Are there genetic influences on addiction: evidence from family, adoption and twin studies.
paper
Cited
Public
Unavailable
- Authors
- Agrawal, Arpana; Lynskey, Michael T
- Year
- 2008
- Journal
- Addiction (Abingdon, England)
- PMID
- 18494843
- DOI
- 10.1111/j.1360-0443.2008.02213.x
AIMS: In this exciting era of gene discovery, we review evidence from family, adoption and twin studies that examine the genetic basis for addiction. With a focus on the classical twin design that utilizes data on monozygotic and dizygotic twins, we discuss support in favor of heritable influences on alcohol, nicotine, cannabis and other illicit drug dependence. METHODS: We review whether these genetic factors also influence earlier stages (e.g. experimentation) of the addictive process and whether there are genetic influences specific to each psychoactive substance. RESULTS: Converging evidence from these studies supports the role of moderate to high genetic influences on addiction with estimates ranging from 0.30 to 0.70. The changing role of these heritable factors as a function of gender, age and cultural characteristics is also discussed. We highlight the importance of the interplay between genes and the environment as it relates to risk for addiction and the utility of the children-of-twins design for emerging studies of gene-environment interaction is presented. CONCLUSIONS: Despite the advances being made by low-cost high-throughput whole genome association assays, we posit that information garnered from twin studies, especially extended twin designs with power to examine gene-environment interactions, will continue to form the foundation for genomic research.
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| Etiology of longitudinal associations between subjective effects and substance use disorders in a clinical sample. | Gresko SA et al. | β | 2026 | β |
| Neurobiology, psychotherapeutic interventions, and emerging therapies in addiction: a systematic review. | Lomas C | β | 2026 | β |
| Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis. | Tu W et al. | β | 2025 | β |
| Sweet-liking and sugar supplementation as innovative components in substance use disorder treatment: A systematic review. | van Amsterdam J et al. | β | 2025 | β |
| A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice. | Hose L et al. | β | 2024 | β |
| AUD in perspective. | de Bejczy A et al. | β | 2024 | β |
| Bitter taste function-related genes are implicated in the behavioral association between taste preference and ethanol preference in male mice. | Koh AP et al. | β | 2024 | β |
| Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores. | Vilar-RibΓ³ L et al. | β | 2024 | β |
| Exploring perceptions of genetic risk and the transmission of substance use disorders. | Keller A et al. | β | 2024 | β |
| Generalized genetic liability to substance use disorders. | Miller AP et al. | β | 2024 | β |
| Molecular and Environmental Determinants of Addictive Substances. | Lorek M et al. | β | 2024 | β |
| Neural Network Connectivity Following Opioid Dependence is Altered by a Common Genetic Variant in the Β΅-Opioid Receptor, <i>OPRM1</i> A118G. | Xie Y et al. | β | 2024 | β |
| Neurological Disorders Induced by Drug Use: Effects of Adolescent and Embryonic Drug Exposure on Behavioral Neurodevelopment. | Karatayev O et al. | β | 2024 | β |
| Perceived parental alcohol problems and drinking patterns among adolescents in Sweden. | Workie HM et al. | β | 2024 | β |
| Why do people use drugs? A neglected question. | McLoughlin A | β | 2024 | β |
| Association of GABA receptor delta subunit gene variations with increased risk of methamphetamine dependence. | Xie X et al. | β | 2023 | β |
| Does Morphine Exposure Before Gestation Change Anxiety-Like Behavior During Morphine Dependence in Male Wistar Rats? | Sabzevari S et al. | β | 2023 | β |
| Health Benefits of Esports: A Systematic Review Comparing the Cardiovascular and Mental Health Impacts of Esports. | Seffah KD et al. | β | 2023 | β |
| Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task. | Elton A et al. | β | 2023 | β |
| A Brief Overview of the Neuropharmacology of Opioid Addiction. | Grothusen JR et al. | β | 2022 | β |
| Association of Alcohol Use Disorder Risk With <i>ADH1B, DRD2, FAAH, SLC39A8, GCKR</i>, and <i>PDYN</i> Genetic Polymorphisms. | Legaki E et al. | β | 2022 | β |
| Associations between the <i>COMT</i> rs4680 Gene Polymorphism and Personality Dimensions and Anxiety in Patients with a Diagnosis of Other Stimulants Dependence. | Chmielowiec K et al. | β | 2022 | β |
| Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference. | Nathan FM et al. | β | 2022 | β |
| Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach. | Yeung EW et al. | β | 2022 | β |
| FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. | Vereczkei A et al. | β | 2022 | β |
| Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse. | Corongiu S et al. | β | 2022 | β |
| Multidimensional Impulsive Personality Traits Mediate the Effect of Parent Substance Use Disorder on Adolescent Alcohol and Cannabis Use. | Waddell JT et al. | β | 2022 | β |
| Promoter Specific Methylation of <i>SSTR4</i> is Associated With Alcohol Dependence in Han Chinese Males. | Zhao R et al. | β | 2022 | β |
| The influence of chromosome 4 on high ethanol consumption and blood pressure. | Anjos PAR et al. | β | 2022 | β |
| Who Is at Risk of Developing Cannabis Dependence? Findings From an Extensive Online Study on Cannabis Users. | Binkowska AA et al. | β | 2022 | β |
| Altered excitatory transmission in striatal neurons after chronic ethanol consumption in selectively bred crossed high alcohol-preferring mice. | Rangel-Barajas C et al. | β | 2021 | β |
| Association between polymorphism in gene related to the dopamine circuit and motivations for drinking in patients with alcohol use disorder. | CΓ©spedes IC et al. | β | 2021 | β |
| A systematic review of gene-by-intervention studies of alcohol and other substance use. | Neale ZE et al. | β | 2021 | β |
| Bibliometric Insights in Genetic Factors of Substance-Related Disorders: Intellectual Developments, Turning Points, and Emerging Trends. | Wang K et al. | β | 2021 | β |
| Coronary heart disease in mothers and fathers of adult children with alcohol use disorders. | Calling S et al. | β | 2021 | β |
| Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. | Johnstone AL et al. | β | 2021 | β |
| Epigenetics of alcohol use disorder-A review of recent advances in DNA methylation profiling. | Longley MJ et al. | β | 2021 | β |
| Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation. | Lohoff FW et al. | β | 2021 | β |
| Factors modulating the incubation of drug and non-drug craving and their clinical implications. | Venniro M et al. | β | 2021 | β |
| Genetic and Depressive Traits Moderate the Reward-Enhancing Effects of Acute Nicotine in Young Light Smokers. | Whitton AE et al. | β | 2021 | β |
| Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study. | Al-Eitan LN et al. | β | 2021 | β |
| Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of collaborative cross mouse strains and their inbred founders. | Bagley JR et al. | β | 2021 | β |
| High Trait Attention Promotes Resilience and Reduces Binge Drinking Among College Students With a Family History of Alcohol Use Disorder. | Elton A et al. | β | 2021 | β |
| Identification of the Risk Genes Associated With Vulnerability to Addiction: Major Findings From Transgenic Animals. | Jordan CJ et al. | β | 2021 | β |
| Nerve Growth Factor in Alcohol Use Disorders. | Ceci FM et al. | β | 2021 | β |
| Problem drinking as intentional risky behavior: Examining the association between state health insurance coverage and excessive alcohol consumption. | Azagba S et al. | β | 2021 | β |
| Risk and resilience for alcohol use disorder revealed in brain functional connectivity. | Elton A et al. | β | 2021 | β |
| The effect of mental health on social capital: An instrumental variable analysis. | Lebenbaum M et al. | β | 2021 | β |
| The Gut Microbiome and Substance Use Disorder. | Russell JT et al. | β | 2021 | β |
| Association of parental substance use disorder with offspring cognition: a population family-based study. | Khemiri L et al. | β | 2020 | β |
| Associations between major depressive symptoms and drinking onset: Do sex and age matter? | Cheng HG et al. | β | 2020 | β |
| Convergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption. | Baranger DAA et al. | β | 2020 | β |
| Genome-Wide DNA Methylation Analysis in Male Methamphetamine Users With Different Addiction Qualities. | Liu L et al. | β | 2020 | β |
| Identification and Characterization of Biomarkers and Their Role in Opioid Addiction by Integrated Bioinformatics Analysis. | Zhang X et al. | β | 2020 | β |
| Intergenerational transmission of alcohol misuse: mediation and interaction by school performance in a Swedish birth cohort. | Almquist YB et al. | β | 2020 | β |
| Motives for Alcohol and Marijuana Use as Predictors of Use and Problem Use Among Young Adult College Students. | Patterson A et al. | β | 2020 | β |
