Age of alcohol-dependence onset: associations with severity of dependence and seeking treatment.
paper
Cited
Public
Unavailable
- Authors
- Hingson, Ralph W; Heeren, Timothy; Winter, Michael R
- Year
- 2006
- Journal
- Pediatrics
- PMID
- 16950966
- DOI
- 10.1542/peds.2006-0223
OBJECTIVE: We explored whether people who become alcohol dependent at younger ages are more likely to seek alcohol-related help or treatment or experience chronic relapsing dependence. METHODS: In 2001-2002 the National Institute on Alcohol Abuse and Alcoholism completed a face-to-face interview survey with a multistage probability sample of 43,093 adults aged > or = 18, with a response rate of 81%. We focused on 4778 persons diagnosable as alcohol dependent ever in their lives using Diagnositic and Statistical Manual of Mental Disorders, Fourth Edition criteria. Logistic regression examined whether respondents ever sought alcohol-related help or treatment, controlling for respondent demographics, number of dependence symptoms experienced, smoking and illicit drug use, childhood antisocial personality and depression, family history of alcoholism, and age of drinking onset. RESULTS: Of persons ever alcohol dependent, 15% were diagnosable before age 18, 47% before age 21, and two thirds before age 25. Twenty-eight percent reported > or = 2 dependence episodes, 45% experienced an episode exceeding 1 year, and 34% reported 6 or 7 dependence criteria. Relative to those first alcohol dependent at > or = 30 years, 21% of those ever dependent, the odds of ever seeking help were lower among those first dependent before ages 18, 20, and 25. Yet, persons first dependent at < or = 25 years had significantly greater odds of experiencing multiple dependence episodes, episodes exceeding 1 year, and more dependence symptoms. Analyses indicated that the previously reported increased odds that persons who start to drink at an early age develop features of chronic relapsing dependence may have resulted from early drinkers being more likely to develop alcohol dependence at younger ages. This, in turn, increased their odds of experiencing multiple and longer episodes of alcohol dependence with more symptoms. CONCLUSIONS: Adolescents need to be screened and counseled about alcohol, and treatment services should be reinforced by programs and policies to delay age of first alcohol dependence.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Chemogenetic activation of an A2 nucleus of the solitary tract to lateral parabrachial nucleus noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in male and female mice. | Drinkuth CR et al. | β | 2026 | β |
| Corticotropin-Releasing Factor Modulates Binge-Like Ethanol Drinking in a Sex-Dependent Manner: Impact of Amygdala Deletion and Inhibition of a Central Amygdala to Lateral Hypothalamus Circuit. | Bendrath SC et al. | β | 2025 | β |
| The sleep-anxiety dysregulation model of alcohol use disorder risk: A nine-year longitudinal machine learning study. | Zainal NH et al. | β | 2025 | β |
| Acceptability, feasibility and fidelity of the culturally adapted version of Unplugged ("Yo Se Lo Que Quiero"), a substance use preventive program among adolescents in Chile: a pilot randomized controlled study. | Salgado G et al. | β | 2024 | β |
| Acceptability, feasibility and fidelity of the culturally adapted version of Unplugged (βYo Se Lo Que Quieroβ), a substance use preventive program among adolescents in Chile: a pilot randomized controlled study | Salgado G et al. | β | 2024 | β |
| Alcohol dependence syndrome in patients with alcoholic liver disease: A cross sectional observational study. | Bharath CS et al. | β | 2024 | β |
| Alcohol, HMGB1, and Innate Immune Signaling in the Brain. | Crews FT et al. | β | 2024 | β |
| Good parent-child relationship protects against alcohol use in maltreated adolescent females carrying the <i>MAOA</i>-uVNTR susceptibility allele. | Bendre M et al. | β | 2024 | β |
| Increased white blood cellΒ in young adults with family histories of alcohol and other substance use disorders. | Mithaiwala MN et al. | β | 2024 | β |
| Multi-modal neuroimaging reveals differences in alcohol-cue reactivity but not neurometabolite concentrations in adolescents who drink alcohol. | Kirkland AE et al. | β | 2024 | β |
| Alcohol cue reactivity in the brain: Age-related differences in the role of social processes in addiction in male drinkers. | Kuhns L et al. | β | 2023 | β |
| Exploring participants' experiences of mental health and stigma in American colleges. | Dias S et al. | β | 2023 | β |
| Factors Associated with Relapses in Alcohol and Substance Use Disorder. | YazΔ±cΔ± AB et al. | β | 2023 | β |
| Immune dysregulation and pathophysiology of alcohol consumption and alcoholic liver disease. | Martinez-Castillo M et al. | β | 2023 | β |
| Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood. | Crews FT et al. | β | 2023 | β |
