Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
paper
Cited
Public
Unavailable
- Authors
- Luo, Xingguang; Kranzler, Henry R; Zuo, Lingjun; Wang, Shuang; Schork, Nicholas J; Gelernter, Joel
- Year
- 2006
- Journal
- American journal of human genetics
- PMID
- 16685648
- DOI
- 10.1086/504113
- PMCID
- PMC1474098
The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and alcohol dependence (AD) have long been studied in many populations, but not comprehensively. In the present study, we genotyped 16 markers within the ADH gene cluster (including the ADH1A, ADH1B, ADH1C, ADH5, ADH6, and ADH7 genes), 4 markers within the ALDH2 gene, and 38 unlinked ancestry-informative markers in a case-control sample of 801 individuals. Associations between markers and disease were analyzed by a Hardy-Weinberg equilibrium (HWE) test, a conventional case-control comparison, a structured association analysis, and a novel diplotype trend regression (DTR) analysis. Finally, the disease alleles were fine mapped by a Hardy-Weinberg disequilibrium (HWD) measure (J). All markers were found to be in HWE in controls, but some markers showed HWD in cases. Genotypes of many markers were associated with AD. DTR analysis showed that ADH5 genotypes and diplotypes of ADH1A, ADH1B, ADH7, and ALDH2 were associated with AD in European Americans and/or African Americans. The risk-influencing alleles were fine mapped from among the markers studied and were found to coincide with some well-known functional variants. We demonstrated that DTR was more powerful than many other conventional association methods. We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Gene-based Hardy-Weinberg equilibrium test using genotype count data: application to six types of cancers. | Nishino J et al. | — | 2025 | → |
| Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank. | Naseri A et al. | — | 2024 | → |
| Human adaptations to diet: Biological and cultural coevolution. | Jelenkovic A et al. | — | 2024 | → |
| The biochemistry of the carcinogenic alcohol metabolite acetaldehyde. | Thomas LA et al. | — | 2024 | → |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | — | 2021 | → |
| Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. | Luo X et al. | — | 2021 | → |
| Association of ADH7 Gene Polymorphism with Schizophrenia in the Han Population of Northern China: a Case-Control Study. | Zeng K et al. | — | 2020 | → |
| Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank | Naseri A et al. | — | 2020 | — |
| An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD<sup>+</sup> and Disulfiram. | J CP et al. | — | 2019 | → |
| Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. | Sun Y et al. | — | 2019 | → |
| ADH1B: From alcoholism, natural selection, and cancer to the human phenome. | Polimanti R et al. | — | 2018 | → |
| Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. | Edenberg HJ et al. | — | 2018 | → |
| Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students. | Thomas NS et al. | — | 2018 | → |
| Body composition, serum lipid levels, and transcriptomic characterization in the adipose tissue of male pigs in response to sex hormone deficiency. | Yao Y et al. | — | 2018 | → |
| Distinct Prognostic Values of Alcohol Dehydrogenase Family Members for Non-Small Cell Lung Cancer. | Wang P et al. | — | 2018 | → |
| Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma. | Cui Q et al. | — | 2018 | → |
| Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students. | Zaso MJ et al. | — | 2018 | → |
| Analysis of the Association of Nonsynonymous Polymorphisms in ADH Genes with Hazardous Drinking in HIV-1-Positive Individuals. | Wolf JM et al. | — | 2017 | → |
| Integrative variants, haplotypes and diplotypes of the CAPN3 and FRMD5 genes and several environmental exposures associate with serum lipid variables. | Guo T et al. | — | 2017 | → |
| Interaction between ADH1B*3 and alcohol-facilitating social environments in alcohol behaviors among college students of african descent. | Desalu JM et al. | — | 2017 | → |
| Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. | Wall TL et al. | — | 2016 | → |
| Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence? | Hart AB et al. | — | 2016 | → |
| Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. | Grotewiel M et al. | — | 2015 | → |
| Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis. | Vatansever S et al. | — | 2015 | → |
| Alcohol Exposure <i>In Utero</i> and Child Academic Achievement. | von Hinke Kessler Scholder S et al. | — | 2014 | → |
| ALDH2*2 but not ADH1B*2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and pharmacodynamic findings. | Peng GS et al. | — | 2014 | → |
| Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. | Yang C et al. | — | 2014 | → |
| Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China. | Zhang J et al. | — | 2014 | → |
| Genome-wide association discoveries of alcohol dependence. | Zuo L et al. | — | 2014 | → |
| Less drinking, yet more problems: understanding African American drinking and related problems. | Zapolski TC et al. | — | 2014 | → |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | — | 2014 | → |
| Use of diplotypes - matched haplotype pairs from homologous chromosomes - in gene-disease association studies. | Zuo L et al. | — | 2014 | → |
| Alcohol-metabolizing genes and alcohol phenotypes in an Israeli household sample. | Meyers JL et al. | — | 2013 | → |
| Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. | Zuo L et al. | — | 2013 | → |
| Diplotyper: diplotype-based association analysis. | Kim S et al. | — | 2013 | → |
