Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis.
paper
Primary
Public
Unavailable
- Authors
- Edenberg, Howard J; Xuei, Xiaoling; Chen, Hui-Ju; Tian, Huijun; Wetherill, Leah Flury; Dick, Danielle M; Almasy, Laura; Bierut, Laura; Bucholz, Kathleen K; Goate, Alison; Hesselbrock, Victor; Kuperman, Samuel; Nurnberger, John; Porjesz, Bernice; Rice, John; Schuckit, Marc; Tischfield, Jay; Begleiter, Henri; Foroud, Tatiana
- Year
- 2006
- Journal
- Human molecular genetics
- PMID
- 16571603
- DOI
- 10.1093/hmg/ddl073
Linkage evidence indicated that gene(s) located on chromosome 4q, in the region of the alcohol dehydrogenase (ADH) genes, affected risk for alcoholism. We genotyped 110 single nucleotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism in a set of families with multiple alcoholic members, using the pedigree disequilibrium test. There was strong evidence that variations in ADH4 are associated with alcoholism: 12 SNPs were significantly associated. The region of strongest association ran from intron 1 to 19.5 kb beyond the 3' end of the gene. Haplotype tag SNPs were selected for the block in the ADH4 gene that provided evidence of association and subsequently used in association analysis; the haplotype was significantly associated with alcoholism (P=0.01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk. Among African-Americans, there was evidence that the ADH1B*3 allele was protective.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Ancient Yellow River ancestry and divergent admixture histories in the Qiang people. | Zeng W et al. | β | 2026 | β |
| Novel haplotypes of genetic polymorphisms in alcohol metabolizing enzymes in Kampala, Uganda. | Okwasiimire R et al. | β | 2025 | β |
| Novel Haplotypes of genetic polymorphisms in alcohol metabolizing enzymes in Kampala, Uganda | Okwasiimire R et al. | β | 2025 | β |
| Recent advances in alcohol metabolism: from the gut to the brain. | Goldman MR et al. | β | 2025 | β |
| Human adaptations to diet: Biological and cultural coevolution. | Jelenkovic A et al. | β | 2024 | β |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | β | 2024 | β |
| Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes. | McKay L et al. | β | 2024 | β |
| 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics. | Gameiro-Ros I et al. | β | 2023 | β |
| <i>ADH1B</i>, <i>ADH1B/C</i> and <i>CYP2E1</i> Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. | Kukowka A et al. | β | 2023 | β |
| Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium. | Young KL et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | β | 2023 | β |
| The Promise of an Evolutionary Perspective of Alcohol Consumption. | Clites BL et al. | β | 2023 | β |
| Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review. | Tsermpini EE et al. | β | 2022 | β |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | β | 2021 | β |
| Characterization of Hepatitis B Virus Integrations Identified in Hepatocellular Carcinoma Genomes. | Mathkar PP et al. | β | 2021 | β |
| Genetic Basis of Dual Diagnosis: A Review of Genome-Wide Association Studies (GWAS) Focusing on Patients with Mood or Anxiety Disorders and Co-Occurring Alcohol-Use Disorders. | Stoychev K et al. | β | 2021 | β |
| Association of ADH7 Gene Polymorphism with Schizophrenia in the Han Population of Northern China: a Case-Control Study. | Zeng K et al. | β | 2020 | β |
| Genetic variation in alcohol dehydrogenase is associated with neurocognition in men with HIV and history of alcohol use disorder: preliminary findings. | Saloner R et al. | β | 2020 | β |
| The Role of Alcohol Metabolism in the Pathology of Alcohol Hangover. | Mackus M et al. | β | 2020 | β |
| A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. | Hari Dass SA et al. | β | 2019 | β |
| Associations of <i>BRAP</i> polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test. | Kim JW et al. | β | 2019 | β |
| Genetics of alcohol use disorder: a review. | Deak JD et al. | β | 2019 | β |
| GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network. | Xiang B et al. | β | 2019 | β |
| Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. | Wang X et al. | β | 2019 | β |
| Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. | Edenberg HJ et al. | β | 2018 | β |
| Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students. | Thomas NS et al. | β | 2018 | β |
| A multiple mediator analysis approach to quantify the effects of the ADH1B and ALDH2 genes on hepatocellular carcinoma risk. | Shih S et al. | β | 2018 | β |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | β | 2018 | β |
| Modeling of Human Hepatic and Gastrointestinal Ethanol Metabolism with Kinetic-Mechanism-Based Full-Rate Equations of the Component Alcohol Dehydrogenase Isozymes and Allozymes. | Chi YC et al. | β | 2018 | β |
