A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
paper
Cited
Public
Unavailable
- Authors
- Thorgeirsson, Thorgeir E; Geller, Frank; Sulem, Patrick; Rafnar, Thorunn; Wiste, Anna; Magnusson, Kristinn P; Manolescu, Andrei; Thorleifsson, Gudmar; Stefansson, Hreinn; Ingason, Andres; Stacey, Simon N; Bergthorsson, Jon T; Thorlacius, Steinunn; Gudmundsson, Julius; Jonsson, Thorlakur; Jakobsdottir, Margret; Saemundsdottir, Jona; Olafsdottir, Olof; Gudmundsson, Larus J; Bjornsdottir, Gyda; Kristjansson, Kristleifur; Skuladottir, Halla; Isaksson, Helgi J; Gudbjartsson, Tomas; Jones, Gregory T; Mueller, Thomas; GottsΓ€ter, Anders; Flex, Andrea; Aben, Katja K H; de Vegt, Femmie; Mulders, Peter F A; Isla, Dolores; Vidal, Maria J; Asin, Laura; Saez, Berta; Murillo, Laura; Blondal, Thorsteinn; Kolbeinsson, Halldor; Stefansson, Jon G; Hansdottir, Ingunn; Runarsdottir, Valgerdur; Pola, Roberto; Lindblad, Bengt; van Rij, Andre M; Dieplinger, Benjamin; Haltmayer, Meinhard; Mayordomo, Jose I; Kiemeney, Lambertus A; Matthiasson, Stefan E; Oskarsson, Hogni; Tyrfingsson, Thorarinn; Gudbjartsson, Daniel F; Gulcher, Jeffrey R; Jonsson, Steinn; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
- Year
- 2008
- Journal
- Nature
- PMID
- 18385739
- DOI
- 10.1038/nature06846
- PMCID
- PMC4539558
Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking behaviour and nicotine dependence (ND) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Smoking is the major risk factor for lung cancer (LC) and is one of the main risk factors for peripheral arterial disease (PAD). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genome-wide association study that used low-quantity smokers as controls, and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Disruption of <i>chrna5</i> blunts aversion and adaptive transcriptomic responses to nicotine and alcohol. | Goel T et al. | β | 2026 | β |
| Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects. | Zhang X et al. | β | 2026 | β |
| Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer. | Peng T et al. | β | 2026 | β |
| Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction. | He Y et al. | β | 2026 | β |
| Unveiling the hidden genetic conundrum linking pulmonary diseases and neuropsychiatric disorders: Novel insights from advanced omics-based analyses of the lung-brain axis. | Ding S et al. | β | 2026 | β |
| A Machine Learning Tool to Predict Survival After First Surgery in Peripheral Artery Disease Patients. | Doneda M et al. | β | 2025 | β |
| Analysis of the Relationship Between <i>CHRNA</i>3/5 and <i>EPHX1</i> Polymorphisms to Tobacco Intake and Development of Chronic Obstructive Pulmonary Disease (COPD). | Prudente Bartholo T et al. | β | 2025 | β |
| A polygenic risk score for peripheral artery disease and major adverse limb events. | Al Said S et al. | β | 2025 | β |
| Biochemical Diagnosis in Substance and Non-substance Addiction. | Shen W et al. | β | 2025 | β |
| Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis. | Li X et al. | β | 2025 | β |
| Common genetic basis and causality between central nervous system disease and cancer. | Tan S et al. | β | 2025 | β |
| JCS/JCC/JSPCCS 2024 Guideline on Genetic Testing and Counseling in Cardiovascular Disease. | Imai Y et al. | β | 2025 | β |
| Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6. | Yang D et al. | β | 2025 | β |
| <i>chrna3</i> Modulates Alcohol Response. | Raine J et al. | β | 2025 | β |
| Multi-trait association analysis reveals shared genetic architecture between lung cancer and cardiometabolic diseases. | Lyu Q et al. | β | 2025 | β |
| Perspectives on the Ξ±5 nicotinic acetylcholine receptor in lung cancer progression. | Cai J et al. | β | 2025 | β |
| Polygenic Risk Score Is Associated with Developing and Dying from Lung Cancer in the National Lung Screening Trial. | Young RP et al. | β | 2025 | β |
| Relationship between tobacco smoking and metabolic syndrome: a Mendelian randomization analysis. | Lin CC et al. | β | 2025 | β |
| Retroelement co-option disrupts the cancer transcriptional programme. | Loong J et al. | β | 2025 | β |
| Silencing circLDLRAD3 Inhibits Lung Cancer Progression by Regulating the miR-497-5p/PFKP Axis. | Zhou H et al. | β | 2025 | β |
| The pathogenic mutations in smokers with non-small cell lung cancer: a next-generation sequencing study. | Yan S et al. | β | 2025 | β |
| Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report. | Hill SY et al. | β | 2025 | β |
| Abundant extrasynaptic expression of Ξ±3Ξ²4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice. | Tsuzuki A et al. | β | 2024 | β |
| Addressing causal relationship between drinking behavior and metabolic syndrome: one-sample Mendelian randomization analysis. | Yang CW et al. | β | 2024 | β |
| Clarifying Chronic Obstructive Pulmonary Disease Genetic Associations Observed in Biobanks via Mediation Analysis of Smoking. | Bazemore K et al. | β | 2024 | β |
| Comprehensive Analysis of the Gene Expression Profiles of Rat Brain Tissues under Environmental Exposure to Nicotine. | Liu W et al. | β | 2024 | β |
| Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample. | Cinciripini PM et al. | β | 2024 | β |
| Integrative analysis of genetics, epigenetics and RNA expression data reveal three susceptibility loci for smoking behavior in Chinese Han population. | Li MD et al. | β | 2024 | β |
| Interaction between Continuous Pack-Years Smoked and Polygenic Risk Score on Lung Cancer Risk: Prospective Results from the Framingham Heart Study. | Duncan MS et al. | β | 2024 | β |
| Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan. | Al-Eitan L et al. | β | 2024 | β |
| JCS/JCC/JSPCCS 2024 Guideline on Genetic Testing and Counseling in Cardiovascular Disease. | Imai Y et al. | β | 2024 | β |
| Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals. | Romero Villela PN et al. | β | 2024 | β |
| Lung cancer in patients who have never smoked - an emerging disease. | LoPiccolo J et al. | β | 2024 | β |
| Metagenome-assembled bacterial genomes derived from various aging flue-cured tobacco samples. | Li M et al. | β | 2024 | β |
| Reduction of nicotine content in tobacco through microbial degradation: research progress and potential applications. | Li ZJ et al. | β | 2024 | β |
| Smoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder. | Venkatesh SK et al. | β | 2024 | β |
| Targeting signaling pathways with andrographolide in cancer therapy (Review). | Shaharudin NS et al. | β | 2024 | β |
| The Gap of Health Inequalities Amongst Lung Cancer Patients of Different Socioeconomic Status: A Brief Reference to the Greek Reality. | Sofianidi A et al. | β | 2024 | β |
| The therapeutic potential of RNA m(6)A in lung cancer. | Yu J et al. | β | 2024 | β |
| "Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression. | Bortolato M et al. | β | 2024 | β |
| Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35. | Cullina S et al. | β | 2023 | β |
| An in-depth association analysis of genetic variants within nicotine-related loci: Meeting in middle of GWAS and genetic fine-mapping. | Mo C et al. | β | 2023 | β |
| Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa). | Wootton RE et al. | β | 2023 | β |
| Candidate gene-environment interactions in substance abuse: A systematic review. | Jiang Z et al. | β | 2023 | β |
| Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking. | Bierut L et al. | β | 2023 | β |
| Deciphering gene contributions and etiologies of somatic mutational signatures of cancer. | Ji X et al. | β | 2023 | β |
| Genetic Associations Between Smoking- and Glaucoma-Related Traits. | Tran JH et al. | β | 2023 | β |
| Genetic differences between smokers and never-smokers with lung cancer. | KuΕnierczyk P | β | 2023 | β |
| Genomic medicine to reduce tobacco and related disorders: Translation to precision prevention and treatment. | Chen LS et al. | β | 2023 | β |
| Global burden of cancers attributable to tobacco smoking, 1990-2019: an ecological study. | Sharma R et al. | β | 2023 | β |
| Hierarchical association of COPD to principal genetic components of biological systems. | Carlin DE et al. | β | 2023 | β |
| Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. | Levey DF et al. | β | 2023 | β |
| Multifactorial Diseases of the Heart, Kidneys, Lungs, and Liver and Incident Cancer: Epidemiology and Shared Mechanisms. | Shi C et al. | β | 2023 | β |
| New medications development for smoking cessation. | Lengel D et al. | β | 2023 | β |
| SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection. | Wang Q et al. | β | 2023 | β |
| Sequence variants affecting the genome-wide rate of germline microsatellite mutations. | Kristmundsdottir S et al. | β | 2023 | β |
| Smoking is an independent but not a causal risk factor for moderate to severe psoriasis: A Mendelian randomization study of 105,912 individuals. | NΓ€slund-Koch C et al. | β | 2023 | β |
| The Joint Link of the rs1051730 and rs1902341 Polymorphisms and Cigarette Smoking to Peripheral Artery Disease and Atherosclerotic Lesions of Different Arterial Beds. | Zhabin S et al. | β | 2023 | β |
| 'Two-faces' of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment. | Liu Y et al. | β | 2023 | β |
| Understanding the habenula: A major node in circuits regulating emotion and motivation. | Ables JL et al. | β | 2023 | β |
| Association of Polymorphism <i>CHRNA5</i> and <i>CHRNA3</i> Gene in People Addicted to Nicotine. | Chmielowiec K et al. | β | 2022 | β |
| Association of smoking and polygenic risk with the incidence of lung cancer: a prospective cohort study. | Zhang P et al. | β | 2022 | β |
| Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies. | Chang XW et al. | β | 2022 | β |
| Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk. | Yang W et al. | β | 2022 | β |
| Eosinophilia and Lung Cancer: Analysis From Real-World Data and Mendelian Randomization Study. | Wang Z et al. | β | 2022 | β |
| Etiology of lung cancer: Evidence from epidemiologic studies. | Zou K et al. | β | 2022 | β |
| Functional studies of lung cancer GWAS beyond association. | Long E et al. | β | 2022 | β |
| Genetic basis of cardiovascular aging is at the core of human longevity. | Marian AJ | β | 2022 | β |
| Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies. | Goldberg LR et al. | β | 2022 | β |
| Hedgehog-interacting protein acts in the habenula to regulate nicotine intake. | Caligiuri SPB et al. | β | 2022 | β |
| <i>CHRNA5</i> rs16969968 and <i>CHRNA3</i> rs578776 polymorphisms are associated with multiple nicotine dependence phenotypes in Bangladeshi smokers. | Chaity NI et al. | β | 2022 | β |
| Inflammatory and Prothrombotic Biomarkers, DNA Polymorphisms, MicroRNAs and Personalized Medicine for Patients with Peripheral Arterial Disease. | PoredoΕ‘ P et al. | β | 2022 | β |
| Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy. | de Alencar VTL et al. | β | 2022 | β |
| MicrobiomeGWAS: A Tool for Identifying Host Genetic Variants Associated with Microbiome Composition. | Hua X et al. | β | 2022 | β |
| Neurobiological Mechanisms of Nicotine Reward and Aversion. | Wills L et al. | β | 2022 | β |
| Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review. | White O et al. | β | 2022 | β |
| Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARΞ³-Dependent Mechanism. | Liu J et al. | β | 2022 | β |
| SNP rs9387478 at ROS1-DCBLD1 Locus is Significantly Associated with Lung Cancer Risk and Poor Survival in Indian Population. | Chongtham J et al. | β | 2022 | β |
| Strong and weak cross-inheritance of substance use disorders in a nationally representative sample. | Zhang H et al. | β | 2022 | β |
| The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine. | Butnariu LI et al. | β | 2022 | β |
| The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients. | Saber Cherif L et al. | β | 2022 | β |
| The translational challenges of precision oncology. | Pich O et al. | β | 2022 | β |
| A Likelihood Ratio Test for Gene-Environment Interaction Based on the Trend Effect of Genotype Under an Additive Risk Model Using the Gene-Environment Independence Assumption. | de Rochemonteix M et al. | β | 2021 | β |
| APOBEC3B deletion polymorphism and lung cancer risk in the southern Chinese population. | Ben X et al. | β | 2021 | β |
| A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator. | Sanyal N et al. | β | 2021 | β |
| A role for club cells in smoking-associated lung adenocarcinoma. | Behrend SJ et al. | β | 2021 | β |
| Association Between NAT2 Polymorphism and Lung Cancer Risk: A Systematic Review and Meta-Analysis. | Zhu K et al. | β | 2021 | β |
| Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia. | Diabasana Z et al. | β | 2021 | β |
| Chr15q25 genetic variant (rs16969968) independently confers risk of lung cancer, COPD and smoking intensity in a prospective study of high-risk smokers. | Hopkins RJ et al. | β | 2021 | β |
| Clarifying the Genetic Influences on Nicotine Dependence and Quantity of Use in Cigarette Smokers. | Verhulst B et al. | β | 2021 | β |
| Dynamic change in the association of a cigarettes-per-day polygenic risk score across the numeric range of its corresponding phenotype over adolescence and young adulthood. | Deutsch AR et al. | β | 2021 | β |
| Epidemiology of lung cancer. | Thandra KC et al. | β | 2021 | β |
| Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples. | Fan R et al. | β | 2021 | β |
| Genetic Determinants of Peripheral Artery Disease. | Klarin D et al. | β | 2021 | β |
| Genetic Modifiers of Oral Nicotine Consumption in <i>Chrna5</i> Null Mutant Mice. | Meyers E et al. | β | 2021 | β |
| Genetic overlap and causal associations between smoking behaviours and mental health. | Barkhuizen W et al. | β | 2021 | β |
| Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival. | Mu R et al. | β | 2021 | β |
| Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer. | Musolf AM et al. | β | 2021 | β |
| Genome-Wide Association Study of Peripheral Artery Disease. | van Zuydam NR et al. | β | 2021 | β |
| Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease. | Kim W et al. | β | 2021 | β |
| Genome-wide gene-smoking interaction study identified novel susceptibility loci for non-small cell lung cancer in Chinese populations. | Wang Y et al. | β | 2021 | β |
| Investigating the CYP2B6 rs3745274 and rs3211371 polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran. | Sadat Aghabozorg Afjeh S et al. | β | 2021 | β |
| Lung cancer risk in never-smokers: An overview of environmental and genetic factors. | Cheng ES et al. | β | 2021 | β |
| Mechanisms of Nicotine Addiction. | Picciotto MR et al. | β | 2021 | β |
| Nicotinic acetylcholine gene cluster CHRNA5-A3-B4 variants influence smoking status in a Bangladeshi population. | Chaity NI et al. | β | 2021 | β |
| Pharmacogenetics factors influencing smoking cessation success; the importance of nicotine metabolism. | Perez-Paramo YX et al. | β | 2021 | β |
| Premature atherosclerotic peripheral artery disease: An underrecognized and undertreated disorder with a rising global prevalence. | Mehta A et al. | β | 2021 | β |
| Proof of Concept of a Personalized Genetic Risk Tool to Promote Smoking Cessation: High Acceptability and Reduced Cigarette Smoking. | Ramsey AT et al. | β | 2021 | β |
| The effect of CHRNA3 rs1051730 C>T and ABCB1 rs3842 A>G polymorphisms on non-small cell lung cancer and nicotine dependence in Iranian population. | Veiskarami P et al. | β | 2021 | β |
| The shared genetic architecture between epidemiological and behavioral traits with lung cancer. | Pettit RW et al. | β | 2021 | β |
| The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies. | Byun J et al. | β | 2021 | β |
| Vincamine, a safe natural alkaloid, represents a novel anticancer agent. | Al-Rashed S et al. | β | 2021 | β |
| White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy. | Ye Z et al. | β | 2021 | β |
| Ξ±3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake. | Elayouby KS et al. | β | 2021 | β |
| 2018 Langley Award for Basic Research on Nicotine and Tobacco: Bringing Precision Medicine to Smoking Cessation. | Bierut LJ | β | 2020 | β |
| A brief history of human disease genetics. | Claussnitzer M et al. | β | 2020 | β |
| Altered habenula resting state functional connectivity in deprived veteran tobacco smokers: A pilot study. | Jennings C et al. | β | 2020 | β |
| Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria. | Mimouni A et al. | β | 2020 | β |
| Balancing neurotrophin pathway and sortilin function: Its role in human disease. | Al-Yozbaki M et al. | β | 2020 | β |
| CHRNA5 rs16969968 polymorphism is associated with lung cancer risk: A meta-analysis. | Zhou W et al. | β | 2020 | β |
| Cocaine potently blocks neuronal Ξ±<sub>3</sub>Ξ²<sub>4</sub> nicotinic acetylcholine receptors in SH-SY5Y cells. | Ma ZG et al. | β | 2020 | β |
| Comparison of haplotype-based tests for detecting gene-environment interactions with rare variants. | Papachristou C et al. | β | 2020 | β |
| COPD-dependent effects of genetic variation in key inflammation pathway genes on lung cancer risk. | Watza D et al. | β | 2020 | β |
| Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk. | Kabbani N et al. | β | 2020 | β |
| Do Nicotinic Receptors Modulate High-Order Cognitive Processing? | Koukouli F et al. | β | 2020 | β |
| Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study. | Wootton RE et al. | β | 2020 | β |
| Examining the effect of smoking on suicidal ideation and attempts: triangulation of epidemiological approaches. | Harrison R et al. | β | 2020 | β |
| Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. | Quach BC et al. | β | 2020 | β |
| Exploring the Effects of Cigarette Smoking on Inflammatory Bowel Disease Using Mendelian Randomization. | Jones DP et al. | β | 2020 | β |
| Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: A review. | Pezzuto A et al. | β | 2020 | β |
| Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. | Klarin D et al. | β | 2020 | β |
| Genetic Determinants of Lung Cancer Prognosis in Never Smokers: A Pooled Analysis in the International Lung Cancer Consortium. | Brhane Y et al. | β | 2020 | β |
| Genetics of Smoking Behaviors in American Indians. | Henderson JA et al. | β | 2020 | β |
| Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution. | Icick R et al. | β | 2020 | β |
| Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. | Chen J et al. | β | 2020 | β |
| Herpes zoster and the subsequent risk of prostate cancer in an Asian population: A nationwide population-based cohort study. | Tsao YH et al. | β | 2020 | β |
| Inherited lung cancer: a review. | de Alencar VTL et al. | β | 2020 | β |
| Low-Dose Nicotine Activates EGFR Signaling via Ξ±5-nAChR and Promotes Lung Adenocarcinoma Progression. | Wang ML et al. | β | 2020 | β |
| Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction. | Wittenberg RE et al. | β | 2020 | β |
| Participatory Design of a Personalized Genetic Risk Tool to Promote Behavioral Health. | Ramsey AT et al. | β | 2020 | β |
| Predictors of Current DSM-5 PTSD Diagnosis and Symptom Severity Among Deployed Veterans: Significance of Predisposition, Stress Exposure, and Genetics. | Hu Y et al. | β | 2020 | β |
| Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis. | Zhang H et al. | β | 2020 | β |
| Secondary analysis of case-control association studies: Insights on weighting-based inference motivate a new specification test. | Li F et al. | β | 2020 | β |
| Stability in effects of different smoking-related polygenic risk scores over age and smoking phenotypes. | Deutsch AR et al. | β | 2020 | β |
| The causal effects of health conditions and risk factors on social and socioeconomic outcomes: Mendelian randomization in UK Biobank. | Harrison S et al. | β | 2020 | β |
| The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake. | Antolin-Fontes B et al. | β | 2020 | β |
| The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges. | Maskos U | β | 2020 | β |
| The Ξ±5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates Ξ±4Ξ²2<sup>*</sup> and Ξ±3Ξ²4<sup>*</sup> Receptors. | Scholze P et al. | β | 2020 | β |
| Variants in the CHRNA5-CHRNA3-CHRNB4 Region of Chromosome 15 Predict Gastrointestinal Adverse Events in the Transdisciplinary Tobacco Use Research Center Smoking Cessation Trial. | Culverhouse RC et al. | β | 2020 | β |
| Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q. | Musolf AM et al. | β | 2020 | β |
| Ξ±5-nAChR modulates melanoma growth through the Notch1 signaling pathway. | Dang N et al. | β | 2020 | β |
| Ξ²4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement. | Husson M et al. | β | 2020 | β |
| Acetylcholine receptors: Key players in cancer development. | Chen J et al. | β | 2019 | β |
| Acetylcholine signaling system in progression of lung cancers. | Friedman JR et al. | β | 2019 | β |
| A decade in psychiatric GWAS research. | Horwitz T et al. | β | 2019 | β |
| An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations. | Jiang K et al. | β | 2019 | β |
| Association between TGF-Ξ²1 rs1982073/rs1800469 polymorphism and lung cancer susceptibility: An updated meta-analysis involving 7698 cases and controls. | Chen G et al. | β | 2019 | β |
| Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies. | Brand JS et al. | β | 2019 | β |
| Bivariate logistic Bayesian LASSO for detecting rare haplotype association with two correlated phenotypes. | Yuan X et al. | β | 2019 | β |
| Chronic Obstructive Pulmonary Disease Risk and Smoking Cessation Changes Induced by <i>CHRNA5-A3</i> and <i>CHRNB3-A6</i> Variation in a Chinese Male Population. | Zhao L et al. | β | 2019 | β |
| Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. | Lutz SM et al. | β | 2019 | β |
| Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in African Americans. | Jones CC et al. | β | 2019 | β |
| Daily cooking duration and its joint effects with genetic polymorphisms on lung cancer incidence: Results from a Chinese prospective cohort study. | Wang G et al. | β | 2019 | β |
| Disparity in age at lung cancer diagnosis between current and former smokers. | Campling BG et al. | β | 2019 | β |
| From controlled to compulsive drug-taking: The role of the habenula in addiction. | Mathis V et al. | β | 2019 | β |
| From genetics to biology: advancing mental health research in the Genomics ERA. | Alexander Arguello P et al. | β | 2019 | β |
| Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. | Ragland MF et al. | β | 2019 | β |
| Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. | MacKillop J et al. | β | 2019 | β |
| Genetic variants in nicotinic receptors and smoking cessation in Parkinson's disease. | Chuang YH et al. | β | 2019 | β |
| Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway. | HΓ€llfors J et al. | β | 2019 | β |
| Genome-wide association study of peripheral artery disease in the Million Veteran Program. | Klarin D et al. | β | 2019 | β |
| Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. | Wang H et al. | β | 2019 | β |
| Identification of nicotinic acetylcholine receptor subunits in different lung cancer cell lines and the inhibitory effect of alpha-conotoxin TxID on lung cancer cell growth. | Qian J et al. | β | 2019 | β |
| Identifying genetic markers associated with susceptibility to cardiovascular diseases. | Shukla H et al. | β | 2019 | β |
| Impact of CHRNA5 polymorphisms on the risk of schizophrenia in the Chinese Han population. | Zhan D et al. | β | 2019 | β |
| Interpreting Behavior Genetic Models: Seven Developmental Processes to Understand. | Briley DA et al. | β | 2019 | β |
| Is Schizophrenia a Risk Factor for Breast Cancer?-Evidence From Genetic Data. | Byrne EM et al. | β | 2019 | β |
| Mining and validating the expression pattern and prognostic value of acetylcholine receptors in non-small cell lung cancer. | Ma G et al. | β | 2019 | β |
| Nicotine Pharmacokinetics in Rat Brain and Blood by Simultaneous Microdialysis, Stable-Isotope Labeling, and UHPLC-HRMS: Determination of Nicotine Metabolites. | Xu Y et al. | β | 2019 | β |
| Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence. | Garcia-Rivas V et al. | β | 2019 | β |
| Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population. | Silva MR et al. | β | 2019 | β |
| Precision oncology of lung cancer: genetic and genomic differences in Chinese population. | Shen H et al. | β | 2019 | β |
| Secular trends in smoking in relation to prevalent and incident smoking-related disease: A prospective population-based study. | Tonnesen P et al. | β | 2019 | β |
| Smoking and Increased White and Red Blood Cells. | Pedersen KM et al. | β | 2019 | β |
| Smoking, Systemic Inflammation, and Airflow Limitation: A Mendelian Randomization Analysis of 98Β 085 Individuals From the General Population. | Γolak Y et al. | β | 2019 | β |
| The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors. | Lee HW et al. | β | 2019 | β |
| The study of interactions between genome and exposome in the development of systemic lupus erythematosus. | Leffers HCB et al. | β | 2019 | β |
| Using genomic profiling for understanding and improving response to smoking cessation treatment. | Bierut LJ | β | 2019 | β |
| A Decade of GWAS Results in Lung Cancer. | BossΓ© Y et al. | β | 2018 | β |
| A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants. | Nedeljkovic I et al. | β | 2018 | β |
| A little rein on addiction. | Mathuru AS | β | 2018 | β |
| A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. | Coverstone ED et al. | β | 2018 | β |
| Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population. | Liu Q et al. | β | 2018 | β |
| Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes. | Qin J et al. | β | 2018 | β |
| Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers. | Jensen KP et al. | β | 2018 | β |
| CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population. | PΓ©rez-Morales R et al. | β | 2018 | β |
| Diverse reprogramming codes for neuronal identity. | Tsunemoto R et al. | β | 2018 | β |
| Education, Smoking, and Cohort Change: Forwarding a Multidimensional Theory of the Environmental Moderation of Genetic Effects. | Wedow R et al. | β | 2018 | β |
| Environmental, genetic and epigenetic contributions to cocaine addiction. | Pierce RC et al. | β | 2018 | β |
| Epigenetic signatures of starting and stopping smoking. | McCartney DL et al. | β | 2018 | β |
| Evaluating the effect of nicotinic cholinergic receptor genes on the risk of nonsyndromic cleft lip with or without cleft palate. | Wang M et al. | β | 2018 | β |
| Food addiction: a valid concept? | Fletcher PC et al. | β | 2018 | β |
| From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation. | Salloum NC et al. | β | 2018 | β |
| Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease. | Lang BM et al. | β | 2018 | β |
| Genetics of biologically based psychological differences. | Sallis H et al. | β | 2018 | β |
| Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. | Hancock DB et al. | β | 2018 | β |
| Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. | Zhou H et al. | β | 2018 | β |
| Genome-wide association study of familial lung cancer. | Byun J et al. | β | 2018 | β |
| Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). | Saccone NL et al. | β | 2018 | β |
| Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced lung cancer. | Fusco JP et al. | β | 2018 | β |
| Human Genetics of Addiction: New Insights and Future Directions. | Hancock DB et al. | β | 2018 | β |
| Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue. | Bhalala OG et al. | β | 2018 | β |
| Identification of shared genetic variants between schizophrenia and lung cancer. | Zuber V et al. | β | 2018 | β |
| Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. | Ji X et al. | β | 2018 | β |
| Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment. | Liu W et al. | β | 2018 | β |
| Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts. | Taylor M et al. | β | 2018 | β |
| Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How. | Chen LS et al. | β | 2018 | β |
| Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology. | Wood DE et al. | β | 2018 | β |
| Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions. | Klenowski PM et al. | β | 2018 | β |
| Multi-environment fitness landscapes of a tRNA gene. | Li C et al. | β | 2018 | β |
| Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. | Teitelbaum AM et al. | β | 2018 | β |
| Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. | Feng Y et al. | β | 2018 | β |
| Pathways to precision medicine in smoking cessation treatments. | Chen LS et al. | β | 2018 | β |
| Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction. | Reginsson GW et al. | β | 2018 | β |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | β | 2018 | β |
| Preparing the Way: Exploiting Genomic Medicine to Stop Smoking. | Bierut LJ et al. | β | 2018 | β |
| Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats. | Wang T et al. | β | 2018 | β |
| Statistical Analysis of Multiple Phenotypes in Genetic Epidemiologic Studies: From Cross-Phenotype Associations to Pleiotropy. | Salinas YD et al. | β | 2018 | β |
| Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis. | Snetselaar R et al. | β | 2018 | β |
| The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT study. | Johnsen MB et al. | β | 2018 | β |
| The epidemiology of lung cancer. | de Groot PM et al. | β | 2018 | β |
| The fifth subunit in Ξ±3Ξ²4 nicotinic receptor is more than an accessory subunit. | Crespi A et al. | β | 2018 | β |
| The genetics of smoking in individuals with chronic obstructive pulmonary disease. | Obeidat M et al. | β | 2018 | β |
| The nature of nurture: Effects of parental genotypes. | Kong A et al. | β | 2018 | β |
| The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. | Saccone NL et al. | β | 2018 | β |
| Toward the implementation of genomic applications for smoking cessation and smoking-related diseases. | Ramsey AT et al. | β | 2018 | β |
| Using imputed genotype data in the joint score tests for genetic association and gene-environment interactions in case-control studies. | Song M et al. | β | 2018 | β |
| Ξ±-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to Ξ±7-nAChR overexpressed non-small cell lung cancer. | Mei D et al. | β | 2018 | β |
| Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes. | Xu H et al. | β | 2017 | β |
| A new functional IDH2 genetic variant is associated with the risk of lung cancer. | Li J et al. | β | 2017 | β |
| A polymorphism in miR-1262 regulatory region confers the risk of lung cancer in Chinese population. | Xie K et al. | β | 2017 | β |
| Association between UGT1A1*28*28 genotype and lung cancer in the Japanese population. | Nishikawa Y et al. | β | 2017 | β |
| Association study of genetic variation in DNA repair pathway genes and risk of basal cell carcinoma. | Lin Y et al. | β | 2017 | β |
| Atlas of human diseases influenced by genetic variants with extreme allele frequency differences. | Sulovari A et al. | β | 2017 | β |
| Bayesian association scan reveals loci associated with human lifespan and linked biomarkers. | McDaid AF et al. | β | 2017 | β |
| Biochemical Diagnosis in Substance and Non-substance Addiction. | Shen W et al. | β | 2017 | β |
| Biomarkers and Genetics in Peripheral Artery Disease. | Hazarika S et al. | β | 2017 | β |
| Common, germline genetic variations in the novel tumor suppressor <i>BAP1</i> and risk of developing different types of cancer. | Lin M et al. | β | 2017 | β |
| Decreased Survival After Combining Thoracic Irradiation and an Anti-PD-1 Antibody Correlated With Increased T-cell Infiltration Into Cardiac and Lung Tissues. | Myers CJ et al. | β | 2017 | β |
| Detecting rare and common haplotype-environment interaction under uncertainty of gene-environment independence assumption. | Zhang Y et al. | β | 2017 | β |
| Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis. | Ma Y et al. | β | 2017 | β |
| Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. | Melroy-Greif WE et al. | β | 2017 | β |
| Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. | Bordas A et al. | β | 2017 | β |
| Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies. | Musolf AM et al. | β | 2017 | β |
| Functional variants in DCAF4 associated with lung cancer risk in European populations. | Liu H et al. | β | 2017 | β |
| Genetic polymorphisms and lung cancer risk: Evidence from meta-analyses and genome-wide association studies. | Liu C et al. | β | 2017 | β |
| Genetics of addictive behavior: the example of nicotine dependence. | Gorwood P et al. | β | 2017 | β |
| Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium. | Feng Y et al. | β | 2017 | β |
| Genetic variation in the exome: Associations with alcohol and tobacco co-use. | Otto JM et al. | β | 2017 | β |
| Genome-wide association studies of cancer: current insights and future perspectives. | Sud A et al. | β | 2017 | β |
| Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. | Yin X et al. | β | 2017 | β |
| Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons. | Deflorio C et al. | β | 2017 | β |
| Individual differences in the neuropsychopathology of addiction. | George O et al. | β | 2017 | β |
| Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. | Skaaby T et al. | β | 2017 | β |
| Lung cancer, genetic predisposition and smoking: the Nordic Twin Study of Cancer. | Hjelmborg J et al. | β | 2017 | β |
| Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. | Patel CJ et al. | β | 2017 | β |
| Peripheral Arterial Disease Genetics: Progress to Date and Challenges Ahead. | Belkin N et al. | β | 2017 | β |
| Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. | Schuit E et al. | β | 2017 | β |
| Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer. | Xie K et al. | β | 2017 | β |
| Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments. | Sakata K et al. | β | 2017 | β |
| Retrograde inhibition by a specific subset of interpeduncular Ξ±5 nicotinic neurons regulates nicotine preference. | Ables JL et al. | β | 2017 | β |
| Safety and Effectiveness of Bone Marrow Cell Concentrate in the Treatment of Chronic Critical Limb Ischemia Utilizing a Rapid Point-of-Care System. | Ponemone V et al. | β | 2017 | β |
| Selection against variants in the genome associated with educational attainment. | Kong A et al. | β | 2017 | β |
| Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population. | Wen L et al. | β | 2017 | β |
| Simultaneous Modeling of Disease Status and Clinical Phenotypes To Increase Power in Genome-Wide Association Studies. | Bilow M et al. | β | 2017 | β |
| SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population | Pandey N et al. | β | 2017 | β |
| Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. | Zhou F et al. | β | 2017 | β |
| Systematic integration of biomedical knowledge prioritizes drugs for repurposing. | Himmelstein DS et al. | β | 2017 | β |
| Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American. | Zhang TX et al. | β | 2017 | β |
| Targeted sequencing of chromosome 15q25 identified novel variants associated with risk of lung cancer and smoking behavior in Chinese. | Cheng Y et al. | β | 2017 | β |
| The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study. | Johnsen MB et al. | β | 2017 | β |
| The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. | Barrie ES et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| The Genomic Architecture of Interactions Between Natural Genetic Polymorphisms and Environments in Yeast Growth. | Wei X et al. | β | 2017 | β |
| The habenula in psychiatric disorders: More than three decades of translational investigation. | Fakhoury M | β | 2017 | β |
| The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease. | Cloonan SM et al. | β | 2017 | β |
| The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese. | Abe M et al. | β | 2017 | β |
| The Population Health Benefits Of A Healthy Lifestyle: Life Expectancy Increased And Onset Of Disability Delayed. | Mehta N et al. | β | 2017 | β |
| Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine : Meeting report on a symposium held in Dortmund May 7-8, 2015. | Golka K et al. | β | 2017 | β |
| Tobacco use disorder and treatment: new challenges and opportunities. | Ziedonis D et al. | β | 2017 | β |
| Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them | Lawlor DA et al. | β | 2017 | β |
| Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them. | Lawlor D et al. | β | 2017 | β |
| Ξ±5 nicotinic receptors link smoking to schizophrenia. | Liu XA et al. | β | 2017 | β |
| A hybrid parametric and empirical likelihood model for evaluating interactions in case-control Studies. | Qin J et al. | β | 2016 | β |
| An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School. | Vandenbergh DJ et al. | β | 2016 | β |
| A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. | Yuan H et al. | β | 2016 | β |
| A Novel Pathway-Based Approach Improves Lung Cancer Risk Prediction Using Germline Genetic Variations. | Qian DC et al. | β | 2016 | β |
| A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences. | Thorgeirsson TE et al. | β | 2016 | β |
| Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland. | Kita-Milczarska K et al. | β | 2016 | β |
| Association between smoking behaviour and genetic variants of glial cell line-derived neurotrophic factor. | Kotyuk E et al. | β | 2016 | β |
| Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis. | Qu X et al. | β | 2016 | β |
| Association of polymorphisms in the telomere-related gene ACYP2 with lung cancer risk in the Chinese Han population. | Chen N et al. | β | 2016 | β |
| Association of the functional BCL-2 rs2279115 genetic variant and small cell lung cancer. | Yang X et al. | β | 2016 | β |
| Associations between smoking behavior-related alleles and the risk of melanoma. | Wu W et al. | β | 2016 | β |
| Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. | Zuo L et al. | β | 2016 | β |
| Causal Inference in Developmental Origins of Health and Disease (DOHaD) Research. | Gage SH et al. | β | 2016 | β |
| Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males. | Zhang Y et al. | β | 2016 | β |
| Combining Telomerase Reverse Transcriptase Genetic Variant rs2736100 with Epidemiologic Factors in the Prediction of Lung Cancer Susceptibility. | Wang X et al. | β | 2016 | β |
| Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | Wen L et al. | β | 2016 | β |
| Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions. | Yang J et al. | β | 2016 | β |
| Curbing the burden of lung cancer. | Urman A et al. | β | 2016 | β |
| Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S. | Tu H et al. | β | 2016 | β |
| Epidemiology of Lung Cancer. | Schwartz AG et al. | β | 2016 | β |
| Evidence of CNIH3 involvement in opioid dependence. | Nelson EC et al. | β | 2016 | β |
| Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. | David SP et al. | β | 2016 | β |
| Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study. | Yuan JM et al. | β | 2016 | β |
| Genetic imaging consortium for addiction medicine: From neuroimaging to genes. | Mackey S et al. | β | 2016 | β |
| Genetic mapping of canine fear and aggression. | Zapata I et al. | β | 2016 | β |
| Genetic Relationship between Schizophrenia and Nicotine Dependence. | Chen J et al. | β | 2016 | β |
| Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis. | Chen LS et al. | β | 2016 | β |
| Genetic Risk for Lung Cancer and the Benefits of Quitting Smoking. | Hall FS | β | 2016 | β |
| Genetic scores of smoking behaviour in a Chinese population. | Yang S et al. | β | 2016 | β |
| Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. | Ward-Caviness CK et al. | β | 2016 | β |
| Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer. | Wang Y et al. | β | 2016 | β |
| Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries. | Baurley JW et al. | β | 2016 | β |
| Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. | Zanetti KA et al. | β | 2016 | β |
| Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. | Ware JJ et al. | β | 2016 | β |
| G = E: What GWAS Can Tell Us about the Environment. | Gage SH et al. | β | 2016 | β |
| How can we Improve on Modeling Nicotine Addiction to Develop Better Smoking Cessation Treatments? | Shoaib M et al. | β | 2016 | β |
| Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. | Cloonan SM et al. | β | 2016 | β |
| Narrative review of genes, environment, and cigarettes. | Do E et al. | β | 2016 | β |
| Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. | Schaal C et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors and cancer. | Dang N et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| Non-small cell lung cancer: current treatment and future advances. | Zappa C et al. | β | 2016 | β |
| Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. | Patel YM et al. | β | 2016 | β |
| Parametric Linkage Analysis Identifies Five Novel Genome-Wide Significant Loci for Familial Lung Cancer. | Musolf AM et al. | β | 2016 | β |
| Peripheral Artery Disease and Aortic Disease. | Criqui MH et al. | β | 2016 | β |
| Pharmacogenomics of platinum-based chemotherapy sensitivity in NSCLC: toward precision medicine. | Yin JY et al. | β | 2016 | β |
| Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study. | Reddon H et al. | β | 2016 | β |
| Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. | Zuber V et al. | β | 2016 | β |
| Pleiotropic effects of Chr15q25 nicotinic gene cluster and the relationship between smoking, cognition and ADHD. | Schuch JB et al. | β | 2016 | β |
| Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. | Otto JM et al. | β | 2016 | β |
| Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls. | Kang X et al. | β | 2016 | β |
| Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. | Olfson E et al. | β | 2016 | β |
| Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. | Zuo L et al. | β | 2016 | β |
| Risk factors for lung cancer worldwide. | Malhotra J et al. | β | 2016 | β |
| Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. | Johnson JR et al. | β | 2016 | β |
| Smokescreen: a targeted genotyping array for addiction research. | Baurley JW et al. | β | 2016 | β |
| Snus use and risk of schizophrenia and non-affective psychosis. | MunafΓ² MR et al. | β | 2016 | β |
| Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014. | Aas M et al. | β | 2016 | β |
| The CHRNA5-A3-B4 Gene Cluster and Smoking: From Discovery to Therapeutics. | Lassi G et al. | β | 2016 | β |
| The importance of gene-environment interactions in human obesity. | Reddon H et al. | β | 2016 | β |
| The Long-Term Consequences of Vietnam-Era Conscription and Genotype on Smoking Behavior and Health. | Schmitz L et al. | β | 2016 | β |
| Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan. | Joshi PK et al. | β | 2016 | β |
| A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. | Jensen KP et al. | β | 2015 | β |
| [A genetic view of addiction]. | Ramoz N et al. | β | 2015 | β |
| A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. | Hancock DB et al. | β | 2015 | β |
| Analyzing large-scale samples confirms the association between the rs1051730 polymorphism and lung cancer susceptibility. | Han Z et al. | β | 2015 | β |
| A recurrent mutation in PARK2 is associated with familial lung cancer. | Xiong D et al. | β | 2015 | β |
| A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer. | Gao F et al. | β | 2015 | β |
| Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study. | Buczkowski K et al. | β | 2015 | β |
| Association Between the LIG1 Polymorphisms and Lung Cancer Risk: A Meta-analysis of Case-Control Studies. | Li D et al. | β | 2015 | β |
| Association of 5-HTTLPR polymorphism with smoking behaviors: A meta-analysis. | Li H et al. | β | 2015 | β |
| Biomarkers for precision medicine in airways disease. | Rooney C et al. | β | 2015 | β |
| Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date. | Mamoun M et al. | β | 2015 | β |
| Cardiovascular Effects of Exposure to Cigarette Smoke and Electronic Cigarettes: Clinical Perspectives From the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology. | Morris PB et al. | β | 2015 | β |
| CHRNA3 rs1051730 polymorphism and lung cancer susceptibility in Asian population: a meta-analysis. | Zhan P et al. | β | 2015 | β |
| CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers. | Wu XY et al. | β | 2015 | β |
| CHRNA5 polymorphisms and risk of lung cancer in Chinese Han smokers. | Huang CY et al. | β | 2015 | β |
| CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis. | Chen LS et al. | β | 2015 | β |
| Chronic obstructive pulmonary disease. | Barnes PJ et al. | β | 2015 | β |
| Crucial role of nicotinic Ξ±5 subunit variants for Ca2+ fluxes in ventral midbrain neurons. | Sciaccaluga M et al. | β | 2015 | β |
| CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence. | Riccardi LN et al. | β | 2015 | β |
| Deciphering associations for lung cancer risk through imputation and analysis of 12,316 cases and 16,831 controls. | Wang Y et al. | β | 2015 | β |
| Deciphering Genome Environment Wide Interactions Using Exposed Subjects Only. | Zhao LP et al. | β | 2015 | β |
| Effect of occupational exposures on lung cancer susceptibility: a study of gene-environment interaction analysis. | Malhotra J et al. | β | 2015 | β |
| Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium. | Linneberg A et al. | β | 2015 | β |
| Effect of the rs1051730-rs16969968 variant and smoking cessation treatment: a meta-analysis. | Leung T et al. | β | 2015 | β |
| Genetic Polymorphism, Telomere Biology and Non-Small Lung Cancer Risk. | Wei R et al. | β | 2015 | β |
| Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers. | Chen X et al. | β | 2015 | β |
| Genetics of smoking behaviour. | Ware JJ et al. | β | 2015 | β |
| Genome-wide association studies of late-onset cardiovascular disease. | Smith JG et al. | β | 2015 | β |
| Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. | Gelernter J et al. | β | 2015 | β |
| Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. | Hancock DB et al. | β | 2015 | β |
| Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. | Morris RW et al. | β | 2015 | β |
| Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction. | Pujades-Rodriguez M et al. | β | 2015 | β |
| High affinity Ξ±3Ξ²4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice. | Khroyan TV et al. | β | 2015 | β |
| High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study. | WinslΓΈw UC et al. | β | 2015 | β |
| How Genetic and Other Biological Factors Interact with Smoking Decisions. | Bierut L et al. | β | 2015 | β |
| Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes. | Zhong X et al. | β | 2015 | β |
| Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population. | Han S et al. | β | 2015 | β |
| Identification of Deleterious SNPs and Their Effects on Structural Level in CHRNA3 Gene. | Chandramohan V et al. | β | 2015 | β |
| Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. | Brenner DR et al. | β | 2015 | β |
| iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis. | Huang YT et al. | β | 2015 | β |
| Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls. | Yang Z et al. | β | 2015 | β |
| Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking. | Tyndale RF et al. | β | 2015 | β |
| Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations. | Jin G et al. | β | 2015 | β |
| Lung cancer screening-why do it? Tobacco, the history of screening, and future challenges. | de Groot PM et al. | β | 2015 | β |
| Magnetically optimized SERS assay for rapid detection of trace drug-related biomarkers in saliva and fingerprints. | Yang T et al. | β | 2015 | β |
| New Insights Into Tobacco-Induced Vascular Disease: Clinical Ramifications. | Cooke JP | β | 2015 | β |
| New mechanisms and perspectives in nicotine withdrawal. | Jackson KJ et al. | β | 2015 | β |
| Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes. | Bandiera FC et al. | β | 2015 | β |
| Nicotinic receptor contributions to smoking: insights from human studies and animal models. | Brunzell DH et al. | β | 2015 | β |
| Novel perspectives in cancer therapy: Targeting ion channels. | Arcangeli A et al. | β | 2015 | β |
| Pharmacogenetics of nicotine and associated smoking behaviors. | Tanner JA et al. | β | 2015 | β |
| Pharmacological stress is required for the anti-alcohol effect of the Ξ±3Ξ²4* nAChR partial agonist AT-1001. | Cippitelli A et al. | β | 2015 | β |
| Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases. | Daly AK | β | 2015 | β |
| Positive Selection on Loci Associated with Drug and Alcohol Dependence. | Sadler B et al. | β | 2015 | β |
| Prospective evaluation of C-reactive protein, smoking and lung cancer death in the Third National Health and Nutrition Examination Survey. | Bittoni MA et al. | β | 2015 | β |
| R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability. | Chen HY et al. | β | 2015 | β |
| Response to Transdermal Selegiline Smoking Cessation Therapy and Markers in the 15q24 Chromosomal Region. | Sarginson JE et al. | β | 2015 | β |
| Rethinking the association between smoking and schizophrenia. | Gage SH et al. | β | 2015 | β |
| Risky Business: Pathways to Progress in Biologically Informed Studies of Psychopathology. | Agrawal A et al. | β | 2015 | β |
| Simultaneous determination of nicotine and its nine metabolites in rat blood utilizing microdialysis coupled with UPLC-tandem mass spectrometry for pharmacokinetic application. | Mao J et al. | β | 2015 | β |
| Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases. | ZiΓ³Εkowska-Suchanek I et al. | β | 2015 | β |
| The association of rs1051730 genotype on adherence to and consumption of prescribed nicotine replacement therapy dose during a smoking cessation attempt. | Ware JJ et al. | β | 2015 | β |
| The contribution of rare and common variants in 30 genes to risk nicotine dependence. | Yang J et al. | β | 2015 | β |
| The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions. | Kullo IJ et al. | β | 2015 | β |
| The genetics of diabetic complications. | Ahlqvist E et al. | β | 2015 | β |
| The nicotinic cholinergic system function in the human brain. | Nees F | β | 2015 | β |
| The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15. | Ji X et al. | β | 2015 | β |
| The role of iron in pulmonary pathology. | Khiroya H et al. | β | 2015 | β |
| The Role of Nicotine in Schizophrenia. | Featherstone RE et al. | β | 2015 | β |
| The SNP rs931794 in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis. | Wang Q et al. | β | 2015 | β |
| Tobacco smoking is causally associated with antipsychotic medication use and schizophrenia, but not with antidepressant medication use or depression. | Wium-Andersen MK et al. | β | 2015 | β |
| Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures. | Bergen AW et al. | β | 2015 | β |
| UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. | Teng Y et al. | β | 2015 | β |
| Views on electronic cigarette use in tobacco screening and cessation in an Alaska Native healthcare setting. | Hiratsuka VY et al. | β | 2015 | β |
| [Why screen for lung cancer in patients with arterial disease?]. | Lederlin M et al. | β | 2015 | β |
| Withdrawal: Expanding a Key Addiction Construct. | Piper ME | β | 2015 | β |
| Acetylcholine receptor pathway in lung cancer: New twists to an old story. | Niu XM et al. | β | 2014 | β |
| Addiction science: Uncovering neurobiological complexity. | Volkow ND et al. | β | 2014 | β |
| ADHD diagnosis may influence the association between polymorphisms in nicotinic acetylcholine receptor genes and tobacco smoking. | Polina ER et al. | β | 2014 | β |
| A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood. | Robles AI et al. | β | 2014 | β |
| A glimpse into the future - Personalized medicine for smoking cessation. | Bierut LJ et al. | β | 2014 | β |
| A review of cancer risk prediction models with genetic variants. | Wang X et al. | β | 2014 | β |
| Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease. | Flint J et al. | β | 2014 | β |
| Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies. | Zhao DP et al. | β | 2014 | β |
| Association between interleukin-8 -251A/T polymorphism and risk of lung cancer: a meta-analysis. | Gao P et al. | β | 2014 | β |
| Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case-control studies. | Yuan Y et al. | β | 2014 | β |
| Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study. | Park SL et al. | β | 2014 | β |
| Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers. | Zhu AZ et al. | β | 2014 | β |
| Association of genes involved in calcium and potassium pathways with opioid dependence. | Wang JC et al. | β | 2014 | β |
| A unification of mediation and interaction: a 4-way decomposition. | VanderWeele TJ | β | 2014 | β |
| Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. | Tang H et al. | β | 2014 | β |
| Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide. | Bloom AJ et al. | β | 2014 | β |
| Biomarkers of tobacco smoke exposure. | Mattes W et al. | β | 2014 | β |
| Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway. | Γ svold BO et al. | β | 2014 | β |
| Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. | Shi J et al. | β | 2014 | β |
| CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population. | He P et al. | β | 2014 | β |
| Chronic Obstructive Pulmonary Disease Genetics: A Review of the Past and a Look Into the Future. | Hardin M et al. | β | 2014 | β |
| Combined analysis with copy number variation identifies risk loci in lung cancer. | Li X et al. | β | 2014 | β |
| Cumulative effect of genome-wide association study-identified genetic variants for bladder cancer. | Wang M et al. | β | 2014 | β |
| Curious cases: Altered dose-response relationships in addiction genetics. | Uhl GR et al. | β | 2014 | β |
| Determining the causes and consequences of nicotine dependence: emerging genetic research methods. | Ware JJ et al. | β | 2014 | β |
| Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data. | Jorge SE et al. | β | 2014 | β |
| Evaluation of differential cytotoxic effects of the oil spill dispersant Corexit 9500. | Zheng M et al. | β | 2014 | β |
| Fifty years of tobacco carcinogenesis research: from mechanisms to early detection and prevention of lung cancer. | Hecht SS et al. | β | 2014 | β |
| Finding genomic function for genetic associations in nicotine addiction research: the ENCODE project's role in future pharmacogenomic analysis. | Vandenbergh DJ et al. | β | 2014 | β |
| Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses. | Cui K et al. | β | 2014 | β |
| Gene-environment dependence creates spurious gene-environment interaction. | Dudbridge F et al. | β | 2014 | β |
| Genetic association of BSF2 polymorphism and susceptibility to lung cancer. | Wang H et al. | β | 2014 | β |
