Review of twin and adoption studies of adolescent substance use.
paper
Cited
Public
Unavailable
- Authors
- Hopfer, Christian J; Crowley, Thomas J; Hewitt, John K
- Year
- 2003
- Journal
- Journal of the American Academy of Child and Adolescent Psychiatry
- PMID
- 12921479
- DOI
- 10.1097/01.CHI.0000046848.56865.54
OBJECTIVE: To review studies of adolescent substance use and abuse with genetically informative designs. METHOD: Twin and adoption studies of adolescent substance use were searched in Medline using keywords. RESULTS: Of 19 studies that used adolescent samples, 18 examined initiation or use of substances and 1 examined abuse. Of the 7 retrospective studies using adult samples, 6 examined problematic behaviors such as substance dependence. Genetic and shared environmental influences on adolescent substance use are moderated by the specific substance, age, gender, specific contexts, religiousness, and region. There is some evidence for a common genetic influence on substance use across substances. Genetic influences on adolescent substance use may act through an influence on disinhibited behavior. Shared environment contributed to adolescent substance use consistently across all adolescent samples and common shared environmental influences influenced initiation into tobacco and alcohol use. While parental alcohol use had a small influence on adolescent shared environment, sibling influences were substantial. CONCLUSIONS: Twin and adoption studies have increased our understanding of genetic and environmental influences on adolescent substance use and its initiation; however, more studies focusing on clinical syndromes of abuse and dependence are needed.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Etiology of longitudinal associations between subjective effects and substance use disorders in a clinical sample. | Gresko SA et al. | β | 2026 | β |
| A Systematic Investigation of the Common Genetic Architecture of Substance Use Traits and the Relationship with Mental Health. | Pasman JA et al. | β | 2025 | β |
| Family Environment and Community Context for Longitudinal Cigarette Smoking Trajectories Among Chinese Young People. | Wang X et al. | β | 2025 | β |
| Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study. | Choi M et al. | β | 2025 | β |
| Causation and Common Liability in the Progression of the U.S. Opioid Crisis. | Dash GF et al. | β | 2024 | β |
| Religion, spirituality, and pediatric mental health: a scoping review of research on religion and spirituality in the Journal of the American Academy of Child and Adolescent Psychiatry from 2000 to 2023. | Elzamzamy K et al. | β | 2024 | β |
| Normalization of Prevention Principles and Practices to Reduce Substance Use Disorders Through an Integrated Dissemination and Implementation Framework. | Sloboda Z et al. | β | 2023 | β |
| Paternal and Maternal Problem Drinking and Lifetime Problem Drinking of Their Adult Children. | SipilΓ€ PN et al. | β | 2023 | β |
| Substance Use Screening and Prevention for Adolescents in Pediatric Primary Care: A Randomized Clinical Trial using the Family Check-Up. | GalΓ‘n CA et al. | β | 2023 | β |
| Are we overlooking alcohol use by younger children? | Skylstad V et al. | β | 2022 | β |
| Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study. | Gresko SA et al. | β | 2022 | β |
| Associations between the CADM2 gene, substance use, risky sexual behavior, and self-control: A phenome-wide association study. | Arends RM et al. | β | 2021 | β |
| Developmental Cascades from Polygenic and Prenatal Substance Use to Adolescent Substance Use: Leveraging Severity and Directionality of Externalizing and Internalizing Problems to Understand Pubertal and Harsh Discipline-Related Risk. | Marceau K et al. | β | 2021 | β |
| Distress Tolerance as a Mechanism Linking Violence Exposure to Problematic Alcohol use in Adolescence. | Heleniak C et al. | β | 2021 | β |
| Effect of Environmental Enrichment on the Brain and on Learning and Cognition by Animals. | Zentall TR | β | 2021 | β |
| Estimating causal and time-varying effects of maternal smoking on youth smoking. | Kim S et al. | β | 2021 | β |
| Estimating the familial risk of psychiatric illnesses: A review of family history scores. | Ali F et al. | β | 2021 | β |
| Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats. | Barbosa-MΓ©ndez S et al. | β | 2021 | β |
| Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence. | Bellia F et al. | β | 2020 | β |
| A Twin Study on the Association Between Psychotic Experiences and Tobacco Use During Adolescence. | Barkhuizen W et al. | β | 2019 | β |
| Blunted Reward Sensitivity and Trait Disinhibition Interact to Predict Substance Use Problems. | Joyner KJ et al. | β | 2019 | β |
| Genetic and environmental influences on developmental trajectories of adolescent alcohol use. | Zheng Y et al. | β | 2019 | β |
| Target-related parietal P3 and medial frontal theta index the genetic risk for problematic substance use. | Harper J et al. | β | 2019 | β |