| Quantitative trait loci for sensitivity to acute ethanol and ethanol consummatory behaviors in rats. | Mandt BH et al. | β | 2018 | β |
| Analysis of the Association of Nonsynonymous Polymorphisms in ADH Genes with Hazardous Drinking in HIV-1-Positive Individuals. | Wolf JM et al. | β | 2017 | β |
| Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. | Peng Q et al. | β | 2017 | β |
| Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults. | Xi B et al. | β | 2017 | β |
| Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. | Liu J et al. | β | 2016 | β |
| Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study. | Williams LA et al. | β | 2016 | β |
| Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. | Wu LS et al. | β | 2016 | β |
| Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. | Wall TL et al. | β | 2016 | β |
| Differential Effect of Initiating Moderate Red Wine Consumption on 24-h Blood Pressure by Alcohol Dehydrogenase Genotypes: Randomized Trial in Type 2 Diabetes. | Gepner Y et al. | β | 2016 | β |
| Genetic influences on adolescent behavior. | Dick DM et al. | β | 2016 | β |
| Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. | Chartier KG et al. | β | 2016 | β |
| Mendelian randomisation suggests no beneficial effect of moderate alcohol consumption on the severity of nonalcoholic fatty liver disease. | Sookoian S et al. | β | 2016 | β |
| Overview of the Genetics of Alcohol Use Disorder. | Tawa EA et al. | β | 2016 | β |
| Risk and predictors of hepatocellular carcinoma for chronic hepatitis B patients with newly developed cirrhosis. | Chien J et al. | β | 2016 | β |
| Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. | Johnson JR et al. | β | 2016 | β |
| Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. | Manzardo AM et al. | β | 2015 | β |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | BΓΌhler KM et al. | β | 2015 | β |
| Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample. | Aliev F et al. | β | 2015 | β |
| Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. | Xu K et al. | β | 2015 | β |
| Metabolic methanol: molecular pathways and physiological roles. | Dorokhov YL et al. | β | 2015 | β |
| The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder: The Therapeutic Potential of Micronutrient Supplementation. | Jurnak F | β | 2015 | β |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | β | 2014 | β |
| An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7. | Jairam S et al. | β | 2014 | β |
| Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. | Peng Q et al. | β | 2014 | β |
| Evaluation of the influence of alcohol dehydrogenase polymorphisms on alcohol elimination rates in African Americans. | Marshall VJ et al. | β | 2014 | β |
| Family-based association analysis of alcohol dependence criteria and severity. | Wetherill L et al. | β | 2014 | β |
| Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. | Enoch MA | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. | Gelernter J et al. | β | 2014 | β |
| Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. | Zhang H et al. | β | 2014 | β |
| Less drinking, yet more problems: understanding African American drinking and related problems. | Zapolski TC et al. | β | 2014 | β |
| Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. | Kos MZ et al. | β | 2014 | β |
| Protective variant associated with alcohol dependence in a Mexican American cohort. | Norden-Krichmar TM et al. | β | 2014 | β |
| Role of microglia in ethanol-induced neurodegenerative disease: Pathological and behavioral dysfunction at different developmental stages. | Yang JY et al. | β | 2014 | β |
| Single-nucleotide polymorphisms interact to affect ADH7 transcription. | Jairam S et al. | β | 2014 | β |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | β | 2014 | β |
| Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. | Yan J et al. | β | 2014 | β |
| Addiction: lifestyle choice or medical diagnosis? | Nutt D | β | 2013 | β |
| Case-control association testing of common variants from sequencing of DNA pools. | McRae AF et al. | β | 2013 | β |
| Cloning and molecular evolution of the aldehyde dehydrogenase 2 gene (Aldh2) in bats (Chiroptera). | Chen Y et al. | β | 2013 | β |
| Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. | Kos MZ et al. | β | 2013 | β |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | β | 2013 | β |
| Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. | Park BL et al. | β | 2013 | β |
| Genetic influences on the development of alcoholism. | Enoch MA | β | 2013 | β |
| Genetic resistance to liver fibrosis on A/J mouse chromosome 17. | DeSantis DA et al. | β | 2013 | β |
| Genetics and alcoholism. | Edenberg HJ et al. | β | 2013 | β |
