The genetic epidemiology of cannabis use, abuse and dependence.
paper
Cited
Public
Unavailable
- Authors
- Agrawal, Arpana; Lynskey, Michael T
- Year
- 2006
- Journal
- Addiction (Abingdon, England)
- PMID
- 16696624
- DOI
- 10.1111/j.1360-0443.2006.01399.x
AIMS: The genetic etiology of cannabis use, abuse and dependence has elicited significant interest from genetic epidemiologists. METHODS: Genetically informative studies, including family, twin and adoption studies that have examined the role of genetic and environmental influences on the various stages of cannabis involvement, and the genetic relationship between cannabis, licit drugs and other hard drugs, are reviewed. RESULTS: Findings across a number of such studies have indicated that there is a genetic basis to each stage of cannabis involvement although a proportion of the genetic factors influencing individual stages may be specific to that stage. Multivariate analyses that explore the association between cannabis and licit (alcohol and tobacco) as well as hard drugs (e.g. cocaine, opioids), using multiple methodological strategies, suggest the role of common genetic and environmental influences influencing the liability to cannabis and other drug involvement. CONCLUSIONS: The substantial evidence for the heritability of cannabis use, abuse and dependence underscore the importance of linkage and association studies that aim to find genes of etiologic significance.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria. | SooHoo JF et al. | β | 2025 | β |
| Prenatal cannabis exposure and the risk for neuropsychiatric anomalies in the offspring: a systematic review and meta-analysis. | Bassalov H et al. | β | 2024 | β |
| Substance Use Disorder. | Swimmer KR et al. | β | 2024 | β |
| The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies. | Austin-Zimmerman I et al. | β | 2024 | β |
| Hypothalamic-pituitary-adrenal and sympathetic nervous system responses to social evaluative stress in chronic cannabis users and non-users. | Simon SG et al. | β | 2023 | β |
| Physical inactivity during adolescence heightens risk for cannabis use disorder in adulthood. | Tarter RE et al. | β | 2023 | β |
| Pleiotropic loci for cannabis use disorder severity in multi-ancestry high-risk populations. | Peng Q et al. | β | 2023 | β |
| THC and CBD: Villain versus Hero? Insights into Adolescent Exposure. | Pintori N et al. | β | 2023 | β |
| Cannabis Use and Parenting Practices among Young People: The Impact of Parenting Styles, Parental Cannabis-Specific Rules, and Parental Cannabis Use. | KokotoviΔ KO et al. | β | 2022 | β |
| Comorbidity and Coaggregation of Major Depressive Disorder and Bipolar Disorder and Cannabis Use Disorder in a Controlled Family Study. | Quick CR et al. | β | 2022 | β |
| Consensus paper of the WFSBP task force on cannabis, cannabinoids and psychosis. | D'Souza DC et al. | β | 2022 | β |
| Pleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations | Peng Q et al. | β | 2022 | β |
| Prenatal alcohol and tobacco exposures and the risk of cannabis use in offspring: Findings from a population-based cohort study. | Duko B et al. | β | 2022 | β |
| Associations of cannabis- and tobacco-related problem severity with reward and punishment sensitivity and impulsivity in adolescent daily cigarette smokers. | Hammond CJ et al. | β | 2021 | β |
| Cannabis and Depression. | Feingold D et al. | β | 2021 | β |
| Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings. | Kesner AJ et al. | β | 2021 | β |
| Estimating the familial risk of psychiatric illnesses: A review of family history scores. | Ali F et al. | β | 2021 | β |
| Genetics of substance use disorders: a review. | Deak JD et al. | β | 2021 | β |
| Adolescent cannabinoid exposure interacts with other risk factors in schizophrenia: A review of the evidence from animal models. | Dunn AL et al. | β | 2020 | β |
| Sex and Strain Variation in Initial Sensitivity and Rapid Tolerance to Ξ9-Tetrahydrocannabinol. | Parks C et al. | β | 2020 | β |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | β | 2020 | β |
| Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals. | Eirich A et al. | β | 2019 | β |
| Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. | Cheng W et al. | β | 2019 | β |
| Determining Risks for Cannabis Use Disorder in the Face of Changing Legal Policies. | Taylor M et al. | β | 2019 | β |
| <i>CNR1</i> and <i>FAAH</i> variation and affective states induced by marijuana smoking. | Palmer RHC et al. | β | 2019 | β |
| Identifying subtypes of cannabis users based on simultaneous polysubstance use. | Davis CN et al. | β | 2019 | β |
| Multiplex analysis of genetic polymorphisms within UGT1A9, a gene involved in phase II of Ξ<sup>9</sup>-THC metabolism. | Schneider JS et al. | β | 2019 | β |
| Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance. | Meyers JL et al. | β | 2019 | β |
| Gene variants and educational attainment in cannabis use: mediating role of DNA methylation. | Gerra MC et al. | β | 2018 | β |
| GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. | Pasman JA et al. | β | 2018 | β |
| Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design. | Hines LA et al. | β | 2018 | β |
| The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity. | Struik D et al. | β | 2018 | β |
