Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine.
paper
Cited
Public
Unavailable
- Authors
- Ehringer, Marissa A; Clegg, Hilary V; Collins, Allan C; Corley, Robin P; Crowley, Thomas; Hewitt, John K; Hopfer, Christian J; Krauter, Kenneth; Lessem, Jeffrey; Rhee, Soo Hyun; Schlaepfer, Isabel; Smolen, Andrew; Stallings, Michael C; Young, Susan E; Zeiger, Joanna S
- Year
- 2007
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 17226798
- DOI
- 10.1002/ajmg.b.30464
Nicotine addiction and alcohol dependence are highly comorbid disorders that are likely to share overlapping genetic components. We have examined two neuronal nicotinic receptor subunit genes (CHRNA4 and CHRNB2) for possible associations with nicotine and alcohol phenotypes, including measures of frequency of use and measures of initial subjective response in the period shortly after first using the drugs. The subjects were 1,068 ethnically diverse young adults participating in ongoing longitudinal studies of adolescent drug behaviors at the University of Colorado, representing both clinical and community samples. Analysis of six SNPs in the CHRNA4 gene provided modest support for an association with past 6 month use of alcohol in Caucasians (three SNPs with P < 0.08), but no evidence for an association with tobacco and CHRNA4 was detected. However, a SNP (rs2072658) located immediately upstream of CHRNB2 was associated with the initial subjective response to both alcohol and tobacco. This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cholinergic Receptor Nicotinic Beta 2 Subunit Promotes the Peritoneal Disseminating Metastasis of Colorectal Cancer. | Umeda S et al. | β | 2025 | β |
| Sex-dependent factors of alcohol and neuroimmune mechanisms. | Cruz B et al. | β | 2023 | β |
| Effects of adolescent substance use disorders on central cholinergic function. | Hauser SR et al. | β | 2021 | β |
| Novel Putative Positive Modulators of Ξ±4Ξ²2 nAChRs Potentiate Nicotine Reward-Related Behavior. | Cooper SY et al. | β | 2021 | β |
| Spontaneous Ultrasonic Vocalization Transmission in Adult, Male Long-Evans Rats Is Age-Dependent and Sensitive to EtOH Modulation. | Mittal N et al. | β | 2020 | β |
| The role of nicotinic acetylcholine receptors in alcohol-related behaviors. | Miller CN et al. | β | 2020 | β |
| The Impact of Genes on Adolescent Substance Use: A Developmental Perspective. | Trucco EM et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| Varenicline modulates ethanol and saccharin consumption in adolescent male and female C57BL/6J mice. | Kamens HM et al. | β | 2018 | β |
| A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems. | Richmond-Rakerd LS et al. | β | 2017 | β |
| Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. | Yin X et al. | β | 2017 | β |
| Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse. | Cross SJ et al. | β | 2017 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| Tobacco and alcohol use during adolescence: Interactive mechanisms in animal models. | Abreu-VillaΓ§a Y et al. | β | 2017 | β |
| African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. | Levran O et al. | β | 2016 | β |
| An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School. | Vandenbergh DJ et al. | β | 2016 | β |
| Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. | Zuo L et al. | β | 2016 | β |
| Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions. | Yang J et al. | β | 2016 | β |
| CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. | Cannon DS et al. | β | 2016 | β |
| Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence. | Kamens HM et al. | β | 2016 | β |
| Genetic Risk Determinants for Cigarette Smoking Dependence in Mexican Mestizo Families. | Svyryd Y et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| Utilizing mutual information for detecting rare and common variants associated with a categorical trait. | Sun L et al. | β | 2016 | β |
| CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy. | Rocha Santos J et al. | β | 2015 | β |
| Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. | Manzardo AM et al. | β | 2015 | β |
| Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. | Grotewiel M et al. | β | 2015 | β |
| Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. | Reyes-Gibby CC et al. | β | 2015 | β |
| Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers. | Chen X et al. | β | 2015 | β |
| Nicotinic receptor contributions to smoking: insights from human studies and animal models. | Brunzell DH et al. | β | 2015 | β |
| The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype. | Csala I et al. | β | 2015 | β |
| Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults. | Coon H et al. | β | 2014 | β |
| Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults. | Cannon DS et al. | β | 2014 | β |
| Genetic Association of CHRNB3 and CHRNA6 Gene Polymorphisms with Nicotine Dependence Syndrome Scale in Korean Population. | Won WY et al. | β | 2014 | β |
| Genetics and genomics of alcohol sensitivity. | Morozova TV et al. | β | 2014 | β |
| Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. | Harenza JL et al. | β | 2014 | β |
| A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity. | Wen Y et al. | β | 2013 | β |
| Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study. | Choquet H et al. | β | 2013 | β |