| Genome-wide DNA methylation analysis in alcohol dependence. | Zhang R et al. | β | 2013 | β |
| Retinoid metabolism is altered in human and mouse cicatricial alopecia. | Everts HB et al. | β | 2013 | β |
| ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study. | Turchi C et al. | β | 2012 | β |
| ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. | Ehlers CL et al. | β | 2012 | β |
| Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study. | Lind PA et al. | β | 2012 | β |
| Chronic alcohol exposure alters gene expression in HepG2 cells. | Pochareddy S et al. | β | 2012 | β |
| Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey. | Aktas EO et al. | β | 2012 | β |
| DNA methylation patterns in alcoholics and family controls. | Thapar M et al. | β | 2012 | β |
| Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans. | Alaimo JT et al. | β | 2012 | β |
| Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. | Lewis SJ et al. | β | 2012 | β |
| Identifying genetic variation for alcohol dependence. | Agrawal A et al. | β | 2012 | β |
| Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. | Agrawal A et al. | β | 2012 | β |
| Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood. | van Beek JH et al. | β | 2012 | β |
| The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. | Morozova TV et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| The role of alcohol dehydrogenase genes in head and neck cancers: a systematic review and meta-analysis of ADH1B and ADH1C. | Chang JS et al. | β | 2012 | β |
| Treatment- and population-dependent activity patterns of behavioral and expression QTLs. | Ziebarth JD et al. | β | 2012 | β |
| A candidate gene association study of alcohol consumption in young women. | Agrawal A et al. | β | 2011 | β |
| Alcohol research: past, present, and future. | Gunzerath L et al. | β | 2011 | β |
| A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. | Wang KS et al. | β | 2011 | β |
| Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. | Preuss UW et al. | β | 2011 | β |
| Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. | Gizer IR et al. | β | 2011 | β |
| Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. | Lydall GJ et al. | β | 2011 | β |
| Diversification of the ADH1B gene during expansion of modern humans. | Li H et al. | β | 2011 | β |
| Fine mapping quantitative trait loci that influence alcohol preference behavior in the High and Low Alcohol Preferring (HAP and LAP) mice. | Bice PJ et al. | β | 2011 | β |
| Genetics of alcohol dependence. | Kimura M et al. | β | 2011 | β |
| Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. | Baik I et al. | β | 2011 | β |
| Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. | Liu J et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| Variation in the ADH1B proximal promoter affects expression. | Pochareddy S et al. | β | 2011 | β |
| A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. | Ehlers CL et al. | β | 2010 | β |
| ADH1A variation predisposes to personality traits and substance dependence. | Zuo L et al. | β | 2010 | β |
| ADH1B*2 allele is protective against alcoholism but not chronic liver disease in the Hungarian population. | Toth R et al. | β | 2010 | β |
| ADH1B*3 and response to alcohol in African-Americans. | McCarthy DM et al. | β | 2010 | β |
| Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. | Mukamal KJ et al. | β | 2010 | β |
| A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. | Wei S et al. | β | 2010 | β |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | β | 2010 | β |
| A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. | Kalsi G et al. | β | 2010 | β |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | β | 2010 | β |
| Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. | Dick DM et al. | β | 2010 | β |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | β | 2010 | β |
| Genes and alcohol. | Osby U et al. | β | 2010 | β |
| Genetic and environmental risk factors for adolescent-onset substance use disorders. | Meyers JL et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. | Nelson EC et al. | β | 2010 | β |
| Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). | Pochareddy S et al. | β | 2010 | β |
| Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001. | Boyles AL et al. | β | 2010 | β |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | β | 2010 | β |
| Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. | Zhang Z et al. | β | 2010 | β |
| Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. | Ray LA et al. | β | 2010 | β |
| Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. | Mustavich LF et al. | β | 2010 | β |
| ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. | Birley AJ et al. | β | 2009 | β |