| Genetic influences on smoking and clinical disease. Understanding behavioral and biological pathways with mediation analysis. | Lutz SM et al. | β | 2014 | β |
| Genetics and smoking. | Loukola A et al. | β | 2014 | β |
| Genetic variability in the regulation of gene expression in ten regions of the human brain. | Ramasamy A et al. | β | 2014 | β |
| Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. | Gelernter J et al. | β | 2014 | β |
| Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. | Gelernter J et al. | β | 2014 | β |
| Genome-wide association study of smoking behaviours among Bangladeshi adults. | Argos M et al. | β | 2014 | β |
| Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. | Loukola A et al. | β | 2014 | β |
| Germline mutations in driver oncogenes and inherited lung cancer risk independent of smoking history. | Oxnard GR et al. | β | 2014 | β |
| Habenular expression of rare missense variants of the Ξ²4 nicotinic receptor subunit alters nicotine consumption. | Slimak MA et al. | β | 2014 | β |
| Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients. | He Y et al. | β | 2014 | β |
| Inflammation-related genetic variations and survival in patients with advanced non-small cell lung cancer receiving first-line chemotherapy. | Pu X et al. | β | 2014 | β |
| Integrative genomics of chronic obstructive pulmonary disease. | Hobbs BD et al. | β | 2014 | β |
| Lung cancer risk and genetic variants in East Asians: a meta-analysis. | Zhang Q et al. | β | 2014 | β |
| Lung cancer screening: review and performance comparison under different risk scenarios. | Tota JE et al. | β | 2014 | β |
| Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates. | Taylor AE et al. | β | 2014 | β |
| Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) polymorphisms are associated with NSCLC risk in a Chinese population. | Wang Y et al. | β | 2014 | β |
| Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. | Fowler CD et al. | β | 2014 | β |
| Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling. | Dao DQ et al. | β | 2014 | β |
| Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. | Schaal C et al. | β | 2014 | β |
| Parental history and the risk of subsequent vascular events in patients with clinically manifest vascular disease: the effects of sex of the parent and vascular disease location. | Weijmans M et al. | β | 2014 | β |
| Prenatal glucocorticoids and maternal smoking during pregnancy independently program adult nicotine dependence in daughters: a 40-year prospective study. | Stroud LR et al. | β | 2014 | β |
| Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats. | Wang T et al. | β | 2014 | β |
| Protection genes in nucleus accumbens shell affect vulnerability to nicotine self-administration across isogenic strains of adolescent rat. | Chen H et al. | β | 2014 | β |
| Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk. | Wu H et al. | β | 2014 | β |
| Quantitative assessment of the influence of common variations (rs8034191 and rs1051730) at 15q25 and lung cancer risk. | Hu B et al. | β | 2014 | β |
| Quantitative assessment of the influence of TP63 gene polymorphisms and lung cancer risk: evidence based on 93,751 subjects. | Zhang L et al. | β | 2014 | β |
| Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. | Wang Y et al. | β | 2014 | β |
| Role of a genetic variant on the 15q25.1 lung cancer susceptibility locus in smoking-associated nasopharyngeal carcinoma. | Ji X et al. | β | 2014 | β |
| Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. | Korhonen T et al. | β | 2014 | β |
| Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. | Tseng TS et al. | β | 2014 | β |
| Scientific overview: 2013 BBC plenary symposium on tobacco addiction. | De Biasi M et al. | β | 2014 | β |
| Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden. | Priest JR et al. | β | 2014 | β |
| Single-nucleotide polymorphisms of LIG1 associated with risk of lung cancer. | Chen YZ et al. | β | 2014 | β |
| Stratified medicine for mental disorders. | Schumann G et al. | β | 2014 | β |
| Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. | Nguyen JD et al. | β | 2014 | β |
| The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. | Pedneault M et al. | β | 2014 | β |
| The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study. | Kullo IJ et al. | β | 2014 | β |
| The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. | Thompson PM et al. | β | 2014 | β |
| The future has begun in radiogenomics! | Andreassen CN | β | 2014 | β |
| The role of the habenula in drug addiction. | Velasquez KM et al. | β | 2014 | β |
| Two rare variations, D478N and D478E, that occur at the same amino acid residue in nicotinic acetylcholine receptor (nAChR) Ξ±2 subunit influence nAChR function. | Dash B et al. | β | 2014 | β |
| Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. | Bloom AJ et al. | β | 2014 | β |
| Whole-genome analyses of lung function, height and smoking. | Janss L et al. | β | 2014 | β |
| A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity. | Wen Y et al. | β | 2013 | β |
| Abnormal social behavior in nicotinic acetylcholine receptor Ξ²4 subunit-null mice. | Salas R et al. | β | 2013 | β |
| A common biological basis of obesity and nicotine addiction. | Thorgeirsson TE et al. | β | 2013 | β |
| A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. | Zayats T et al. | β | 2013 | β |
| A COPULA-MODEL BASED SEMIPARAMETRIC INTERACTION TEST UNDER THE CASE-CONTROL DESIGN. | Zhang H et al. | β | 2013 | β |
| Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression. | Gallego X et al. | β | 2013 | β |
| Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway. | Gabrielsen ME et al. | β | 2013 | β |
| Association between CHRNA3 rs1051730 genotype and lung cancer risk in Chinese Han population: a case-control study. | Ren JH et al. | β | 2013 | β |
| Association between the telomerase reverse transcriptase (TERT) rs2736098 polymorphism and cancer risk: evidence from a case-control study of non-small-cell lung cancer and a meta-analysis. | Wu H et al. | β | 2013 | β |
| Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population. | Wang Y et al. | β | 2013 | β |
| Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction. | Greenbaum L et al. | β | 2013 | β |
| A three-way decomposition of a total effect into direct, indirect, and interactive effects. | VanderWeele TJ | β | 2013 | β |
| Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. | Brothers JF et al. | β | 2013 | β |
| Capacity building and collaborative research on cross-national studies in the Asian region. | Hser YI et al. | β | 2013 | β |
| Chemoprevention of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. | Szabo E et al. | β | 2013 | β |
| CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users. | Zhu AZ et al. | β | 2013 | β |
| CHRNA5 polymorphism and susceptibility to lung cancer in a Chinese population. | Shen B et al. | β | 2013 | β |
| Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry. | Wang JC et al. | β | 2013 | β |
| Clinico-pathological features and management of lung cancer patients with atherosclerotic vascular diseases. | Shoji F et al. | β | 2013 | β |
| Current genetics and epigenetics of smoking/tobacco-related cardiovascular disease. | Breitling LP | β | 2013 | β |
| Current status on biochemistry and molecular biology of microbial degradation of nicotine. | Gurusamy R et al. | β | 2013 | β |
| Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. | Siedlinski M et al. | β | 2013 | β |
| Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. | Stephens SH et al. | β | 2013 | β |
| DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial. | Doherty JA et al. | β | 2013 | β |
| EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women. | Chen KY et al. | β | 2013 | β |
| Environmental confounding in gene-environment interaction studies. | Vanderweele TJ et al. | β | 2013 | β |
| Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. | Alberg AJ et al. | β | 2013 | β |
| Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4. | Scherf DB et al. | β | 2013 | β |
| Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. | Walsh KM et al. | β | 2013 | β |
| Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors. | Flora AV et al. | β | 2013 | β |
| Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations. | Tekpli X et al. | β | 2013 | β |
| Genetic instrumental variable studies of effects of prenatal risk factors. | Wehby GL et al. | β | 2013 | β |
| Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents. | Nees F et al. | β | 2013 | β |
| Genetics. Herit-ability. | Flint J et al. | β | 2013 | β |
| Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer. | Bai L et al. | β | 2013 | β |
| Genetic susceptibility to lung cancer and co-morbidities. | Yang IA et al. | β | 2013 | β |
| Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. | Dong J et al. | β | 2013 | β |
| High expression of CHRNA1 is associated with reduced survival in early stage lung adenocarcinoma after complete resection. | Chang PM et al. | β | 2013 | β |
| Histamine-2 receptor antagonists and risk of lung cancer in diabetic patients β an exploratory analysis. | Hsu CL et al. | β | 2013 | β |
| Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations. | Deng Q et al. | β | 2013 | β |
| Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study. | Meyers JL et al. | β | 2013 | β |
| Is susceptibility locus for lung cancer in the 15q25 nicotinic acetylcholine receptor gene cluster CHRNA5-A3-B4 associated with risk of gastric cancer? | Wu H et al. | β | 2013 | β |
| LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer. | Liu WB et al. | β | 2013 | β |
| Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population. | Islam MS et al. | β | 2013 | β |
| Mechanistic links between COPD and lung cancer. | Houghton AM | β | 2013 | β |
| Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. | Dani JA et al. | β | 2013 | β |
| Molecular mechanisms underlying behaviors related to nicotine addiction. | Picciotto MR et al. | β | 2013 | β |
| Molecular profile of lung cancer in never smokers. | Subramanian J et al. | β | 2013 | β |
| Multiple isoforms and differential allelic expression of CHRNA5 in lung tissue and lung adenocarcinoma. | Falvella FS et al. | β | 2013 | β |
| New Insights Into Aortic Diseases: A Report From the Third International Meeting on Aortic Diseases (IMAD3). | Kuivaniemi H et al. | β | 2013 | β |
| Nicotine-modulated subunit stoichiometry affects stability and trafficking of Ξ±3Ξ²4 nicotinic receptor. | Mazzo F et al. | β | 2013 | β |
| Nicotine reduction: strategic research plan. | Hatsukami DK et al. | β | 2013 | β |
| Nicotinic acetylcholine receptors mediate lung cancer growth. | Improgo MR et al. | β | 2013 | β |
| Nicotinic acetylcholine receptor subunits Ξ±4 and Ξ±5 associated with smoking behaviour and lung cancer are regulated by upstream open reading frames. | Eggert M et al. | β | 2013 | β |
| Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. | Bergen AW et al. | β | 2013 | β |
| Non-neuronal cholinergic system in airways and lung cancer susceptibility. | Saracino L et al. | β | 2013 | β |
| Normative theorizing about genetics. | Farrelly C | β | 2013 | β |
| Oral premalignancy: the roles of early detection and chemoprevention. | Foy JP et al. | β | 2013 | β |
| Pathway-based analysis using genome-wide association data from a Korean non-small cell lung cancer study. | Lee D et al. | β | 2013 | β |
| Pleiotropy in complex traits: challenges and strategies. | Solovieff N et al. | β | 2013 | β |
| Predicting PTSD using the New York Risk Score with genotype data: potential clinical and research opportunities. | Boscarino JA et al. | β | 2013 | β |
| Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons. | GΓΆrlich A et al. | β | 2013 | β |
| Replication study in Chinese population and meta-analysis supports association of the 5p15.33 locus with lung cancer. | Ke J et al. | β | 2013 | β |
| RGS17: an emerging therapeutic target for lung and prostate cancers. | Bodle CR et al. | β | 2013 | β |
| Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study. | HΓ€llfors J et al. | β | 2013 | β |
| Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population. | Zhao Z et al. | β | 2013 | β |
| Smoking and psychopathology increasingly associated in recent birth cohorts. | Talati A et al. | β | 2013 | β |
| Smoking status, snus use, and variation at the CHRNA5-CHRNA3-CHRNB4 locus in relation to obesity: the GLACIER study. | Varga TV et al. | β | 2013 | β |
| Testing for direct genetic effects using a screening step in family-based association studies. | Lutz SM et al. | β | 2013 | β |
| The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study. | BjΓΈrngaard JH et al. | β | 2013 | β |
| The Impact of Cigarette Quitting during Pregnancy on Other Prenatal Health Behaviors. | Wehby GL et al. | β | 2013 | β |
| The intergenerational transmission of smoking in adulthood: a 25-year study of maternal and offspring maladaptive attributes. | Brook JS et al. | β | 2013 | β |
| The SNP rs402710 in 5p15.33 is associated with lung cancer risk: a replication study in Chinese population and a meta-analysis. | Lu X et al. | β | 2013 | β |
| Update in lung cancer and mesothelioma 2012. | Powell CA et al. | β | 2013 | β |
| Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders. | Bessa C et al. | β | 2013 | β |
| Using Mendelian randomisation to infer causality in depression and anxiety research. | Gage SH et al. | β | 2013 | β |
| Variants in the 15q24/25 locus associate with lung function decline in active smokers. | Mohamed Hoesein FA et al. | β | 2013 | β |
| Adult mice voluntarily progress to nicotine dependence in an oral self-selection assay. | Locklear LL et al. | β | 2012 | β |