| US Epidemiology of Cannabis Use and Associated Problems. | Hasin DS | β | 2018 | β |
| Commentary on Kosty et al. (2017): Understanding risk classes for cannabis use disorder requires knowledge of exposure, environment and genetic effects. | Hines LA | β | 2017 | β |
| Cross-Cultural Effects of Cannabis Use Disorder: Evidence to Support a Cultural Neuroscience Approach. | Prashad S et al. | β | 2017 | β |
| Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood. | Ashenhurst JR et al. | β | 2017 | β |
| Medical Marijuana: Just the Beginning of a Long, Strange Trip? | Ciccone CD | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| Cue-induced striatal activity in frequent cannabis users independently predicts cannabis problem severity three years later. | Vingerhoets WA et al. | β | 2016 | β |
| Developmental pathways from prenatal marijuana exposure to Cannabis Use Disorder in young adulthood. | Sonon K et al. | β | 2016 | β |
| Evidence-Based Prevention for Adolescent Substance Use. | Harrop E et al. | β | 2016 | β |
| Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate. | Hill SY et al. | β | 2016 | β |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | β | 2016 | β |
| Adolescent Substance Misusers with and without Delinquency: Death, Mental and Physical Disorders, and Criminal Convictions from Age 21 to 45. | Larm P et al. | β | 2015 | β |
| Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. | Yohn NL et al. | β | 2015 | β |
| Natural course of cannabis use disorders. | Farmer RF et al. | β | 2015 | β |
| Prenatal marijuana exposure predicts marijuana use in young adulthood. | Sonon KE et al. | β | 2015 | β |
| The role of general parenting and cannabis-specific parenting practices in adolescent cannabis and other illicit drug use. | Vermeulen-Smit E et al. | β | 2015 | β |
| Three-Year Course of Cannabis Dependence and Prediction of Persistence. | van der Pol P et al. | β | 2015 | β |
| Cannabis use in adolescence and risk of future disability pension: a 39-year longitudinal cohort study. | Danielsson AK et al. | β | 2014 | β |
| Early adolescent patterns of alcohol, cigarettes, and marijuana polysubstance use and young adult substance use outcomes in a nationally representative sample. | Moss HB et al. | β | 2014 | β |
| Genetic and environmental risk factors for illicit substance use and use disorders: Joint analysis of self and co-twin ratings. | Ystrom E et al. | β | 2014 | β |
| Genetic predisposition to schizophrenia associated with increased use of cannabis. | Power RA et al. | β | 2014 | β |
| Legal substance use and the development of a DSM-IV cannabis use disorder during adolescence: the TRAILS study. | Prince van Leeuwen A et al. | β | 2014 | β |
| Substance use in children of parents with chronic pain - the HUNT study. | KaasbΓΈll J et al. | β | 2014 | β |
| Towards a comprehensive developmental model of cannabis use disorders. | Blanco C et al. | β | 2014 | β |
| CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. | Rotter A et al. | β | 2013 | β |
| Childhood conduct disorder trajectories, prior risk factors and cannabis use at age 16: birth cohort study. | Heron J et al. | β | 2013 | β |
| Exploring drug-target interaction networks of illicit drugs. | Atreya RV et al. | β | 2013 | β |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | β | 2013 | β |
| Substance-specific environmental influences on drug use and drug preference in animals and humans. | Badiani A | β | 2013 | β |
| The evolutionary paradox and the missing heritability of schizophrenia. | van Dongen J et al. | β | 2013 | β |
| Trends in detection rates of risky marijuana use in Colorado health care settings. | Richmond MK et al. | β | 2013 | β |
| Alcohol and marijuana use in the context of tobacco dependence treatment: impact on outcome and mediation of effect. | Hendricks PS et al. | β | 2012 | β |
| Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. | Schacht JP et al. | β | 2012 | β |
| Associations of alcohol, nicotine, cannabis, and drug use/dependence with educational attainment: evidence from cotwin-control analyses. | Grant JD et al. | β | 2012 | β |
| Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence. | Korhonen T et al. | β | 2012 | β |
| Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. | Han S et al. | β | 2012 | β |
| No association of candidate genes with cannabis use in a large sample of Australian twin families. | Verweij KJ et al. | β | 2012 | β |
| Shared environmental contributions to substance use. | Baker JH et al. | β | 2012 | β |
| Substance use disorders and adoption: findings from a national sample. | Yoon G et al. | β | 2012 | β |
| The interplay between parental monitoring and the dopamine D4 receptor gene in adolescent cannabis use. | Otten R et al. | β | 2012 | β |
| Two-part random effects growth modeling to identify risks associated with alcohol and cannabis initiation, initial average use and changes in drug consumption in a sample of adult, male twins. | Gillespie NA et al. | β | 2012 | β |
| Understanding genetic risk for substance use and addiction: a guide for non-geneticists. | Urbanoski KA et al. | β | 2012 | β |
| A genome-wide association study of DSM-IV cannabis dependence. | Agrawal A et al. | β | 2011 | β |