| Genome-wide DNA methylation analysis in alcohol dependence. | Zhang R et al. | — | 2013 | → |
| NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. | Zuo L et al. | — | 2013 | → |
| Rare ADH variant constellations are specific for alcohol dependence. | Zuo L et al. | — | 2013 | → |
| Anxiogenic and stress-inducing effects of peripherally administered acetaldehyde in mice: similarities with the disulfiram-ethanol reaction. | Escrig MA et al. | — | 2012 | → |
| A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism. | Cadoni G et al. | — | 2012 | → |
| Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study. | Lind PA et al. | — | 2012 | → |
| Association of a genetic polymorphism of the alcohol-metabolizing enzyme ADH1C with alcohol dependence: results of a case-control study. | Kortunay S et al. | — | 2012 | → |
| Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain). | Muñoz X et al. | — | 2012 | → |
| Common and specific liability to addiction: approaches to association studies of opioid addiction. | Nielsen DA et al. | — | 2012 | → |
| Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey. | Aktas EO et al. | — | 2012 | → |
| Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. | Lewis SJ et al. | — | 2012 | → |
| Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. | Zuo L et al. | — | 2012 | → |
| Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. | Pei YF et al. | — | 2012 | → |
| Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. | Zuo L et al. | — | 2012 | → |
| Piecing together the puzzle of acetaldehyde as a neuroactive agent. | Correa M et al. | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. | McKay JD et al. | — | 2011 | → |
| Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. | Gizer IR et al. | — | 2011 | → |
| GENES AS INSTRUMENTS FOR STUDYING RISK BEHAVIOR EFFECTS: AN APPLICATION TO MATERNAL SMOKING AND OROFACIAL CLEFTS. | Wehby G et al. | — | 2011 | → |
| Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. | Liu J et al. | — | 2011 | → |
| Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. | Li D et al. | — | 2011 | → |
| The enduring influence of drinking motives on alcohol consumption after fateful trauma. | Beseler CL et al. | — | 2011 | → |
| ADH1A variation predisposes to personality traits and substance dependence. | Zuo L et al. | — | 2010 | → |
| ADH1B*3 and response to alcohol in African-Americans. | McCarthy DM et al. | — | 2010 | → |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | — | 2010 | → |
| ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. | Birley AJ et al. | — | 2009 | → |
| A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women. | Zuccolo L et al. | — | 2009 | → |
| Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | — | 2009 | → |
| Associations of ALDH2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults. | Hendershot CS et al. | — | 2009 | → |
| Association study of DTNBP1 with schizophrenia in a US sample. | Zuo L et al. | — | 2009 | → |
| Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. | Gelernter J et al. | — | 2009 | → |
| Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. | Peng GS et al. | — | 2009 | → |
| Ethanol intake and ethanol-induced locomotion and locomotor sensitization in Cyp2e1 knockout mice. | Correa M et al. | — | 2009 | → |
| Genetics of alcohol dependence. | Gelernter J et al. | — | 2009 | → |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | — | 2009 | → |
| Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. | Shibata K et al. | — | 2009 | → |
| Heroin addiction in African Americans: a hypothesis-driven association study. | Levran O et al. | — | 2009 | → |
| Influence of a drinking quantity and frequency measure on the prevalence and demographic correlates of DSM-IV alcohol dependence. | Keyes KM et al. | — | 2009 | → |
| Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. | Chen YC et al. | — | 2009 | → |
| Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. | Li H et al. | — | 2009 | → |
| The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. | Zuo L et al. | — | 2009 | → |
| ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. | Luo X et al. | — | 2008 | → |
| Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH et al. | — | 2008 | → |
| Molecular genetics of alcohol dependence and related endophenotypes. | Strat YL et al. | — | 2008 | → |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | — | 2008 | → |
| Association between CDH1 haplotypes and gastric cancer risk in a Japanese population. | Yamada H et al. | — | 2007 | → |
| Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. | Yang BZ et al. | — | 2007 | → |
| CNR1 variation modulates risk for drug and alcohol dependence. | Zuo L et al. | — | 2007 | → |
| Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans. | Scott DM et al. | — | 2007 | → |
| Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. | Luo X et al. | — | 2007 | → |
| Personality traits of agreeableness and extraversion are associated with ADH4 variation. | Luo X et al. | — | 2007 | → |
| Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. | Peng GS et al. | — | 2007 | → |
| The serotonin transporter: sequence variation in Macaca fascicularis and its relationship to dominance. | Miller-Butterworth CM et al. | — | 2007 | → |
| Variation in GABRA2 predicts drinking behavior in project MATCH subjects. | Bauer LO et al. | — | 2007 | → |
| Generalized genomic distance-based regression methodology for multilocus association analysis. | Wessel J et al. | — | 2006 | → |