| The characteristics and treatment outcomes of people with very late onset of problem drinking. | Seddon J et al. | β | 2023 | β |
| The impact of age on olfactory alcohol cue-reactivity: AΒ functional magnetic resonance imaging study in adolescent and adult male drinkers. | Cousijn J et al. | β | 2023 | β |
| Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review. | Kuhns L et al. | β | 2022 | β |
| Alcohol use disorder and non-fatal suicide attempt: findings from a Swedish National Cohort Study. | Edwards AC et al. | β | 2022 | β |
| Alcohol Use Disorder: Neurobiology and Therapeutics. | Yang W et al. | β | 2022 | β |
| Association of PDYN 68-bp VNTR polymorphism with sublingual buprenorphine/naloxone treatment and with opioid or alcohol use disorder: Effect on craving, depression, anxiety and age onset of first use. | Kaya-AkyΓΌzlΓΌ D et al. | β | 2022 | β |
| Demographic factors and delay of treatment for alcohol use disorders among 6584 Danish men receiving alcohol treatment. | Christoffersen LAN et al. | β | 2022 | β |
| Early life stress and substance use disorders: The critical role of adolescent substance use. | Kirsch DE et al. | β | 2022 | β |
| Education matters: longitudinal pathways to mid-life heavy drinking in a national cohort of black Americans. | Mulia N et al. | β | 2022 | β |
| Predicting adolescent alcohol and other drug problems using electronic health records data. | Chi FW et al. | β | 2022 | β |
| Sublingual buprenorphine/naloxone treatment is not affected by OPRM1 A118G and BDNF Va66Met polymorphisms, but alters the plasma beta-endorphin and BDNF levels in individuals with opioid use disorder. | Kaya-AkyΓΌzlΓΌ D et al. | β | 2022 | β |
| The Identification With All Humanity (IWAH) scale: its psychometric properties and associations with help-seeking during COVID-19. | Feng Y et al. | β | 2022 | β |
| The Prognostic Role of DSM-5 Alcohol Use Disorder Severity and Age of Onset in Treatment Outcome Among Adults Aged 60. | Behrendt S et al. | β | 2022 | β |
| Age at onset and age at treatment of alcohol use disorders: Associations with educational level and intelligence. | Christoffersen LAN et al. | β | 2021 | β |
| Childhood maltreatment, prefrontal-paralimbic gray matter volume, and substance use in young adults and interactions with risk for bipolar disorder. | Kirsch DE et al. | β | 2021 | β |
| Lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female TH-ires-cre mice. | Burnham NW et al. | β | 2021 | β |
| Lifetime psychiatric hospital diagnoses among 8,412 Danish men registered in an outpatient alcohol clinic. | Christoffersen LAN et al. | β | 2021 | β |
| Negative affect and alcohol craving in trauma-exposed young adult drinkers. | Berenz EC et al. | β | 2021 | β |
| Three-Year Outcomes After Brief Treatment of Substance Use and Mood Symptoms. | Parthasarathy S et al. | β | 2021 | β |
| Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice with Increased Astrocyte Expression of IL-6. | Gruol DL et al. | β | 2020 | β |
| Behavioral processes and risk for problem substance use in adolescents. | Acheson A | β | 2020 | β |
| Consequences of alcohol use, and its association with psychological distress, sensitivity to emotional contagion and age of onset of alcohol use, in Uruguayan youth with or without college degree. | Ruiz P et al. | β | 2020 | β |
| Effects of high fructose corn syrup on ethanol self-administration in rats. | Ayoub SM et al. | β | 2020 | β |
| Gender differences in the effects of cannabidiol on ethanol binge drinking in mice. | Viudez-MartΓnez A et al. | β | 2020 | β |
| Onset and Severity of Early Disruptive Behavioral Disorders in Treatment-Seeking Substance Use Disorder Patients with and without Attention-Deficit/Hyperactivity Disorder. | GonzΓ‘lez RA et al. | β | 2020 | β |
| Posttraumatic stress disorder symptoms, relationship quality, and risky alcohol use among trauma-exposed students. | Paltell KC et al. | β | 2020 | β |
| Alcohol use disorder relapse factors: A systematic review. | Sliedrecht W et al. | β | 2019 | β |
| Bupropion, Alone and in Combination with Naltrexone, Blunts Binge-Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice. | Navarro M et al. | β | 2019 | β |
| Locus of control is associated with tobacco and alcohol consumption in young adults of the Avon Longitudinal Study of Parents and Children. | Lassi G et al. | β | 2019 | β |
| Psychosocial correlates in treatment seeking gamblers: Differences in early age onset gamblers vs later age onset gamblers. | Sharman S et al. | β | 2019 | β |
| Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. | Zhang H et al. | β | 2018 | β |
| Can We Predict Which Adolescents Will Engage in Outpatient Substance Abuse Treatment? | Christie GI et al. | β | 2018 | β |
| Does exposure to parental substance use disorders increase offspring risk for a substance use disorder? A longitudinal follow-up study into young adulthood. | Yule AM et al. | β | 2018 | β |
