Origins and consequences of age at first drink. I. Associations with substance-use disorders, disinhibitory behavior and psychopathology, and P3 amplitude.
paper
Cited
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Unavailable
- Authors
- McGue, M; Iacono, W G; Legrand, L N; Malone, S; Elkins, I
- Year
- 2001
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 11505047
BACKGROUND: Although an early age at first drink has been repeatedly associated with substantially elevated rates of alcoholism, the mechanisms underlying this association remain unclear. We investigated whether the association of age at first drink (AFD) with alcoholism was more consistent with the hypothesis that the former causes the latter or the hypothesis that both are manifestations of some common vulnerability. METHODS: We investigated whether substance use and mental health disorders, education, IQ, and personality were associated with AFD in a sample of 2670 adults; whether P3 amplitude was associated with AFD in a sample of 1127 17 year olds; and whether indicators of disinhibitory psychopathology assessed at age 11 predicted AFD by age 14 in a sample of 1343 adolescents. RESULTS: In adults, AFD was associated not only with alcohol dependence, but also with a broad array of indicators of disinhibitory behavior and psychopathology including nicotine dependence, illicit drug abuse and dependence, conduct disorder, antisocial personality disorder, underachievement in school, and the personality trait of constraint. In 17 year olds, AFD was also associated with reduced P3 amplitude, a well-documented psychophysiological marker of alcoholism risk. Finally, in the early-adolescence sample, measures of behavioral disinhibition, including oppositionality, hyperactivity/impulsivity, and inattentiveness assessed at age 11 predicted drinking onset by age 14. CONCLUSIONS: Our findings indicated that AFD is not specifically associated with alcoholism but rather is correlated with a broad range of indicators of disinhibited behavior and psychopathology. Moreover, individuals who first drink at a relatively early age manifest elevated rates of disinhibitory behavior and psychopathology before they first try alcohol. Taken together, these findings suggest that the association of AFD with alcoholism reflects, at least in part, a common underlying vulnerability to disinhibitory behavior. Whether an early AFD directly influences risk of adult alcoholism remains unclear.
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| Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adults. | Buchmann AF et al. | — | 2009 | → |
| Neurobehavior disinhibition, parental substance use disorder, neighborhood quality and development of cannabis use disorder in boys. | Ridenour TA et al. | — | 2009 | → |
| Personality disorders in alcohol-dependent individuals: relationship with alcohol dependence severity. | Preuss UW et al. | — | 2009 | → |
| Some thoughts about the epidemiology of alcohol and drug use among American Indian/Alaska Native populations. | Young RS et al. | — | 2009 | → |
| The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use. | Perlman G et al. | — | 2009 | → |
| The relationships of the level of response to alcohol and additional characteristics to alcohol use disorders across adulthood: a discrete-time survival analysis. | Trim RS et al. | — | 2009 | → |
| The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use. | Dick DM et al. | — | 2009 | → |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | — | 2009 | → |
| Underage alcohol use: summary of developmental processes and mechanisms: ages 16-20. | Brown SA et al. | — | 2009 | → |
| Variations by age and sex in alcohol-related problematic behaviour per drinking volume and heavier drinking occasion. | Livingston M et al. | — | 2009 | → |
| Visual P3 amplitude and self-reported psychopathic personality traits: frontal reduction is associated with self-centered impulsivity. | Carlson SR et al. | — | 2009 | → |
| A developmental perspective on alcohol and youths 16 to 20 years of age. | Brown SA et al. | — | 2008 | → |
| Adolescent stressors, psychopathology, and young adult substance dependence: a prospective study. | King KM et al. | — | 2008 | → |
