In the AA sample, we found two major haplotypes in CHRNA3, with the first, G-C-T, formed by rs1317286-rs12914385-rs2869546, at a frequency of 14% showing significant associations with all the three ND measures (P = 0.016 ~ 0.043); and a second one, T-C-G, formed by rs2869546-rs6495308-rs3743075, at a frequency of 41%, revealing a significant association with SQ (P = 0.041; Table 4). Again, none of these associations remained significant after correction for multiple testing.
