Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.
paper
Cited
Public
Unavailable
- Authors
- Osier, M; Pakstis, A J; Kidd, J R; Lee, J F; Yin, S J; Ko, H C; Edenberg, H J; Lu, R B; Kidd, K K
- Year
- 1999
- Journal
- American journal of human genetics
- PMID
- 10090900
- DOI
- 10.1086/302317
- PMCID
- PMC1377839
Two of the three class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode known functional variants that act on alcohol with different efficiencies. Variants at both these genes have been implicated in alcoholism in some populations because allele frequencies differ between alcoholics and controls. Specifically, controls have higher frequencies of the variants with higher Vmax (ADH2*2 and ADH3*1). In samples both of alcoholics and of controls from three Taiwanese populations (Chinese, Ami, and Atayal) we found significant pairwise disequilibrium for all comparisons of the two functional polymorphisms and a third, presumably neutral, intronic polymorphism in ADH2. The class I ADH genes all lie within 80 kb on chromosome 4; thus, variants are not inherited independently, and haplotypes must be analyzed when evaluating the risk of alcoholism. In the Taiwanese Chinese we found that, only among those chromosomes containing the ADH3*1 variant (high Vmax), the proportions of chromosomes with ADH2*1 (low Vmax) and those with ADH2*2 (high Vmax) are significantly different between alcoholics and controls (P<10-5). The proportions of chromosomes with ADH3*1 and those with ADH3*2 are not significantly different between alcoholics and controls, on a constant ADH2 background (with ADH2*1, P=.83; with ADH2*2, P=.53). Thus, the observed differences in the frequency of the functional polymorphism at ADH3, between alcoholics and controls, can be accounted for by the disequilibrium with ADH2 in this population.
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| Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews. | Gu S et al. | — | 2018 | → |
| Alcohol and head and neck cancer. | Kawakita D et al. | — | 2017 | → |
| The Analysis of Polymorphism of Alcohol Dehydrogenase 3 (ADH3) Gene and Influence of Liver Function Status in Indonesia. | Suhartini et al. | — | 2017 | → |
| Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer. | Peng Q et al. | — | 2016 | → |
| ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men. | Yin G et al. | — | 2016 | → |
| Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. | Wall TL et al. | — | 2016 | → |
| Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India. | Roy N et al. | — | 2016 | → |
| Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. | Chartier KG et al. | — | 2016 | → |
| Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. | Hashimoto M et al. | — | 2016 | → |
| Under-Researched Demographics: Heavy Episodic Drinking and Alcohol-Related Problems Among Asian Americans. | Iwamoto DK et al. | — | 2016 | → |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | Bühler KM et al. | — | 2015 | → |
| Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese. | Chang YH et al. | — | 2015 | → |
| Genetic polymorphism in alcohol dehydrogenase 2 (ADH2) gene and alcoholic liver cirrhosis risk. | He L et al. | — | 2015 | → |
| Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis. | Vatansever S et al. | — | 2015 | → |
| Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. | Way M et al. | — | 2015 | → |
| Allelic variants of ADH, ALDH and the five factor model of personality in alcohol dependence syndrome. | Salujha SK et al. | — | 2014 | → |
| Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms. | Mead EA et al. | — | 2014 | → |
| Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. | Park BL et al. | — | 2013 | → |
| Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China. | Wu M et al. | — | 2013 | → |
| The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence. | Wang TY et al. | — | 2013 | → |
| Aboriginal fractions: enumerating identity in Taiwan. | Liu JA | — | 2012 | → |
| ADH1B polymorphism, alcohol consumption, and binge drinking in Slavic Caucasians: results from the Czech HAPIEE study. | Hubacek JA et al. | — | 2012 | → |
| Association of a genetic polymorphism of the alcohol-metabolizing enzyme ADH1C with alcohol dependence: results of a case-control study. | Kortunay S et al. | — | 2012 | → |
| Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey. | Aktas EO et al. | — | 2012 | → |
| Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. | Li D et al. | — | 2012 | → |
| Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| Alcohol-metabolizing enzyme gene polymorphisms in the Basque Country, Morocco, and Ecuador. | Celorrio D et al. | — | 2011 | → |
| Diversification of the ADH1B gene during expansion of modern humans. | Li H et al. | — | 2011 | → |
| Genetics of alcohol dependence. | Kimura M et al. | — | 2011 | → |
| Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. | Kendler KS et al. | — | 2011 | → |
| Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. | Liu J et al. | — | 2011 | → |
| Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. | Li D et al. | — | 2011 | → |
| ADH1B*2 allele is protective against alcoholism but not chronic liver disease in the Hungarian population. | Toth R et al. | — | 2010 | → |
| ADH1B*3 and response to alcohol in African-Americans. | McCarthy DM et al. | — | 2010 | → |