| Independent predictors of mortality in adolescents ascertained for conduct disorder and substance use problems, their siblings and community controls. | Border R et al. | β | 2018 | β |
| Predictors of adult outcomes in clinically- and legally-ascertained youth with externalizing problems. | Border R et al. | β | 2018 | β |
| Predictors of initiation of nicotine, alcohol, cannabis, and cocaine use: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). | Blanco C et al. | β | 2018 | β |
| The Developmental Unfolding of Sibling Influences on Alcohol Use over Time. | Samek DR et al. | β | 2018 | β |
| The gene-environmental architecture of the development of adolescent substance use. | Vitaro F et al. | β | 2018 | β |
| The genetic and environmental architecture of substance use development from early adolescence into young adulthood: a longitudinal twin study of comorbidity of alcohol, tobacco and illicit drug use. | Waaktaar T et al. | β | 2018 | β |
| The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design. | Iacono WG et al. | β | 2018 | β |
| A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents. | Maes HH et al. | β | 2017 | β |
| Executive functions and substance use: Relations in late adolescence and early adulthood. | Gustavson DE et al. | β | 2017 | β |
| Review of Teenlink: A health service for children and adolescents of parents with substance use. | Zehetner A et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| Attention Deficit/Hyperactivity Disorder (ADHD) Symptoms Predict Alcohol Expectancy Development. | Squeglia LM et al. | β | 2016 | β |
| Genetic influences on adolescent behavior. | Dick DM et al. | β | 2016 | β |
| Investigating Progression in Substance Use Initiation Using a Discrete-Time Multiple Event Process Survival Mixture (MEPSUM) Approach. | Richmond-Rakerd LS et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| Racial differences in heritability of cigarette smoking in adolescents and young adults. | Bares CB et al. | β | 2016 | β |
| Tobacco and alcohol use among adolescents in South Africa: shared and unshared risks. | Morojele NK et al. | β | 2016 | β |
| Amphetamine self-administration and dopamine function: assessment of geneβΓβenvironment interactions in Lewis and Fischer 344 rats. | Meyer AC et al. | β | 2015 | β |
| Does age of onset of risk behaviors mediate the relationship between child abuse and neglect and outcomes in middle adulthood? | Horan JM et al. | β | 2015 | β |
| Drinking experience uncovers genetic influences on alcohol expectancies across adolescence. | Young-Wolff KC et al. | β | 2015 | β |
| Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume. | Dalwani MS et al. | β | 2015 | β |
| Genetic and environmental contributions to the association between attention deficit hyperactivity disorder and alcohol dependence in adulthood: A large population-based twin study. | Capusan AJ et al. | β | 2015 | β |
| Genetic and environmental influences on adolescents' smoking involvement: a multi-informant twin study. | Seglem KB et al. | β | 2015 | β |
| Genetic relationship between the addiction diagnosis in adults and their childhood measure of addiction liability. | Vanyukov M et al. | β | 2015 | β |
| No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls. | MΓΌller KU et al. | β | 2015 | β |
| Parental Knowledge is a Contextual Amplifier of Associations of Pubertal Maturation and Substance Use. | Marceau K et al. | β | 2015 | β |
| Parent involvement, sibling companionship, and adolescent substance use: A longitudinal, genetically informed design. | Samek DR et al. | β | 2015 | β |
| Sibling Facilitation Mediates the Association Between Older and Younger Sibling Alcohol Use in Late Adolescence. | Samek DR et al. | β | 2015 | β |
| Temperament disturbances measured in infancy progress to substance use disorder 20 years later. | Horner MS et al. | β | 2015 | β |
| The prospective association between sipping alcohol by the sixth grade and later substance use. | Jackson KM et al. | β | 2015 | β |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | β | 2014 | β |
| A new approach to researching the etiology of cannabis use disorder: integrating transmissible and nontransmissible risk within a developmental framework. | Tarter R et al. | β | 2014 | β |
| Genetic and environmental influences on gambling and substance use in early adolescence. | Vitaro F et al. | β | 2014 | β |
| Genetic and environmental interplay in risky drinking in adolescents: a literature review. | Guerrini I et al. | β | 2014 | β |
| Moderators of the association between peer and target adolescent substance use. | Marschall-LΓ©vesque S et al. | β | 2014 | β |
| [Relations between nicotine dependence and cannabis dependence in adolescents]. | Chabrol H et al. | β | 2014 | β |
| Smoking at the workplace: Effects of genetic and environmental causal accounts on attitudes towards smoking employees and restrictive policies. | Dar-Nimrod I et al. | β | 2014 | β |
