Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.
paper
Cited
Public
Unavailable
- Authors
- Luczak, Susan E; Glatt, Stephen J; Wall, Tamara L
- Year
- 2006
- Journal
- Psychological bulletin
- PMID
- 16822169
- DOI
- 10.1037/0033-2909.132.4.607
Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians. For each gene, possession of 1 variant *2 allele was protective against alcohol dependence, and possession of a 2nd *2 allele did not offer significant additional protection. The protective effects of these 2 gene polymorphisms were independent. Diagnostic criteria, recruitment strategy, and Japanese ethnicity moderated the effect of ALDH2*2. Recruitment strategy and gender moderated the effect of ADH1B*2. These findings highlight the importance of methodological issues and potential gene-gene and gene-environment interactions that must be considered when examining relationships between genetic polymorphisms and phenotypes.
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