A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence.
paper
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- Authors
- Stallings, Michael C; Corley, Robin P; Hewitt, John K; Krauter, Kenneth S; Lessem, Jeffrey M; Mikulich, Susan K; Rhee, Soo Hyun; Smolen, Andrew; Young, Susan E; Crowley, Thomas J
- Year
- 2003
- Journal
- Drug and alcohol dependence
- PMID
- 12757967
- DOI
- 10.1016/s0376-8716(03)00031-0
This study describes results from a genome-wide search for quantitative trait loci (QTL) influencing substance dependence vulnerability in adolescence. We utilized regression-based multipoint (and single-point) QTL mapping procedures designed for selected sibpair samples. Selected sibling pairs included 250 proband-sibling pairs from 192 families. Clinical probands (13-19 years of age) were drawn from consecutive admissions to substance abuse treatment facilities in the Denver metropolitan area; siblings of probands ranged in age from 12 to 25 years. In addition to the selected sample, a community-based sample of 3676 adolescents and young adults were utilized to define a clinically-significant, heritable, age- and sex-normed index of substance dependence vulnerability-a priori and independent of our linkage results. Siblings and their parents were genotyped for 374 STR micro-satellite markers distributed across the 22 autosomes (average inter-marker distance=9.2 cM). Non-parametric single-point linkage results indicated 17 markers on 11 chromosomes with nominally significant tests of linkage; six markers with LOD scores greater than 1.0 and one marker (D3S1614) with a LOD score of 2.2. Multipoint mapping corroborated two locations and provided preliminary evidence for linkage to regions on chromosome 3q24-25 (near markers D3S1279 and D3S1614) and chromosome 9q34 (near markers D9S1826 and D9S1838).
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|---|---|---|---|---|
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| Does puberty affect the development of behavior problems as a mediator, moderator, or unique predictor? | Beltz AM et al. | — | 2020 | → |
| Alcohol use, psychiatric disorders and gambling behaviors: A multi-sample study testing causal relationships via the co-twin control design. | Huggett SB et al. | — | 2019 | → |
| No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. | Border R et al. | — | 2019 | → |
| Independent predictors of mortality in adolescents ascertained for conduct disorder and substance use problems, their siblings and community controls. | Border R et al. | — | 2018 | → |
| Executive functions and substance use: Relations in late adolescence and early adulthood. | Gustavson DE et al. | — | 2017 | → |
| Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling. | Toritsuka M et al. | — | 2017 | → |
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| Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. | Schwantes-An TH et al. | — | 2016 | → |
| Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence. | Kamens HM et al. | — | 2016 | → |
| Test for association of common variants in GRM7 with alcohol consumption. | Melroy-Greif WE et al. | — | 2016 | → |
| Bivariate Trajectories of Substance Use and Antisocial Behavior: Associations with Emerging Adult Outcomes in a High-Risk Sample. | Trim RS et al. | — | 2015 | → |
| Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence. | Palmer RH et al. | — | 2015 | → |
| Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume. | Dalwani MS et al. | — | 2015 | → |
| Genetic influences on pubertal development and links to behavior problems. | Corley RP et al. | — | 2015 | → |
| Identification and functional characterisation of a novel dopamine beta hydroxylase gene variant associated with attention deficit hyperactivity disorder. | Tong J et al. | — | 2015 | → |
| Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. | Melroy WE et al. | — | 2014 | → |
| Modeling pubertal timing and tempo and examining links to behavior problems. | Beltz AM et al. | — | 2014 | → |
| Evidence for a genetic component for substance dependence in Native Americans. | Ehlers CL et al. | — | 2013 | → |
| Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. | Vereczkei A et al. | — | 2013 | → |
| Nominal association with CHRNA4 variants and nicotine dependence. | Kamens HM et al. | — | 2013 | → |
| Prevalence and predictors of injection drug use and risky sexual behaviors among adolescents in substance treatment. | Thurstone C et al. | — | 2013 | → |
| Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. | Stephens SH et al. | — | 2012 | → |
| Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study. | Gizer IR et al. | — | 2012 | → |
| Subjective effects for alcohol, tobacco, and marijuana association with cross-drug outcomes. | Zeiger JS et al. | — | 2012 | → |
| Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. | Gilmore CS et al. | — | 2010 | → |
| Genetically informative research on adolescent substance use: methods, findings, and challenges. | Lynskey MT et al. | — | 2010 | → |
| Genetic and environmental risk factors for adolescent-onset substance use disorders. | Meyers JL et al. | — | 2010 | → |
| Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. | Ehlers CL et al. | — | 2010 | → |
| Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. | Saccone NL et al. | — | 2010 | → |
| Subjective effects to marijuana associated with marijuana use in community and clinical subjects. | Zeiger JS et al. | — | 2010 | → |
| Perceived peer delinquency and the genetic predisposition for substance dependence vulnerability. | Button TM et al. | — | 2009 | → |
| Substance use disorder genetic research: investigators and participants grapple with the ethical issues. | Coors ME et al. | — | 2009 | → |
| Association of candidate genes with antisocial drug dependence in adolescents. | Corley RP et al. | — | 2008 | → |
| Autosomal linkage analysis for cannabis use behaviors in Australian adults. | Agrawal A et al. | — | 2008 | → |
| Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. | Ehlers CL et al. | — | 2008 | → |
| Genes and cigarette smoking. | Munafò MR et al. | — | 2008 | → |
| Genetic variation in the dopamine pathway and smoking cessation. | David SP et al. | — | 2008 | → |
| Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. | Nielsen DA et al. | — | 2008 | → |
| Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. | Paletzki RF et al. | — | 2008 | → |
| Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. | Hartman CA et al. | — | 2008 | → |
| Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Agrawal A et al. | — | 2008 | → |
| Neurobiological processes in adolescent addictive disorders. | Schepis TS et al. | — | 2008 | → |
| The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. | Schlaepfer IR et al. | — | 2008 | → |
| Toward DSM-V: an item response theory analysis of the diagnostic process for DSM-IV alcohol abuse and dependence in adolescents. | Gelhorn H et al. | — | 2008 | → |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | — | 2007 | → |
| Genomic screen for substance dependence and body mass index in southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems. | Sakai JT et al. | — | 2007 | → |
| The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition. | Schlaepfer IR et al. | — | 2007 | → |
| Adolescents and substance-related disorders: research agenda to guide decisions on Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). | Crowley TJ | — | 2006 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |
| Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependence. | Button TM et al. | — | 2006 | → |
| Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients. | Young SE et al. | — | 2006 | → |
| Molecular genetics of addiction vulnerability. | Uhl GR | — | 2006 | → |
| Substance use disorder trajectory classes: diachronic integration of onset age, severity, and course. | Clark DB et al. | — | 2006 | → |
| Subtypes of illicit drug users: a latent class analysis of data from an Australian twin sample. | Lynskey MT et al. | — | 2006 | → |
| The genetic epidemiology of cannabis use, abuse and dependence. | Agrawal A et al. | — | 2006 | → |
| Combining research approaches to advance our understanding of drug addiction. | van den Bree MB | — | 2005 | → |
| Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. | Kreek MJ et al. | — | 2005 | → |
| Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. | Beuten J et al. | — | 2005 | → |
| Genes associated with addiction: alcoholism, opiate, and cocaine addiction. | Kreek MJ et al. | — | 2004 | → |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | — | 2004 | → |
| Genotyping of three single nucleotide polymorphisms following whole genome preamplification of DNA collected from buccal cells. | Haberstick BC et al. | — | 2004 | → |
| Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology. | Cubells JF et al. | — | 2004 | → |
| Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. | Vink JM et al. | — | 2004 | → |
| Mate similarity for substance dependence and antisocial personality disorder symptoms among parents of patients and controls. | Sakai JT et al. | — | 2004 | → |
| Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. | Uhl GR | — | 2004 | → |
| Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process. | Uhl GR | — | 2004 | → |
| Variation in recombination rate may bias human genetic disease mapping studies. | Boyle AS et al. | — | 2004 | → |
| Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. | Anchordoquy HC et al. | — | 2003 | → |