Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians.
paper
Cited
Public
Unavailable
- Authors
- Wall, Tamara L; Carr, Lucinda G; Ehlers, Cindy L
- Year
- 2003
- Journal
- The American journal of psychiatry
- PMID
- 12505800
- DOI
- 10.1176/appi.ajp.160.1.41
OBJECTIVE: Two alcohol dehydrogenase genes (ADH2 and ADH3 on chromosome 4) and one aldehyde dehydrogenase gene (ALDH2 on chromosome 12) exhibit functional polymorphisms. The goal of this study was to determine whether any associations exist between the ADH2, ADH3, and ALDH2 polymorphisms and alcohol dependence in a group of Native Americans. An additional goal was to determine if any associations exist between these polymorphisms and the endophenotype, maximum number of drinks ever consumed in a 24-hour period. METHOD: Mission Indian adults (N=340) were recruited for participation from reservations in southern California. Each participant completed an interview with the Semi-Structured Assessment for the Genetics of Alcoholism. A blood sample was collected from each participant for genotyping at the ALDH2, ADH2, and ADH3 loci. RESULTS: Sixty percent of all participants (72% of men and 53% of women) met lifetime DSM-III-R criteria for alcohol dependence. A significant difference in the ADH2 allele distributions was found between alcohol-dependent and non-alcohol-dependent participants. Those with alcohol dependence were significantly less likely to have the ADH2*3 allele (odds ratio=0.28) and significantly more likely to have the ADH2*1 allele (odds ratio=2.00) than those who were not alcohol dependent. Individuals with ADH2*3 reported a lower number of maximum drinks ever consumed in a 24-hour period, compared to those without this allele. CONCLUSIONS: These results are consistent with genetic linkage studies showing protective associations for alcohol dependence and related behavior on chromosome 4 and suggest that ADH2 polymorphisms may account for these findings. These results also highlight the utility of evaluating protective factors in populations with high rates of alcohol dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms. | Simon L et al. | — | 2022 | → |
| Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review. | Tsermpini EE et al. | — | 2022 | → |
| Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population. | Peng Q et al. | — | 2021 | → |
| Prenatal alcohol exposure prevalence as measured by direct ethanol metabolites in meconium in a Native American tribe of the southwest. | Bakhireva LN et al. | — | 2019 | → |
| Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. | Edenberg HJ et al. | — | 2018 | → |
| Association of alcohol dehydrogenase 1C gene *1/*2 polymorphism with alcohol Dependence(AD) in Turkey: A meta-analysis. | Zhang S et al. | — | 2018 | → |
| Distinct Prognostic Values of Alcohol Dehydrogenase Family Members for Non-Small Cell Lung Cancer. | Wang P et al. | — | 2018 | → |
| Early Life Stress as a Predictor of Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder. | Lee RS et al. | — | 2018 | → |
| Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. | Peng Q et al. | — | 2017 | → |
| Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations. | Diószegi J et al. | — | 2017 | → |
| Review: Genetic and environmental risk factors for alcohol use disorders in American Indians and Alaskan Natives. | Enoch MA et al. | — | 2017 | → |
| Review: Prevalence and co-occurrence of addictions in US ethnic/racial groups: Implications for genetic research. | Luczak SE et al. | — | 2017 | → |
| Review: Use of Asian samples in genetic research of alcohol use disorders: Genetic variation of alcohol metabolizing enzymes and the effects of acetaldehyde. | Matsushita S et al. | — | 2017 | → |
| Transcriptome-wide analysis reveals the progress of Cordyceps militaris subculture degeneration. | Yin J et al. | — | 2017 | → |
| Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. | Wall TL et al. | — | 2016 | → |
| Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample. | Gilder DA et al. | — | 2016 | → |
| Overview of the Genetics of Alcohol Use Disorder. | Tawa EA et al. | — | 2016 | → |
| Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. | Otto JM et al. | — | 2016 | → |
| Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol. | Ehlers CL et al. | — | 2015 | → |
| Metabolic methanol: molecular pathways and physiological roles. | Dorokhov YL et al. | — | 2015 | → |
| Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. | Peng Q et al. | — | 2014 | → |
| Framing ethnic variations in alcohol outcomes from biological pathways to neighborhood context. | Chartier KG et al. | — | 2014 | → |
| Genetics of alcoholism. | Edenberg HJ et al. | — | 2014 | → |
| Evidence for a genetic component for substance dependence in Native Americans. | Ehlers CL et al. | — | 2013 | → |
| Genetic influences on the development of alcoholism. | Enoch MA | — | 2013 | → |
| Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD. | Ehlers CL et al. | — | 2013 | → |
| Measuring historical trauma in an American Indian community sample: contributions of substance dependence, affective disorder, conduct disorder and PTSD. | Ehlers CL et al. | — | 2013 | → |
| ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. | Ehlers CL et al. | — | 2012 | → |
| Alcohol use disorders and perceived drinking norms: ethnic differences in Israeli adults. | Shmulewitz D et al. | — | 2012 | → |
| Association of a genetic polymorphism of the alcohol-metabolizing enzyme ADH1C with alcohol dependence: results of a case-control study. | Kortunay S et al. | — | 2012 | → |
| Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. | Li D et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| The role of alcohol dehydrogenase genes in head and neck cancers: a systematic review and meta-analysis of ADH1B and ADH1C. | Chang JS et al. | — | 2012 | → |
| Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. | Gizer IR et al. | — | 2011 | → |
| Genetics of alcohol dependence. | Kimura M et al. | — | 2011 | → |
| Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. | Liu J et al. | — | 2011 | → |
| Linkage analyses of stimulant dependence, craving, and heavy use in American Indians. | Ehlers CL et al. | — | 2011 | → |
| Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. | Li D et al. | — | 2011 | → |
| ADH1B*3 and response to alcohol in African-Americans. | McCarthy DM et al. | — | 2010 | → |
| EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study. | Ehlers CL et al. | — | 2010 | → |
| EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study. | Ehlers CL et al. | — | 2010 | → |
| Genome-wide scan for self-rating of the effects of alcohol in American Indians. | Ehlers CL et al. | — | 2010 | → |
| Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. | Ray LA et al. | — | 2010 | → |
| Why do we Need to Control Alcohol Use Through Legislative Measures? A South East Asia Perspective? | Saddichha S et al. | — | 2010 | → |
| Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. | Vaswani M et al. | — | 2009 | → |
| Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. | Peng GS et al. | — | 2009 | → |
| Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. | Tolstrup JS et al. | — | 2008 | → |
| Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. | Ehlers CL et al. | — | 2008 | → |
| Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH et al. | — | 2008 | → |
| Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. | Ehlers CL et al. | — | 2008 | → |
| Factors associated with remission from alcohol dependence in an American Indian community group. | Gilder DA et al. | — | 2008 | → |
| Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer. | Li DP et al. | — | 2008 | → |
| P3 components of the event-related potential and marijuana dependence in Southwest California Indians. | Ehlers CL et al. | — | 2008 | → |
| Role of acetaldehyde in ethanol-induced elevation of the neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one in rats. | Boyd KN et al. | — | 2008 | → |
| Age of first marijuana use and the occurrence of marijuana use disorders in Southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| A haplotype analysis of CYP2E1 polymorphisms in relation to alcoholic phenotypes in Mexican Americans. | Yang M et al. | — | 2007 | → |
| Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview. | Green RF et al. | — | 2007 | → |
| Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad. | Ehlers CL et al. | — | 2007 | → |
| Genomic screen for substance dependence and body mass index in southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| Heritability of illicit drug use and transition to dependence in Southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| Linking antisocial behavior, substance use, and personality: an integrative quantitative model of the adult externalizing spectrum. | Krueger RF et al. | — | 2007 | → |
| P3 components and adolescent binge drinking in Southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. | Edenberg HJ | — | 2007 | → |
| Variations in ADH and ALDH in Southwest California Indians. | Ehlers CL | — | 2007 | → |
| Age at first intoxication and alcohol use disorders in Southwest California Indians. | Ehlers CL et al. | — | 2006 | → |
| Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. | Nishizawa D et al. | — | 2006 | → |
| Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians. | Gilder DA et al. | — | 2006 | → |
| Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? | Zintzaras E et al. | — | 2006 | → |
| Genomic screen for loci associated with tobacco usage in Mission Indians. | Ehlers CL et al. | — | 2006 | → |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | — | 2006 | → |
| Non-reporting and inconsistent reporting of race and ethnicity in articles that claim associations among genotype, outcome, and race or ethnicity. | Shanawani H et al. | — | 2006 | → |
| Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. | Guindalini C et al. | — | 2005 | → |
| Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. | Wall TL | — | 2005 | → |
| Heritability of substance dependence in a native American population. | Wilhelmsen KC et al. | — | 2005 | → |
| Occupational and environmental health in the 21st century: the new frontier in genetics and disease prevention. | Rischitelli DG et al. | — | 2005 | → |
| The level of response to alcohol in daughters of alcoholics and controls. | Eng MY et al. | — | 2005 | → |
| Alcoholism: genes and mechanisms. | Oroszi G et al. | — | 2004 | → |
| Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians. | Ehlers CL et al. | — | 2004 | → |
| Association of metabolic gene polymorphisms with alcohol consumption in controls. | Raimondi S et al. | — | 2004 | → |
| Comorbidity of select anxiety and affective disorders with alcohol dependence in southwest California Indians. | Gilder DA et al. | — | 2004 | → |
| Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. | Lee SL et al. | — | 2004 | → |
| Genes associated with addiction: alcoholism, opiate, and cocaine addiction. | Kreek MJ et al. | — | 2004 | → |
| Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. | Quertemont E | — | 2004 | → |
| Genomic screen for loci associated with alcohol dependence in Mission Indians. | Ehlers CL et al. | — | 2004 | → |
| Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders. | Higuchi S et al. | — | 2004 | → |
| Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. | Crabb DW et al. | — | 2004 | → |
| The clinical course of alcoholism in 243 Mission Indians. | Ehlers CL et al. | — | 2004 | → |
| The endophenotype concept in psychiatry: etymology and strategic intentions. | Gottesman II et al. | — | 2003 | → |