| Parental and life-course influences on symptomatic airflow obstruction. | Li LSK et al. | β | 2020 | β |
| The Association Between Adverse Child Health, Psychological, Educational and Social Outcomes, and Nondependent Parental Substance: A Rapid Evidence Assessment. | McGovern R et al. | β | 2020 | β |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | β | 2020 | β |
| Translational Molecular Approaches in Substance Abuse Research. | Fulton SL et al. | β | 2020 | β |
| Age of alcohol use initiation and psychiatric symptoms among young adult trauma survivors. | Berenz EC et al. | β | 2019 | β |
| Alterations in resting-state functional connectivity in substance use disorders and treatment implications. | Wilcox CE et al. | β | 2019 | β |
| Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis. | Wang CW et al. | β | 2019 | β |
| Fathers' alcohol use and suicidal behaviour in offspring during youth and young adulthood. | Landberg J et al. | β | 2019 | β |
| From controlled to compulsive drug-taking: The role of the habenula in addiction. | Mathis V et al. | β | 2019 | β |
| Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. | MacKillop J et al. | β | 2019 | β |
| Genetics of alcohol use disorder: a review. | Deak JD et al. | β | 2019 | β |
| Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster. | Highfill CA et al. | β | 2019 | β |
| Mini Review: Socio-Cultural Influences on the Link Between ADHD and SUD. | Slobodin O et al. | β | 2019 | β |
| PCSK9 is Increased in Cerebrospinal Fluid of Individuals With Alcohol Use Disorder. | Lee JS et al. | β | 2019 | β |
| Shared and specific associations of substance use disorders on adverse outcomes: A national prospective study. | Franco S et al. | β | 2019 | β |
| The psychological and genetic factors of the addictive behaviors (PGA) study. | Kotyuk E et al. | β | 2019 | β |
| The spurious relationship between ecstasy use and neurocognitive deficits: A Bradford Hill review. | Amoroso T | β | 2019 | β |
| Transgenerational influence of parental morphine exposure on pain perception, anxiety-like behavior and passive avoidance memory among male and female offspring of Wistar rats. | Ahmadian-Moghadam H et al. | β | 2019 | β |
| A Family Affair: Family Typologies of Problems and Midlife Well-Being. | Fingerman KL et al. | β | 2018 | β |
| Effect of rat parental morphine exposure on passive avoidance memory and morphine conditioned place preference in male offspring. | Akbarabadi A et al. | β | 2018 | β |
| Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation. | Gray JC et al. | β | 2018 | β |
| Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use. | Lee JS et al. | β | 2018 | β |
| Genetics of Cocaine and Methamphetamine Consumption and Preference in<i>Drosophila melanogaster</i> | Highfill CA et al. | β | 2018 | β |
| Impact of exposure to alcohol marketing and subsequent drinking patterns among youth and young adults. | Cukier S et al. | β | 2018 | β |
| Independent associations and effect modification between lifetime substance use and recent mood disorder diagnosis with household food insecurity. | Davison KM et al. | β | 2018 | β |
| Making Connections Between Parenting Practices and Adolescent Substance Use. | Burdzovic Andreas J | β | 2018 | β |
| Mechanisms of cortisol - Substance use development associations: Hypothesis generation through gene enrichment analysis. | Marceau K et al. | β | 2018 | β |
| NGF gene polymorphisms are not associated with heroin dependence in a Taiwanese male population. | Tsou CC et al. | β | 2018 | β |
| Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention. | Chen J et al. | β | 2018 | β |
| Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. | Obed A et al. | β | 2018 | β |
| The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction. | Muskiewicz DE et al. | β | 2018 | β |
| Transition to drug co-use among adolescent cannabis users: The role of decision-making and mental health. | Lopez-Quintero C et al. | β | 2018 | β |
| A functional neuregulin-1 gene variant and stressful life events: Effect on drug use in a longitudinal population-representative cohort study. | Vaht M et al. | β | 2017 | β |
| Age of Drinking Initiation as a Risk Factor for Alcohol Use Disorder Symptoms is Moderated by ALDH2*2 and Ethnicity. | Luczak SE et al. | β | 2017 | β |
| Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology. | Chastain LG et al. | β | 2017 | β |
| Alcohol use disorder and GABA<sub>B</sub> receptor gene polymorphisms in an Italian sample: haplotype frequencies, linkage disequilibrium and association studies. | Caputo F et al. | β | 2017 | β |
