
| Wnt signaling in form deprivation myopia of the mice retina. | Ma M et al. | β | 2014 | β |
| A genome-wide association study for reading and language abilities in two population cohorts. | Luciano M et al. | β | 2013 | β |
| A genome-wide association study of a sustained pattern of antidepressant response. | Hunter AM et al. | β | 2013 | β |
| A genome-wide association study of behavioral disinhibition. | McGue M et al. | β | 2013 | β |
| A genome-wide association study of sleep habits and insomnia. | Byrne EM et al. | β | 2013 | β |
| A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. | Kapoor M et al. | β | 2013 | β |
| A microRNA-135a/b binding polymorphism in CD133 confers decreased risk and favorable prognosis of lung cancer in Chinese by reducing CD133 expression. | Cheng M et al. | β | 2013 | β |
| A rapid gene-based genome-wide association test with multivariate traits. | Basu S et al. | β | 2013 | β |
| Assessing methods for assigning SNPs to genes in gene-based tests of association using common variants. | Petersen A et al. | β | 2013 | β |
| Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk. | Liu H et al. | β | 2013 | β |
| Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies. | Qian J et al. | β | 2013 | β |
| Association testing strategy for data from dense marker panels. | Lee D et al. | β | 2013 | β |
| Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles. | Dharuri H et al. | β | 2013 | β |
| Cancer pharmacogenomics: strategies and challenges. | Wheeler HE et al. | β | 2013 | β |
| Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD. | Bralten J et al. | β | 2013 | β |
| Common variation contributes to the genetic architecture of social communication traits. | St Pourcain B et al. | β | 2013 | β |
| Empirical pathway analysis, without permutation. | Zhou YH et al. | β | 2013 | β |
| Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. | Ikeda M et al. | β | 2013 | β |
| Fast association tests for genes with FAST. | Chanda P et al. | β | 2013 | β |
| Gene-based testing of interactions in association studies of quantitative traits. | Ma L et al. | β | 2013 | β |
| Gene-environment interactions in genome-wide association studies: current approaches and new directions. | Winham SJ et al. | β | 2013 | β |
| Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. | Costello EJ et al. | β | 2013 | β |
| Genetic variants associated with disordered eating. | Wade TD et al. | β | 2013 | β |
| Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. | Lu Y et al. | β | 2013 | β |
| Genome-wide association study identifies loci affecting blood copper, selenium and zinc. | Evans DM et al. | β | 2013 | β |
| Genome-wide association study of a quantitative disordered gambling trait. | Lind PA et al. | β | 2013 | β |
| Genome-wide association study of atypical psychosis. | Kanazawa T et al. | β | 2013 | β |
| Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits. | Ebejer JL et al. | β | 2013 | β |
| Genome-wide association study of shared components of reading disability and language impairment. | Eicher JD et al. | β | 2013 | β |
| Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. | Jahanshad N et al. | β | 2013 | β |
| GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. | Rietveld CA et al. | β | 2013 | β |
| Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy. | Kavanagh DH et al. | β | 2013 | β |
| Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. | Gaudet MM et al. | β | 2013 | β |
| Integrated analysis of genome-wide genetic and epigenetic association data for identification of disease mechanisms. | Ke X et al. | β | 2013 | β |
| Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training. | Ghosh S et al. | β | 2013 | β |
| Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. | Yazar S et al. | β | 2013 | β |
| ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population. | Yim DH et al. | β | 2013 | β |
| Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies. | Liu G et al. | β | 2013 | β |
| Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density at forearm. | Zheng HF et al. | β | 2013 | β |
| NCK2 is significantly associated with opiates addiction in African-origin men. | Liu Z et al. | β | 2013 | β |
| Network analysis of GWAS data. | Leiserson MD et al. | β | 2013 | β |
| Network-based interpretation of genomic variation data. | HalldΓ³rsson BV et al. | β | 2013 | β |
| Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. | International Multiple Sclerosis Genetics Consortium | β | 2013 | β |
| New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. | Postula M et al. | β | 2013 | β |
| Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. | Cheng CY et al. | β | 2013 | β |
| No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia. | Heilmann S et al. | β | 2013 | β |
| Overview of Behavioral Genetics Research for Family Researchers. | Samek D et al. | β | 2013 | β |
| Pathway-based analysis of genomic variation data. | Atias N et al. | β | 2013 | β |
| Pathway-based analysis using genome-wide association data from a Korean non-small cell lung cancer study. | Lee D et al. | β | 2013 | β |
