Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
paper
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- Authors
- Liu, Pengyuan; Vikis, Haris G; Wang, Daolong; Lu, Yan; Wang, Yian; Schwartz, Ann G; Pinney, Susan M; Yang, Ping; de Andrade, Mariza; Petersen, Gloria M; Wiest, Jonathan S; Fain, Pamela R; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Coons, Teresa; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E; Wu, Xifeng; Spitz, Margaret R; Eisen, Timothy; Houlston, Richard S; Amos, Christopher I; Anderson, Marshall W; You, Ming
- Year
- 2008
- Journal
- Journal of the National Cancer Institute
- PMID
- 18780872
- DOI
- 10.1093/jnci/djn268
- PMCID
- PMC2538550
Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
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|---|---|---|---|---|
| Common genetic basis and causality between central nervous system disease and cancer. | Tan S et al. | — | 2025 | → |
| High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology of Lung Cancer Consortium. | Liu Y et al. | — | 2025 | → |
| Interaction between Continuous Pack-Years Smoked and Polygenic Risk Score on Lung Cancer Risk: Prospective Results from the Framingham Heart Study. | Duncan MS et al. | — | 2024 | → |
| Lung cancer in patients who have never smoked - an emerging disease. | LoPiccolo J et al. | — | 2024 | → |
| Exploring the Association Between PRC2 Genes Variants and Lung Cancer Risk in Chinese Han Population. | Gao M et al. | — | 2023 | → |
| Association of Polymorphism <i>CHRNA5</i> and <i>CHRNA3</i> Gene in People Addicted to Nicotine. | Chmielowiec K et al. | — | 2022 | → |
| Etiology of lung cancer: Evidence from epidemiologic studies. | Zou K et al. | — | 2022 | → |
| <i>CHRNA5</i> rs16969968 and <i>CHRNA3</i> rs578776 polymorphisms are associated with multiple nicotine dependence phenotypes in Bangladeshi smokers. | Chaity NI et al. | — | 2022 | → |
| Mapping of global, regional and national incidence, mortality and mortality-to-incidence ratio of lung cancer in 2020 and 2050. | Sharma R | — | 2022 | → |
| APOBEC3B deletion polymorphism and lung cancer risk in the southern Chinese population. | Ben X et al. | — | 2021 | → |
| Rare deleterious germline variants and risk of lung cancer. | Liu Y et al. | — | 2021 | → |
| Targeting lung cancer screening to individuals at greatest risk: the role of genetic factors. | Lebrett MB et al. | — | 2021 | → |
| Therapeutic Potential of Olaparib in Combination With Pembrolizumab in a Young Patient With a Maternally Inherited BRCA2 Germline Variant: A Research Report. | Waddington T et al. | — | 2021 | → |
| The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies. | Byun J et al. | — | 2021 | → |
| 2018 Langley Award for Basic Research on Nicotine and Tobacco: Bringing Precision Medicine to Smoking Cessation. | Bierut LJ | — | 2020 | → |
| Annotation and extraction of age and temporally-related events from clinical histories. | Hong J et al. | — | 2020 | → |
| Nicotinic-nAChR signaling mediates drug resistance in lung cancer. | Cheng WL et al. | — | 2020 | → |
| Potential Genes Associated with the Survival of Lung Adenocarcinoma Were Identified by Methylation. | Shen Z et al. | — | 2020 | → |
| Acetylcholine signaling system in progression of lung cancers. | Friedman JR et al. | — | 2019 | → |
| Disparity in age at lung cancer diagnosis between current and former smokers. | Campling BG et al. | — | 2019 | → |
| Identifying prognosis and metastasis-associated genes associated with Ewing sarcoma by weighted gene co-expression network analysis. | Wang B et al. | — | 2019 | → |
| Molecular links between COPD and lung cancer: new targets for drug discovery? | Caramori G et al. | — | 2019 | → |
| Using genomic profiling for understanding and improving response to smoking cessation treatment. | Bierut LJ | — | 2019 | → |
| A Decade of GWAS Results in Lung Cancer. | Bossé Y et al. | — | 2018 | → |
| Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. | Rosenberger A et al. | — | 2018 | → |
| Genome-Wide Association Studies of Cancer in Diverse Populations. | Park SL et al. | — | 2018 | → |
| Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer. | Liu Y et al. | — | 2018 | → |
| Weak sharing of genetic association signals in three lung cancer subtypes: evidence at the SNP, gene, regulation, and pathway levels. | O'Brien TD et al. | — | 2018 | → |