| A flexible Bayesian model for studying gene-environment interaction. | Yu K et al. | β | 2012 | β |
| Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. | Bousman CA et al. | β | 2012 | β |
| Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. | Broms U et al. | β | 2012 | β |
| ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. | Wang KS et al. | β | 2012 | β |
| A risk model for lung cancer incidence. | Hoggart C et al. | β | 2012 | β |
| Assessing the impact of nicotine dependence genes on the risk of facial clefts: An example of the use of national registry and biobank data. | Jugessur A et al. | β | 2012 | β |
| Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. | Dong J et al. | β | 2012 | β |
| Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. | MunafΓ² MR et al. | β | 2012 | β |
| Association between genetic variations in surfactant protein d and emphysema, interstitial pneumonia, and lung cancer in a Japanese population. | Ishii T et al. | β | 2012 | β |
| Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population. | Zhou H et al. | β | 2012 | β |
| Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. | Kim WJ et al. | β | 2012 | β |
| Association of neurexin 3 polymorphisms with smoking behavior. | Docampo E et al. | β | 2012 | β |
| Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia. | Calleja-Macias I et al. | β | 2012 | β |
| Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue. | Fehringer G et al. | β | 2012 | β |
| Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966. | Kaakinen M et al. | β | 2012 | β |
| Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. | Walsh KM et al. | β | 2012 | β |
| A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation. | Verhagen M et al. | β | 2012 | β |
| AT-1001: a high affinity and selective Ξ±3Ξ²4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats. | Toll L et al. | β | 2012 | β |
| Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence. | Kheradmand F et al. | β | 2012 | β |
| Autologous bone marrow cell therapy for peripheral arterial disease. | Botti C et al. | β | 2012 | β |
| BDNF Val66Met variant and smoking in a Chinese population. | Zhang XY et al. | β | 2012 | β |
| Calling amplified haplotypes in next generation tumor sequence data. | Dewal N et al. | β | 2012 | β |
| CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. | Hardin M et al. | β | 2012 | β |
| CHRNA3 genotype, nicotine dependence, lung function and disease in the general population. | Kaur-Knudsen D et al. | β | 2012 | β |
| CHRNB3 is more strongly associated with FagerstrΓΆm test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results. | Rice JP et al. | β | 2012 | β |
| Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS). | Bracci PM et al. | β | 2012 | β |
| Class A scavenger receptor deficiency exacerbates lung tumorigenesis by cultivating a procarcinogenic microenvironment in humans and mice. | Ben J et al. | β | 2012 | β |
| Clinical applications of gene-based risk prediction for lung cancer and the central role of chronic obstructive pulmonary disease. | Young RP et al. | β | 2012 | β |
| Common and specific liability to addiction: approaches to association studies of opioid addiction. | Nielsen DA et al. | β | 2012 | β |
| Comparison of pathway analysis approaches using lung cancer GWAS data sets. | Fehringer G et al. | β | 2012 | β |
| Connecting ncRNA Cigarette Smoking Studies with Tobacco Use Behaviors and Health Outcomes. | Ehringer MA | β | 2012 | β |
| Correlation between polymorphisms of nicotine acetylcholine acceptor subunit CHRNA3 and lung cancer susceptibility. | Shen B et al. | β | 2012 | β |
| Cotinine conundrum--a step forward but questions remain. | Spitz MR et al. | β | 2012 | β |
| Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions. | Harmey D et al. | β | 2012 | β |
| Development of pluripotent stem cells for vascular therapy. | Volz KS et al. | β | 2012 | β |
| Direct-to-consumer genetic testing for addiction susceptibility: a premature commercialisation of doubtful validity and value. | Mathews R et al. | β | 2012 | β |
| Emerging genetics of COPD. | Berndt A et al. | β | 2012 | β |
| Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. | Stephens SH et al. | β | 2012 | β |
| From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. | Ware JJ et al. | β | 2012 | β |
| Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. | Yang L et al. | β | 2012 | β |
| Function of human Ξ±3Ξ²4Ξ±5 nicotinic acetylcholine receptors is reduced by the Ξ±5(D398N) variant. | George AA et al. | β | 2012 | β |
| Gene-centric analysis of serum cotinine levels in African and European American populations. | Hamidovic A et al. | β | 2012 | β |
| Genetic architectures of psychiatric disorders: the emerging picture and its implications. | Sullivan PF et al. | β | 2012 | β |
| Genetic association analysis of complex diseases incorporating intermediate phenotype information. | Li Y et al. | β | 2012 | β |
| Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. | Wassel CL et al. | β | 2012 | β |
| Genetic epidemiology of cigarette smoke-induced lung disease. | Schwartz AG | β | 2012 | β |
| Genetic factors control nicotine self-administration in isogenic adolescent rat strains. | Chen H et al. | β | 2012 | β |
| Genetics of peripheral artery disease. | Leeper NJ et al. | β | 2012 | β |
| Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. | VanderWeele TJ et al. | β | 2012 | β |
| Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. | Tyrrell J et al. | β | 2012 | β |
| Genome-wide meta-analyses of smoking behaviors in African Americans. | David SP et al. | β | 2012 | β |
| Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers. | Sakoda LC et al. | β | 2012 | β |
| Habenular signaling in nicotine reinforcement. | Fowler CD et al. | β | 2012 | β |
| Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment. | Boscarino JA et al. | β | 2012 | β |
| Imaging vascular nicotine receptors: a new window onto vascular disease. | Cooke JP | β | 2012 | β |
| Incidence, treatment options, and outcomes of lung cancer in patients with chronic obstructive pulmonary disease. | Schroedl C et al. | β | 2012 | β |
| Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. | Hartz SM et al. | β | 2012 | β |
| Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium. | CotΓ© ML et al. | β | 2012 | β |
| Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. | Timofeeva MN et al. | β | 2012 | β |
| Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma. | Shi J et al. | β | 2012 | β |
| Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort. | Orloff MS et al. | β | 2012 | β |
| Investigation on cardiovascular risk prediction using genetic information. | Pu LN et al. | β | 2012 | β |
| Ion channel mutations in neuronal diseases: a genetics perspective. | Steinlein OK | β | 2012 | β |
| Ion channels in hematopoietic and mesenchymal stem cells. | Pillozzi S et al. | β | 2012 | β |
| Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. | Yoon D et al. | β | 2012 | β |
| Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. | Kazma R et al. | β | 2012 | β |
| Lung cancer epidemiology, risk factors, and prevention. | de Groot P et al. | β | 2012 | β |
| Lung cancer screening. | Wood DE et al. | β | 2012 | β |
| Lung carcinogenesis by tobacco smoke. | Hecht SS | β | 2012 | β |
| Mendelian randomization: application to cardiovascular disease. | Timpson NJ et al. | β | 2012 | β |
| Meta-analysis on pharmacogenetics of platinum-based chemotherapy in non small cell lung cancer (NSCLC) patients. | Yin JY et al. | β | 2012 | β |
| Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk. | Wang J et al. | β | 2012 | β |
| Molecular changes in smoking-related lung cancer. | Begum S | β | 2012 | β |
| Nicotine and pathological angiogenesis. | Lee J et al. | β | 2012 | β |
| Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes. | Chen LS et al. | β | 2012 | β |
| Nicotinic acetylcholine receptor signaling in atherogenesis. | Santanam N et al. | β | 2012 | β |
| Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD. | Budulac SE et al. | β | 2012 | β |
| Overexpression of Ξ±3/Ξ±5/Ξ²4 nicotinic receptor subunits modifies impulsive-like behavior. | ViΓ±als X et al. | β | 2012 | β |
| Parental intermittent claudication as risk factor for claudication in adults. | Prushik SG et al. | β | 2012 | β |
| Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population. | Li Z et al. | β | 2012 | β |
| Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review. | Hurley LL et al. | β | 2012 | β |
| Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model. | Li H et al. | β | 2012 | β |
| PTSD is a risk factor for cardiovascular disease: time for increased screening and clinical intervention. | Boscarino JA | β | 2012 | β |
| Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS et al. | β | 2012 | β |
| Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population. | Bae EY et al. | β | 2012 | β |
| Screening for lung cancer: Who should be screened? | Jett J | β | 2012 | β |
| Smoking and body weight: evidence using genetic instruments. | Wehby GL et al. | β | 2012 | β |
| Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. | Chen LS et al. | β | 2012 | β |
| Smoking cessation for the neurologic patient. | Tavee J | β | 2012 | β |
| Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. | King DP et al. | β | 2012 | β |
| Striatal Ξ±5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum. | Exley R et al. | β | 2012 | β |
| Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis. | Gu M et al. | β | 2012 | β |
| Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. | Mocellin S et al. | β | 2012 | β |
| The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses. | Lubke GH et al. | β | 2012 | β |
| The CHRNA5-A3-B4 gene cluster in nicotine addiction. | Berrettini WH et al. | β | 2012 | β |
| The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer. | Liu H et al. | β | 2012 | β |
| The genetic basis of addictive disorders. | Ducci F et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| The influence of race and ethnicity on the biology of cancer. | Henderson BE et al. | β | 2012 | β |
| Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. | Gallego X et al. | β | 2012 | β |
| Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. | Palmer AA et al. | β | 2012 | β |
| Twins and the mystery of missing heritability: the contribution of gene-environment interactions. | Kaprio J | β | 2012 | β |
| Updates on the COPD gene list. | BossΓ© Y | β | 2012 | β |
| Utility of genetically modified mice for understanding the neurobiology of substance use disorders. | Fowler CD et al. | β | 2012 | β |
| Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. | Kapoor M et al. | β | 2012 | β |
| Why have tobacco control policies stalled? Using genetic moderation to examine policy impacts. | Fletcher JM | β | 2012 | β |
| A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. | Wei C et al. | β | 2011 | β |
| Acetylcholine receptor (AChR) Ξ±5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (Ξ±4Ξ²2)βΞ±5 AChR function. | Kuryatov A et al. | β | 2011 | β |
| A CHRNA5 allele related to nicotine addiction and schizophrenia. | Hong LE et al. | β | 2011 | β |
| ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. | Chen J et al. | β | 2011 | β |
| A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. | Hollander MC et al. | β | 2011 | β |
| Addiction as a systems failure: focus on adolescence and smoking. | Baler RD et al. | β | 2011 | β |
| Admixture mapping of lung cancer in 1812 African-Americans. | Schwartz AG et al. | β | 2011 | β |
| [Advances in early diagnosis of lung cancer]. | Liu Y et al. | β | 2011 | β |
| A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. | Hu Z et al. | β | 2011 | β |
| A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. | McKay JD et al. | β | 2011 | β |
| An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. | Yu H et al. | β | 2011 | β |
| An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease. | Gao J et al. | β | 2011 | β |
| A powerful hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study. | Wang J et al. | β | 2011 | β |
| A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. | Heath AC et al. | β | 2011 | β |
| A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. | Chen D et al. | β | 2011 | β |
| A sirA-like gene, sirA2, is essential for 3-succinoyl-pyridine metabolism in the newly isolated nicotine-degrading Pseudomonas sp. HZN6 strain. | Qiu J et al. | β | 2011 | β |
| Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study. | Wei S et al. | β | 2011 | β |
| Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population. | Sorice R et al. | β | 2011 | β |
| Association of CHRNA4 polymorphisms with smoking behavior in two populations. | Han S et al. | β | 2011 | β |
| Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC). | Ji M et al. | β | 2011 | β |
| Association of smoking with tumor size at diagnosis in non-small cell lung cancer. | Chen X et al. | β | 2011 | β |
| Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. | Ware JJ et al. | β | 2011 | β |
| Associations of nicotine intake measures with CHRN genes in Finnish smokers. | Keskitalo-Vuokko K et al. | β | 2011 | β |
| Aversion to nicotine is regulated by the balanced activity of Ξ²4 and Ξ±5 nicotinic receptor subunits in the medial habenula. | Frahm S et al. | β | 2011 | β |
| A weighting approach to causal effects and additive interaction in case-control studies: marginal structural linear odds models. | VanderWeele TJ et al. | β | 2011 | β |
| Black and White adults' perspectives on the genetics of nicotine addiction susceptibility. | Park ER et al. | β | 2011 | β |
| CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men. | Fu G et al. | β | 2011 | β |
| CHRNA3 rs1051730 genotype and short-term smoking cessation. | MunafΓ² MR et al. | β | 2011 | β |
| CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. | Krais AM et al. | β | 2011 | β |
| Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. | Sakoda LC et al. | β | 2011 | β |
| Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk. | Wang Y et al. | β | 2011 | β |
| Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis. | Murphy SE et al. | β | 2011 | β |
| Chronic obstructive pulmonary disease and lung cancer: new molecular insights. | Adcock IM et al. | β | 2011 | β |
| Cigarette smoke inhibits brain mitochondrial adaptations of exercised mice. | Speck AE et al. | β | 2011 | β |
| Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour. | Rodriguez S et al. | β | 2011 | β |
| Common pathogenic mechanisms and pathways in the development of COPD and lung cancer. | Yang IA et al. | β | 2011 | β |
| Current status of genome-wide association studies in cancer. | Chung CC et al. | β | 2011 | β |
| Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease. | Kedmi M et al. | β | 2011 | β |
| Do biological differences help explain tobacco-related disparities? | PΓ©rez-Stable EJ et al. | β | 2011 | β |
| Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. | Breitling LP et al. | β | 2011 | β |
| Epidemiology, epigenetics and the 'Gloomy Prospect': embracing randomness in population health research and practice. | Smith GD | β | 2011 | β |
| Epidemiology, radiology, and genetics of nicotine dependence in COPD. | Kim DK et al. | β | 2011 | β |
| Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. | Wang J et al. | β | 2011 | β |
| European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene. | Rafnar T et al. | β | 2011 | β |
| Evolving concepts in lung carcinogenesis. | Gomperts BN et al. | β | 2011 | β |
| False-Negative-Rate Based Approach for Selecting Top Single-Nucleotide Polymorphisms in the First Stage of a Two-Stage Genome-Wide Association Study. | Huang Z et al. | β | 2011 | β |
| FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer. | Young RP et al. | β | 2011 | β |
| Family history is a risk factor for COPD. | Hersh CP et al. | β | 2011 | β |
| Family history of peripheral artery disease is associated with prevalence and severity of peripheral artery disease: the San Diego population study. | Wassel CL et al. | β | 2011 | β |
| Functionally significant nicotine acetylcholine receptor subunit Ξ±5 promoter haplotypes are associated with susceptibility to lung cancer in Chinese. | Zheng X et al. | β | 2011 | β |
| GENES AS INSTRUMENTS FOR STUDYING RISK BEHAVIOR EFFECTS: AN APPLICATION TO MATERNAL SMOKING AND OROFACIAL CLEFTS. | Wehby G et al. | β | 2011 | β |
| Genetic association of bipolar disorder with the Ξ²(3) nicotinic receptor subunit gene. | Hartz SM et al. | β | 2011 | β |
| Genetic evidence linking lung cancer and COPD: a new perspective. | Young RP et al. | β | 2011 | β |
| Genetic influences on peripheral arterial disease in a twin population. | Wahlgren CM et al. | β | 2011 | β |
| Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. | Timofeeva MN et al. | β | 2011 | β |
| Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies. | Obeidat M et al. | β | 2011 | β |
| Genetics of lung-cancer susceptibility. | Brennan P et al. | β | 2011 | β |
| Genetics of sputum gene expression in chronic obstructive pulmonary disease. | Qiu W et al. | β | 2011 | β |
| Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. | Freathy RM et al. | β | 2011 | β |
| Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer. | Xiong F et al. | β | 2011 | β |
| Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. | Gago-Dominguez M et al. | β | 2011 | β |
| Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | β | 2011 | β |
| Genome-wide association studies for detecting cancer susceptibility. | Hosking FJ et al. | β | 2011 | β |
| Genome-wide association studies for discovery of genes involved in asthma. | Akhabir L et al. | β | 2011 | β |
| Genome-wide association studies of alcohol dependence and substance use disorders. | Treutlein J et al. | β | 2011 | β |
| Genome-wide association study of smoking behaviours in patients with COPD. | Siedlinski M et al. | β | 2011 | β |
| Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. | Wu X et al. | β | 2011 | β |
| Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk. | Rafnar T et al. | β | 2011 | β |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | β | 2011 | β |
| Genomics of cardiovascular disease. | O'Donnell CJ et al. | β | 2011 | β |
| GSTM1 null genotype in COPD and lung cancer: evidence of a modifier or confounding effect? | Young RP et al. | β | 2011 | β |
| GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. | Chen X et al. | β | 2011 | β |
| How do we safely get people to stop smoking? | Lam DC et al. | β | 2011 | β |
| How the genetics of lung cancer may overlap with COPD. | Young RP et al. | β | 2011 | β |
| Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD. | Young RP et al. | β | 2011 | β |
| Inhibition of the nicotinic acetylcholine receptors by cobra venom Ξ±-neurotoxins: is there a perspective in lung cancer treatment? | Alama A et al. | β | 2011 | β |
| In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression. | Doyle GA et al. | β | 2011 | β |
| Lung cancer in never smokers. | Yang P | β | 2011 | β |
| Lung cancer: New biological insights and recent therapeutic advances. | Ramalingam SS et al. | β | 2011 | β |
| Lung cancer risk prediction: Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial models and validation. | Tammemagi CM et al. | β | 2011 | β |
| Mapping rare and common causal alleles for complex human diseases. | Raychaudhuri S | β | 2011 | β |
| Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. | Sarginson JE et al. | β | 2011 | β |
| Mechanisms involved in lung cancer development in COPD. | Caramori G et al. | β | 2011 | β |
| Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis. | Liu WB et al. | β | 2011 | β |
| Molecular biology of lung cancer: clinical implications. | Larsen JE et al. | β | 2011 | β |
| Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats. | Quan L et al. | β | 2011 | β |
| Naturally occurring variants of human Ξ9 nicotinic receptor differentially affect bronchial cell proliferation and transformation. | Chikova A et al. | β | 2011 | β |
| Neurophysiology of Nicotine Addiction. | Dani JA et al. | β | 2011 | β |
| Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer. | Improgo MR et al. | β | 2011 | β |
| Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study. | Kaur-Knudsen D et al. | β | 2011 | β |
| Nicotinic acetylcholine receptors and predisposition to lung cancer. | Tournier JM et al. | β | 2011 | β |
| Non-small-cell lung cancer. | Goldstraw P et al. | β | 2011 | β |
| Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. | Pande M et al. | β | 2011 | β |
| Peripheral arterial disease in diabetes: is there a role for genetics? | Katwal AB et al. | β | 2011 | β |
| Post-traumatic stress disorder and cardiovascular disease link: time to identify specific pathways and interventions. | Boscarino JA | β | 2011 | β |
| Practical and theoretical considerations in study design for detecting gene-gene interactions using MDR and GMDR approaches. | Chen GB et al. | β | 2011 | β |
| Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior. | Tuesta LM et al. | β | 2011 | β |
| Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. | Wassenaar CA et al. | β | 2011 | β |
| "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. | Drgon T et al. | β | 2011 | β |
| [Research progress of lung cancer on single nuleotide polymorphism]. | Hua F et al. | β | 2011 | β |
| Reward, addiction, withdrawal to nicotine. | De Biasi M et al. | β | 2011 | β |
| Risk perceptions and family history of lung cancer: differences by smoking status. | Chen LS et al. | β | 2011 | β |
| Screening for lung cancer: for patients at increased risk for lung cancer, it works. | Jett JR et al. | β | 2011 | β |
| Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption. | Sulem P et al. | β | 2011 | β |
| Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC). | Xun WW et al. | β | 2011 | β |
| Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada. | Conlon MS et al. | β | 2011 | β |
| 'Smoking genes': a genetic association study. | Verde Z et al. | β | 2011 | β |
| Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population. | Jaworowska E et al. | β | 2011 | β |
| Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. | Chen J et al. | β | 2011 | β |
| The Frequency of Epidermal Growth Factor Receptor Mutation of Nonsmall Cell Lung Cancer according to the Underlying Pulmonary Diseases. | Usui K et al. | β | 2011 | β |
| The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. | Lori A et al. | β | 2011 | β |
| The prevalence of pulmonary fibrosis combined with emphysema in patients with lung cancer. | Usui K et al. | β | 2011 | β |
| The role of nicotine in the pathogenesis of atherosclerosis. | Lee J et al. | β | 2011 | β |
| The Role of the Habenula in Nicotine Addiction. | Baldwin PR et al. | β | 2011 | β |
| The state of genome-wide association studies in pulmonary disease: a new perspective. | Todd JL et al. | β | 2011 | β |
| Treatment for tobacco dependence: a potential application for stratified medicine? | Brock AJ et al. | β | 2011 | β |
| TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. | Ducci F et al. | β | 2011 | β |
| Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. | Chen J et al. | β | 2011 | β |
| Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. | Culverhouse RC et al. | β | 2011 | β |
| Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. | Yuan JM et al. | β | 2011 | β |
| Using Ascertainment for Targeted Resequencing to Increase Power to Identify Causal Variants. | Swartz MD et al. | β | 2011 | β |
| Variant within the promoter region of the CHRNA3 gene associated with FTN dependence is not related to self-reported willingness to quit smoking. | Marques-Vidal P et al. | β | 2011 | β |
| Variation in TP63 is associated with lung adenocarcinoma in the UK population. | Wang Y et al. | β | 2011 | β |
| Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. | Paliwal A et al. | β | 2010 | β |
| A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder. | Zhang J et al. | β | 2010 | β |
| A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. | Hong LE et al. | β | 2010 | β |
| A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. | Lind PA et al. | β | 2010 | β |
| A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. | Yoon KA et al. | β | 2010 | β |
| Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report. | Girard N et al. | β | 2010 | β |
| A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves. | Meng XJ et al. | β | 2010 | β |
| Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. | Hecht SS et al. | β | 2010 | β |
| Architecture of inherited susceptibility to common cancer. | Fletcher O et al. | β | 2010 | β |
| A rigorous and comprehensive validation: common genetic variations and lung cancer. | Yang P et al. | β | 2010 | β |
| ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. | Improgo MR et al. | β | 2010 | β |
| A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. | Liu P et al. | β | 2010 | β |
| A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. | Kiemeney LA et al. | β | 2010 | β |
| Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. | Li MD et al. | β | 2010 | β |
| Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. | Lips EH et al. | β | 2010 | β |
| Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent. | Skelding KA et al. | β | 2010 | β |
| Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. | Mobascher A et al. | β | 2010 | β |
| Association of CHRN genes with "dizziness" to tobacco. | Ehringer MA et al. | β | 2010 | β |
| Association of the CHRNA3 locus with lung cancer risk and prognosis in Chinese Han population. | Niu X et al. | β | 2010 | β |
| Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. | Li MD et al. | β | 2010 | β |
| Association study of 182 candidate genes in anorexia nervosa. | Pinheiro AP et al. | β | 2010 | β |
| Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome. | McKeigue PM et al. | β | 2010 | β |
| Biomarkers in cancer epidemiology: an integrative approach. | Boffetta P | β | 2010 | β |
| Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients. | Carcereny E et al. | β | 2010 | β |
| Candidate variants at 6p21.33 and 6p22.1 and risk of non-small cell lung cancer in a Chinese population. | Zhang M et al. | β | 2010 | β |
| ChIP-chip analysis of neurexins and other candidate genes for addiction and neuropsychiatric disorders. | Pedrosa E et al. | β | 2010 | β |
| Cognitive effects of nicotine: genetic moderators. | Herman AI et al. | β | 2010 | β |
| Commentary: gene-environment interactions and smoking-related cancers. | Thorgeirsson TE et al. | β | 2010 | β |
| Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. | Bierut LJ | β | 2010 | β |
| Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence. | Ray R et al. | β | 2010 | β |
| Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases. | Zhong H et al. | β | 2010 | β |
| CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. | Liu WB et al. | β | 2010 | β |
| Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. | Liu P et al. | β | 2010 | β |
| Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. | Elliott KS et al. | β | 2010 | β |
| Explanatory pluralism in the medical sciences: theory and practice. | De Vreese L et al. | β | 2010 | β |