| Pathways systematically associated to Hirschsprung's disease. | FernΓ‘ndez RM et al. | β | 2013 | β |
| Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease. | VΓ©lez JI et al. | β | 2013 | β |
| Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. | Aslibekyan S et al. | β | 2013 | β |
| Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test. | Swanson DM et al. | β | 2013 | β |
| Regional replication of association with refractive error on 15q14 and 15q25 in the Age-Related Eye Disease Study cohort. | Simpson CL et al. | β | 2013 | β |
| Resequencing three candidate genes for major depressive disorder in a Dutch cohort. | Verbeek EC et al. | β | 2013 | β |
| Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts. | Vardarajan B et al. | β | 2013 | β |
| SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases. | Jiao S et al. | β | 2013 | β |
| Sherlock: detecting gene-disease associations by matching patterns of expression QTL and GWAS. | He X et al. | β | 2013 | β |
| Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. | Vijai J et al. | β | 2013 | β |
| The association between LRP-1 variants and chylomicron uptake after a high fat meal. | Frazier-Wood AC et al. | β | 2013 | β |
| The future of genomics for developmentalists. | Plomin R et al. | β | 2013 | β |
| The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation. | Verweij KJ et al. | β | 2013 | β |
| The molecular genetic architecture of self-employment. | van der Loos MJ et al. | β | 2013 | β |
| The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations. | Huang D et al. | β | 2013 | β |
| The power of regional heritability analysis for rare and common variant detection: simulations and application to eye biometrical traits. | Uemoto Y et al. | β | 2013 | β |
| TREM2 and neurodegenerative disease. | Bertram L et al. | β | 2013 | β |
| TREM2 and neurodegenerative disease. | Benitez BA et al. | β | 2013 | β |
| TREM2 and neurodegenerative disease. | Reitz C et al. | β | 2013 | β |
| TREM2 and neurodegenerative disease. | Jonsson T et al. | β | 2013 | β |
| TREM2 and neurodegenerative disease. | Guerreiro R et al. | β | 2013 | β |
| TREM2 and neurodegenerative disease. | Bird TD | β | 2013 | β |
| Using genetically informed, randomized prevention trials to test etiological hypotheses about child and adolescent drug use and psychopathology. | Brody GH et al. | β | 2013 | β |
| Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E Ο΅4,and the risk of late-onset Alzheimer disease in African Americans. | Reitz C et al. | β | 2013 | β |
| Weight loss after gastric bypass is associated with a variant at 15q26.1. | Hatoum IJ et al. | β | 2013 | β |
| White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. | Sprooten E et al. | β | 2013 | β |
| A Bayesian method for comparing and combining binary classifiers in the absence of a gold standard. | Keith JM et al. | β | 2012 | β |
| A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. | Jia P et al. | β | 2012 | β |
| Adrenergic alpha-1 pathway is associated with hypertension among Nigerians in a pathway-focused analysis. | Reder NP et al. | β | 2012 | β |
| A gene-based test of association using canonical correlation analysis. | Tang CS et al. | β | 2012 | β |
| A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. | Byrne EM et al. | β | 2012 | β |
| A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. | Service SK et al. | β | 2012 | β |
| A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity. | Lopez LM et al. | β | 2012 | β |
| A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study. | Xue F et al. | β | 2012 | β |
| A multi-SNP locus-association method reveals a substantial fraction of the missing heritability. | Ehret GB et al. | β | 2012 | β |
| An ICA with reference approach in identification of genetic variation and associated brain networks. | Liu J et al. | β | 2012 | β |
| Behavioral variant frontotemporal lobar degeneration with amyotrophic lateral sclerosis with a chromosome 9p21 hexanucleotide repeat. | Friedland RP et al. | β | 2012 | β |
| Breaking free from the chains of pathway annotation: de novo pathway discovery for the analysis of disease processes. | Lehne B et al. | β | 2012 | β |
| Cancer core modules identification through genomic and transcriptomic changes correlation detection at network level. | Li W et al. | β | 2012 | β |
| Common genetic variants and gene-expression changes associated with bipolar disorder are over-represented in brain signaling pathway genes. | Pedroso I et al. | β | 2012 | β |
| Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder. | Pandey A et al. | β | 2012 | β |
| Evaluating SKI as a candidate gene for non-syndromic cleft lip with or without cleft palate. | Mangold E et al. | β | 2012 | β |
| Gene size matters. | Mirina A et al. | β | 2012 | β |
| Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. | Tang W et al. | β | 2012 | β |
| Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. | Wassel CL et al. | β | 2012 | β |
| Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease. | Hong MG et al. | β | 2012 | β |
| Genome-wide association meta-analysis identifies new endometriosis risk loci. | Nyholt DR et al. | β | 2012 | β |
| Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. | Wray NR et al. | β | 2012 | β |
| Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood. | Rye MS et al. | β | 2012 | β |
| Genome-wide association uncovers shared genetic effects among personality traits and mood states. | Luciano M et al. | β | 2012 | β |
| Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. | Wei S et al. | β | 2012 | β |
| GWAS reveals new recessive loci associated with non-syndromic facial clefting. | Camargo M et al. | β | 2012 | β |
| HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis. | Li MX et al. | β | 2012 | β |
| Identification of Alzheimer disease-associated variants in genes that regulate retromer function. | Vardarajan BN et al. | β | 2012 | β |
| Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. | Scott RA et al. | β | 2012 | β |
| Large scale association analysis for drug addiction: results from SNP to gene. | Guo X et al. | β | 2012 | β |
| Loci affecting gamma-glutamyl transferase in adults and adolescents show age Γ SNP interaction and cardiometabolic disease associations. | Middelberg RP et al. | β | 2012 | β |
| Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation. | Wheeler HE et al. | β | 2012 | β |
| Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects. | Cheung CL et al. | β | 2012 | β |
| Meta-analysis of genome-wide association studies for personality. | de Moor MH et al. | β | 2012 | β |
| No association of candidate genes with cannabis use in a large sample of Australian twin families. | Verweij KJ et al. | β | 2012 | β |
| On optimal gene-based analysis of genome scans. | Bacanu SA | β | 2012 | β |
| Pathway analysis of genomic data: concepts, methods, and prospects for future development. | Ramanan VK et al. | β | 2012 | β |
| Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. | Moskvina V et al. | β | 2012 | β |
| Population-based case-control association studies. | Hancock DB et al. | β | 2012 | β |
| Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population. | Yoon D et al. | β | 2012 | β |
| RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia. | Xu J et al. | β | 2012 | β |
| Searching joint association signals in CATIE schizophrenia genome-wide association studies through a refined integrative network approach. | Jia P et al. | β | 2012 | β |
| SNP set association analysis for familial data. | Schifano ED et al. | β | 2012 | β |
| Systematic association analysis of microRNA machinery genes with schizophrenia informs further study. | Zhang F et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study. | Tielbeek JJ et al. | β | 2012 | β |
| Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies. | Schaid DJ et al. | β | 2012 | β |
| A network-based approach to prioritize results from genome-wide association studies. | Akula N et al. | β | 2011 | β |
| Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset. | Gui H et al. | β | 2011 | β |
| Different approaches for dealing with rare variants in family-based genetic studies: application of a Genetic Analysis Workshop 17 problem. | Alfonso de Almeida MA et al. | β | 2011 | β |
| Educational attainment: a genome wide association study in 9538 Australians. | Martin NW et al. | β | 2011 | β |
| Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study. | Moskvina V et al. | β | 2011 | β |
| Finding genes that influence quantitative traits with tree-based clustering. | Wilson IJ et al. | β | 2011 | β |
| Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. | Beesley J et al. | β | 2011 | β |
| GATES: a rapid and powerful gene-based association test using extended Simes procedure. | Li MX et al. | β | 2011 | β |
| Gene-based tests of association. | Huang H et al. | β | 2011 | β |
| Gene- or region-based association study via kernel principal component analysis. | Gao Q et al. | β | 2011 | β |
| Genome partitioning of genetic variation for complex traits using common SNPs. | Yang J et al. | β | 2011 | β |
| Genome-wide association studies establish that human intelligence is highly heritable and polygenic. | Davies G et al. | β | 2011 | β |
| Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. | Wheeler HE et al. | β | 2011 | β |
| Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. | Cornelis MC et al. | β | 2011 | β |
| GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development. | Larsson M et al. | β | 2011 | β |
| Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. | Jin G et al. | β | 2011 | β |
| Identification of QTL genes for BMD variation using both linkage and gene-based association approaches. | Li GH et al. | β | 2011 | β |
| Meta-analysis of genome-wide association for migraine in six population-based European cohorts. | Ligthart L et al. | β | 2011 | β |
| Multi-ethnic studies in complex traits. | Fu J et al. | β | 2011 | β |
| Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways. | Eleftherohorinou H et al. | β | 2011 | β |
| Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods. | Oldmeadow C et al. | β | 2011 | β |
| Six Degrees of Epistasis: Statistical Network Models for GWAS. | McKinney BA et al. | β | 2011 | β |
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