Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task.

paper Primary Public

Authors: Roopesh, Bangalore N; Rangaswamy, Madhavi; Kamarajan, Chella; Chorlian, David B; Stimus, Arthur; Bauer, Lance O; Rohrbaugh, John; O'Connor, Sean J; Kuperman, Samuel; Schuckit, Marc; Porjesz, Bernice
Year: 2009
Journal: Alcoholism, clinical and experimental research
PMID: 19764939
DOI: 10.1111/j.1530-0277.2009.01042.x
PMCID: PMC3601897

#	Section	Preview
0	1. Introduction	N4(00) is a negative component of the event related potential (ERP), occurring predominantly over…
1	1. Introduction	their context (Kutas and Federmeier, 2000). Some of these factors are semantic congruity, antonyms,…
2	1. Introduction	whether the stimulus presented is a word or a non-word. Within this framework, the semantic priming…
3	1. Introduction	the word ‘office’. Recently it has been shown that the N4 amplitude reduction observed to a…
4	1. Introduction	There are different theories regarding what the N4 in a priming paradigm reflects. The often quoted…
5	1. Introduction	This mechanism is said to be influenced by the instructions and the proportions of prime-target…
6	1. Introduction	Nevertheless, compared to the earlier findings, more recent work has shown that semantic matching…
7	1. Introduction	Alcohol dependence has been shown to adversely affect numerous cognitive functions, including…
8	1. Introduction	N4 abnormalities in semantic priming tasks have been observed in alcoholics. For example, Ceballos…
9	1. Introduction — Risk for alcoholism and cognitive functions	Alcoholism is a complex disorder attributed to the interaction of genetic and environmental factors.…
10	1. Introduction — Risk for alcoholism and cognitive functions	Risk status has been associated with deficits in cognitive functioning as revealed by…
11	1. Introduction — Risk for alcoholism and cognitive functions	FHN male offspring in a letter rhyming task (Schmidt and Neville, 1985). These studies indicate that…
12	1. Introduction — Risk for alcoholism and cognitive functions	Hence, as previous work from our laboratory has demonstrated a lack of differentiation in N4…
13	2. Materials and methods — 2.1. Subjects	Subjects were selected from the ongoing Collaborative Study on the Genetics of Alcoholism (COGA), a…
14	2. Materials and methods — 2.1. Subjects	Twenty-three high risk (HR) male offspring from the alcoholic families in COGA (Collaborative Study…
15	2. Materials and methods — 2.1. Subjects	Fetal Alcohol Syndrome or fetal alcohol effects), but who could have additional first degree…
16	2. Materials and methods — 2.1. Subjects	For the ERP protocol, subjects with hepatic encephalopathy/cirrhosis of the liver, multiple…
17	2. Materials and methods — 2.1. Subjects	Each center obtained separate Institutional Review Board approval for the COGA research and written…
18	2. Materials and methods — 2.2. Data recording	All six sites used the identical experimental paradigm and electrophysiological software and…
19	2. Materials and methods — 2.2. Data recording	at 10,000 times on Sensorium EPA-2 Electrophysiology amplifiers (Charlotte, VT), with a high pass…

Citation	PMID	DOI	Status
Almasy, L et al., Am J Hum Genet, 2001, Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism	11102287	10.1086/316936	Primary
Almasy, L et al., Am J Med Genet, 1999, Heritability of event-related brain potentials in families with a history of alcoholism	10402506	—	Primary
Begleiter, H et al., Alcohol Clin Exp Res, 1999, What is inherited in the predisposition toward alcoholism? A proposed model	10443977	10.1111/j.1530-0277.1999.tb04269.x	Primary
Begleiter, H et al., Alcohol Health Res World, 1995, The collaborative study on the genetics of alcoholism	31798102	—	Primary
Begleiter, H et al., Science, 1984, Event-related brain potentials in boys at risk for alcoholism	6474187	10.1126/science.6474187	Cited
Bentin, S et al., Psychophysiology, 1993, Electrophysiological evidence for task effects on semantic priming in auditory word processing	8434079	10.1111/j.1469-8986.1993.tb01729.x	Cited
