Origins and consequences of age at first drink. II. Familial risk and heritability.
paper
Cited
Public
Unavailable
- Authors
- McGue, M; Iacono, W G; Legrand, L N; Elkins, I
- Year
- 2001
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 11515563
BACKGROUND: The association of age at first drink (AFD) and alcoholism may reflect a common inherited vulnerability to disinhibitory behavior and psychopathology rather than a direct influence of the former on the latter. We tested the common-inherited-vulnerability hypothesis by determining whether AFD is familial and heritable. METHODS: A sample of 1,232 14-year-old twins was classified according to their biological parents' AFD. RESULTS: Lifetime symptoms of externalizing disorders (i.e., conduct disorder and oppositional defiant disorder) were significantly higher in the sons but not the daughters of parents whose AFD came before age 15 years. Offspring symptoms of internalizing disorders (i.e., major depressive disorder, separation anxiety disorder, and overanxious disorder) were not significantly associated with parental early use of alcohol in either sons or daughters. Early use of alcohol in mothers but not fathers was associated with a significant increase in both sons' and daughters' risk of alcohol use by age 14. The contribution of genetic and environmental factors to risk of early alcohol use was investigated in a sample of 416 monozygotic (MZ) and 225 like-sex dizygotic (DZ) 14-year-old twin pairs. Twin similarity for early alcohol use was substantially greater in MZ than DZ twins in boys but about equally similar in MZ and DZ twins in girls. Estimated heritability of early alcohol use was significantly greater in boys (55%) than girls (11%), in part because the genetic factors underlying symptoms of disinhibitory psychopathology contributed more to risk of early alcohol use in boys than girls. CONCLUSIONS: Early use of alcohol is familial and, at least in males, heritable. The familial transmission of early alcohol use is caused in part by genetic risk for disinhibitory psychopathology in males and to shared environmental factors in girls. These results provide some support for a common-inherited-vulnerability hypothesis, and suggest that the processes underlying early alcohol use may differ in boys and girls.
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| Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. | Varela RB et al. | — | 2022 | → |
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| Externalizing psychopathology and cognitive functions in patients with early- and late-onset alcohol dependence. | Das A et al. | — | 2021 | → |
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| Family history of alcohol use disorder is associated with brain structural and functional changes in healthy first-degree relatives. | Filippi I et al. | — | 2019 | → |
| Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention. | Cleveland HH et al. | — | 2018 | → |
| Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families. | McCutcheon VV et al. | — | 2018 | → |
| Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample. | Sartor CE et al. | — | 2018 | → |
| Cognitive and behavioural dispositions in offspring at high risk for alcoholism. | Kumar R et al. | — | 2018 | → |
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| Early Cannabis Use and Neurocognitive Risk: A Prospective Functional Neuroimaging Study. | Tervo-Clemmens B et al. | — | 2018 | → |
| An Analysis of the Associations among Cognitive Impulsiveness, Reasoning Process, and Rational Decision Making. | Jelihovschi APG et al. | — | 2017 | → |
| Gender Differences in Risk Factors for Adolescent Binge Drinking and Implications for Intervention and Prevention. | Dir AL et al. | — | 2017 | → |
| Declining Prevalence of Marijuana Use Disorders Among Adolescents in the United States, 2002 to 2013. | Grucza RA et al. | — | 2016 | → |
| Parental divorce and initiation of alcohol use in early adolescence. | Jackson KM et al. | — | 2016 | → |
| The Impact of the Minimum Legal Drinking Age on Alcohol-Related Chronic Disease Mortality. | Plunk AD et al. | — | 2016 | → |
| Adolescent perspectives on the return of individual results in genomic addiction research. | Coors ME et al. | — | 2015 | → |
| Asian American problem drinking trajectories during the transition to adulthood: ethnic drinking cultures and neighborhood contexts. | Cook WK et al. | — | 2015 | → |
| Do child's psychosocial functioning, and parent and family characteristics predict early alcohol use? The TRAILS Study. | Visser L et al. | — | 2015 | → |
| Family history of mental illness or alcohol abuse and the irritable bowel syndrome. | Knight JR et al. | — | 2015 | → |
| Intergenerational Transmission of Externalizing Behavior. | Brook JS et al. | — | 2015 | → |
