The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
paper
Cited
Public
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- Authors
- Verweij, Karin J H; Vinkhuyzen, Anna A E; Benyamin, Beben; Lynskey, Michael T; Quaye, Lydia; Agrawal, Arpana; Gordon, Scott D; Montgomery, Grant W; Madden, Pamela A F; Heath, Andrew C; Spector, Timothy D; Martin, Nicholas G; Medland, Sarah E
- Year
- 2013
- Journal
- Addiction biology
- PMID
- 22823124
- DOI
- 10.1111/j.1369-1600.2012.00478.x
- PMCID
- PMC3548058
While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.
Results of the genome-wide association analyses for lifetime cannabis use. The x-axis shows the chromosome numbers and the y-axis the significance of the association signals (i.e. βlog10(P) value).
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