Genetic and environmental risk factors for adolescent-onset substance use disorders.
paper
Primary
Public
- Authors
- Meyers, Jacquelyn L; Dick, Danielle M
- Year
- 2010
- Journal
- Child and adolescent psychiatric clinics of North America
- PMID
- 20682215
- DOI
- 10.1016/j.chc.2010.03.013
- PMCID
- PMC3661209
Substance dependence disorders are chronic relapsing disorders with immense societal consequences. Twin and family studies have found that there are critical genetic and environmental components in the inheritance of substance use disorders, and modern advances in genetics are making it possible to identify specific variants that may predispose an individual to these disorders. Adolescence is a crucial period for initiation, experimentation, and the establishment of more regular patterns of use of alcohol and other drugs. Adolescent substance use is a known risk factor for the development of later alcohol and substance use problems, as well as related externalizing disorders such as antisocial personality disorder. Understanding the early risk factors and processes that make these youths vulnerable to substance use disorders is crucial to the development of effective strategies for prevention. This article reviews the genetic origins of adolescent substance use problems and the potential this field of research offers for prevention.
The latent genetic externalizing factor.
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| Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps. | Dick DM et al. | — | 2026 | → |
| Etiology of longitudinal associations between subjective effects and substance use disorders in a clinical sample. | Gresko SA et al. | — | 2026 | → |
| Requiem for Many Dreams? Comorbid Substance Use and Disruptive Behaviour Disorders in Adolescents. | Ameen S | — | 2026 | → |
| Childhood exposure to danger increases Black youths' alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis. | Beach SRH et al. | — | 2025 | → |
| Development of the Comprehensive Addiction Risk Evaluation System: Initial Participant Response to an Online Personalized Feedback Program Integrating Genomic, Behavioral, and Environmental Risk Information. | Dick DM et al. | — | 2025 | → |
| Does Combined Stimulant and Psychosocial Treatment in Childhood Attention-Deficit/Hyperactivity Disorder Protect Against Future Substance Use? | Bommersbach TJ et al. | — | 2025 | → |
| Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study. | Choi M et al. | — | 2025 | → |
| Salivary cortisol trajectories among inpatients undergoing substance use disorder treatment: A prospective repeated-measures study. | Otterholt E et al. | — | 2025 | → |
| Transcriptomic markers of psychoactive substance addiction in peripheral blood. | Yakovchik A et al. | — | 2025 | → |
| Youth Correlates of Genetic Liability to Substance Use Disorders | Paul SE et al. | — | 2025 | — |
| Adolescent social isolation increases binge-like alcohol drinking in male but not female high-alcohol-preferring mice. | Cullins EC et al. | — | 2024 | → |
| Age of onset and alcohol and cannabis use disorders among Mexican American young adults: Robust substance-specific effects of early use as a risk factor. | Tam CC et al. | — | 2024 | → |
| <b>Risk and protective factors for cannabis use in adolescence: a population-based survey in schools</b>. | O'Dowd TM et al. | — | 2024 | → |
| Burnout Mediates the Association Between Workaholism and Substance Use: Findings from a French National Company. | Airagnes G et al. | — | 2024 | → |
| Comparative Effects of Cognitive Rehabilitation and Photobiomodulation on Drug Craving in Treatment-Seeking Opioid Addicts. | Hadadgar S et al. | — | 2024 | → |
| Individual Trajectories of Specialist Substance Use Disorder and Mental Health Treatment Utilization Among Young Adults With Substance Use Problems: A Cohort Study. | Bakken R et al. | — | 2024 | → |
| COVID-19 pandemic stressors are associated with reported increases in frequency of drunkenness among individuals with a history of alcohol use disorder. | Meyers JL et al. | — | 2023 | → |
| Family history, childhood maltreatment, and adolescent binge drinking exert synergistic effects on delay discounting and future alcohol use. | Liao J et al. | — | 2023 | → |
| Insomnia as a Risk Factor for Substance Use Disorders in Women. | Berro LF | — | 2023 | → |
| Prenatal alcohol exposure and attention-deficit/hyperactivity disorder independently predict greater substance use in young adulthood. | Dodge NC et al. | — | 2023 | → |
| Sexually dimorphic role of circadian clock genes in alcohol drinking behavior. | de Zavalia N et al. | — | 2023 | → |
| Social media use and cannabis vaping initiation among US youth. | Lee J et al. | — | 2023 | → |
| The association between maternal and paternal substance use and child substance use, internalizing and externalizing problems: a systematic review and meta-analysis. | McGovern R et al. | — | 2023 | → |
| Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study. | Gresko SA et al. | — | 2022 | → |
| Parental and own substance use disorder: The intersection of gender and early adversity. | van Draanen J et al. | — | 2022 | → |
