A new definition of early age at onset in alcohol dependence.
- Authors
- Le Strat, Yann; Grant, Bridget F; Ramoz, Nicolas; Gorwood, Philip
- Year
- 2010
- Journal
- Drug and alcohol dependence
- PMID
- 20018459
- DOI
- 10.1016/j.drugalcdep.2009.11.011
- PMCID
- PMC4313551
OBJECTIVE: The accurate cut-off of an early onset of alcohol dependence is unknown. The objectives of this analysis are (1) to confirm that ages at onset variability in alcohol dependence is best described as a two subgroups entity, (2) to define the most appropriate cut-off, and (3) to test the relevancy of such distinction. METHOD: Data were drawn the Epidemiologic Survey on Alcohol and Related Conditions (NESARC). This study focused on the 4782 adults with lifetime alcohol dependence. RESULTS: The best-fit model distinguished two subgroups of age at onset of alcohol dependence, with a cut-off point at 22 years. Subjects with an earlier onset of alcohol dependence (< or = 22 years old) reported higher lifetime rates of specific phobia, antisocial behaviors and nearly all addictive disorders. CONCLUSIONS: The early onset of alcohol dependence is best defined as beginning before the age of 22 years.
Observed single normal distribution () and theoretical two component mixture distribution () of age at onset of alcohol dependence in the 4697 alcohol-dependent participants of the NESARC sample.
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