| Genetic and Environmental Influences on Gambling: A Meta-Analysis of Twin Studies. | Xuan YH et al. | β | 2017 | β |
| Genetic Counseling for Alcohol Addiction: Assessing Perceptions and Potential Utility in Individuals with Lived Experience and Their Family Members. | Kalb FM et al. | β | 2017 | β |
| Perceived parental alcohol problems and drinking patterns in youth: A cross-sectional study of 69,030 secondary education students in Denmark. | Pisinger VSC et al. | β | 2017 | β |
| Posttraumatic stress disorder and alcohol dependence: Epidemiology and order of onset. | Berenz EC et al. | β | 2017 | β |
| Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms. | Richardson BD et al. | β | 2017 | β |
| SNP by SNP by environment interaction network of alcoholism. | Zollanvari A et al. | β | 2017 | β |
| The adolescent brain at risk for substance use disorders: a review of functional MRI research on motor response inhibition. | Koyama MS et al. | β | 2017 | β |
| The association between the nicotinic acetylcholine receptor Ξ±4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults. | Jeong JE et al. | β | 2017 | β |
| The association of prenatal cocaine exposure, externalizing behavior and adolescent substance use. | Minnes S et al. | β | 2017 | β |
| The biology of addiction. | MacNicol B | β | 2017 | β |
| The relationship between initial route of heroin administration and speed of transition to daily heroin use. | Hines LA et al. | β | 2017 | β |
| Addictive-Like Eating, Body Mass Index, and Psychological Correlates in a Community Sample of Preadolescents. | Laurent JS et al. | β | 2016 | β |
| Alcohol-related genes show an enrichment of associations with a persistent externalizing factor. | Ashenhurst JR et al. | β | 2016 | β |
| Alcohol use disorders. | Connor JP et al. | β | 2016 | β |
| Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4. | Degenhardt F et al. | β | 2016 | β |
| Annual Research Review: On the developmental neuropsychology of substance use disorders. | Conrod PJ et al. | β | 2016 | β |
| Association between AUTS2 haplotypes and alcohol dependence in a Japanese population. | Narita S et al. | β | 2016 | β |
| A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal. | Walter NA et al. | β | 2016 | β |
| Does parental drinking influence children's drinking? A systematic review of prospective cohort studies. | Rossow I et al. | β | 2016 | β |
| Does the familial transmission of drinking patterns persist into young adulthood? A 10-year follow up. | Karlsson P et al. | β | 2016 | β |
| Epidemiology of DSM-5 Drug Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III. | Grant BF et al. | β | 2016 | β |
| Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users. | Palmer RH et al. | β | 2016 | β |
| Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. | Flagel SB et al. | β | 2016 | β |
| Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease. | Anstee QM et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| No association between <i>GSTM1</i> and <i>GSTT1</i> genetic polymorphisms and susceptibility to opium sapΒ dependence. | Saify K et al. | β | 2016 | β |
| Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules. | Wingo T et al. | β | 2016 | β |
| Overview of the Genetics of Alcohol Use Disorder. | Tawa EA et al. | β | 2016 | β |
| Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. | Otto JM et al. | β | 2016 | β |
| Resting state functional connectivity analysis for addiction medicine: From individual loci to complex networks. | Pariyadath V et al. | β | 2016 | β |
| The association between post-traumatic stress disorder and lifetime DSM-5 psychiatric disorders among veterans: Data from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III). | Smith SM et al. | β | 2016 | β |
| The Epidemiology of DSM-5 Nicotine Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III. | Chou SP et al. | β | 2016 | β |
| The increasing global health priority of substance use in young people. | Degenhardt L et al. | β | 2016 | β |
| Treatment of alcohol use disorders in patients with alcoholic liver disease. | Addolorato G et al. | β | 2016 | β |
| Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome. | BrΓΌckmann C et al. | β | 2016 | β |
| Adolescent Substance Misusers with and without Delinquency: Death, Mental and Physical Disorders, and Criminal Convictions from Age 21 to 45. | Larm P et al. | β | 2015 | β |
| Chronic methamphetamine abuse and corticostriatal deficits revealed by neuroimaging. | London ED et al. | β | 2015 | β |
