Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.
paper
Cited
Public
- Authors
- Li, Dawei; Zhao, Hongyu; Gelernter, Joel
- Year
- 2011
- Journal
- Biological psychiatry
- PMID
- 21497796
- DOI
- 10.1016/j.biopsych.2011.02.024
- PMCID
- PMC3142297
BACKGROUND: The alcohol dehydrogenase 1B gene (ADH1B) is hypothesized to affect predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg [*1] and His [*1]) has been reported to be associated with reduced rates of alcohol and drug dependence. Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence. METHODS: Using the cumulative association study literature from the past 21 years from both English- and Chinese-language publications, this meta-analysis seeks to clarify the contradictory findings and to examine whether the aggregate data provide new evidence of significant association. RESULTS: The results, based on a large sample size (9638 cases and 9517 controls), suggested strong associations with alcohol dependence and abuse as well as alcohol-induced liver diseases, with an allelic (Arg vs. His) p value being 1 Γ 10(-36) and odds ratio (OR) (95% confidence intervals [CI]) 2.06 (1.84-2.31) under the random effects model. The dominant and recessive models produced larger ORs of 2.17 and 3.05, respectively. When more stringent criteria and subgroup analyses were imposed, the associations remained consistent and were strongest in various Asian groups (allelic p = 7 Γ 10(-42) and OR (95% CI) = 2.24 [1.99-2.51] with ORs of 2.16 and 4.11 for dominant and recessive models, respectively). CONCLUSIONS: Our findings provide further strong evidence for the involvement of the ADH1B gene in the pathogenesis of alcohol dependence and abuse as well as for some alcohol-induced medical diseases in the multiple ethnic populations--in particular, certain Asian populations.
Forest plots of ln(OR) with 95% CI for the allelic analysis. Black squares indicate the ln(OR) (ln(OR) can be better fitted than OR), with the size of the square inversely proportional to its variance, and horizontal lines represent the 95% CIs. The pooled results are indicated by the unshaded black diamond. Two studies, including Day 1991 and Ehlers 2007 (East Indian Trinidadian) (Cys), are not shown on the forest plots because the scale of the wide CIs can not fit into the current plot.*, alcoholic patients without alcoholic liver disease, cirrhosis or pancreatitis.
Retrospective analysis for the allelic analysis. Analysis in retrospect was based on publication year since 1990.
His48 allele frequencies among different populations. Blue and red represent His48 and Arg48, respectively. Upper graphs are based on the patients and , lower graphs on controls. Only those 57 studies that described their geographic origins specifically are shown on the map. The geographical borders(111) of Taiwan aboriginals were based on a previous study.
1β20 of 32
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Do Patients With Alcoholic Cirrhosis Accurately Recognize Their Alcohol Tolerance? A Study Comparing Self-Perception and ALDH2/ADH1B Genotype. | Tadokoro T et al. | β | 2026 | β |
| Advances in identifying risk factors of metabolic dysfunction-associated alcohol-related liver disease. | Ye RQ et al. | β | 2025 | β |
| Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations. | Sahu P et al. | β | 2025 | β |
| Assessing the association between ADH5 and ALDH1A1 genetic variants and substance use disorder risk in a Jordanian male population. | Al-Eitan L et al. | β | 2025 | β |
| Genetic analysis of alcohol use disorder: GWAS of alcohol use disorders identification test (AUDIT) and polygenic risk scores in an east slavic population. | Trofimov M et al. | β | 2025 | β |
| Genetic Polymorphisms of <i>ALDH2</i> and <i>ADH1B</i> in Alcohol-Induced Liver Injury: Molecular Mechanisms of Inflammation and Disease Progression in East Asian Populations. | Tadokoro T et al. | β | 2025 | β |
| Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries. | Wang L et al. | β | 2025 | β |
| Role of Metabolism onΒ Alcohol Preference, Addiction, and Treatment. | Quintanilla ME et al. | β | 2025 | β |
| Unraveling time-dependent genetic components underlying alcohol response. | Hikino K et al. | β | 2025 | β |