| A longitudinal study of risk factors for incident drug use in adults: findings from a representative sample of the US population. | Harrington M et al. | β | 2011 | β |
| DRD2 and DRD4 in relation to regular alcohol and cannabis use among adolescents: does parenting modify the impact of genetic vulnerability? The TRAILS study. | Creemers HE et al. | β | 2011 | β |
| Effects of the serotonin transporter (5-HTTLPR) and Ξ±2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study. | MerenΓ€kk L et al. | β | 2011 | β |
| Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. | Hendershot CS et al. | β | 2011 | β |
| Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. | Gillespie NA et al. | β | 2011 | β |
| Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability. | Ehlers CL et al. | β | 2010 | β |
| Common genetic contributions to alcohol and cannabis use and dependence symptomatology. | Sartor CE et al. | β | 2010 | β |
| Cool, but is it credible? Adolescents' and parents' approaches to genetic testing. | Rew L et al. | β | 2010 | β |
| Daily marijuana users with past alcohol problems increase alcohol consumption during marijuana abstinence. | Peters EN et al. | β | 2010 | β |
| Externalizing behavior problems and cigarette smoking as predictors of cannabis use: the TRAILS Study. | Korhonen T et al. | β | 2010 | β |
| From genotype to EEG endophenotype: a route for post-genomic understanding of complex psychiatric disease? | de Geus EJ | β | 2010 | β |
| Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies. | Verweij KJ et al. | β | 2010 | β |
| Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. | Ehlers CL et al. | β | 2010 | β |
| Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins. | Agrawal A et al. | β | 2010 | β |
| Tobacco, cannabis, and other illicit drug use among Finnish adolescent twins: causal relationship or correlated liabilities? | Huizink AC et al. | β | 2010 | β |
| Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence. | Benyamina A et al. | β | 2009 | β |
| Candidate genes for cannabis use disorders: findings, challenges and directions. | Agrawal A et al. | β | 2009 | β |
| Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. | Onaivi ES | β | 2009 | β |
| Cannabis use disorder: epidemiology and management. | Copeland J et al. | β | 2009 | β |
| Contribution of parental and school personnel smoking to health risk behaviours among Finnish adolescents. | Virtanen M et al. | β | 2009 | β |
| Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. | Agrawal A et al. | β | 2009 | β |
| Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. | Okochi T et al. | β | 2009 | β |
| Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. | Ehlers CL et al. | β | 2009 | β |
| Incorporating the family as a critical context in genetic studies of children: implications for understanding pathways to risky behavior and substance use. | Rende R et al. | β | 2009 | β |
| The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults. | Hartman CA et al. | β | 2009 | β |
| The familial aggregation of cannabis use disorders. | Merikangas KR et al. | β | 2009 | β |
| The prevalence and significance of cannabis use in patients prescribed chronic opioid therapy: a review of the extant literature. | Reisfield GM et al. | β | 2009 | β |
| Adolescent cannabis users at 24 years: trajectories to regular weekly use and dependence in young adulthood. | Swift W et al. | β | 2008 | β |
| Adolescents' self-defined tobacco use status, marijuana use, and tobacco dependence. | Okoli CTC et al. | β | 2008 | β |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | β | 2008 | β |
| Autosomal linkage analysis for cannabis use behaviors in Australian adults. | Agrawal A et al. | β | 2008 | β |
| Behavioral disinhibition and the development of early-onset addiction: common and specific influences. | Iacono WG et al. | β | 2008 | β |
| Early cannabis use and DSM-IV nicotine dependence: a twin study. | Agrawal A et al. | β | 2008 | β |
| Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies. | Heiman GA et al. | β | 2008 | β |
| Gene-environment interplay between cannabis and psychosis. | Henquet C et al. | β | 2008 | β |
| Is there evidence for symptoms of cannabis withdrawal in the national epidemiologic survey of alcohol and related conditions? | Agrawal A et al. | β | 2008 | β |
| Role of individual, peer and family factors in the use of cannabis and other illicit drugs: a longitudinal analysis among Finnish adolescent twins. | Korhonen T et al. | β | 2008 | β |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | β | 2008 | β |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | β | 2007 | β |
| Life-time cannabis use and late onset mood and anxiety disorders. | Lynskey MT | β | 2007 | β |
| Personality differences in monozygotic twins discordant for cannabis use. | Vink JM et al. | β | 2007 | β |
| Prevalence and correlates of cannabis use in developed and developing countries. | Hall W et al. | β | 2007 | β |
| Genetic epidemiology of cannabis use, abuse and dependence: a comment on Agrawal and Lynskey (2006). | Kaprio J | β | 2006 | β |
| The genetics of cannabis involvement in humans: a genetic epidemiological perspective. | Collier DA | β | 2006 | β |