| Alcohol consumption indices of genetic risk for alcohol dependence. | Grant JD et al. | β | 2009 | β |
| Alcohol sensitivity in Drosophila: translational potential of systems genetics. | Morozova TV et al. | β | 2009 | β |
| Alleles of alcohol and acetaldehyde metabolism genes modulate susceptibility to oesophageal cancer from alcohol consumption. | Brooks PJ et al. | β | 2009 | β |
| A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women. | Zuccolo L et al. | β | 2009 | β |
| Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. | Vaswani M et al. | β | 2009 | β |
| Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. | Sherva R et al. | β | 2009 | β |
| Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | β | 2009 | β |
| Associations of ALDH2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults. | Hendershot CS et al. | β | 2009 | β |
| Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. | Gelernter J et al. | β | 2009 | β |
| Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. | Peng GS et al. | β | 2009 | β |
| [Genetic factors of alcohol-dependence]. | Pinto E et al. | β | 2009 | β |
| Genetics of alcohol dependence. | Gelernter J et al. | β | 2009 | β |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | β | 2009 | β |
| Influence of a drinking quantity and frequency measure on the prevalence and demographic correlates of DSM-IV alcohol dependence. | Keyes KM et al. | β | 2009 | β |
| New insights into the genetics of addiction. | Li MD et al. | β | 2009 | β |
| Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. | Chen YC et al. | β | 2009 | β |
| Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. | Kimura Y et al. | β | 2009 | β |
| ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. | Luo X et al. | β | 2008 | β |
| Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts. | Ebrahim S et al. | β | 2008 | β |
| Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH et al. | β | 2008 | β |
| A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. | Dick DM et al. | β | 2008 | β |
| Ethnic related selection for an ADH Class I variant within East Asia. | Li H et al. | β | 2008 | β |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | β | 2008 | β |
| Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Agrawal A et al. | β | 2008 | β |
| Molecular genetics of alcohol dependence and related endophenotypes. | Strat YL et al. | β | 2008 | β |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | β | 2008 | β |
| Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. | Luo X et al. | β | 2008 | β |
| Regulatory polymorphisms and their contribution to interindividual differences in the expression of enzymes influencing drug and toxicant disposition. | Hines RN et al. | β | 2008 | β |
| Substance dependence low-density whole genome association study in two distinct American populations. | Yu Y et al. | β | 2008 | β |
| The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence. | Le Strat Y et al. | β | 2008 | β |
| The expression of NMDA receptor subunit mRNA in human chronic alcoholics. | Ridge JP et al. | β | 2008 | β |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | β | 2008 | β |
| The tachykinin receptor 3 is associated with alcohol and cocaine dependence. | Foroud T et al. | β | 2008 | β |
| Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase. | Beulens JW et al. | β | 2007 | β |
| Association of alcohol craving with alpha-synuclein (SNCA). | Foroud T et al. | β | 2007 | β |
| Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. | Yang BZ et al. | β | 2007 | β |
| Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad. | Ehlers CL et al. | β | 2007 | β |
| Effect of ADH1B genotype on alcohol consumption in young Israeli Jews. | Spivak B et al. | β | 2007 | β |
| Haplotype analysis at the alcohol dehydrogenase gene region in New Zealand MΔori. | Hall DA et al. | β | 2007 | β |
| Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans. | Scott DM et al. | β | 2007 | β |
| Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. | Carr LG et al. | β | 2007 | β |
| Joint effects of eNOS gene T-786C and ADH2 Arg47His polymorphisms on the risk of premature coronary artery disease. | Jia C et al. | β | 2007 | β |
| Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. | Foroud T et al. | β | 2007 | β |
| Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. | Luo X et al. | β | 2007 | β |
| Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. | Peng GS et al. | β | 2007 | β |
| The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. | Edenberg HJ | β | 2007 | β |
| Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism. | Grucza RA et al. | β | 2006 | β |
| Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism. | Ciccocioppo R et al. | β | 2006 | β |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | β | 2006 | β |