| Early Initiation of Substance Use as an Indicator of Problematic Substance Use Among Young Men Who Have Sex with Men (YMSM). | Kecojevic A et al. | β | 2018 | β |
| Life satisfaction and happiness associated with depressive symptoms among university students: a cross-sectional study in Korea. | Seo EH et al. | β | 2018 | β |
| Preparing Mexican-Origin Community Health Advocates (Promotores) to Conduct SBIRT for Problem Drinking in the Emergency Room. | Ramos R et al. | β | 2018 | β |
| Concurrent polysubstance use in a longitudinal study of US youth: associations with sexual orientation. | Kecojevic A et al. | β | 2017 | β |
| Effects on alcohol use of a Swedish school-based prevention program for early adolescents: a longitudinal study. | Beckman L et al. | β | 2017 | β |
| The relationship between initial route of heroin administration and speed of transition to daily heroin use. | Hines LA et al. | β | 2017 | β |
| Use of the 5 As for Teen Alcohol Use. | Friedman JL et al. | β | 2017 | β |
| Youth social behaviour and network therapy (Y-SBNT): adaptation of a family and social network intervention for young people who misuse alcohol and drugs - a randomised controlled feasibility trial. | Watson J et al. | β | 2017 | β |
| Brief school-based interventions and behavioural outcomes for substance-using adolescents. | Carney T et al. | β | 2016 | β |
| Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice. | Sprow GM et al. | β | 2016 | β |
| Neurobiology of addiction: a neurocircuitry analysis. | Koob GF et al. | β | 2016 | β |
| Transgenic mice with increased astrocyte expression of IL-6 show altered effects of acute ethanol on synaptic function. | Hernandez RV et al. | β | 2016 | β |
| A multilevel structural equation model of within- and between-person associations among subjective responses to alcohol, craving, and laboratory alcohol self-administration. | Wardell JD et al. | β | 2015 | β |
| A randomised controlled feasibility trial of family and social network intervention for young people who misuse alcohol and drugs: study protocol (Y-SBNT). | Watson J et al. | β | 2015 | β |
| Delay to first treatment contact for alcohol use disorder. | Chapman C et al. | β | 2015 | β |
| Examining Racial/Ethnic Disparities in the Association between Adolescent Sleep and Alcohol or Marijuana Use. | Troxel WM et al. | β | 2015 | β |
| Gender-Specific Analyses of the Prevalence and Factors Associated with Substance Use and Misuse among Bosniak Adolescents. | Zenic N et al. | β | 2015 | β |
| Impact of age at onset of cannabis use on cannabis dependence and driving under the influence in the United States. | Le Strat Y et al. | β | 2015 | β |
| Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. | Salvatore JE et al. | β | 2015 | β |
| Prevalence and correlates of substance use among trans female youth ages 16-24 years in the San Francisco Bay Area. | Rowe C et al. | β | 2015 | β |
| The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. | Hines LA et al. | β | 2015 | β |
| The National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) Waves 1 and 2: review and summary of findings. | Hasin DS et al. | β | 2015 | β |
| Age of first drinking and adult alcohol problems: systematic review of prospective cohort studies. | Maimaris W et al. | β | 2014 | β |
| Age of pathological gambling onset: clinical and treatment-related features. | Shin YC et al. | β | 2014 | β |
| Association of gene polymorphisms encoding dopaminergic system components and platelet MAO-B activity with alcohol dependence and alcohol dependence-related phenotypes. | Nedic Erjavec G et al. | β | 2014 | β |
| Binge alcohol consumption in emerging adults: anterior cingulate cortical "thinness" is associated with alcohol use patterns. | Mashhoon Y et al. | β | 2014 | β |
| Early adolescent patterns of alcohol, cigarettes, and marijuana polysubstance use and young adult substance use outcomes in a nationally representative sample. | Moss HB et al. | β | 2014 | β |
| How do we 'learn' addiction? Risk factors and mechanisms getting addicted to alcohol. | HΓ€gele C et al. | β | 2014 | β |
| Influence of adolescent heavy session drinking on the systemic and brain innate immune system. | Ward RJ et al. | β | 2014 | β |
| Romantic relationship status and alcohol use and problems across the first year of college. | Salvatore JE et al. | β | 2014 | β |
| The contribution of emotional maltreatment to alcohol dependence in a treatment-seeking sample. | Potthast N et al. | β | 2014 | β |
| Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens. | Alaux-Cantin S et al. | β | 2013 | β |
| Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. | Sparta DR et al. | β | 2013 | β |
| Characteristics of developmentally early alcohol use disorder symptom reports: a prospective-longitudinal community study. | Behrendt S et al. | β | 2013 | β |
| Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. | Chorlian DB et al. | β | 2013 | β |
| Quick screen to detect current substance use disorder in adolescents and the likelihood of future disorder. | Kirisci L et al. | β | 2013 | β |
| Testing the Conjoint Influence of Impulsivity and Drinking Restraint on Alcohol Use Consequences in College Student Drinkers. | Mitchell JN et al. | β | 2013 | β |
| The effects of employment among adolescents at-risk for future substance use. | Osilla KC et al. | β | 2013 | β |
| Usefulness of a survey on underage drinking in a rural American Indian community health clinic. | Gilder DA et al. | β | 2013 | β |
| Adolescent brain development and underage drinking in the United States: identifying risks of alcohol use in college populations. | Silveri MM | β | 2012 | β |
| Binge drinking trajectories from adolescence to young adulthood: the effects of peer social network. | Hahm HC et al. | β | 2012 | β |
| Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. | Sparrow AM et al. | β | 2012 | β |
| Early attentional modulation by alcohol-related cues in young binge drinkers: an event-related potentials study. | Petit G et al. | β | 2012 | β |
| Is alcohol dependence best viewed as a chronic relapsing disorder? | Cunningham JA et al. | β | 2012 | β |
| Substance abuse prevalence and its relation to scholastic achievement and sport factors: an analysis among adolescents of the Herzegovina-Neretva Canton in Bosnia and Herzegovina. | Sekulic D et al. | β | 2012 | β |
| The neurobiology of binge-like ethanol drinking: evidence from rodent models. | Sprow GM et al. | β | 2012 | β |
| The relationship between age of gambling onset and adolescent problematic gambling severity. | Rahman AS et al. | β | 2012 | β |
| Alcohol problems in young adults transitioning from adolescence to adulthood: The association with race and gender. | Chartier KG et al. | β | 2011 | β |
| Efficacy of a web-based, tailored, alcohol prevention/intervention program for college students: 3-month follow-up. | Bingham CR et al. | β | 2011 | β |
| Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism. | Kimura M et al. | β | 2011 | β |
| Hospitalizations for alcohol and drug overdoses in young adults ages 18-24 in the United States, 1999-2008: results from the Nationwide Inpatient Sample. | White AM et al. | β | 2011 | β |
| Past year treatment status and alcohol abuse symptoms among US adults with alcohol dependence. | Kuramoto SJ et al. | β | 2011 | β |
| The epidemiology of DSM-IV alcohol use disorders amongst young adults in the Australian population. | Mewton L et al. | β | 2011 | β |
| The role of mental disorders in the risk and speed of transition to alcohol use disorders among community youth. | Behrendt S et al. | β | 2011 | β |
| Age of drinking onset as a moderator of the efficacy of parent-based, brief motivational, and combined intervention approaches to reduce drinking and consequences among college students. | Mallett KA et al. | β | 2010 | β |
| A new definition of early age at onset in alcohol dependence. | Le Strat Y et al. | β | 2010 | β |
| Consilient research approaches in studying gene x environment interactions in alcohol research. | Sher KJ et al. | β | 2010 | β |
| Developing a Group Motivational Interviewing Intervention for Adolescents At-Risk for Developing an Alcohol or Drug use Disorder. | D'Amico EJ et al. | β | 2010 | β |
| Mental health problems and help-seeking behavior among college students. | Hunt J et al. | β | 2010 | β |
| Late-onset pathological gambling: clinical correlates and gender differences. | Grant JE et al. | β | 2009 | β |
| Personality disorders in alcohol-dependent individuals: relationship with alcohol dependence severity. | Preuss UW et al. | β | 2009 | β |
| Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. | Roopesh BN et al. | β | 2009 | β |
| Sleep and substance use and abuse in adolescents. | Gromov I et al. | β | 2009 | β |
| A technological approach to reaching a hidden population of problem drinkers. | Lieberman DZ et al. | β | 2008 | β |
| DSM-IV criteria endorsement patterns in alcohol dependence: relationship to severity. | Moss HB et al. | β | 2008 | β |
| Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. | Ji D et al. | β | 2008 | β |
| Mental health of college students and their non-college-attending peers: results from the National Epidemiologic Study on Alcohol and Related Conditions. | Blanco C et al. | β | 2008 | β |
| Risk and speed of transitions to first alcohol dependence symptoms in adolescents: a 10-year longitudinal community study in Germany. | Behrendt S et al. | β | 2008 | β |
| Screening, brief intervention, and referral to treatment for adolescents. | Levy S et al. | β | 2008 | β |
| Childhood-onset pathologic skin picking: clinical characteristics and psychiatric comorbidity. | Odlaug BL et al. | β | 2007 | β |