| Alcohol Use Disorder Symptoms Rather than Alcohol Exposure Predict Experiences of Cannabis Use Disorder Symptoms among Adolescents and Young Adults. | Dierker LC et al. | — | 2021 | → |
| Child reward neurocircuitry and parental substance use history: Findings from the Adolescent Brain Cognitive Development Study. | Kwarteng AE et al. | — | 2021 | → |
| Effects of depression, anxiety and screen use on adolescent substance use. | Cioffredi LA et al. | — | 2021 | → |
| Prevalence and Correlates of Illicit Drug Use among Norwegian Nightlife Patrons. | Jørgenrud B et al. | — | 2021 | → |
| Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study. | AshaRani PV et al. | — | 2021 | → |
| A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction | Sun J et al. | — | 2020 | → |
| Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use. | Bares CB et al. | — | 2020 | → |
| Longitudinal Relations among Adolescent Risk Behavior, Family Cohesion, Violence Exposure, and Mental Health in a National Sample. | Goodrum NM et al. | — | 2020 | → |
| Psychosocial and socio-environmental factors associated with adolescents' tobacco and other substance use in Bangladesh. | Khan MMA et al. | — | 2020 | → |
| Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents. | Compton KS et al. | — | 2019 | → |
| Risk Factors for Drug Overdose in Young People: A Systematic Review of the Literature. | Lyons RM et al. | — | 2019 | → |
| Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention. | Cleveland HH et al. | — | 2018 | → |
| Cannabis use disorder and male sex predict medical cannabis card status in a sample of high risk adolescents. | Kim J et al. | — | 2018 | → |
| Demographic and socioenvironmental predictors of premorbid marijuana use among patients with first-episode psychosis. | Pauselli L et al. | — | 2018 | → |
| Inhalant use in adolescents in northern Russia. | Koposov R et al. | — | 2018 | → |
| Research Review: What have we learned about adolescent substance use? | Gray KM et al. | — | 2018 | → |
| The Opioid Crisis and Schools-A Commentary. | Welsh JW et al. | — | 2018 | → |
| Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents. | Bountress K et al. | — | 2017 | → |
| Genotype × Environment Interaction in Smoking Behaviors: A Systematic Review. | Do EK et al. | — | 2017 | → |
| Inhalant Use and Mental Health Problems in Russian Juvenile Delinquents. | Zachrison L et al. | — | 2017 | → |
| The adolescent brain at risk for substance use disorders: a review of functional MRI research on motor response inhibition. | Koyama MS et al. | — | 2017 | → |
| The association of addictive-like eating with food intake in children. | Richmond RL et al. | — | 2017 | → |
| Parental Substance Abuse As an Early Traumatic Event. Preliminary Findings on Neuropsychological and Personality Functioning in Young Drug Addicts Exposed to Drugs Early. | Parolin M et al. | — | 2016 | → |
| Risk and protective factors for heavy binge alcohol use among American Indian adolescents utilizing emergency health services. | Tingey L et al. | — | 2016 | → |
| The blind side of addiction: A call for increased awareness of developmentally informed youth addiction scholarship. | Kaminer Y et al. | — | 2016 | → |
| Alcohol-induced impairment in adolescents admitted to inpatient treatment after heavy episodic drinking: effects of age and gender. | Mick I et al. | — | 2015 | → |
| Did the 18 Drinking Age Promote High School Dropout? Implications for Current Policy. | Plunk AD et al. | — | 2015 | → |
| Genetic and Environmental Interplay in Adolescent Substance Use Disorders. | Hines LA et al. | — | 2015 | → |
| Sensation seeking and cocaine dependence in adults with reported childhood ADHD. | Ballon N et al. | — | 2015 | → |
| Chronic disease prevention in primary care: how and when will genomics impact? | Walter FM et al. | — | 2014 | → |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | — | 2014 | → |
| Genetic and environmental risk factors for illicit substance use and use disorders: Joint analysis of self and co-twin ratings. | Ystrom E et al. | — | 2014 | → |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | — | 2014 | → |
| A systematic review of the relationships between family functioning, pubertal timing and adolescent substance use. | Hummel A et al. | — | 2013 | → |
| Attitude and risk of substance use in adolescents diagnosed with Asperger syndrome. | Ramos M et al. | — | 2013 | → |
| Genetic and environmental predictors of latent trajectories of alcohol use from adolescence to adulthood: a male twin study. | Wichers M et al. | — | 2013 | → |
| Increases in alcohol consumption in women and elderly groups: evidence from an epidemiological study. | Geels LM et al. | — | 2013 | → |
| Use of psychoactive substances by adolescents: current panorama. | Lopes GM et al. | — | 2013 | → |
| An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology. | Lynskey MT et al. | — | 2012 | → |
| The co-occurring use and misuse of cannabis and tobacco: a review. | Agrawal A et al. | — | 2012 | → |
| Substance use and exercise participation among young adults: parallel trajectories in a national cohort-sequential study. | Terry-McElrath YM et al. | — | 2011 | → |