Genes contributing to the development of alcoholism: an overview.
- Authors
- Edenberg, Howard J
- Year
- 2012
- Journal
- Alcohol research : current reviews
- PMID
- 23134049
- DOI
- 10.35946/arcr.v34.3.08
- PMCID
- PMC3711246
Genetic factors (i.e., variations in specific genes) account for a substantial portion of the risk for alcoholism. However, identifying those genes and the specific variations involved is challenging. Researchers have used both case-control and family studies to identify genes related to alcoholism risk. In addition, different strategies such as candidate gene analyses and genome-wide association studies have been used. The strongest effects have been found for specific variants of genes that encode two enzymes involved in alcohol metabolism-alcohol dehydrogenase and aldehyde dehydrogenase. Accumulating evidence indicates that variations in numerous other genes have smaller but measurable effects.
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