| Endocannabinoid signalling in reward and addiction. | Parsons LH et al. | β | 2015 | β |
| Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III. | Grant BF et al. | β | 2015 | β |
| Examining the role of psychological distress in linking childhood maltreatment and alcohol use in young adulthood. | Shin SH et al. | β | 2015 | β |
| Genetic and environmental contributions to the association between attention deficit hyperactivity disorder and alcohol dependence in adulthood: A large population-based twin study. | Capusan AJ et al. | β | 2015 | β |
| Genetic and Environmental Interplay in Adolescent Substance Use Disorders. | Hines LA et al. | β | 2015 | β |
| Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: a critical evaluation. | Gray JC et al. | β | 2015 | β |
| Is Drinking with Parents Associated with High-Risk Drinking among Adolescents? | Pape H et al. | β | 2015 | β |
| Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. | Yohn NL et al. | β | 2015 | β |
| Prenatal stress and adult drug-seeking behavior: interactions with genes and relation to nondrug-related behavior. | Kippin TE et al. | β | 2015 | β |
| Psychological, social and familial factors associated with tobacco cessation among young adults. | Bowes L et al. | β | 2015 | β |
| Psychosocial Correlates of AUDIT-C Hazardous Drinking Risk Status: Implications for Screening and Brief Intervention in College Settings. | Wahesh E et al. | β | 2015 | β |
| Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry. | Palmer RH et al. | β | 2015 | β |
| Strain dependence of adolescent Cannabis influence on heroin reward and mesolimbic dopamine transmission in adult Lewis and Fischer 344 rats. | Cadoni C et al. | β | 2015 | β |
| Temperament disturbances measured in infancy progress to substance use disorder 20 years later. | Horner MS et al. | β | 2015 | β |
| The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. | Hines LA et al. | β | 2015 | β |
| The epidemiology and genetics of binge eating disorder (BED). | Davis C | β | 2015 | β |
| The media and behavioral genetics: Alternatives coexisting with addiction genetics. | Dingel MJ et al. | β | 2015 | β |
| The role of childhood maltreatment in the altered trait and global expression of personality in cocaine addiction. | Brents LK et al. | β | 2015 | β |
| Unemployment and substance use in young adults: does educational attainment modify the association? | Melchior M et al. | β | 2015 | β |
| A preliminary case study of androgen receptor gene polymorphism association with impulsivity in women with alcoholism. | Mettman DJ et al. | β | 2014 | β |
| Community, siblings, heritability and the risk for drug abuse. | Hopfer C | β | 2014 | β |
| Genetic and environmental influences on the relationship between adult ADHD symptoms and self-reported problem drinking in 6024 Dutch twins. | Derks EM et al. | β | 2014 | β |
| Genetic and environmental risk factors for illicit substance use and use disorders: Joint analysis of self and co-twin ratings. | Ystrom E et al. | β | 2014 | β |
| Genetic strategies for probing conscientiousness and its relationship to aging. | South SC et al. | β | 2014 | β |
| Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system. | Buisman-Pijlman FT et al. | β | 2014 | β |
| Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants. | Wang S et al. | β | 2014 | β |
| Legal substance use and the development of a DSM-IV cannabis use disorder during adolescence: the TRAILS study. | Prince van Leeuwen A et al. | β | 2014 | β |
| Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. | George O et al. | β | 2014 | β |
| Psychometric properties of the Icelandic NEO-FFI in a general population sample compared to a sample recruited for a study on the genetics of addiction. | Bjornsdottir G et al. | β | 2014 | β |
| Reflections on the enduring value of critical scholarship. | Moore D | β | 2014 | β |
| Risk-assessment and risk-taking behavior predict potassium- and amphetamine-induced dopamine response in the dorsal striatum of rats. | Palm S et al. | β | 2014 | β |
| Smoking at the workplace: Effects of genetic and environmental causal accounts on attitudes towards smoking employees and restrictive policies. | Dar-Nimrod I et al. | β | 2014 | β |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | β | 2014 | β |
| Twin studies advance the understanding of gene-environment interplay in human nutrigenomics. | Pallister T et al. | β | 2014 | β |
| Youth tobacco use type and associations with substance use disorders. | Cavazos-Rehg PA et al. | β | 2014 | β |
