For the Cys allele, evidence of significant association was detected with P value of 7×10−5 and OR of 2.74 (1.67, 4.51) under the recessive model (ArgArg vs. ArgCys + CysCys). Statistical significance was also identified in allelic analysis (Table 1). The studies of AD and alcohol abuse combined with those from the Cys allele showed stronger association with allelic P value of 1×10−38 (OR = 2.08 (1.86, 2.32)).