| The effects of social contact on drug use: behavioral mechanisms controlling drug intake. | Strickland JC et al. | β | 2014 | β |
| Exploring alternate processes contributing to the association between maternal smoking and the smoking behavior among young adult offspring. | Selya AS et al. | β | 2013 | β |
| Four factors for the initiation of substance use by young adulthood: a 10-year follow-up twin and sibling study of marital conflict, monitoring, siblings, and peers. | Neiderhiser JM et al. | β | 2013 | β |
| Genetic matters: thirty years of progress using mouse models in nicotinic research. | Marks MJ | β | 2013 | β |
| Modeling the association between sexual maturation, transmissible risk, and peer relationships during childhood and adolescence on development of substance use disorder in young adulthood. | Horner MS et al. | β | 2013 | β |
| Overview of Behavioral Genetics Research for Family Researchers. | Samek D et al. | β | 2013 | β |
| Parent and child cigarette use: a longitudinal, multigenerational study. | Vuolo M et al. | β | 2013 | β |
| Peer deviance, alcohol expectancies, and adolescent alcohol use: explaining shared and nonshared environmental effects using an adoptive sibling pair design. | Samek DR et al. | β | 2013 | β |
| Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents. | Miranda R et al. | β | 2013 | β |
| Stability and change of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis DSM-IV dependence symptoms. | Palmer RH et al. | β | 2013 | β |
| Connecting ncRNA Cigarette Smoking Studies with Tobacco Use Behaviors and Health Outcomes. | Ehringer MA | β | 2012 | β |
| Epidemiology of substance use disorders. | Merikangas KR et al. | β | 2012 | β |
| Familial influence and childhood trauma in female alcoholism. | Magnusson Γ et al. | β | 2012 | β |
| Fattori psicosociali e comportamenti dei fumatori adolescenti e adulti Risultati e conclusioni da uno studio longitudinale durato trent'anni. | Sherman SJ et al. | β | 2012 | β |
| Gambling, disordered gambling and their association with major depression and substance use: a web-based cohort and twin-sibling study. | Blanco C et al. | β | 2012 | β |
| Genetic and environmental determinants of stress responding. | Clarke TK et al. | β | 2012 | β |
| Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms. | Palmer RH et al. | β | 2012 | β |
| Risk factors for adolescent smoking: parental smoking and the mediating role of nicotine dependence. | Selya AS et al. | β | 2012 | β |
| Shared environmental contributions to substance use. | Baker JH et al. | β | 2012 | β |
| The effects of childhood ADHD symptoms on early-onset substance use: a Swedish twin study. | Chang Z et al. | β | 2012 | β |
| Trends in adolescent alcohol use: effects of age, sex and cohort on prevalence and heritability. | Geels LM et al. | β | 2012 | β |
| Understanding genetic risk for substance use and addiction: a guide for non-geneticists. | Urbanoski KA et al. | β | 2012 | β |
| A systematic evaluation and validation of subtypes of adolescent alcohol use motives: genetic and environmental contributions. | Mackie CJ et al. | β | 2011 | β |
| Biomarkers to optimize the treatment of nicotine dependence. | Schnoll RA et al. | β | 2011 | β |
| Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. | Breese GR et al. | β | 2011 | β |
| Effect of environmental enrichment on escalation of cocaine self-administration in rats. | Gipson CD et al. | β | 2011 | β |
| Effects of the serotonin transporter (5-HTTLPR) and Ξ±2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study. | MerenΓ€kk L et al. | β | 2011 | β |
| Gender differences in ethanol-induced behavioral sensitivity in zebrafish. | Dlugos CA et al. | β | 2011 | β |
| Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. | Hendershot CS et al. | β | 2011 | β |
| Risky alcohol use in adolescence: the role of genetics (DRD2, SLC6A4) and coping motives. | van der Zwaluw CS et al. | β | 2011 | β |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | β | 2011 | β |
| The role of child sexual abuse in the etiology of substance-related disorders. | Maniglio R | β | 2011 | β |
| Alcohol use and the Traveller community in the west of Ireland. | Van Hout MC | β | 2010 | β |
| Confirmation and generalization of an alcohol-dependence locus on chromosome 10q. | Panhuysen CI et al. | β | 2010 | β |
| Early onset alcohol dependence with high density of family history is not "male limited". | Magnusson A et al. | β | 2010 | β |
| Examining the etiology of associations between perceived parenting and adolescents' alcohol use: common genetic and/or environmental liabilities? | Latendresse SJ et al. | β | 2010 | β |
| Gender differences in the relationship of internalizing and externalizing psychopathology to alcohol dependence: likelihood, expression and course. | Dawson DA et al. | β | 2010 | β |
| Genetically informative research on adolescent substance use: methods, findings, and challenges. | Lynskey MT et al. | β | 2010 | β |
| Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds. | Schmid B et al. | β | 2010 | β |
| Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence. | Young SE et al. | β | 2009 | β |
| Common genetic influences on the timing of first use for alcohol, cigarettes, and cannabis in young African-American women. | Sartor CE et al. | β | 2009 | β |
| Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk. | Palmer RH et al. | β | 2009 | β |
| Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. | Saraceno L et al. | β | 2009 | β |
| Hypothalamic-pituitary-adrenal axis and smoking and drinking onset among adolescents: the longitudinal cohort TRacking Adolescents' Individual Lives Survey (TRAILS). | Huizink AC et al. | β | 2009 | β |
| Incorporating the family as a critical context in genetic studies of children: implications for understanding pathways to risky behavior and substance use. | Rende R et al. | β | 2009 | β |
| Mediation of family alcoholism risk by religious affiliation types. | Haber JR et al. | β | 2009 | β |
| Neurobehavioral effects of environmental enrichment and drug abuse vulnerability. | Stairs DJ et al. | β | 2009 | β |
| Sibling Contagion for Drinking in Adolescence: A Micro Process Framework. | Slomkowski C et al. | β | 2009 | β |
| Similarities in drinking behavior of twin's friends: moderation of heritability of alcohol use. | Poelen EA et al. | β | 2009 | β |
| Substance use and behaviour disorders in Puerto Rican youth: a migrant family study. | Merikangas KR et al. | β | 2009 | β |
| The familial aggregation of cannabis use disorders. | Merikangas KR et al. | β | 2009 | β |
| The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use. | Dick DM et al. | β | 2009 | β |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | β | 2009 | β |
| Behavioral disinhibition and the development of early-onset addiction: common and specific influences. | Iacono WG et al. | β | 2008 | β |
| Disentangling the complex association between childhood sexual abuse and alcohol-related problems: a review of methodological issues and approaches. | Sartor CE et al. | β | 2008 | β |
| Does smoking among friends explain apparent genetic effects on current smoking in adolescence and young adulthood? | White VM et al. | β | 2008 | β |
| Early Age-of-onset Drinking Predicts Prescription Drug Misuse Among Teenagers and Young Adults: Results from a National Survey. | Hermos JA et al. | β | 2008 | β |
| Genetic and environmental influences on the rate of progression to alcohol dependence in young women. | Sartor CE et al. | β | 2008 | β |
| HPA-axis activity in alcoholism: examples for a gene-environment interaction. | Clarke TK et al. | β | 2008 | β |
| Parental problem drinking, parenting, and adolescent alcohol use. | van der Zwaluw CS et al. | β | 2008 | β |
| Relative risks of adolescent and young adult alcohol use: the role of drinking fathers, mothers, siblings, and friends. | Scholte RH et al. | β | 2008 | β |
| The interaction of conduct problems and depressed mood in relation to adolescent substance involvement and peer substance use. | Mason WA et al. | β | 2008 | β |
| The relative contribution of genes and environment to alcohol use in early adolescents: are similar factors related to initiation of alcohol use and frequency of drinking? | Poelen EA et al. | β | 2008 | β |
| Understanding the association between adolescent marijuana use and later serious drug use: gateway effect or developmental trajectory? | Cleveland HH et al. | β | 2008 | β |
| College attendance and its effect on drinking behaviors in a longitudinal study of adolescents. | Timberlake DS et al. | β | 2007 | β |
| Genetics and smoking behavior. | Schnoll RA et al. | β | 2007 | β |
| Personality at ages 16 and 17 and drinking problems at ages 18 and 25: genetic analyses of data from Finn Twin16-25. | Viken RJ et al. | β | 2007 | β |
| Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine. | Grice DE et al. | β | 2007 | β |
| Alcohol, drugs, and attention-deficit/ hyperactivity disorder: a model for the study of addictions in youth. | Wilens TE et al. | β | 2006 | β |
| Alcohol use in families: a 15-year prospective follow-up study. | Seljamo S et al. | β | 2006 | β |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | β | 2006 | β |
| Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood. | Pagan JL et al. | β | 2006 | β |
| Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific? | Young SE et al. | β | 2006 | β |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | β | 2006 | β |
| Co-twin dependence modifies heritability of abstinence and alcohol use: a population-based study of Finnish twins. | Penninkilampi-Kerola V et al. | β | 2005 | β |
| Diagnosis, course, and assessment of alcohol abuse and dependence in adolescents. | Chung T et al. | β | 2005 | β |
| The development of alcohol use disorders. | Sher KJ et al. | β | 2005 | β |
| The significance of social connectedness: comment on Slomkowski et al. 2005. | Merikangas KR | β | 2005 | β |
| Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. | Vink JM et al. | β | 2004 | β |