Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism.
paper
Cited
Public
- Authors
- Ray, Lara A; Mackillop, James; Monti, Peter M
- Year
- 2010
- Journal
- Substance use & misuse
- PMID
- 20590398
- DOI
- 10.3109/10826084.2010.482427
- PMCID
- PMC4703313
Individual differences in subjective responses to alcohol consumption represent genetically mediated biobehavioral mechanisms of alcoholism risk (i.e., endophenotype). The objective of this review is three-fold: (1) to provide a critical review the literature on subjective response to alcohol and to discuss the rationale for its conceptualization as an endophenotype for alcoholism; (2) to examine the literature on the neurobiological substrates and associated genetic factors subserving individual differences in subjective response to alcohol; and (3) to discuss the treatment implications of this approach and to propose a framework for conceptualizing, and systematically integrating, endophenotypes into alcoholism treatment.
An endophenotype-pharmacogenetic model of alcoholism treatment
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