The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review.
paper
Cited
Public
- Authors
- Young-Wolff, Kelly C; Enoch, Mary-Anne; Prescott, Carol A
- Year
- 2011
- Journal
- Clinical psychology review
- PMID
- 21530476
- DOI
- 10.1016/j.cpr.2011.03.005
- PMCID
- PMC3192029
Since 2005, a rapidly expanding literature has evaluated whether environmental factors such as socio-cultural context and adversity interact with genetic influences on drinking behaviors. This article critically reviews empirical research on alcohol-related genotype-environment interactions (GxE) and provides a contextual framework for understanding how genetic factors combine with (or are shaped by) environmental factors to influence the development of drinking behaviors and alcohol use disorders. Collectively, evidence from twin, adoption, and molecular genetic studies indicates that the degree of importance of genetic influences on risk for drinking outcomes can vary in different populations and under different environmental circumstances. However, methodological limitations and lack of consistent replications in this literature make it difficult to draw firm conclusions regarding the nature and effect size of alcohol-related GxE. On the basis of this review, we describe several methodological challenges as they relate to current research on GxE in drinking behaviors and provide recommendations to aid future research.
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| # | Section | Preview |
|---|---|---|
| 0 | Current Objectives | This review integrates twin, adoption, and molecular genetic studies of GxE to provide a contextual⦠|
| 1 | Current Objectives | The studies we reviewed were identified by searching PubMed for adoption, twin, and molecular⦠|
| 2 | GxE Studies Using Inferred Measures of Genotypic Variation | We first review studies of alcohol-related GxE based on twin and adoption designs. The goal of these⦠|
| 3 | GxE Studies Using Inferred Measures of Genotypic Variation | Adoption studies are particularly well-suited to the study of GxE because they unambiguously⦠|
| 4 | GxE Studies Using Inferred Measures of Genotypic Variation | Twin studies use the fact that monozygotic (MZ) pairs share 100% of their genetic variation, whereas⦠|
| 5 | GxE Studies Using Inferred Measures of Genotypic Variation | effects, and interactions between genetic and individual-specific environmental factors are⦠|
| 6 | GxE Studies Using Inferred Measures of Genotypic Variation | We identified 16 published studies that investigated how inferred genotype interacts with⦠|
| 7 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Parental and peer influences | There is strong evidence that parental and peer factors are associated with adolescent alcoholβ¦ |
| 8 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Parental and peer influences | To date, four published adoption studies have investigated whether AUD risk is higher among adopteesβ¦ |
| 9 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Parental and peer influences | Based on the Iowa adoption study, Cutrona et al. (1994) reported that women adoptees with aβ¦ |
| 10 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Parental and peer influences | Five twin studies have examined whether parental and peer factors moderate genetic risk forβ¦ |
| 11 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Parental and peer influences | Two studies used reports of substance use by sibling pairs and their friends who participated in theβ¦ |
| 12 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Parental and peer influences | Kendler, Gardner, and Dick (in press) found additional evidence for significant GxE on alcoholβ¦ |
| 13 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Age at first drink | Cross-sectional and longitudinal studies have found that age at first drink is strongly associatedβ¦ |
| 14 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Region of residence | Neighborhood-level risk factors, including low socioeconomic status, residential instability, andβ¦ |
| 15 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Region of residence | A series of three reports using data from the Finn Twin study has examined the role of region ofβ¦ |
| 16 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Region of residence | In an independent study of twins from Minnesota, the heritability of alcohol problems was greater inβ¦ |
| 17 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Religious involvement | Abstinence from alcohol and protection from AUDs has also been associated with religious involvementβ¦ |
| 18 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Religious involvement | Koopmans, Slutske, van Baal, and Boomsma (1999) found that religious upbringing moderated geneticβ¦ |
| 19 | GxE Studies Using Inferred Measures of Genotypic Variation β Environmental Moderators of Inferred Genotype β Marital Status | Married individuals typically drink less heavily than those who are divorced, separated, or who haveβ¦ |
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