| Addictive behaviors and addiction-prone personality traits: associations with a dopamine multilocus genetic profile. | Davis C et al. | β | 2013 | β |
| Advances in genetic studies of substance abuse in China. | Sun Y et al. | β | 2013 | β |
| A narrative review of binge eating and addictive behaviors: shared associations with seasonality and personality factors. | Davis C | β | 2013 | β |
| ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. | Nelson EC et al. | β | 2013 | β |
| Behavioral genetics and population health interventions for alcohol problems: at odds or oddly in agreement? | Cunningham JA et al. | β | 2013 | β |
| Circumstances and efforts: how important is their correlation for the measurement of inequality of opportunity in health? | Jusot F et al. | β | 2013 | β |
| Escalation of i.v. cocaine intake in peri-adolescent vs. adult rats selectively bred for high (HiS) vs. low (LoS) saccharin intake. | Holtz NA et al. | β | 2013 | β |
| Factors associated with variability and stability of cannabis use in young adulthood. | Silins E et al. | β | 2013 | β |
| Family history of alcohol dependence and gray matter abnormalities in non-alcoholic adults. | Sjoerds Z et al. | β | 2013 | β |
| Four factors for the initiation of substance use by young adulthood: a 10-year follow-up twin and sibling study of marital conflict, monitoring, siblings, and peers. | Neiderhiser JM et al. | β | 2013 | β |
| From passive overeating to "food addiction": a spectrum of compulsion and severity. | Davis C | β | 2013 | β |
| Genetics and epigenetics of alcohol dependence. | Nieratschker V et al. | β | 2013 | β |
| Genetics of alcohol dependence and social work research: do they mix? | Hesselbrock MN et al. | β | 2013 | β |
| Genome-wide gene-set analysis for identification of pathways associated with alcohol dependence. | Biernacka JM et al. | β | 2013 | β |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | β | 2013 | β |
| Pathways to heroin dependence: time to re-appraise self-medication. | Darke S | β | 2013 | β |
| Predictors of alcohol-related problems among depressed and non-depressed women. | Nolen-Hoeksema S et al. | β | 2013 | β |
| Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. | Biernacka JM et al. | β | 2013 | β |
| Revisiting the role of the urban environment in substance use: the case of analgesic overdose fatalities. | CerdΓ‘ M et al. | β | 2013 | β |
| Stability and change of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis DSM-IV dependence symptoms. | Palmer RH et al. | β | 2013 | β |
| The genetics of alcohol dependence. | Rietschel M et al. | β | 2013 | β |
| The ΞΌ-opioid receptor and treatment response to naltrexone. | Thorsell A | β | 2013 | β |
| Associations of alcohol, nicotine, cannabis, and drug use/dependence with educational attainment: evidence from cotwin-control analyses. | Grant JD et al. | β | 2012 | β |
| Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. | Yang BZ et al. | β | 2012 | β |
| Borderline personality traits and substance use: genetic factors underlie the association with smoking and ever use of cannabis, but not with high alcohol consumption. | Distel MA et al. | β | 2012 | β |
| Connectomic intermediate phenotypes for psychiatric disorders. | Fornito A et al. | β | 2012 | β |
| Direct-to-consumer genetic testing for addiction susceptibility: a premature commercialisation of doubtful validity and value. | Mathews R et al. | β | 2012 | β |
| Does family history of alcohol problems influence college and university drinking or substance use? A meta-analytical review. | Elliott JC et al. | β | 2012 | β |
| Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence. | Korhonen T et al. | β | 2012 | β |
| Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms. | Palmer RH et al. | β | 2012 | β |
| Global DNA promoter methylation in frontal cortex of alcoholics and controls. | Manzardo AM et al. | β | 2012 | β |
| Heritability of preferences for multiple cues of mate quality in humans. | Zietsch BP et al. | β | 2012 | β |
| Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction. | Sweitzer MM et al. | β | 2012 | β |
| Mexican immigration to the US and alcohol and drug use opportunities: does it make a difference in alcohol and/or drug use? | Borges G et al. | β | 2012 | β |
| Personality and alcohol use: the role of impulsivity. | Shin SH et al. | β | 2012 | β |
| Recreational gamblers with and without parental addiction. | Schreiber LR et al. | β | 2012 | β |
| Shared environmental contributions to substance use. | Baker JH et al. | β | 2012 | β |