| Adolescent Suicidal Behavior and Substance Use: Developmental Mechanisms. | Dawes MA et al. | — | 2008 | → |
| Affective circuitry and risk for alcoholism in late adolescence: differences in frontostriatal responses between vulnerable and resilient children of alcoholic parents. | Heitzeg MM et al. | — | 2008 | → |
| Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. | Dawson DA et al. | — | 2008 | → |
| Association of candidate genes with antisocial drug dependence in adolescents. | Corley RP et al. | — | 2008 | → |
| Behavioral disinhibition and the development of early-onset addiction: common and specific influences. | Iacono WG et al. | — | 2008 | → |
| Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States. | Grucza RA et al. | — | 2008 | → |
| Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology. | Carlson SR et al. | — | 2008 | → |
| Drinking trajectories following an initial lapse. | Witkiewitz K et al. | — | 2008 | → |
| Impulsivity, age of first alcohol use and substance use disorders among male adolescents: a population based case-control study. | von Diemen L et al. | — | 2008 | → |
| Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. | Verdejo-García A et al. | — | 2008 | → |
| Level of response to alcohol within the context of alcohol-related domains: an examination of longitudinal approaches assessing changes over time. | Trim RS et al. | — | 2008 | → |
| Parental smoking and adolescent problem behavior: an adoption study of general and specific effects. | Keyes M et al. | — | 2008 | → |
| Self-reported health functioning in Swedish alcohol-dependent individuals: age and gender perspectives. | Berglund K et al. | — | 2008 | → |
| The adolescent origins of substance use disorders. | McGue M et al. | — | 2008 | → |
| The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. | Schlaepfer IR et al. | — | 2008 | → |
| Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. | Dick DM et al. | — | 2007 | → |
| An important new phenotype and some next-step questions: commentary on Sartor et al. (2007). | Zucker RA | — | 2007 | → |
| Attention-deficit/hyperactivity disorder risk for heavy drinking and alcohol use disorder is age specific. | Molina BS et al. | — | 2007 | → |
| [Early onset of alcohol and tobacco use--indicator of enhanced risk of addiction?]. | Laucht M et al. | — | 2007 | → |
| Early onset problem behavior, young adult psychopathology, and contextual risk. | Keyes MA et al. | — | 2007 | → |
| Effects of home access and availability of alcohol on young adolescents' alcohol use. | Komro KA et al. | — | 2007 | → |
| Externalizing symptoms among children of alcoholic parents: Entry points for an antisocial pathway to alcoholism. | Hussong AM et al. | — | 2007 | → |
| How gene-stress-behavior interactions can promote adolescent alcohol use: the roles of predrinking allostatic load and childhood behavior disorders. | Zimmermann US et al. | — | 2007 | → |
| Impulsivity, neural deficits, and the addictions: the "oops" factor in relapse. | Adinoff B et al. | — | 2007 | → |
| Mendelian randomization: a novel test of the gateway hypothesis and models of gene-environment interplay. | Irons DE et al. | — | 2007 | → |
| Patterns and correlates of drinking in offspring from the San Diego Prospective Study. | Schuckit MA et al. | — | 2007 | → |
| Prospective associations of social self-control with drug use among youth from regular and alternative high schools. | Pokhrel P et al. | — | 2007 | → |
| Should personality traits be considered when refining substance misuse treatment programs? | Staiger PK et al. | — | 2007 | → |
| The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. | Sartor CE et al. | — | 2007 | → |
| Age at first intoxication and alcohol use disorders in Southwest California Indians. | Ehlers CL et al. | — | 2006 | → |
| Association between P3 event-related brain potential amplitude and adolescent problem behavior. | Iacono WG et al. | — | 2006 | → |
| Association of DRD4 exon III polymorphism with auditory P300 amplitude in 8-year-old children. | Vogel CI et al. | — | 2006 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |
| Childhood depressive symptoms and early onset of alcohol use. | Wu P et al. | — | 2006 | → |
| Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific? | Young SE et al. | — | 2006 | → |