| Maternal HIV, substance use role modeling, and adolescent girls' alcohol use. | Cederbaum JA et al. | — | 2015 | → |
| Maternal risk taking on the balloon analogue risk task as a prospective predictor of youth alcohol use escalation. | Banducci AN et al. | — | 2015 | → |
| Prevalence and correlates of sipping alcohol in a prospective middle school sample. | Jackson KM et al. | — | 2015 | → |
| Structural connectivity of neural reward networks in youth at risk for substance use disorders. | Squeglia LM et al. | — | 2015 | → |
| The prospective association between sipping alcohol by the sixth grade and later substance use. | Jackson KM et al. | — | 2015 | → |
| Age at first drink, drinking, binge drinking, and DSM-5 alcohol use disorder among Hispanic national groups in the United States. | Caetano R et al. | — | 2014 | → |
| Developmental change in the relationship between alcohol and drug use before sex and sexual risk behavior in young men who have sex with men. | Newcomb ME et al. | — | 2014 | → |
| Early age of alcohol initiation is not the cause of alcohol use disorders in adulthood, but is a major indicator of genetic risk. A population-based twin study. | Ystrom E et al. | — | 2014 | → |
| Genetic and environmental influences on the ages of drinking and gambling initiation: evidence for distinct aetiologies and sex differences. | Richmond-Rakerd LS et al. | — | 2014 | → |
| Heavy alcohol use, marijuana use, and concomitant use by adolescents are associated with unique and shared cognitive decrements. | Winward JL et al. | — | 2014 | → |
| Longitudinal test of a developmental model of the transition to early drinking. | Settles RE et al. | — | 2014 | → |
| White matter integrity in alcohol-naive youth with a family history of alcohol use disorders. | Squeglia LM et al. | — | 2014 | → |
| Alcohol use during the transition from middle school to high school: national panel data on prevalence and moderators. | Jackson KM et al. | — | 2013 | → |
| Behind the wheel and on the map: Genetic and environmental associations between drunk driving and other externalizing behaviors. | Quinn PD et al. | — | 2013 | → |
| Comorbidities and continuities as ontogenic processes: toward a developmental spectrum model of externalizing psychopathology. | Beauchaine TP et al. | — | 2013 | → |
| Developmental psychopathology: a paradigm shift or just a relabeling? | Rutter M | — | 2013 | → |
| Dose-related effects for the precipitation of psychopathology by opioid or tranquilizer/sedative nonmedical prescription use: results from the National Epidemiologic Survey on Alcohol and Related Conditions. | Schepis TS et al. | — | 2013 | → |
| Effects of sibship size and composition on younger brothers' and sisters' alcohol use initiation: findings from an Australian twin sample. | Richmond-Rakerd LS et al. | — | 2013 | → |
| Moderating effect of age on the association between alcohol use and sexual risk in MSM: evidence for elevated risk among younger MSM. | Newcomb ME | — | 2013 | → |
| Neural correlates of impulsivity in healthy males and females with family histories of alcoholism. | DeVito EE et al. | — | 2013 | → |
| Onset to First Alcohol Use in Early Adolescence: A Network Diffusion Model. | Light JM et al. | — | 2013 | → |
| Predicting early initiation of alcohol use: a prospective study of Australian children. | Scholes-Balog KE et al. | — | 2013 | → |
| Relationship between motor threshold and externalizing symptoms in subjects at high risk for alcohol dependence: a TMS Study. | Muralidharan K et al. | — | 2013 | → |
| Religion/spirituality, risk, and the development of alcohol dependence in female twins. | Haber JR et al. | — | 2013 | → |
| The moderating effect of family involvement on substance use risk factors in adolescents with severe emotional and behavioral challenges. | Schlauch RC et al. | — | 2013 | → |
| Trajectories of multiple adolescent health risk behaviors in a low-income African American population. | Mustanski B et al. | — | 2013 | → |
| Why is adolescence a key period of alcohol initiation and who is prone to develop long-term problem use?: A review of current available data. | Petit G et al. | — | 2013 | → |
| Adolescent brain development and underage drinking in the United States: identifying risks of alcohol use in college populations. | Silveri MM | — | 2012 | → |
| Familial confounding of the association between maternal smoking during pregnancy and offspring substance use and problems. | D'Onofrio BM et al. | — | 2012 | → |
| Prevalence and association of dental injuries with socioeconomic conditions and alcohol/drug use in adolescents between 15 and 19 years of age. | Jorge KO et al. | — | 2012 | → |
| Substance abuse and suicide risk among adolescents. | — | — | 2012 | → |
| Substance abuse and suicide risk among adolescents. | Pompili M et al. | — | 2012 | → |
