A genome-wide association study of DSM-IV cannabis dependence.
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- Authors
- Agrawal, Arpana; Lynskey, Michael T; Hinrichs, Anthony; Grucza, Richard; Saccone, Scott F; Krueger, Robert; Neuman, Rosalind; Howells, William; Fisher, Sherri; Fox, Louis; Cloninger, Robert; Dick, Danielle M; Doheny, Kimberly F; Edenberg, Howard J; Goate, Alison M; Hesselbrock, Victor; Johnson, Eric; Kramer, John; Kuperman, Samuel; Nurnberger, John I; Pugh, Elizabeth; Schuckit, Marc; Tischfield, Jay; GENEVA Consortium; Rice, John P; Bucholz, Kathleen K; Bierut, Laura J
- Year
- 2011
- Journal
- Addiction biology
- PMID
- 21668797
- DOI
- 10.1111/j.1369-1600.2010.00255.x
- PMCID
- PMC3117436
Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.
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