| Family history and lung cancer risk: international multicentre case-control study in Eastern and Central Europe and meta-analyses. | Lissowska J et al. | β | 2010 | β |
| Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. | Hansen HM et al. | β | 2010 | β |
| From smoking to lung cancer: the CHRNA5/A3/B4 connection. | Improgo MR et al. | β | 2010 | β |
| Gene--environment-wide association studies: emerging approaches. | Thomas D | β | 2010 | β |
| Genetic basis for susceptibility to lung cancer: Recent progress and future directions. | Yokota J et al. | β | 2010 | β |
| Genetic polymorphisms in the polycomb group gene EZH2 and the risk of lung cancer. | Yoon KA et al. | β | 2010 | β |
| Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization. | Schulze TG | β | 2010 | β |
| Genetic self knowledge and the future of epidemiologic confounding. | VanderWeele TJ | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Genetics of drug dependence. | Gelernter J et al. | β | 2010 | β |
| Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. | Lu Y et al. | β | 2010 | β |
| Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. | Wang X et al. | β | 2010 | β |
| Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. | De Ruyck K et al. | β | 2010 | β |
| Genome wide association for addiction: replicated results and comparisons of two analytic approaches. | Drgon T et al. | β | 2010 | β |
| Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. | Uhl GR et al. | β | 2010 | β |
| Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. | Uhl GR et al. | β | 2010 | β |
| Genome-wide association studies and beyond. | Witte JS | β | 2010 | β |
| Genome-wide association studies and cancer. | Jorgenson E et al. | β | 2010 | β |
| Genome-wide association studies: a powerful tool for neurogenomics. | Cowperthwaite MC et al. | β | 2010 | β |
| Genome-wide association studies in common cancers--what have we learnt? | Varghese JS et al. | β | 2010 | β |
| Genome-wide association studies of cancer predisposition. | Stadler ZK et al. | β | 2010 | β |
| Genome-wide association study identifies five loci associated with lung function. | Repapi E et al. | β | 2010 | β |
| Genome-wide association study in discordant sibships identifies multiple inherited susceptibility alleles linked to lung cancer. | Galvan A et al. | β | 2010 | β |
| Genome-wide meta-analyses identify multiple loci associated with smoking behavior. | Tobacco and Genetics Consortium | β | 2010 | β |
| Genomics of premature atherosclerotic vascular disease. | Seo D et al. | β | 2010 | β |
| GPC5 rs2352028 variant and risk of lung cancer in never smokers. | Landi MT et al. | β | 2010 | β |
| Grand challenges and opportunities for molecular psychiatry research: a perspective. | Li MD | β | 2010 | β |
| Highlights of the Year in JACC 2009. | DeMaria AN et al. | β | 2010 | β |
| Human behavioral informatics in genetic studies of neuropsychiatric disease: multivariate profile-based analysis. | Bloss CS et al. | β | 2010 | β |
| Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. | Grucza RA et al. | β | 2010 | β |
| Integrin signaling and lung cancer. | Caccavari F et al. | β | 2010 | β |
| International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. | Truong T et al. | β | 2010 | β |
| Intra-person variation of urinary biomarkers of oxidative stress and inflammation. | Wu X et al. | β | 2010 | β |
| Leveraging informatics for genetic studies: use of the electronic medical record to enable a genome-wide association study of peripheral arterial disease. | Kullo IJ et al. | β | 2010 | β |
| Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. | Pillai SG et al. | β | 2010 | β |
| Lung cancer genomic signatures. | AgullΓ³-OrtuΓ±o MT et al. | β | 2010 | β |
| Lung function and airway diseases. | Weiss ST | β | 2010 | β |
| Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk. | Wang J et al. | β | 2010 | β |
| Mendelian randomization in the era of genomewide association studies. | Sleiman PM et al. | β | 2010 | β |
| Meta-analysis and imputation refines the association of 15q25 with smoking quantity. | Liu JZ et al. | β | 2010 | β |
| Meta-analysis of 15 genome-wide linkage scans of smoking behavior. | Han S et al. | β | 2010 | β |
| Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder. | McEachin RC et al. | β | 2010 | β |
| Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. | Saccone NL et al. | β | 2010 | β |
| Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. | Saccone NL et al. | β | 2010 | β |
| Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. | Berrendero F et al. | β | 2010 | β |
| Nicotine addiction. | Benowitz NL | β | 2010 | β |
| Nicotine dependence may link the 15q25 locus to lung cancer risk. | Galvan A et al. | β | 2010 | β |
| Nicotine-mediated signals modulate cell death and survival of T lymphocytes. | Oloris SC et al. | β | 2010 | β |
| Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. | Erlich PM et al. | β | 2010 | β |
| Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. | Amos CI et al. | β | 2010 | β |
| Occupational toxicology of asbestos-related malignancies. | Lotti M et al. | β | 2010 | β |
| Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence. | Johnson EO et al. | β | 2010 | β |
| Peripheral artery disease and genetics: is there a cause-and-effect relationship? | Chi YW et al. | β | 2010 | β |
| Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment. | Mroziewicz M et al. | β | 2010 | β |
| Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities. | Hersh CP | β | 2010 | β |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | β | 2010 | β |
| Pharmacogenetics of smoking cessation therapy. | Kortmann GL et al. | β | 2010 | β |
| Power to detect selective allelic amplification in genome-wide scans of tumor data. | Dewal N et al. | β | 2010 | β |
| Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5. | Falvella FS et al. | β | 2010 | β |
| Refining the tobacco dependence phenotype using the Wisconsin Inventory of Smoking Dependence Motives: II. Evidence from a laboratory self-administration assay. | Piasecki TM et al. | β | 2010 | β |
| Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. | Truong T et al. | β | 2010 | β |
| Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the FagerstrΓΆm test for nicotine dependence. | Wessel J et al. | β | 2010 | β |
| Risk gene variants for nicotine dependence: a success story in neuropsychiatric genetics with possible applications to drug development. | Winterer G | β | 2010 | β |
| Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. | Winterer G et al. | β | 2010 | β |
| Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. | Wang Y et al. | β | 2010 | β |
| Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. | Jackson KJ et al. | β | 2010 | β |
| Search for cancer risk factors with microarray-based genome-wide association studies. | Zhang L et al. | β | 2010 | β |
| Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. | Thorgeirsson TE et al. | β | 2010 | β |
| Several common variants modulate heart rate, PR interval and QRS duration. | Holm H et al. | β | 2010 | β |
| Smoking, nicotine and neuropsychiatric disorders. | Dome P et al. | β | 2010 | β |
| Substance use disorders: realizing the promise of pharmacogenomics and personalized medicine. | Hutchison KE | β | 2010 | β |
| The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. | Lambrechts D et al. | β | 2010 | β |
| The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. | Hsiung CA et al. | β | 2010 | β |
| The evolving discipline of molecular epidemiology of cancer. | Spitz MR et al. | β | 2010 | β |
| The impact of smoking in Crohn's disease: no smoke without fire. | Aldhous MC et al. | β | 2010 | β |
| The molecular pathology of cancer. | Harris TJ et al. | β | 2010 | β |
| The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. | Improgo MR et al. | β | 2010 | β |
| The P300 event-related potential and smoking--a population-based case-control study. | Mobascher A et al. | β | 2010 | β |
| The potential for using risk models in future lung cancer screening trials. | Field JK et al. | β | 2010 | β |
| The pursuit of genome-wide association studies: where are we now? | Ku CS et al. | β | 2010 | β |
| The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. | Memmott RM et al. | β | 2010 | β |
| Validity of recall of tobacco use in two prospective cohorts. | Brigham J et al. | β | 2010 | β |
| Variants in FAM13A are associated with chronic obstructive pulmonary disease. | Cho MH et al. | β | 2010 | β |
| Variation at the TERT locus and predisposition for cancer. | Baird DM | β | 2010 | β |
| Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. | Sherva R et al. | β | 2010 | β |
| Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. | Zhang H et al. | β | 2010 | β |
| Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. | Miki D et al. | β | 2010 | β |
| What can human genetics teach us about the causes of cardiovascular disease? | Newton-Cheh C et al. | β | 2010 | β |
| Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence - role of gene-gene interaction, personality, and environmental factors. | Greenbaum L et al. | β | 2010 | β |
| A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. | Young RP et al. | β | 2009 | β |
| A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. | Landi MT et al. | β | 2009 | β |
| alpha7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma? | Paleari L et al. | β | 2009 | β |
| Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. | Keskitalo K et al. | β | 2009 | β |
| Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study. | Koshiol J et al. | β | 2009 | β |
| Commentary on Chen et al. (2009): gene-environment interactions in nicotine dependence. | Kaprio J | β | 2009 | β |
| Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin. | Roman J et al. | β | 2009 | β |
| Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. | Broderick P et al. | β | 2009 | β |
| Developments in genomics to improve understanding, diagnosis and management of aneurysms and peripheral artery disease. | Tromp G et al. | β | 2009 | β |
| Does nicotine replacement therapy cause cancer? Evidence from the Lung Health Study. | Murray RP et al. | β | 2009 | β |
| Genetic epidemiology of smoking behavior and nicotine dependence. | Kaprio J | β | 2009 | β |
| Genetics and genomics of chronic obstructive pulmonary disease. | Silverman EK et al. | β | 2009 | β |
| [Genetics in chronic obstructive pulmonary disease]. | SΓΈrheim IC et al. | β | 2009 | β |
| Genetics of COPD and emphysema. | Wan ES et al. | β | 2009 | β |
| Genome-wide association scans for secondary traits using case-control samples. | Monsees GM et al. | β | 2009 | β |
| Genome-wide association studies and the genetic dissection of complex traits. | Sebastiani P et al. | β | 2009 | β |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | β | 2009 | β |
| Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. | Liu Y et al. | β | 2009 | β |
| High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications. | Ocak S et al. | β | 2009 | β |
| Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. | Liu PY et al. | β | 2009 | β |
| Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. | DeMeo DL et al. | β | 2009 | β |
| Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. | Chen LS et al. | β | 2009 | β |
| Light and intermittent cigarette smokers: a review (1989-2009). | Coggins CR et al. | β | 2009 | β |
| Long-term smoking behavior patterns predicting self-reported chronic bronchitis. | Hukkinen M et al. | β | 2009 | β |
| Lung cancer in never smokers: a call to action. | Rudin CM et al. | β | 2009 | β |
| Lung cancer in never smokers: molecular profiles and therapeutic implications. | Rudin CM et al. | β | 2009 | β |
| [Lung cancer in smokers and never-smokers]. | Helland A et al. | β | 2009 | β |
| Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research. | Smolonska J et al. | β | 2009 | β |
| Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs. | Rana BK et al. | β | 2009 | β |
| Nicotine dependence and genetic variation in the nicotinic receptors. | Bierut LJ | β | 2009 | β |
| Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. | Davis R et al. | β | 2009 | β |
| Nicotine response genetics in the zebrafish. | Petzold AM et al. | β | 2009 | β |
| Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. | Taly A et al. | β | 2009 | β |
| Older smokers' motivation and attempts to quit smoking: epidemiological insight into the question of lifestyle versus addiction. | Breitling LP et al. | β | 2009 | β |
| Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. | Schwartz AG et al. | β | 2009 | β |
| Role of genetic variants in the CHRNA5-CHRNA3-CHRNB4 cluster in nicotine dependence risk: importance of gene-environment interplay. | Greenbaum L et al. | β | 2009 | β |
| Selected summaries from the XVI World Congress of Psychiatric Genetics, Osaka, Japan, 11-15 October 2008. | Bergen S et al. | β | 2009 | β |
| Smoking and lung cancer: causality, Cornfield and an early observational meta-analysis. | Smith GD | β | 2009 | β |
| Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. | Launay JM et al. | β | 2009 | β |
| The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. | Saccone NL et al. | β | 2009 | β |
| The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009. | Payton A | β | 2009 | β |
| The role of biomarkers and genetics in peripheral arterial disease. | McDermott MM et al. | β | 2009 | β |
| Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events. | Breitling LP et al. | β | 2009 | β |
| Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. | Chen X et al. | β | 2009 | β |