Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

paper Cited Public

Authors: Li, Ming D; Xu, Qing; Lou, Xiang-Yang; Payne, Thomas J; Niu, Tianhua; Ma, Jennie Z
Year: 2010
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 19859904
DOI: 10.1002/ajmg.b.31043
PMCID: PMC2924635

#	Section	Preview
0	Introduction	Cigarette smoking is the most preventable cause of morbidity and death, resulting in more than…
1	Introduction	The psychopharmacologic effects of nicotine are mediated primarily by functionally diverse neuronal…
2	Introduction	Several subunit genes have been investigated for association with ND and other smoking-related…
3	Introduction	Considering that the participants in these studies were primarily European Americans (EAs) or of…
4	Materials and Methods — Participants and ND measures	Participants were recruited primarily from the Mid-South states of Tennessee, Mississippi, and…
5	Materials and Methods — Participants and ND measures	The ND of each smoker was ascertained by three of the measures used most commonly in tobacco…
6	Materials and Methods — Participants and ND measures	The participants were 1366 individuals from 402 AA families and 671 individuals from 200 EA…
7	Materials and Methods — DNA samples, SNP selection, and SNP genotyping	DNA was isolated from the blood of each participant using a DNA Maxi kit from Qiagen, Inc.…
8	Materials and Methods — DNA samples, SNP selection, and SNP genotyping	All SNPs were genotyped using the TaqMan assay in a 384-well microplate format (Applied Biosystems…
9	Materials and Methods — Association analysis	The PedCheck program (O’Connell and Weeks 1998) was used to detect any genotyping inconsistencies.…
10	Materials and Methods — Association analysis	value of the Z statistic using Monte Carlo sampling under the null distribution of no linkage and no…
11	Materials and Methods — Interaction analysis of variants in CHRNA5/A3/B4 cluster	Gene–gene interactions of SNPs in the CHRNA5/A3/B4 cluster were analyzed using a newly developed…
12	Materials and Methods — Power analysis	Power analysis for single-locus main effects as well as two-locus interactive effects was performed…
13	Results — Individual SNP-based association analysis	We evaluated 22 SNPs in the CHRNA5/A3/B4 cluster in two independent ethnic samples. Association of…
14	Results — Individual SNP-based association analysis	We found substantial differences between the EA and AA samples in the allele frequencies for several…
15	Results — Haplotype block structure and LD analysis	The pair-wise D’ values of 22 SNPs for the three genes in a total of 77 kb of nucleotide sequence…
16	Results — Haplotype-based association analysis	Using the FBAT program, we performed haplotype-based association analysis for all possible…
17	Results — Haplotype-based association analysis	In the AA sample, we found two major haplotypes in CHRNA3, with the first, G-C-T, formed by…
18	Results — Haplotype-based association analysis	Regarding the EA sample, we also found two haplotypes each in CHRNA5 and CHRNA3 that showed…
19	Results — Interaction analysis of CHRNA5/A3/B4 gene cluster	With the PGMDR method, we analyzed interactions for all possible combinations of two to seven SNPs…

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In this knowledge base

Title	Year	PMID
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	2016	27166759
Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers.	2014	24733007
Identification of CHRNA5 rare variants in African-American heavy smokers.	2014	24682045
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.	2013	23249876
Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.	2011	21079997
Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.	2010	20808433
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	2010	20584212
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.	2010	20700436

External

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CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study.	Yang X et al.	—	2019	→
Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population.	Liu Q et al.	—	2018	→
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Two <i>CHRN</i> susceptibility variants for COPD are genetic determinants of emphysema and chest computed tomography manifestations in Chinese patients.	Zhao Z et al.	—	2017	→
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