Bentin, S, Lang Speech, 1989, Electrophysiological studies of visual word perception, lexical organization, and semantic processing: a tutorial review	2701178	10.1177/002383098903200302	Cited
Brown, C et al., J Cogn Neurosci, 1993, The processing nature of the N400: evidence from masked priming	23972118	10.1162/jocn.1993.5.1.34	Cited
Bucholz, KK et al., J Stud Alcohol, 1994, A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA	8189735	10.15288/jsa.1994.55.149	Primary
Ceballos, NA et al., Prog Neuropsychopharmacol Biol Psychiatry, 2005, N400 as an index of semantic expectancies: differential effects of alcohol and cocaine dependence	15967560	10.1016/j.pnpbp.2005.04.036	Primary
Chwilla, DJ et al., The Quarterly Journal of Experimental Psychology, 1998, The mechanism underlying backward priming in a lexical decision task: Spreading activation versus semantic matching	—	—	—
Cohen, HL et al., Alcohol Clin Exp Res, 1997, Neurophysiological correlates of response production and inhibition in alcoholics	9394110	—	Cited
Collins, AM et al., Psychol Rev, 1975, A spreading-activation theory of semantic processing	—	—	—
Cotton, NS, J Stud Alcohol, 1979, The familial incidence of alcoholism: a review	376949	10.15288/jsa.1979.40.89	Cited
Cuijpers, P et al., Addiction, 1999, Psychiatric disorders in adult children of problem drinkers: prevalence, first onset and comparison with other risk factors	10790901	10.1046/j.1360-0443.1999.941014895.x	Cited
Curran, T et al., Electroencephalogr Clin Neurophysiol, 1993, Topography of the N400: brain electrical activity reflecting semantic expectancy	7684968	10.1016/0168-5597(93)90004-9	Cited
De Groot, AMB et al., Acta Psychologica, 1986, Primed lexical decision: The effect of varying the stimulus-onset asynchrony of prime and target	—	—	—
Deacon, D et al., Brain Res Cogn Brain Res, 1999, The lifetime of automatic semantic priming effects may exceed two seconds	10076091	10.1016/s0926-6410(98)00034-2	Cited
Deacon, D et al., Brain Res Cogn Brain Res, 2000, Event-related potential indices of semantic priming using masked and unmasked words: evidence that the N400 does not reflect a post-lexical process	10729697	10.1016/s0926-6410(99)00050-6	Cited
Deacon, D et al., Cortex, 2004, Evidence for a new conceptualization of semantic representation in the left and right cerebral hemispheres	15259327	10.1016/s0010-9452(08)70140-0	Cited
den Heyer, K et al., Mem Cognit, 1983, Strategic factors in a lexical-decision task: evidence for automatic and attention-driven processes	6633256	10.3758/bf03202452	Cited
Drejer, K et al., Alcohol Clin Exp Res, 1985, A prospective study of young men at high risk for alcoholism: neuropsychological assessment	3911808	10.1111/j.1530-0277.1985.tb05590.x	Cited
Fein, G et al., Alcohol Clin Exp Res, 2006, Visual P300s in long-term abstinent chronic alcoholics	17117965	10.1111/j.1530-0277.2006.00246.x	Cited
Fischler, I et al., Psychophysiology, 1983, Brain potentials related to stages of sentence verification	6356204	10.1111/j.1469-8986.1983.tb00920.x	Cited
Forbes, CT, Graded and Classified Spelling Lists for Teachers Grades 2–8, 1968	—	—	—
Franklin, MS et al., Clin Neurophysiol, 2007, Semantic priming modulates the N400, N300, and N400RP	17336145	10.1016/j.clinph.2007.01.012	Cited
Frederick, JA et al., Current Psychiatry Reports, 2006, Beyond the DSM: Defining endophenotypes for genetic studies of substance abuse	16539892	10.1007/s11920-006-0014-2	Cited
Ganis, G et al., J Cogn Neurosci, 1996, The search for "common sense": an electrophysiological study of the comprehension of words and pictures in reading	23971417	10.1162/jocn.1996.8.2.89	Cited
Goodwin, DS, Arch Gen Psychiatry, 1979, Alcoholism and heredity: A review and hypothesis	367310	10.1001/archpsyc.1979.01780010063006	Cited
Grant, BF et al., J Subst Abuse, 1997, Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey	9494942	10.1016/s0899-3289(97)90009-2	Cited