| Alcohol consumption and risk of psoriasis: Results from observational and genetic analyses in more than 100,000 individuals from the Danish general population. | Jordan A et al. | β | 2024 | β |
| Evidence for sex differences in the impact of cytochrome P450 genotypes on early subjective effects of cannabis. | Davis CN et al. | β | 2024 | β |
| Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens. | Zhang H et al. | β | 2024 | β |
| The biochemistry of the carcinogenic alcohol metabolite acetaldehyde. | Thomas LA et al. | β | 2024 | β |
| Contribution of Genetic Polymorphisms in Human Health. | Chiarella P et al. | β | 2023 | β |
| Genetic influences on alcohol flushing in East Asian populations. | Cho Y et al. | β | 2023 | β |
| <i>ADH1B</i>, <i>ADH1B/C</i> and <i>CYP2E1</i> Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. | Kukowka A et al. | β | 2023 | β |
| Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer. | Chang TG et al. | β | 2023 | β |
| Mind The Gap: Differences in Alcohol Use Screening And Discussions Among Adults Comparing Asian American And Other Racial And Ethnic Subgroups in the United States, 2015-2019. | Mauro PM et al. | β | 2023 | β |
| Understanding the Mechanisms of Action and Effects of Drugs of Abuse. | CiucΔ Anghel DM et al. | β | 2023 | β |
| A database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population. | Lee J et al. | β | 2022 | β |
| Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review. | Tsermpini EE et al. | β | 2022 | β |
| Association of Alcohol Use Disorder Risk With <i>ADH1B, DRD2, FAAH, SLC39A8, GCKR</i>, and <i>PDYN</i> Genetic Polymorphisms. | Legaki E et al. | β | 2022 | β |
| Genome-wide meta-analysis of alcohol use disorder in East Asians. | Zhou H et al. | β | 2022 | β |
| Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex. | Ochi R et al. | β | 2022 | β |
| Signatures of Convergent Evolution and Natural Selection at the Alcohol Dehydrogenase Gene Region are Correlated with Agriculture in Ethnically Diverse Africans. | McQuillan MA et al. | β | 2022 | β |
| The Impact of Taste Preference-Related Gene Polymorphisms on Alcohol Consumption Behavior: A Systematic Review. | Kurshed AAM et al. | β | 2022 | β |
| Characterization of Hepatitis B Virus Integrations Identified in Hepatocellular Carcinoma Genomes. | Mathkar PP et al. | β | 2021 | β |
| Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder. | Castaldelli-Maia JM et al. | β | 2021 | β |
| Genetic and Environmental Susceptibility to Alcoholic Hepatitis. | Morgan MY et al. | β | 2021 | β |
| Genetic Variants of Alcohol Metabolizing Enzymes and Alcohol-Related Liver Cirrhosis Risk. | Ayuso P et al. | β | 2021 | β |
| Machine learning enables new insights into genetic contributions to liver fat accumulation. | Haas ME et al. | β | 2021 | β |
| The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses. | Li W et al. | β | 2021 | β |
| ADH1Bβ2 Is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption. | Vilar-Gomez E et al. | β | 2020 | β |
| Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population. | Govind P et al. | β | 2020 | β |
| Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function. | Schmitt RE et al. | β | 2020 | β |
| Differentiating Types of Self-Reported Alcohol Abstinence. | Gordon KS et al. | β | 2020 | β |
| Ethanol metabolism: The good, the bad, and the ugly. | Wilson DF et al. | β | 2020 | β |
| Functional validity, role, and implications of heavy alcohol consumption genetic loci. | Thompson A et al. | β | 2020 | β |
| Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers. | Stickel F et al. | β | 2020 | β |
| Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity? | Lawson DJ et al. | β | 2020 | β |
| Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk. | Bach P et al. | β | 2019 | β |
| Genetic determinants of beverage consumption: Implications for nutrition and health. | Cornelis MC | β | 2019 | β |
| Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. | Sun Y et al. | β | 2019 | β |
| Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20Β 328 research participants of European ancestry. | Sanchez-Roige S et al. | β | 2019 | β |
| Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. | Gelernter J et al. | β | 2019 | β |
| Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians. | Zaso MJ et al. | β | 2019 | β |
| ADH1B: From alcoholism, natural selection, and cancer to the human phenome. | Polimanti R et al. | β | 2018 | β |
| Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. | Edenberg HJ et al. | β | 2018 | β |
| An improved PCR-CTPP assay for the detection of ADH1B Arg48His polymorphism. | Jiang S et al. | β | 2018 | β |
| Association of alcohol dehydrogenase 1C gene *1/*2 polymorphism with alcohol Dependence(AD) in Turkey: A meta-analysis. | Zhang S et al. | β | 2018 | β |
| Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. | Gelernter J et al. | β | 2018 | β |
| Genome-wide meta-analysis of copy number variations with alcohol dependence. | Sulovari A et al. | β | 2018 | β |
| Human Genetics of Addiction: New Insights and Future Directions. | Hancock DB et al. | β | 2018 | β |
| Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students. | Zaso MJ et al. | β | 2018 | β |
| Patterns of shared signatures of recent positive selection across human populations. | Johnson KE et al. | β | 2018 | β |
| Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. | Sloan ME et al. | β | 2018 | β |
| Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. | Walters RK et al. | β | 2018 | β |
| Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage. | Neuman MG et al. | β | 2017 | β |
| Analysis of the Association of Nonsynonymous Polymorphisms in ADH Genes with Hazardous Drinking in HIV-1-Positive Individuals. | Wolf JM et al. | β | 2017 | β |
| Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations. | DiΓ³szegi J et al. | β | 2017 | β |
| Emerging roles for ncRNAs in alcohol use disorders. | Mayfield RD | β | 2017 | β |
| Excessive alcohol consumption increases mortality in later life: a genetic analysis of the health in men cohort study. | Almeida OP et al. | β | 2017 | β |
| Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. | Treutlein J et al. | β | 2017 | β |
| Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. | Jorgenson E et al. | β | 2017 | β |
| Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study. | Way MJ et al. | β | 2017 | β |
| Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry | Sanchez-Roige S et al. | β | 2017 | β |
| The genetics of alcohol dependence and alcohol-related liver disease. | Stickel F et al. | β | 2017 | β |
| The impact of short-term exposure to air pollutants on the onset of out-of-hospital cardiac arrest: A systematic review and meta-analysis. | Zhao R et al. | β | 2017 | β |
| Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. | Justice AC et al. | β | 2017 | β |
| ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer. | Li D et al. | β | 2016 | β |
| Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis. | Mao N et al. | β | 2016 | β |
| Causal Role of Alcohol Consumption in an Improved Lipid Profile: The Atherosclerosis Risk in Communities (ARIC) Study. | Vu KN et al. | β | 2016 | β |
| Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. | Chartier KG et al. | β | 2016 | β |
| Long noncoding RNAs in psychiatric disorders. | Zuo L et al. | β | 2016 | β |
| Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women. | Polimanti R et al. | β | 2016 | β |
| Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence? | Hart AB et al. | β | 2016 | β |
| Candidate gene study for smoking, alcohol use, and body weight in a sample of pregnant women. | Wehby GL et al. | β | 2015 | β |
| Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers. | Meyers JL et al. | β | 2015 | β |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | BΓΌhler KM et al. | β | 2015 | β |
| Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. | Grotewiel M et al. | β | 2015 | β |
| Eye color: A potential indicator of alcohol dependence risk in European Americans. | Sulovari A et al. | β | 2015 | β |
| Genetic polymorphism in alcohol dehydrogenase 2 (ADH2) gene and alcoholic liver cirrhosis risk. | He L et al. | β | 2015 | β |
| Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. | Way M et al. | β | 2015 | β |
| Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. | Forero DA et al. | β | 2015 | β |
| The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders. | Oniszczenko W et al. | β | 2015 | β |
| The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores. | Mbarek H et al. | β | 2015 | β |
| The impact of focusing a program to prevent heavier drinking on a pre-existing phenotype, the low level of response to alcohol. | Schuckit MA et al. | β | 2015 | β |
| XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. | Juraeva D et al. | β | 2015 | β |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | β | 2014 | β |
| ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes. | Lawlor DA et al. | β | 2014 | β |
| ADH1B Arg48His allele frequency map: filling in the gap for Central Europe. | Treutlein J et al. | β | 2014 | β |
| Alcohol consumption and cognitive impairment in older men: a mendelian randomization study. | Almeida OP et al. | β | 2014 | β |
| Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. | Kilcoyne B et al. | β | 2014 | β |
| ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. | Quillen EE et al. | β | 2014 | β |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | β | 2014 | β |
| Association of gamma-aminobutyric acid A receptor Ξ±2 gene (GABRA2) with alcohol use disorder. | Li D et al. | β | 2014 | β |
| Association of the HTR2A gene with alcohol and heroin abuse. | Cao J et al. | β | 2014 | β |
| Effect of the allelic variant of alcohol dehydrogenase ADH1B*2 on ethanol metabolism. | Kang G et al. | β | 2014 | β |
| Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. | Yang C et al. | β | 2014 | β |
| Gene-environment interaction. | Manuck SB et al. | β | 2014 | β |
| Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China. | Zhang J et al. | β | 2014 | β |
| Genome-wide association discoveries of alcohol dependence. | Zuo L et al. | β | 2014 | β |
| Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. | Gelernter J et al. | β | 2014 | β |
| Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants. | Wang S et al. | β | 2014 | β |
| Predictors of subgroups based on maximum drinks per occasion over six years for 833 adolescents and young adults in COGA. | Schuckit MA et al. | β | 2014 | β |
| Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits. | Silverwood RJ et al. | β | 2014 | β |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | β | 2014 | β |
| The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men. | Sartor CE et al. | β | 2014 | β |
| The triangular association of ADH1B genetic polymorphism, alcohol consumption and the risk of depression in older men. | Almeida OP et al. | β | 2014 | β |
| Alcohol consumption on pancreatic diseases. | Herreros-Villanueva M et al. | β | 2013 | β |
| Alcohol-metabolizing genes and alcohol phenotypes in an Israeli household sample. | Meyers JL et al. | β | 2013 | β |
| Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. | Cao J et al. | β | 2013 | β |
| Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men. | Yokoyama A et al. | β | 2013 | β |
| Genetic polymorphisms of pharmacogenomic VIP variants in the Kyrgyz population from northwest China. | Yunus Z et al. | β | 2013 | β |
| Multi-cultural association of the serotonin transporter gene (SLC6A4) with substance use disorder. | Cao J et al. | β | 2013 | β |
| Peter Riederer "70th birthday" neurobiological foundations of modern addiction treatment. | Jacob C | β | 2013 | β |
| The genetics of alcohol dependence. | Rietschel M et al. | β | 2013 | β |
| ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. | Bierut LJ et al. | β | 2012 | β |
| Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. | Li D et al. | β | 2012 | β |
| Genes contributing to the development of alcoholism: an overview. | Edenberg HJ | β | 2012 | β |
| Genes encoding enzymes involved in ethanol metabolism. | Hurley TD et al. | β | 2012 | β |
| Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. | Frank J et al. | β | 2012 | β |
| Identifying genetic variation for alcohol dependence. | Agrawal A et al. | β | 2012 | β |
| Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. | Agrawal A et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |