Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis.
paper
Cited
Public
Unavailable
- Authors
- Yang, Shu-Juan; Yokoyama, Akira; Yokoyama, Tetsuji; Huang, Yu-Chuan; Wu, Si-Ying; Shao, Ying; Niu, Jin; Wang, Jie; Liu, Yu; Zhou, Xiao-Qiao; Yang, Chun-Xia
- Year
- 2010
- Journal
- World journal of gastroenterology
- PMID
- 20806441
- DOI
- 10.3748/wjg.v16.i33.4210
- PMCID
- PMC2932928
AIM: To evaluate the contribution of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) polymorphisms to the risk of esophageal cancer. METHODS: Nineteen articles were included by searching MEDLINE, EMBASE and the Chinese Biomedical Database, 13 on ADH1B and 18 on ALDH2. We performed a meta-analysis of case-control studies including 13 studies on ADH1B (cases/controls: 2390/7100) and 18 studies on ALDH2 (2631/6030). RESULTS: The crude odds ratio [OR (95% confidence interval)] was 2.91 (2.04-4.14) for ADH1B*1/*1 (vs ADH1B*2/*2) and 1.32 (1.17-1.49) for ADH1B*1/*2. The crude OR for ALDH2*1/*2 (vs ALDH2*1/*1) was 2.52 (1.76-3.61). ADH1B*1/*1 increased the risk of esophageal cancer among never/rare [1.56 (0.93-2.61)], moderate [2.71 (1.37-5.35)], and heavy drinkers [3.22 (2.27-4.57)]. ADH1B*1/*2 was associated with a modest risk among moderate drinkers [1.43 (1.09-1.87)]. ALDH2*1/*2 increased the risk among never/rare [1.28 (0.91-1.80)], moderate [3.12 (1.95-5.01)], and heavy [7.12 (4.67-10.86)] drinkers, and among ex-drinkers [5.64 (1.57-20.25)]. ALDH2*2/*2 increased the risk among drinkers [4.42 (1.72-11.36)]. ADH1B*1/*1 plus ALDH2*1/*2 was associated with the highest risk for heavy drinkers [12.45 (2.9-53.46)]. The results of the meta-regression analysis showed that the effects of ADH1B*1/*1 and ALDH2*1/*2 increased with the level of alcohol consumption. ALDH2*1/*2 was associated with a high risk among Taiwan Chinese and Japanese drinkers, as opposed to a moderate risk among drinkers in high-incidence regions of Mainland China. ADH1B*1/*1 in heavy drinkers and ALDH2*1/*2 in moderate-to-heavy drinkers was associated with similarly high risk among both men and women. CONCLUSION: ADH1B/ALDH2 genotypes affect the risk of esophageal cancer, and the risk is modified by alcohol consumption, ethnicity, and gender.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Transoral surgery for hypopharyngeal and laryngeal cancers in Japan: Current status from a nationwide multicenter retrospective study. | Araki K et al. | β | 2026 | β |
| ALDH2 Deficiency and Alcohol Intake in the United States: Opportunity for Precision Cancer Prevention. | Forman D et al. | β | 2025 | β |
| Comparison of Somatic Mutations in Primary Squamous Cell Carcinomas of the Hypopharynx and the Esophagus Developed in Individual Patients. | Matsui H et al. | β | 2025 | β |
| Genetic Polymorphisms of <i>ALDH2</i> and <i>ADH1B</i> in Alcohol-Induced Liver Injury: Molecular Mechanisms of Inflammation and Disease Progression in East Asian Populations. | Tadokoro T et al. | β | 2025 | β |
| Physiologic and molecular effects of alcohol in the esophagus: a narrative review. | Shaker A | β | 2025 | β |
| Alcohol metabolism in alcohol use disorder: a potential therapeutic target. | Lehner T et al. | β | 2024 | β |
| Risk stratification of synchronous gastric cancers including alcohol-related genetic polymorphisms. | Asonuma S et al. | β | 2024 | β |
| Uncovering newly identified aldehyde dehydrogenase 2 genetic variants that lead to acetaldehyde accumulation after an alcohol challenge. | Rwere F et al. | β | 2024 | β |
| Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis. | Zhang B et al. | β | 2023 | β |
| SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common <i>ALDH2</i> alcohol flushing variant. | Guo H et al. | β | 2023 | β |
| Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency. | Montel RA et al. | β | 2022 | β |
| Polyphenols from persimmon fruit attenuate acetaldehyde-induced DNA double-strand breaks by scavenging acetaldehyde. | Matsuzaki K et al. | β | 2022 | β |
| Study protocol of brief intervention using gene polymorphism information for excessive drinking among Japanese college students and adults aged 20-30 years: a randomized controlled trial. | Owaki Y et al. | β | 2022 | β |
| The <i>ALDH2</i> rs671 polymorphism is associated with athletic status and muscle strength in a Japanese population. | Kikuchi N et al. | β | 2022 | β |
| The prognostic role of fatty acid metabolism-related genes in patients with gastric cancer. | Xu W et al. | β | 2022 | β |
| Update on Management of Squamous Cell Esophageal Cancer. | Waters JK et al. | β | 2022 | β |
| Associations between <i>ALDH</i> Genetic Variants, Alcohol Consumption, and the Risk of Nasopharyngeal Carcinoma in an East Asian Population. | Liao WL et al. | β | 2021 | β |
| Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women. | Yokoyama A et al. | β | 2021 | β |
| Interaction between ALDH2 rs671 and life habits affects the risk of hypertension in Koreans: A STROBE observational study. | Kim SS et al. | β | 2021 | β |
| Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in Taiwan. | Hsu MH et al. | β | 2021 | β |
| Risk factors for esophageal iodine-unstained lesions and changing trends among Japanese alcohol-dependent men (2003-2018). | Yokoyama A et al. | β | 2021 | β |
| Effectiveness of planned surveillance for detecting second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma. | Shinozaki T et al. | β | 2020 | β |
| Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice. | Hirohashi K et al. | β | 2020 | β |
| Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk. | Suo C et al. | β | 2019 | β |
| Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women. | Yokoyama A et al. | β | 2019 | β |
| Genetic determinants of beverage consumption: Implications for nutrition and health. | Cornelis MC | β | 2019 | β |
| Local Acetaldehyde-An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis. | Nieminen MT et al. | β | 2018 | β |
| Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. | Yokoyama A et al. | β | 2017 | β |
| Alcohol, stem cells and cancer. | Gu S et al. | β | 2017 | β |
| ALDH2-deficiency as genetic epidemiologic and biochemical model for the carcinogenicity of acetaldehyde. | Lachenmeier DW et al. | β | 2017 | β |
| A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture. | Takeshima K et al. | β | 2017 | β |
| Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults. | Wang H et al. | β | 2017 | β |
| Cancers Attributable to Alcohol Consumption in Nigeria: 2012-2014. | Odutola MK et al. | β | 2017 | β |
| Effects of alcohol consumption, ALDH2 rs671 polymorphism, and Helicobacter pylori infection on the gastric cancer risk in a Korean population. | Yang S et al. | β | 2017 | β |
| Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium. | Mizumoto A et al. | β | 2017 | β |
| Prevention of alcohol-related health harm in the workplace. | Takeshita T | β | 2017 | β |
| Slow-release L-cysteine capsule prevents gastric mucosa exposure to carcinogenic acetaldehyde: results of a randomised single-blinded, cross-over study of Helicobacter-associated atrophic gastritis. | HellstrΓΆm PM et al. | β | 2017 | β |
| Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men. | Hirata K et al. | β | 2017 | β |
| Alcoholic beverages, obesity, physical activity and other nutritional factors, and cancer risk: A review of the evidence. | Latino-Martel P et al. | β | 2016 | β |
| Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis. | Mao N et al. | β | 2016 | β |
| Associations Between Alcohol Consumption and Leukocyte Telomere Length Modified by a Common Polymorphism of ALDH2. | Shin C et al. | β | 2016 | β |
| Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. | Wall TL et al. | β | 2016 | β |
| Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine. | Hall MA et al. | β | 2016 | β |
| Esophagus cancer and occupational exposure to asbestos: results from a meta-analysis of epidemiology studies. | Li B et al. | β | 2016 | β |
| Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. | Hashimoto M et al. | β | 2016 | β |
| Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know? | Simonds NI et al. | β | 2016 | β |
| Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. | Cai Q et al. | β | 2015 | β |
| [Associations between ALDH2 and ADH1B Genotypes and Ethanol-Induced Cutaneous Erythema in Young Japanese Women]. | Hayashida M et al. | β | 2015 | β |
| Effects of ALDH2 genotype, PPI treatment and L-cysteine on carcinogenic acetaldehyde in gastric juice and saliva after intragastric alcohol administration. | Maejima R et al. | β | 2015 | β |
| Estimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses. | Roerecke M et al. | β | 2015 | β |
| Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers. | Yokoyama A et al. | β | 2015 | β |
| Multiple criteria optimization joint analyses of microarray experiments in lung cancer: from existing microarray data to new knowledge. | Camacho-CΓ‘ceres KI et al. | β | 2015 | β |
| Sex-specific differences in the association of a common aldehyde dehydrogenase 2 gene polymorphism and alcohol consumption with stroke risk in a Korean population: a prospective cohort study. | Shin C et al. | β | 2015 | β |
| A pooled analysis of the ERCC2 Asp312Asn polymorphism and esophageal cancer susceptibility. | Wen F et al. | β | 2014 | β |
| Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk. | Zhao H et al. | β | 2014 | β |
| Roles of the ALDH2 and ADH1B genotypes on the association between alcohol intake and serum adiponectin levels among Japanese male workers. | Maeda S et al. | β | 2014 | β |
| Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population. | Chang SC et al. | β | 2014 | β |
| A health-risk appraisal model and endoscopic mass screening for esophageal cancer in Japanese men. | Yokoyama A et al. | β | 2013 | β |
| Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya. | Nieminen MT et al. | β | 2013 | β |
| ALDH2 genotype has no effect on salivary acetaldehyde without the presence of ethanol in the systemic circulation. | Helminen A et al. | β | 2013 | β |
| A meta-analysis of HIF-1Ξ± and esophageal squamous cell carcinoma (ESCC) risk. | Sun G et al. | β | 2013 | β |
| Genetic instrumental variable studies of effects of prenatal risk factors. | Wehby GL et al. | β | 2013 | β |
| Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China. | Wu M et al. | β | 2013 | β |
| ADH IB expression, but not ADH III, is decreased in human lung cancer. | Mutka SC et al. | β | 2012 | β |
| Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics. | Yukawa Y et al. | β | 2012 | β |
| Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men. | Yokoyama A et al. | β | 2012 | β |
| Genes encoding enzymes involved in ethanol metabolism. | Hurley TD et al. | β | 2012 | β |
| Genetic polymorphisms of ALDH2 and ADH2 are not associated with risk of hepatocellular carcinoma among East Asians. | Zhou D et al. | β | 2012 | β |
| Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. | Duell EJ et al. | β | 2012 | β |
| Identifying genetic variation for alcohol dependence. | Agrawal A et al. | β | 2012 | β |
| Interactions of alcohol and tobacco in gastrointestinal cancer. | Salaspuro M | β | 2012 | β |
| Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. | AgrΓ©us L et al. | β | 2012 | β |
| Acetaldehyde and gastric cancer. | Salaspuro M | β | 2011 | β |
| Alcohol drinking and esophageal squamous cell carcinoma with focus on light-drinkers and never-smokers: a systematic review and meta-analysis. | Islami F et al. | β | 2011 | β |
| ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. | Zhang Y et al. | β | 2011 | β |
| Genetic testing for aldehyde dehydrogenase 2 deficiency in young adults. | Hendershot CS | β | 2011 | β |
| Meta-analysis of alcohol consumption and risk of extrahepatic bile system cancer. | Kan HP et al. | β | 2011 | β |
| p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia. | Yokoyama A et al. | β | 2011 | β |
| Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. | Li D et al. | β | 2011 | β |
| XPD Lys751Gln polymorphism and esophageal cancer risk: a meta-analysis involving 2288 cases and 4096 controls. | Yuan L et al. | β | 2011 | β |