Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts.
- Authors
- Agrawal, Arpana; Grant, Julia D; Littlefield, Andrew; Waldron, Mary; Pergadia, Michele L; Lynskey, Michael T; Madden, Pamela A F; Todorov, Alexandre; Trull, Timothy; Bucholz, Kathleen K; Todd, Richard D; Sher, Kenneth; Heath, Andrew C
- Year
- 2009
- Journal
- Journal of studies on alcohol and drugs
- PMID
- 19261227
- DOI
- 10.15288/jsad.2009.70.157
- PMCID
- PMC2653602
OBJECTIVE: The purpose of this study was to develop a quantitative measure of alcohol consumption for gene-mapping studies. METHOD: Using a sample of 3,787 young-adult twin women and an independent sample of 489 men and women from a college drinking study, we developed an alcohol-consumption factor score indexed by (1) maximum typical consumption (log-transformed quantity frequency [LQNTFRQ]), (2) maximum drinks in a 24-hours period (LMAXALC), (3) frequency of drinking five or more drinks per day (FIVE), and (4) frequency of drinking to intoxication (INTOX). We tested (1) for factorial and psychometric equivalence across samples and genders; (2) for construct validity and its equivalence, across samples and genders, using measures of tobacco and cannabis use and family history of alcoholism; and (3) to determine the heritability of the alcohol-consumption factor score using a genetic psychometric model. RESULTS: A single-factor model fit well with factor loadings ranging from .60 to .90. With rare exception, we found support for measurement invariance across the two samples and across genders. Measures of nicotine and cannabis use as well as family history of alcoholism were associated, to a similar extent across samples and genders, with the underlying alcohol-consumption factor. Psychometric twin modeling revealed that each of the alcohol-consumption measures (h2=34%-47%) and the underlying factor score (h2=50%) were heritable, with the remainder of the variance attributable to individual-specific environmental factors. This moderately heritable alcohol-consumption factor also accounted for a majority of the genetic variance in LQNTFRQ, LMAXALC, FIVE, and INTOX. CONCLUSIONS: Quantitative measures of alcohol consumption with the favorable attributes of measurement invariance, construct validity, and moderate heritability can greatly enhance future gene-mapping efforts, supplementing information afforded by conventional diagnostic measures of alcohol abuse/dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A sense of urgency: Trait impulsivity in co-occurring bipolar and alcohol use disorder. | Brand K et al. | — | 2024 | → |
| Alcohol use disorder criteria exhibit different comorbidity patterns. | Watts AL et al. | — | 2023 | → |
| Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases. | Kapoor M et al. | — | 2021 | → |
| Depression, Environmental Reward, Coping Motives and Alcohol Consumption During the COVID-19 Pandemic. | McPhee MD et al. | — | 2020 | → |
| High-Intensity Drinking in Adult Australian Twins. | Dash GF et al. | — | 2020 | → |
| Are Some Alcohol Use Disorder Criteria More (or Less) Externalizing than Others? Distinguishing Alcohol Use Symptomatology from General Externalizing Psychopathology. | McDowell YE et al. | — | 2019 | → |
| Not all alcohol use disorder criteria are equally severe: Toward severity grading of individual criteria in college drinkers. | Boness CL et al. | — | 2019 | → |
| The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample. | Johnson EC et al. | — | 2019 | → |
| Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations. | Almli LM et al. | — | 2018 | → |
| Genetic and environmental sources of covariation between early drinking and adult functioning. | Waldron JS et al. | — | 2017 | → |
| Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. | Jorgenson E et al. | — | 2017 | → |
| Alcohol problem recognition and help seeking in adolescents and young adults at varying genetic and environmental risk. | Glass JE et al. | — | 2015 | → |
| Development of a face-to-face injunctive norms brief motivational intervention for college drinkers and preliminary outcomes. | Prince MA et al. | — | 2015 | → |
| Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. | Xu K et al. | — | 2015 | → |
| Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila. | Morozova TV et al. | — | 2015 | → |
| Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry. | Palmer RH et al. | — | 2015 | → |
| Heritability of usual alcohol intoxication and hangover in male twins: the NAS-NRC Twin Registry. | Wu SH et al. | — | 2014 | → |
| Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. | Costello EJ et al. | — | 2013 | → |
| Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites. | Hamidovic A et al. | — | 2013 | → |
| Preconceptional motivational interviewing interventions to reduce alcohol-exposed pregnancy risk. | Ingersoll KS et al. | — | 2013 | → |
| The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems. | Meyers JL et al. | — | 2013 | → |
| The genetics of alcohol dependence. | Rietschel M et al. | — | 2013 | → |
| A prospective study of stress and alcohol craving in heavy drinkers. | Tartter MA et al. | — | 2012 | → |
| Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers. | Kalu N et al. | — | 2012 | → |
| Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. | Agrawal A et al. | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers. | Kristjansson SD et al. | — | 2012 | → |
| A candidate gene association study of alcohol consumption in young women. | Agrawal A et al. | — | 2011 | → |
| Alcohol use and related problems among college students and their noncollege peers: the competing roles of personality and peer influence. | Quinn PD et al. | — | 2011 | → |
| Collegiate heavy drinking prospectively predicts change in sensation seeking and impulsivity. | Quinn PD et al. | — | 2011 | → |
| Developing a genetically informative measure of alcohol consumption using past-12-month indices. | Agrawal A et al. | — | 2011 | → |
| Does variance in drinking motives explain the genetic overlap between personality and alcohol use disorder symptoms? A twin study of young women. | Littlefield AK et al. | — | 2011 | → |
| Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture. | Dick DM et al. | — | 2011 | → |
| Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies. | Hicks BM et al. | — | 2011 | → |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | — | 2011 | → |
| A comparison of two single-item screeners for hazardous drinking and alcohol use disorder. | Dawson DA et al. | — | 2010 | → |
| Common genetic contributions to alcohol and cannabis use and dependence symptomatology. | Sartor CE et al. | — | 2010 | → |
| Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. | Leeman RF et al. | — | 2010 | → |
| H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. | Nelson EC et al. | — | 2010 | → |
| The relationship between genetic influences on alcohol dependence and on patterns of alcohol consumption. | Kendler KS et al. | — | 2010 | → |
| Alcohol consumption indices of genetic risk for alcohol dependence. | Grant JD et al. | — | 2009 | → |