Grant, BF, Alcohol Health Res World, 1998, The impact of a family history of alcoholism on the relationship between age at onset of alcohol use and DSM-IV alcohol dependence: results from the National Longitudinal Alcohol Epidemiologic Survey	15706789	—	Cited
Grillon, C et al., Biol Psychiatry, 1991, N400 and semantic categorization in schizophrenia	2018820	10.1016/0006-3223(91)90269-r	Cited
Gunter, TC et al., Psychophysiology, 1999, Concerning the automaticity of syntactic processing	10098388	10.1017/s004857729997155x	Cited
Hamberger, MJ et al., Brain Lang, 1995, Event-related potential and behavioral correlates of semantic processing in Alzheimer's patients and normal controls	7712148	10.1006/brln.1995.1002	Cited
Heath, AC et al., Psychol. Med, 1997, Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men	9403910	10.1017/s0033291797005643	Cited
Hegedus, AM et al., Alcohol Clin Exp Res, 1984, Learning achievement in sons of alcoholics	6377954	10.1111/j.1530-0277.1984.tb05522.x	Cited
Hesselbrock, M et al., Addiction, 1999, A validity study of the SSAGA--a comparison with the SCAN	10615721	10.1046/j.1360-0443.1999.94913618.x	Primary
Hill, H et al., Int J Psychophysiol, 2002, Automatic vs. controlled processes in semantic priming--differentiation by event-related potentials	12031295	10.1016/s0167-8760(01)00202-1	Cited
Hines, LM et al., Dialogues Clin Neurosci, 2005, Alcoholism: the dissection for endophenotypes	16262210	10.31887/DCNS.2005.7.2/lhines	Cited
Hingson, RW et al., Pediatrics, 2006, Age of alcohol-dependence onset: associations with severity of dependence and seeking treatment	16950966	10.1542/peds.2006-0223	Cited
Holcomb, PJ, Psychophysiology, 1993, Semantic priming and stimulus degradation: implications for the role of the N400 in language processing	8416062	10.1111/j.1469-8986.1993.tb03204.x	Cited
Jasper, HH, EEG Journal, 1958, The ten twenty electrode system of the international federation	10590970	—	Cited
Ji, J et al., Biol Psychiatry, 1999, Event-related potential index of semantic mnemonic dysfunction in abstinent alcoholics	10071724	10.1016/s0006-3223(98)00062-6	Cited
Kamarajan, C et al., Biol Psychol, 2005, Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task	15925035	10.1016/j.biopsycho.2004.08.004	Primary
Kiefer, M et al., Neuroreport, 2000, Time course of conscious and unconscious semantic brain activation	10943693	10.1097/00001756-200008030-00013	Cited
Kiefer, M, Cognitive Brain Research, 2002, The N400 is modulated by unconsciously perceived masked words: further evidence for an automatic spreading activation account of N400 priming effects	11867248	10.1016/s0926-6410(01)00085-4	Cited
Koivisto, M, Neuropsychologia, 1998, Categorical priming in the cerebral hemispheres: automatic in the left hemisphere, postlexical in the right hemisphere?	9723937	10.1016/s0028-3932(97)00147-4	Cited
Kucera et al., Computational Analysis of Present-Day American English, 1967	—	—	—
Kuehn, BM, Journal of the American Medical Association, 2006, Protective factors may prevent alcoholism	17047205	10.1001/jama.296.15.1828	Cited
Kuperman, S et al., Electroencephalogr Clin Neurophysiol, 1995, Multi-center N400 ERP consistency using a primed and unprimed word paradigm	7607100	10.1016/0013-4694(94)00312-9	Primary
Kutas, M et al., Advances in psychophysiology, 1988, Event-related potential studies of language	—	—	—
Kutas, M et al., Journal of Cognitive Neuroscience, 1989, An electrophysiological probe of incidental semantic association	23968409	10.1162/jocn.1989.1.1.38	Cited
Kutas, M et al., Nature, 1984, Brain potentials during reading reflect word expectancy and semantic association	6690995	10.1038/307161a0	Cited
Kutas, M et al., Neuropsychologia, 1982, The lateral distribution of event-related potentials during sentence processing	7145083	10.1016/0028-3932(82)90031-8	Cited
Kutas, M et al., Preparatory states and processes, 1984, Word expectancy and event-related brain potentials during sentence processing	—	—	—