| The effects of age at drinking onset and stressful life events on alcohol use in adulthood: a replication and extension using a population-based twin sample. | Lee LO et al. | — | 2012 | → |
| Trends in adolescent alcohol use: effects of age, sex and cohort on prevalence and heritability. | Geels LM et al. | — | 2012 | → |
| Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance. | Silveri MM et al. | — | 2011 | → |
| A life course approach to injury prevention: a "lens and telescope" conceptual model. | Hosking J et al. | — | 2011 | → |
| A longitudinal twin study of effects of adolescent alcohol abuse on the neurophysiology of attention and orienting. | Koskinen SM et al. | — | 2011 | → |
| Effect of alcohol consumption in prenatal life, childhood, and adolescence on child development. | Foltran F et al. | — | 2011 | → |
| Friends or foes: social anxiety, peer affiliation, and drinking in middle school. | Anderson KG et al. | — | 2011 | → |
| Gender differences in ethanol-induced behavioral sensitivity in zebrafish. | Dlugos CA et al. | — | 2011 | → |
| Neural activation during inhibition predicts initiation of substance use in adolescence. | Norman AL et al. | — | 2011 | → |
| Non-medical prescription use increases the risk for the onset and recurrence of psychopathology: results from the National Epidemiological Survey on Alcohol and Related Conditions. | Schepis TS et al. | — | 2011 | → |
| Role of genotype in the development of locomotor sensitization to alcohol in adult and adolescent mice: comparison of the DBA/2J and C57BL/6J inbred mouse strains. | Melón LC et al. | — | 2011 | → |
| Role of individual and developmental differences in voluntary cocaine intake in rats. | Schramm-Sapyta NL et al. | — | 2011 | → |
| That instrument is lousy! In search of agreement when using instrumental variables estimation in substance use research. | French MT et al. | — | 2011 | → |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | — | 2011 | → |
| The relationship of pathological gambling to criminality behavior in a sample of Polish male offenders. | Pastwa-Wojciechowska B | — | 2011 | → |
| Does religious involvement protect against early drinking? A behavior genetic approach. | Harden KP | — | 2010 | → |
| Familial loading for alcoholism and offspring behavior: mediating and moderating influences. | Molina BS et al. | — | 2010 | → |
| For distinguished contributions to psychophysiology: William G. Iacono. | Miller GA | — | 2010 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Neural plasticity, human genetics, and risk for alcohol dependence. | Hill SY | — | 2010 | → |
| Predicting drinking onset with discrete-time survival analysis in offspring from the San Diego prospective study. | Trim RS et al. | — | 2010 | → |
| Testing the equal environments assumption in the Children of Twins design. | Koenig LB et al. | — | 2010 | → |
| The association between earlier age of first drink, disinhibited personality, and externalizing psychopathology in young adults. | Zernicke KA et al. | — | 2010 | → |
| Alcoholism and intimate partner violence: effects on children's psychosocial adjustment. | Klostermann K et al. | — | 2009 | → |
| Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. | Schramm-Sapyta NL et al. | — | 2009 | → |
| Association between problem gambling and conduct disorder in a national survey of adolescents and young adults in the United States. | Welte JW et al. | — | 2009 | → |
| Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families: a prospective study. | Hill SY et al. | — | 2009 | → |
| Developmental processes and mechanisms: ages 0-10. | Zucker RA et al. | — | 2009 | → |
| Early-onset drug use and risk for drug dependence problems. | Chen CY et al. | — | 2009 | → |
| Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms. | Agrawal A et al. | — | 2009 | → |
| Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adults. | Buchmann AF et al. | — | 2009 | → |
| Incorporating the family as a critical context in genetic studies of children: implications for understanding pathways to risky behavior and substance use. | Rende R et al. | — | 2009 | → |
| Sibling Contagion for Drinking in Adolescence: A Micro Process Framework. | Slomkowski C et al. | — | 2009 | → |
| The relationships of the level of response to alcohol and additional characteristics to alcohol use disorders across adulthood: a discrete-time survival analysis. | Trim RS et al. | — | 2009 | → |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | — | 2009 | → |
| Abnormalities in cortical and transcallosal inhibitory mechanisms in subjects at high risk for alcohol dependence: a TMS study. | Muralidharan K et al. | — | 2008 | → |
| Adolescent Suicidal Behavior and Substance Use: Developmental Mechanisms. | Dawes MA et al. | — | 2008 | → |
| Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. | Dawson DA et al. | — | 2008 | → |
| Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States. | Grucza RA et al. | — | 2008 | → |
| Early developmental processes and the continuity of risk for underage drinking and problem drinking. | Zucker RA et al. | — | 2008 | → |
| Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies. | Heiman GA et al. | — | 2008 | → |
| Genetic Relations Between Effortful and Attentional Control and Symptoms of Psychopathology in Middle Childhood. | Lemery-Chalfant K et al. | — | 2008 | → |
| Impulsivity, age of first alcohol use and substance use disorders among male adolescents: a population based case-control study. | von Diemen L et al. | — | 2008 | → |
| Likelihood of developing an alcohol and cannabis use disorder during youth: association with recent use and age. | Winters KC et al. | — | 2008 | → |
| Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use. | Silveri MM et al. | — | 2008 | → |
| Research review: DSM-V conduct disorder: research needs for an evidence base. | Moffitt TE et al. | — | 2008 | → |
| Specificity of familial transmission of anxiety and comorbid disorders. | Low NC et al. | — | 2008 | → |
| Ten good reasons to consider biological processes in prevention and intervention research. | Beauchaine TP et al. | — | 2008 | → |
| The adolescent origins of substance use disorders. | McGue M et al. | — | 2008 | → |
| Attention-deficit/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility loci. | Jain M et al. | — | 2007 | → |
| Cognitive deficits in children of alcoholics: At risk before the first sip! | Silva MC et al. | — | 2007 | → |
| Early onset problem behavior, young adult psychopathology, and contextual risk. | Keyes MA et al. | — | 2007 | → |
| Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence. | Benegal V et al. | — | 2007 | → |
| The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. | Sartor CE et al. | — | 2007 | → |
| Adolescents and substance-related disorders: research agenda to guide decisions on Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). | Crowley TJ | — | 2006 | → |
| Age at first intoxication and alcohol use disorders in Southwest California Indians. | Ehlers CL et al. | — | 2006 | → |
| Age of alcohol-dependence onset: associations with severity of dependence and seeking treatment. | Hingson RW et al. | — | 2006 | → |
| A longitudinal examination of the link between parent alcohol problems and youth drinking: the moderating roles of parent and child gender. | Coffelt NL et al. | — | 2006 | → |
| Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. | Dick DM et al. | — | 2006 | → |
| The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective. | McGue M et al. | — | 2006 | → |
| The developmental behavior genetics of drug involvement: overview and comments. | Zucker RA | — | 2006 | → |
| Underage alcohol use, delinquency, and criminal activity. | French MT et al. | — | 2006 | → |
| Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse. | Yoon HH et al. | — | 2006 | → |
| Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. | Liu Y et al. | — | 2005 | → |
| Deficit in beta-endorphin peptide and tendency to alcohol abuse. | Zalewska-Kaszubska J et al. | — | 2005 | → |
| Elementary school drinking: the role of temperament and learning. | Anderson KG et al. | — | 2005 | → |
| Examining personality and alcohol expectancies using functional magnetic resonance imaging (fMRI) with adolescents. | Anderson KG et al. | — | 2005 | → |
| Perceptions of the parent-adolescent relationship: a longitudinal investigation. | McGue M et al. | — | 2005 | → |
| Relationship of age of first drink to child behavioral problems and family psychopathology. | Kuperman S et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Association of age at first drink with current alcohol drinking variables in a national general population sample. | York JL et al. | — | 2004 | → |
| Childhood externalizing and internalizing psychopathology in the prediction of early substance use. | King SM et al. | — | 2004 | → |
| Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. | Schramm-Sapyta NL et al. | — | 2004 | → |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | — | 2004 | → |
| Resting EEG in offspring of male alcoholics: beta frequencies. | Rangaswamy M et al. | — | 2004 | → |
| The natural history of adolescent alcohol use disorders. | Clark DB | — | 2004 | → |
| A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. | Stallings MC et al. | — | 2003 | → |
| Autism families with a high incidence of alcoholism. | Miles JH et al. | — | 2003 | → |
| Longitudinal effects of age at onset and first drinking situations on problem drinking. | Warner LA et al. | — | 2003 | → |
| Review of twin and adoption studies of adolescent substance use. | Hopfer CJ et al. | — | 2003 | → |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | — | 2003 | → |