| How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use? | McKee SA et al. | β | 2013 | β |
| Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. | Hendrickson LM et al. | β | 2013 | β |
| Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. | Bergen AW et al. | β | 2013 | β |
| NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. | Zuo L et al. | β | 2013 | β |
| Nominal association with CHRNA4 variants and nicotine dependence. | Kamens HM et al. | β | 2013 | β |
| Polymorphisms of genes in neurotransmitter systems were associated with alcohol use disorders in a Tibetan population. | Xu Y et al. | β | 2013 | β |
| The Ξ²2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse. | Dawson A et al. | β | 2013 | β |
| Association between nicotinic acetylcholine receptor single nucleotide polymorphisms and smoking cessation. | Spruell T et al. | β | 2012 | β |
| The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis. | Zhang T et al. | β | 2012 | β |
| Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes. | Swan GE et al. | β | 2012 | β |
| Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements. | Childs E et al. | β | 2012 | β |
| Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. | Kapoor M et al. | β | 2012 | β |
| Association of CHRNA4 polymorphisms with smoking behavior in two populations. | Han S et al. | β | 2011 | β |
| Associations of nicotine intake measures with CHRN genes in Finnish smokers. | Keskitalo-Vuokko K et al. | β | 2011 | β |
| CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. | Hoft NR et al. | β | 2011 | β |
| Dizziness and the genetic influences on subjective experiences to initial cigarette use. | Haberstick BC et al. | β | 2011 | β |
| Population composition, public policy, and the genetics of smoking. | Boardman JD et al. | β | 2011 | β |
| Risk and protective factors for nicotine dependence in adolescence. | Hu MC et al. | β | 2011 | β |
| Sensitivity to secondhand smoke exposure predicts future smoking susceptibility. | Lessov-Schlaggar CN et al. | β | 2011 | β |
| Addressing tobacco use disorder in smokers in early remission from alcohol dependence: the case for integrating smoking cessation services in substance use disorder treatment programs. | Kalman D et al. | β | 2010 | β |
| Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. | Li MD et al. | β | 2010 | β |
| Association of CHRN genes with "dizziness" to tobacco. | Ehringer MA et al. | β | 2010 | β |
| Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. | Wang J et al. | β | 2010 | β |
| Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice. | Symons MN et al. | β | 2010 | β |
| Genetic and environmental risk factors for adolescent-onset substance use disorders. | Meyers JL et al. | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. | Kamens HM et al. | β | 2010 | β |
| Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the FagerstrΓΆm test for nicotine dependence. | Wessel J et al. | β | 2010 | β |
| SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. | Esterlis I et al. | β | 2010 | β |
| Subjective effects to marijuana associated with marijuana use in community and clinical subjects. | Zeiger JS et al. | β | 2010 | β |
| The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review. | Crunelle CL et al. | β | 2010 | β |
| A systems biology network model for genetic association studies of nicotine addiction and treatment. | Thomas PD et al. | β | 2009 | β |
| Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. | Greenbaum L et al. | β | 2009 | β |
| Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases? | Quaak M et al. | β | 2009 | β |
| Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. | Wang JC et al. | β | 2009 | β |
| Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases. | Quaak M et al. | β | 2009 | β |
| Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. | Saccone NL et al. | β | 2009 | β |
| New insights into the genetics of addiction. | Li MD et al. | β | 2009 | β |
| Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. | Wang JC et al. | β | 2009 | β |
| SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. | Hoft NR et al. | β | 2009 | β |
| Substance use, trait measures, and subjective response to nicotine in never-smokers stratified on parental smoking history and sex. | Pomerleau OF et al. | β | 2009 | β |
| ADHD and smoking: from genes to brain to behavior. | McClernon FJ et al. | β | 2008 | β |
| A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. | Grucza RA et al. | β | 2008 | β |
| Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. | Sherva R et al. | β | 2008 | β |
| Association of candidate genes with antisocial drug dependence in adolescents. | Corley RP et al. | β | 2008 | β |
| Genetics of nicotine dependence and pharmacotherapy. | Lessov-Schlaggar CN et al. | β | 2008 | β |
| Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. | Portugal GS et al. | β | 2008 | β |
| Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. | Conti DV et al. | β | 2008 | β |
| Nicotinic receptor gene variants influence susceptibility to heavy smoking. | Stevens VL et al. | β | 2008 | β |
| The genetic components of alcohol and nicotine co-addiction: from genes to behavior. | Schlaepfer IR et al. | β | 2008 | β |