Kutas, M et al., Science, 1980, Reading senseless sentences: brain potentials reflect semantic incongruity	7350657	10.1126/science.7350657	Cited
Kutas, M et al., Trends Cogn Sci, 2000, Electrophysiology reveals semantic memory use in language comprehension	11115760	10.1016/s1364-6613(00)01560-6	Cited
Liu, IC et al., Addiction, Genetic and environmental contributions to age of onset of alcohol dependence symptoms in male twins	15500593	10.1111/j.1360-0443.2004.00877.x	Cited
Liu, IC et al., Arch Gen Psychiatry, Genetic and environmental contributions to the development of alcohol dependence in male twins	15351768	10.1001/archpsyc.61.9.897	Cited
Maylor, EA et al., Br J Psychol, 1987, Effects of alcohol on word categorization and recognition memory	3594092	10.1111/j.2044-8295.1987.tb02242.x	Cited
McCarthy, G et al., Electroencephalogr Clin Neurophysiol, 1993, Modulation of semantic processing by spatial selective attention	7684969	10.1016/0168-5597(93)90005-a	Cited
McNamara, T et al., Journal of Memory and Language, 1988, Depth of spreading activation revisited: Semantic mediated priming occurs in lexical decisions	—	—	—
Meyer, DE et al., J Exp Psychol, 1971, Facilitation in recognizing pairs of words: evidence of a dependence between retrieval operations	5134329	10.1037/h0031564	Cited
Neely, JH et al., The Psychology of Learning and Motivation: Advances in Research and Theory, 1989, Semantic context effects on visual word processing: A hybrid prospective-retrospective processing theory	—	—	—
Neely, JH, Semantic priming effects in visual word recognition: A selective review of current findings and theories, 1991	—	—	—
Nixon, SJ et al., Prog Neuropsychopharmacol Biol Psychiatry, 2002, Neurophysiological efficiency in male and female alcoholics	12369267	10.1016/s0278-5846(02)00206-3	Cited
O'Connor, S et al., Electroencephalogr Clin Neurophysiol, 1994, Heritable features of the auditory oddball event-related potential: peaks, latencies, morphology and topography	7511509	10.1016/0168-5597(94)90052-3	Cited
Osterhout, L et al., Electrophysiology of Mind: Event-Related Brain Potentials and Cognition, 1995, Event-related potentials and language comprehension	—	—	—
Pfefferbaum, A et al., Alcohol Clin Exp Res, 1991, Event-related potentials in alcoholic men: P3 amplitude reflects family history but not alcohol consumption	1755518	10.1111/j.1530-0277.1991.tb00611.x	Cited
Polich, J et al., Psychol Bull, 1994, Meta-analysis of P300 amplitude from males at risk for alcoholism	8310100	10.1037/0033-2909.115.1.55	Cited
Porjesz, B et al., Alcohol and alcoholism, 1996, Effects of alcohol on electrophysiological activity of the brain	—	—	—
Porjesz, B et al., Alcohol and the Brain, 1985, Human brain electrophysiology and alcoholism	—	—	—
Porjesz, B et al., Alcohol Clin Exp Res, 1998, Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA Project. Collaborative Study on the Genetics of Alcoholism	9756048	—	Primary
Porjesz, B et al., Alcohol Res Health, 2003, Alcoholism and human electrophysiology	15303626	—	Primary
Porjesz, B et al., Alcohol, 1990, Event-related potentials in individuals at risk for alcoholism	2222850	10.1016/0741-8329(90)90033-9	Cited
Porjesz, B et al., Biol Psychol, 2002, Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes	12385677	10.1016/s0301-0511(02)00060-1	Primary
Porjesz, B et al., Clin Neurophysiol, 2005, The utility of neurophysiological markers in the study of alcoholism	15826840	10.1016/j.clinph.2004.12.016	Primary
Porjesz, B et al., Electroencephalogr Clin Neurophysiol, 1987, The N2 component of the event-related brain potential in abstinent alcoholics	2431876	10.1016/0013-4694(87)90181-7	Cited
Porjesz, B et al., Neuropsychology of alcoholism. Implications for diagnosis and treatment, 1987, Evoked brain potentials and alcoholism	—	—	—
Prabhu, VR et al., Alcohol Clin Exp Res, 2001, Visual p3 in female alcoholics	11329493	—	Primary
Prescott, CA et al., Alcohol Clin Exp Res, 1999, Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins	10443978	10.1111/j.1530-0277.1999.tb04270.x	Cited
Prescott, CA et al., Am J Psychiatry, 1999, Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins	9892295	10.1176/ajp.156.1.34	Cited
Ramachandran, G et al., Alcohol Clin Exp Res, 1996, A simple auditory oddball task in young adult males at high risk for alcoholism	8651469	10.1111/j.1530-0277.1996.tb01035.x	Cited
Realmuto, G et al., Biol Psychiatry, 1993, Event-related potential evidence of dysfunction in automatic processing in abstinent alcoholics	8329490	10.1016/0006-3223(93)90097-w	Cited
Sayette, MA et al., Exp Clin Psychopharmacol, 2001, Parental alcoholism and the effects of alcohol on mediated semantic priming	11764017	—	Cited
Schmidt, AL et al., Alcohol, 1985, Language processing in men at risk for alcoholism: an event-related potential study	4026975	10.1016/0741-8329(85)90129-6	Cited
Schuckit, MA, Am J Addict, 2000, Genetics of the risk for alcoholism	10934572	10.1080/10550490050173172	Cited
Sher, KJ et al., J Abnorm Psychol, 1991, Characteristics of children of alcoholics: putative risk factors, substance use and abuse, and psychopathology	1757657	10.1037//0021-843x.100.4.427	Cited
Sigvardsson, S et al., Arch Gen Psychiatry, 1996, Replication of the Stockholm Adoption Study of alcoholism. Confirmatory cross-fostering analysis	8694681	10.1001/archpsyc.1996.01830080033007	Cited
Silva-Pereyra, J et al., Clin Neurophysiol, 1999, N400 and lexical decisions: automatic or controlled processing?	10400194	10.1016/s1388-2457(99)00009-7	Cited
Tarter, RE et al., Alcohol Clin Exp Res, 1984, Adolescent sons of alcoholics: neuropsychological and personality characteristics	6375434	10.1111/j.1530-0277.1984.tb05842.x	Cited
Taylor, WL, Journalism Quarterly, 1953, 'Cloze procedure': a new tool for measuring readability	—	—	—
Toglia, MP et al., Handbook of Semantic Word Norms, 1978	—	—	—
Volkow, ND et al., Arch Gen Psychiatry, 2006, High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors	16953002	10.1001/archpsyc.63.9.999	Primary
Williams, HL et al., J Stud Alcohol, 1984, Effect of alcohol on recall and recognition as functions of processing levels	6700218	10.15288/jsa.1984.45.10	Cited

In this knowledge base

Title	Year	PMID
Advances in Electrophysiological Research.	2015	26259089
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	2015	26236574
Understanding alcohol use disorders with neuroelectrophysiology.	2014	25307587
Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm.	2010	20659074

External

Title	Authors	Journal	Year	Link
The collaborative study on the genetics of alcoholism: Brain function.	Meyers JL et al.	—	2023	→
Biomarkers and neuromodulation techniques in substance use disorders.	Habelt B et al.	—	2020	→
Predictors of chronicity in alcohol use disorder: an evoked response potential study.	Mishra P et al.	—	2020	→
Uncensored EEG: The role of DC potentials in neurobiology of the brain.	Kovac S et al.	—	2018	→
Advances in Electrophysiological Research.	Kamarajan C et al.	—	2015	→
Endophenotypes for Alcohol Use Disorder: An Update on the Field.	Salvatore JE et al.	—	2015	→
Event-related potentials in substance use disorders: a narrative review based on articles from 1984 to 2012.	Campanella S et al.	—	2014	→
Spatio-temporal processing of words and nonwords: hemispheric laterality and acute alcohol intoxication.	Marinkovic K et al.	—	2014	→
Understanding alcohol use disorders with neuroelectrophysiology.	Rangaswamy M et al.	—	2014	→
Event-Related Theta Power during Lexical-Semantic Retrieval and Decision Conflict is Modulated by Alcohol Intoxication: Anatomically Constrained MEG.	Marinkovic K et al.	—	2012	→
N4 component responses to pre-pulse startle stimuli in young adults: relationship to alcohol dependence.	Ehlers CL et al.	—	2011	→
System identification to characterize human use of ethanol based on generative point-process models of video games with ethanol rewards.	Ozil I et al.	—	2011	→
Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm.	Roopesh BN et al.	—	2010	→