ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review.
paper
Cited
Public
- Authors
- Eng, Mimy Y; Luczak, Susan E; Wall, Tamara L
- Year
- 2007
- Journal
- Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
- PMID
- 17718397
- PMCID
- PMC3860439
Variants of three genes encoding alcohol-metabolizing enzymes, the aldehyde dehydrogenase gene ALDH2 and the alcohol dehydrogenase genes ADH1B and ADH1C, have been associated with reduced rates of alcohol dependence. The genotype prevalence of these genes varies in general samples of different Asian ethnic groups. The ALDH2*2 allele appears to be most prevalent in Chinese-American, Han Chinese and Taiwanese, Japanese, and Korean samples. Much lower rates have been reported in Thais, Filipinos, Indians, and Chinese and Taiwanese aborigines. ADH1B*2 is highly prevalent among Asians, with the exception of Indians. ADH1C*1 also is highly prevalent in Asians, but has only been examined in a few studies of Chinese and Korean samples.
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|---|---|---|
| 0 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Study Design | To identify studies eligible for this analysis, the authors of this article surveyed the Medlineβ¦ |
| 1 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Study Design | Despite the stringent criteria for the selection of studies to be included, the following caveatsβ¦ |
| 2 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ALDH2 Genotypes | The ALDH2*2 allele is thought to occur exclusively in Asians; however, its prevalence varies acrossβ¦ |
| 3 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ALDH2 Genotypes | variation in prevalence rates found among Han Chinese and Taiwanese samples might be explained byβ¦ |
| 4 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ALDH2 Genotypes | The ALDH2*2 allele was less commonly found in aboriginal Chinese and Taiwanese samples (e.g., Ami,β¦ |
| 5 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ALDH2 Genotypes | Data from 10 Japanese studies indicated that 41 to 52 percent of Japanese possessed at least oneβ¦ |
| 6 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ALDH2 Genotypes | Five studies of Korean, Korean-American, and Korean-Chinese samples found that approximatelyβ¦ |
| 7 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ADH1B Genotypes | The ADH1B*2 allele was highly prevalent in Asian ethnic groups, particularly in northeast Asiansβ¦ |
| 8 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ADH1B Genotypes | The ADH1B*2 allele also was commonly found in Japanese people. In 10 studies of Japanese, 81 to 100β¦ |
| 9 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ADH1B Genotypes | The prevalence of ADH1B*2 also was high in three Korean samples, with 88 to 96 percent ofβ¦ |
| 10 | Prevalence of ALDH2,ADH1B, and ADH1C Genotypes in Asian Populations β Results of the Analysis β Distribution of ADH1C Genotypes | ADH1C genotypes only have been examined in a few Chinese and Korean samples, but in these samplesβ¦ |
| 11 | Summary | This literature review highlights the fact that the prevalence of ALDH2, ADH1B, and ADH1C alleles⦠|
1β12 of 12
| Name | Type |
|---|---|
| Aboriginal Chinese and Taiwanese samples local | cohort |
| ADH1B | gene |
| ADH1C | gene |
| alcohol | phenotype |
| alcohol use disorders | phenotype |
| ALDH2 | gene |
| Ami | cohort |
| Asian | cohort |
| Asian ethnic groups local | cohort |
| Atayal local | cohort |
| Bunun local | cohort |
| cardiovascular disease | phenotype |
| central and northern China local | cohort |
| Chinese | cohort |
| Chinese aboriginal populations local | cohort |
| Chinese aborigines local | cohort |
| Chinese-American local | cohort |
| Chinese Americans local | cohort |
| diabetes | phenotype |
| Elunchan local | cohort |
| Filipino | cohort |
| Indian | cohort |
| Japanese | cohort |
| Japanese American | cohort |
| Korean-American local | cohort |
| Korean-Chinese local | cohort |
| Korean Chinese sample local | cohort |
| Koreans | cohort |
| Korean samples local | cohort |
| Malay | cohort |
| Malays local | cohort |
| Mongolian local | cohort |
| Paiwan local | cohort |
| Siberian Yakut local | cohort |
| southwest China local | cohort |
| stroke | phenotype |
| Taiwanese | cohort |
| Taiwanese aborigines local | cohort |
| Thai | cohort |
| Thais local | cohort |
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