No association of candidate genes with cannabis use in a large sample of Australian twin families.
- Authors
- Verweij, Karin J H; Zietsch, Brendan P; Liu, Jimmy Z; Medland, Sarah E; Lynskey, Michael T; Madden, Pamela A F; Agrawal, Arpana; Montgomery, Grant W; Heath, Andrew C; Martin, Nicholas G
- Year
- 2012
- Journal
- Addiction biology
- PMID
- 21507154
- DOI
- 10.1111/j.1369-1600.2011.00320.x
- PMCID
- PMC3393887
While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.
Prevalence of the different response categories for lifetime frequency of cannabis use.
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