Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study.

paper Cited Public

Authors: Ehlers, Cindy L; Gizer, Ian R; Vieten, Cassandra; Wilhelmsen, Kirk C
Year: 2010
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 19937978
DOI: 10.1002/ajmg.b.31050
PMCID: PMC2940710

#	Section	Preview
0	Introduction	National epidemiological samples have demonstrated that cannabis is the most commonly used illicit…
1	Introduction	Twin and family studies have consistently found that cannabis use and use disorders appear to in…
2	Introduction	Disorders of cannabis use may be influenced by a number of genes that are difficult to detect…
3	Introduction	called ‘drug craving’ [see Anton, 1999], and ultimately the development of tolerance to and…
4	Introduction	A few studies have conducted linkage analyses using cannabis dependence, cannabis dependence…
5	Methods — Participants	The UCSF family study recruited probands with lifetime DSM-IV alcohol dependence and the relatives…
6	Methods — Participants	Probands reporting serious drug dependence (defined as use of stimulants, cocaine, or opiates daily…
7	Methods — Participants	Two thousand one hundred and fifty-four individuals were enrolled in the UCSF Family Alcoholism…
8	Methods — Participants	An unselected general population sample of 147 individuals was also recruited to assess phenotype…
9	Methods — Clinical measures and diagnoses	A remote data collection procedure was developed allowing for blood samples and other questionnaires…
10	Methods — Clinical measures and diagnoses	are significantly heritable including: having ever used cannabis, used more than 21 times in a…
11	Methods — DNA collection and genotyping	The DNA extraction procedure and genotyping protocol have been previously described [Wilhelmsen et…
12	Methods — DNA collection and genotyping	The sizes of marker amplimers were determined (blinded to pedigree structure and subject…
13	Methods — DNA collection and genotyping	The genotypes for all of the autosomal markers were analyzed for each family by using Pedigree…
14	Methods — Data analyses	Both genotype and phenotype data were available for 1647 individuals, and phenotype but not genotype…
15	Methods — Data analyses	Analyses were previously conducted to estimate the heritability of the three phenotypes of interest:…
16	Methods — Data analyses	The variance components method implemented in SOLAR [http://solar.sfbrgenetics.org/] was then used…
17	Methods — Data analyses	Because the current sample was selected for alcohol dependence, it should be noted that prevalence…
18	Results — Demographics	The demographic characteristics of this population have been presented previously [see Vieten et…
19	Results — Linkage analyses	Analyses of multipoint variance component LOD scores for the dichotomous DSM-IV cannabis dependence…

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In this knowledge base

Title	Year	PMID
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.	2012	22520967
The genetics of substance dependence.	2012	22703173
Genome-wide scan for self-rating of the effects of alcohol in American Indians.	2010	20505555

External

Title	Authors	Journal	Year	Link
The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.	Verweij KJH et al.	—	2022	→
The genetic basis of the comorbidity between cannabis use and major depression.	Hodgson K et al.	—	2017	→
Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample.	Gilder DA et al.	—	2016	→
Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.	Melroy-Greif WE et al.	—	2016	→
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.	Stringer S et al.	—	2016	→
Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse.	Clark SL et al.	—	2016	→
Childhood maltreatment, stressful life events, and alcohol craving in adult drinkers.	Kim JH et al.	—	2014	→
Have the genetics of cannabis involvement gone to pot?	Agrawal A et al.	—	2014	→
Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD.	Ehlers CL et al.	—	2013	→
Measuring historical trauma in an American Indian community sample: contributions of substance dependence, affective disorder, conduct disorder and PTSD.	Ehlers CL et al.	—	2013	→
[Cannabis: Use and dependence].	Dervaux A et al.	—	2012	→
Cytogenetic risks and possible adverse health effects by narcotic substances dependent.	Movafagh A et al.	—	2012	→
Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study.	Gizer IR et al.	—	2012	→
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.	Han S et al.	—	2012	→
The genetics of substance dependence.	Wang JC et al.	—	2012	→
Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.	Ehlers CL et al.	—	2011	→
Genome-wide scan for self-rating of the effects of alcohol in American Indians.	Ehlers CL et al.	—	2010	→