| The continuing value of twin studies in the omics era. | van Dongen J et al. | β | 2012 | β |
| The genetics of alcohol dependence: advancing towards systems-based approaches. | Palmer RH et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| Understanding genetic risk for substance use and addiction: a guide for non-geneticists. | Urbanoski KA et al. | β | 2012 | β |
| X chromosome inactivation in women with alcoholism. | Manzardo AM et al. | β | 2012 | β |
| DRD2 and DRD4 in relation to regular alcohol and cannabis use among adolescents: does parenting modify the impact of genetic vulnerability? The TRAILS study. | Creemers HE et al. | β | 2011 | β |
| Drugs and addiction: an introduction to epigenetics. | Wong CC et al. | β | 2011 | β |
| Everybody hurts: addiction, drama, and the family in the reality television show Intervention. | Kosovski JR et al. | β | 2011 | β |
| Genetic correlation and gene-environment interaction between alcohol problems and educational level in young adulthood. | Latvala A et al. | β | 2011 | β |
| Genetic origins of the association between verbal ability and alcohol dependence symptoms in young adulthood. | Latvala A et al. | β | 2011 | β |
| Heart rate stress response dampening: the impact of alcohol, family history, and gender on at risk children and siblings. | Croissant B et al. | β | 2011 | β |
| Identifying neurobiological phenotypes associated with alcohol use disorder severity. | Claus ED et al. | β | 2011 | β |
| Parental alcohol dependence, socioeconomic disadvantage and alcohol and cannabis dependence among young adults in the community. | Melchior M et al. | β | 2011 | β |
| Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. | Hendershot CS et al. | β | 2011 | β |
| Reasons for drug abstention: a study of drug use and resilience. | Davis SJ et al. | β | 2011 | β |
| Reduced interhemispheric resting state functional connectivity in cocaine addiction. | Kelly C et al. | β | 2011 | β |
| Sex differences and developmental stability in genetic and environmental influences on psychoactive substance consumption from early adolescence to young adulthood. | Baker JH et al. | β | 2011 | β |
| Stimulant abuse: pharmacology, cocaine, methamphetamine, treatment, attempts at pharmacotherapy. | Ciccarone D | β | 2011 | β |
| The German multi-centre study on smoking-related behavior-description of a population-based case-control study. | Lindenberg A et al. | β | 2011 | β |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | β | 2011 | β |
| Addictions and their familiality in Iceland. | Tyrfingsson T et al. | β | 2010 | β |
| Breaking barriers in the genomics and pharmacogenetics of drug addiction. | Ho MK et al. | β | 2010 | β |
| Comparison of toluene-induced locomotor activity in four mouse strains. | Bowen SE et al. | β | 2010 | β |
| Externalizing behavior problems and cigarette smoking as predictors of cannabis use: the TRAILS Study. | Korhonen T et al. | β | 2010 | β |
| Factors influencing gender differences in smoking and their separate contributions: evidence from South Korea. | Chung W et al. | β | 2010 | β |
| Genetic and environmental influences on disordered gambling in men and women. | Slutske WS et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| Linkage analysis of alcohol dependence symptoms in the community. | Hansell NK et al. | β | 2010 | β |
| Neural markers of genetic vulnerability to drug addiction. | MΓΌller DJ et al. | β | 2010 | β |
| Peer substance involvement modifies genetic influences on regular substance involvement in young women. | Agrawal A et al. | β | 2010 | β |
| Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. | Winterer G et al. | β | 2010 | β |
| The Haven Mother's House Modified Therapeutic Community: Meeting the gap in infant mental health services for pregnant and parenting mothers with drug addiction. | Bromberg SR et al. | β | 2010 | β |
| Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. | Onaivi ES | β | 2009 | β |
| Cognitive functioning in substance abuse and dependence: a population-based study of young adults. | Latvala A et al. | β | 2009 | β |
| New insights into the genetics of addiction. | Li MD et al. | β | 2009 | β |
| Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study. | Saiz PA et al. | β | 2009 | β |
| Time to first cigarette after waking predicts cotinine levels. | Muscat JE et al. | β | 2009 | β |
| Tobacco and cannabis co-occurrence: does route of administration matter? | Agrawal A et al. | β | 2009 | β |
| Transcription factor AP2 beta involved in severe female alcoholism. | Nordquist N et al. | β | 2009 | β |