| Linking substance use and problem behavior across three generations. | Bailey JA et al. | — | 2006 | → |
| Minnesota Center for Twin and Family Research. | Iacono WG et al. | — | 2006 | → |
| Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. | Li CS et al. | — | 2006 | → |
| Personality traits and the development of nicotine, alcohol, and illicit drug disorders: prospective links from adolescence to young adulthood. | Elkins IJ et al. | — | 2006 | → |
| The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective. | McGue M et al. | — | 2006 | → |
| The relationship of behavioural undercontrol to alcoholism in higher-functioning adults. | Schuckit MA et al. | — | 2006 | → |
| Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse. | Yoon HH et al. | — | 2006 | → |
| Adolescence: booze, brains, and behavior. | Monti PM et al. | — | 2005 | → |
| Clinical features of depressed patients with or without a family history of alcoholism. | Sher L et al. | — | 2005 | → |
| Etiological contributions to heavy drinking from late adolescence to young adulthood. | King SM et al. | — | 2005 | → |
| Natural reward-related learning in rats with neonatal ventral hippocampal lesions and prior cocaine exposure. | Chambers RA et al. | — | 2005 | → |
| Pathways to adolescent substance use among sexually abused girls. | Bailey JA et al. | — | 2005 | → |
| Relationship of age of first drink to child behavioral problems and family psychopathology. | Kuperman S et al. | — | 2005 | → |
| Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. | Kamarajan C et al. | — | 2005 | → |
| The association of early adolescent problem behavior with adult psychopathology. | McGue M et al. | — | 2005 | → |
| The neurocognitive effects of alcohol on adolescents and college students. | Zeigler DW et al. | — | 2005 | → |
| Adolescent alcohol initiation: a review of psychosocial risk factors. | Donovan JE | — | 2004 | → |
| Adolescents' performance on the Iowa Gambling Task: implications for the development of decision making and ventromedial prefrontal cortex. | Hooper CJ et al. | — | 2004 | → |
| Age at first drink relates to behavioral measures of impulsivity: the immediate and delayed memory tasks. | Dougherty DM et al. | — | 2004 | → |
| A genome wide search for alcoholism susceptibility genes. | Hill SY et al. | — | 2004 | → |
| Association of age at first drink with current alcohol drinking variables in a national general population sample. | York JL et al. | — | 2004 | → |
| Childhood externalizing and internalizing psychopathology in the prediction of early substance use. | King SM et al. | — | 2004 | → |
| Early adolescent through young adult alcohol and marijuana use trajectories: early predictors, young adult outcomes, and predictive utility. | Flory K et al. | — | 2004 | → |
| Effects of borderline personality disorder features and a family history of alcohol or drug dependence on P300 in adolescents. | Houston RJ et al. | — | 2004 | → |
| Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. | Schramm-Sapyta NL et al. | — | 2004 | → |
| Models of co-occurring substance misuse and psychosis: are personality traits the missing link? | Hides L et al. | — | 2004 | → |
| Reward drive and rash impulsiveness as dimensions of impulsivity: implications for substance misuse. | Dawe S et al. | — | 2004 | → |
| The natural history of adolescent alcohol use disorders. | Clark DB | — | 2004 | → |
| Longitudinal effects of age at onset and first drinking situations on problem drinking. | Warner LA et al. | — | 2003 | → |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | — | 2003 | → |
| Classical twin studies and beyond. | Boomsma D et al. | — | 2002 | → |
| Cohort effects on gender differences in alcohol dependence. | Holdcraft LC et al. | — | 2002 | → |
| Drinks of the father: father's maximum number of drinks consumed predicts externalizing disorders, substance use, and substance use disorders in preadolescent and adolescent offspring. | Malone SM et al. | — | 2002 | → |
| Increase of rat alcohol drinking behavior depends on the age of drinking onset. | Yoshimoto K et al. | — | 2002 | → |
| Substance use disorder and personality disorder. | Sher KJ et al. | — | 2002 | → |
| Origins and consequences of age at first drink. II. Familial risk and heritability. | McGue M et al. | — | 2001 | → |