| Familial risk for lung cancer. | Kanwal M et al. | — | 2017 | → |
| Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma. | Lin YY et al. | — | 2017 | → |
| Novel Mutations of the CHRNA3 Gene in Non-Small Cell Lung Cancer in an Iranian Population | Mehrabi N et al. | — | 2017 | → |
| Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer. | Xie K et al. | — | 2017 | → |
| Prognostic impact of EGFR mutation in non-small-cell lung cancer patients with family history of lung cancer. | Kim JS et al. | — | 2017 | → |
| Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. | Zhou F et al. | — | 2017 | → |
| CHRNA5/CHRNA3 Locus Associates with Increased Mortality among Smokers. | Kupiainen H et al. | — | 2016 | → |
| Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males. | Zhang Y et al. | — | 2016 | → |
| Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | Wen L et al. | — | 2016 | → |
| Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. | Liu Y et al. | — | 2016 | → |
| Nicotinic acetylcholine receptors and cancer. | Dang N et al. | — | 2016 | → |
| Analyzing large-scale samples confirms the association between the rs1051730 polymorphism and lung cancer susceptibility. | Han Z et al. | — | 2015 | → |
| Association of PSMA4 polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population. | Wang T et al. | — | 2015 | → |
| CHRNA3 genetic polymorphism and the risk of lung cancer in the Chinese Han smoking population. | Zhou W et al. | — | 2015 | → |
| Germline mutations causing familial lung cancer. | Tomoshige K et al. | — | 2015 | → |
| Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions. | Weissfeld JL et al. | — | 2015 | → |
| PARK2 gene and familial lung cancer: what is the link? | Xiong D et al. | — | 2015 | → |
| Potentially functional polymorphisms in PAK1 are associated with risk of lung cancer in a Chinese population. | Zheng M et al. | — | 2015 | → |
| R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability. | Chen HY et al. | — | 2015 | → |
| The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population. | Zhu M et al. | — | 2015 | → |
| The SNP rs931794 in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis. | Wang Q et al. | — | 2015 | → |
| Acetylcholine receptor pathway in lung cancer: New twists to an old story. | Niu XM et al. | — | 2014 | → |
| Apoptosis-Related Single Nucleotide Polymorphisms and the Risk of Non-Small Cell Lung Cancer in Women. | Pathak A et al. | — | 2014 | → |
| EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. | Wilson IM et al. | — | 2014 | → |
| Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients. | He Y et al. | — | 2014 | → |
| No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. | Baumert J et al. | — | 2014 | → |
| Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. | Nguyen JD et al. | — | 2014 | → |
| Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. | Alberg AJ et al. | — | 2013 | → |
| Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors. | Flora AV et al. | — | 2013 | → |
| Genetic susceptibility to lung cancer and co-morbidities. | Yang IA et al. | — | 2013 | → |
| RGS17: an emerging therapeutic target for lung and prostate cancers. | Bodle CR et al. | — | 2013 | → |
| Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966. | Kaakinen M et al. | — | 2012 | → |
| From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. | Ware JJ et al. | — | 2012 | → |
| Genetic epidemiology of cigarette smoke-induced lung disease. | Schwartz AG | — | 2012 | → |
| Genome-wide disease association study in chewing tobacco associated oral cancers. | Bhatnagar R et al. | — | 2012 | → |
| Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium. | Coté ML et al. | — | 2012 | → |
| Mendelian randomization: application to cardiovascular disease. | Timpson NJ et al. | — | 2012 | → |
| Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population. | Li Z et al. | — | 2012 | → |
| Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis. | Gu M et al. | — | 2012 | → |
| The CHRNA5-A3-B4 gene cluster in nicotine addiction. | Berrettini WH et al. | — | 2012 | → |
| Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. | Kapoor M et al. | — | 2012 | → |
| An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. | Yu H et al. | — | 2011 | → |
| Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. | Ware JJ et al. | — | 2011 | → |
| Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. | Sakoda LC et al. | — | 2011 | → |
| Chronic obstructive pulmonary disease and lung cancer: new molecular insights. | Adcock IM et al. | — | 2011 | → |
| Current status of genome-wide association studies in cancer. | Chung CC et al. | — | 2011 | → |
| Detection of chromosomal abnormalities using high resolution arrays in clinical cancer research. | Dalmasso C et al. | — | 2011 | → |
| From smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors. | Lee CH et al. | — | 2011 | → |
| Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | — | 2011 | → |
| Lung cancer in never smokers. | Yang P | — | 2011 | → |
| Mechanisms involved in lung cancer development in COPD. | Caramori G et al. | — | 2011 | → |
| Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study. | Kaur-Knudsen D et al. | — | 2011 | → |
| Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. | Wassenaar CA et al. | — | 2011 | → |
| Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population. | Jaworowska E et al. | — | 2011 | → |
| Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. | Chen J et al. | — | 2011 | → |
| A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. | Ioannidis JP et al. | — | 2010 | → |
| [A cross-sectional investigation on risk factors of lung cancer for residents over 40 years old in Chengdu, Sichuan Province, China]. | Chen B et al. | — | 2010 | → |
| A rigorous and comprehensive validation: common genetic variations and lung cancer. | Yang P et al. | — | 2010 | → |
| A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. | Liu P et al. | — | 2010 | → |
| Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines. | Langevin SM et al. | — | 2010 | → |
| Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. | Li MD et al. | — | 2010 | → |
| Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. | Liu P et al. | — | 2010 | → |
| Family history and lung cancer risk: international multicentre case-control study in Eastern and Central Europe and meta-analyses. | Lissowska J et al. | — | 2010 | → |
| From nicotine to breast cancer, implications of cholinergic receptor pathway. | Linnoila RI | — | 2010 | → |
| From smoking to lung cancer: the CHRNA5/A3/B4 connection. | Improgo MR et al. | — | 2010 | → |
| Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. | Lu Y et al. | — | 2010 | → |
| Genome-wide association studies in cancer--current and future directions. | Chung CC et al. | — | 2010 | → |
| Genome-wide association studies of cancer. | Stadler ZK et al. | — | 2010 | → |
| Genome-wide association studies of cancer predisposition. | Stadler ZK et al. | — | 2010 | → |
| Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. | Kohno T et al. | — | 2010 | → |
| Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. | Saccone NL et al. | — | 2010 | → |
| Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. | Saccone NL et al. | — | 2010 | → |
| Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. | Lee CH et al. | — | 2010 | → |
| The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. | Hsiung CA et al. | — | 2010 | → |
| Acetylcholine receptor pathway and lung cancer. | Thunnissen FB | — | 2009 | → |
| Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. | Shiraishi K et al. | — | 2009 | → |
| Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. | Greenbaum L et al. | — | 2009 | → |
| Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. | You M et al. | — | 2009 | → |
| Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. | Liu Y et al. | — | 2009 | → |
| Human genetic variations: Beacons on the pathways to successful ageing. | Cluett C et al. | — | 2009 | → |
| Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. | Chen LS et al. | — | 2009 | → |
| Invited commentary: genes, environment, and hybrid vigor. | Gwinn M et al. | — | 2009 | → |
| Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. | Lester HA et al. | — | 2009 | → |
| Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. | Schwartz AG et al. | — | 2009 | → |
| Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. | Wang JC et al. | — | 2009 | → |
| The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. | Saccone NL et al. | — | 2009 | → |
| Inherited susceptibility to common cancers. | Foulkes WD | — | 2008 | → |
| The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. | Spitz MR et al. | — | 2008 | → |