| A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. | Wei S et al. | — | 2010 | → |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | — | 2010 | → |
| Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. | Yu HS et al. | — | 2010 | → |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | — | 2010 | → |
| Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. | Ray LA et al. | — | 2010 | → |
| The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence-a review. | Huang CL | — | 2010 | → |
| Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. | Mustavich LF et al. | — | 2010 | → |
| ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. | Birley AJ et al. | — | 2009 | → |
| Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | — | 2009 | → |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | — | 2009 | → |
| Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. | Kanda J et al. | — | 2009 | → |
| New insights into the genetics of addiction. | Li MD et al. | — | 2009 | → |
| Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. | Tolstrup JS et al. | — | 2008 | → |
| Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH et al. | — | 2008 | → |
| Coding and non-coding polymorphisms in alcohol dehydrogenase alters protein expression and alcohol-associated erythema. | Pershing LK et al. | — | 2008 | → |
| Ethnic related selection for an ADH Class I variant within East Asia. | Li H et al. | — | 2008 | → |
| Molecular genetics of alcohol dependence and related endophenotypes. | Strat YL et al. | — | 2008 | → |
| Systems genetics of alcoholism. | Sloan CD et al. | — | 2008 | → |
| Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase. | Beulens JW et al. | — | 2007 | → |
| Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview. | Green RF et al. | — | 2007 | → |
| ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. | Eng MY et al. | — | 2007 | → |
| Conservative evolution in duplicated genes of the primate Class I ADH cluster. | Oota H et al. | — | 2007 | → |
| Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department. | Tseng YM et al. | — | 2007 | → |
| Evidence of positive selection on a class I ADH locus. | Han Y et al. | — | 2007 | → |
| Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. | Matsuo K et al. | — | 2007 | → |
| Molecular mechanisms of alcohol-mediated carcinogenesis. | Seitz HK et al. | — | 2007 | → |
| Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. | Peng GS et al. | — | 2007 | → |
| Single nucleotide polymorphisms in alcohol dehydrogenase genes among some Indian populations. | Rao VR et al. | — | 2007 | → |
| The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. | Edenberg HJ | — | 2007 | → |
| ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago. | Montane-Jaime K et al. | — | 2006 | → |
| Alcohol and cancer. | Boffetta P et al. | — | 2006 | → |
| Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol. | Bronley-DeLancey A et al. | — | 2006 | → |
| Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians. | Duranceaux NC et al. | — | 2006 | → |
| Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. | Dannenberg LO et al. | — | 2006 | → |
| Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. | Luo X et al. | — | 2006 | → |
| Distant HNF1 site as a master control for the human class I alcohol dehydrogenase gene expression. | Su JS et al. | — | 2006 | → |
| Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? | Zintzaras E et al. | — | 2006 | → |
| Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. | Hashibe M et al. | — | 2006 | → |
| Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. | Day CP | — | 2006 | → |
| Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. | Choi IG et al. | — | 2006 | → |
| Genetics and alcoholism: how close are we to potential clinical applications? | Quickfall J et al. | — | 2006 | → |
| Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. | Luczak SE et al. | — | 2006 | → |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | — | 2006 | → |
| Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women. | Lorenzo A et al. | — | 2006 | → |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | — | 2006 | → |
| Considerable haplotype diversity within the 23kb encompassing the ADH7 gene. | Han Y et al. | — | 2005 | → |
| Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. | Wall TL | — | 2005 | → |
| Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students. | Wall TL et al. | — | 2005 | → |
| Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorders. | Warren KR et al. | — | 2005 | → |
| Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. | Birley AJ et al. | — | 2005 | → |
| Inferring haplotypes at the NAT2 locus: the computational approach. | Sabbagh A et al. | — | 2005 | → |
| Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study). | Djoussé L et al. | — | 2005 | → |
| Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations. | Ma L et al. | — | 2005 | → |
| Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. | Liu QR et al. | — | 2005 | → |
| Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism. | Choi IG et al. | — | 2005 | → |
| The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. | Peters ES et al. | — | 2005 | → |
| ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. | Konishi T et al. | — | 2004 | → |
| Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population. | Neumark YD et al. | — | 2004 | → |
| Alcoholism: genes and mechanisms. | Oroszi G et al. | — | 2004 | → |
| Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. | Kim SA et al. | — | 2004 | → |
| Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. | Duffy VB et al. | — | 2004 | → |
| Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. | Lee SL et al. | — | 2004 | → |
| Genes associated with addiction: alcoholism, opiate, and cocaine addiction. | Kreek MJ et al. | — | 2004 | → |
| Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. | Quertemont E | — | 2004 | → |
| Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. | Vidal F et al. | — | 2004 | → |
| Population stratification in the candidate gene study: fatal threat or red herring? | Hutchison KE et al. | — | 2004 | → |
| Possible epistatic role of ADH7 in the protection against alcoholism. | Osier MV et al. | — | 2004 | → |
| The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination. | Oota H et al. | — | 2004 | → |
| Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. | Mulligan CJ et al. | — | 2003 | → |
| Estimation of linkage disequilibrium in a sample of the United Kingdom dairy cattle population using unphased genotypes. | Tenesa A et al. | — | 2003 | → |
| Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1. | Risch A et al. | — | 2003 | → |
| Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. | Wall TL et al. | — | 2003 | → |
| The ADH3*2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men. | Konishi T et al. | — | 2003 | → |
| A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. | Osier MV et al. | — | 2002 | → |
| Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations. | Whitfield JB | — | 2002 | → |
| ALFRED: An allele frequency database for anthropology. | Osier MV et al. | — | 2002 | → |
| A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans. | Osier MV et al. | — | 2002 | → |
| Fermenting fruit and the historical ecology of ethanol ingestion: is alcoholism in modern humans an evolutionary hangover? | Dudley R | — | 2002 | → |
| Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population. | Carr LG et al. | — | 2002 | → |
| Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk. | Zavras AI et al. | — | 2002 | → |
| Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. | Boonyaphiphat P et al. | — | 2002 | → |
| Molecular variability in Amerindians: widespread but uneven information. | Salzano FM | — | 2002 | → |
| Neurodevelopmental liabilities in alcohol dependence: central serotonin and dopamine dysfunction. | Naranjo CA et al. | — | 2002 | → |
| Substance abuse vulnerability loci: converging genome scanning data. | Uhl GR et al. | — | 2002 | → |
| The genetics of alcoholism in Polynesians: alcohol and aldehyde dehydrogenase genotypes in young men. | Chambers GK et al. | — | 2002 | → |
| Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa. | Viljoen DL et al. | — | 2001 | → |
| Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. | Ehlers CL et al. | — | 2001 | → |
| Functional relevance of human adh polymorphism. | Eriksson CJ et al. | — | 2001 | → |
| Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. | Fallin D et al. | — | 2001 | → |
| Genetic and environmental influences on alcohol metabolism in humans. | Li TK et al. | — | 2001 | → |
| Genetic polymorphisms of alcohol metabolizing enzymes. | Agarwal DP | — | 2001 | → |
| Multipoint development of the weighted pairwise correlation (WPC) linkage method for pedigrees of arbitrary size and application to the analysis of breast cancer and alcoholism familial data. | Zinn-Justin A et al. | — | 2001 | → |
| Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. | Uhl GR et al. | — | 2001 | → |
| The genetics of alcoholism and alcohol abuse. | Enoch MA et al. | — | 2001 | → |
| The role of acetaldehyde in the actions of alcohol (update 2000). | Eriksson CJ | — | 2001 | → |
| Towards a molecular epidemiology of alcohol dependence: analysing the interplay of genetic and environmental risk factors. | Heath AC et al. | — | 2001 | → |
| Variation in alcohol pharmacokinetics as a risk factor for alcohol dependence. | Whitfield JB et al. | — | 2001 | → |
| Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data. | Fallin D et al. | — | 2000 | → |
| Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. | Borràs E et al. | — | 2000 | → |
| Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations. | Kidd JR et al. | — | 2000 | → |
| Kinetic cooperativity of human liver alcohol dehydrogenase gamma(2). | Charlier HA et al. | — | 2000 | → |
| Pharmacogenetics of the alcohol dehydrogenase system. | Jörnvall H et al. | — | 2000 | → |
| Regulation of the mammalian alcohol dehydrogenase genes. | Edenberg HJ | — | 2000 | → |
| Segregation analysis of drinking problem in elderly men and their first-degree relatives from the Western Collaborative Group Study. | Cheng LS et al. | — | 2000 | → |
| The use of single-nucleotide polymorphism maps in pharmacogenomics. | McCarthy JJ et al. | — | 2000 | → |
| Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. | Chen YC et al. | — | 1999 | → |
| Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. | Chen CC et al. | — | 1999 | → |
| Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. | Williams JT et al. | — | 1999 | → |