value of the Z statistic using Monte Carlo sampling under the null distribution of no linkage and no association (Horvath and others 2004). Three genetic models (additive, dominant, and recessive) were tested for both individual and multi-locus SNPs (i.e., haplotypes). For all PBAT and FBAT association tests, sex and age were used as covariates in the EA and AA samples and sex, age, and ethnicity as covariates in the combined sample. All significant associations were corrected for multiple testing according to the SNP spectral decomposition approach (SNPSpD)(Nyholt 2004) for individual SNP analysis and using Bonferroni correction by dividing the significance level by the number of major haplotypes (> 5.0% in frequency) for haplotype-based association analysis.
