Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins.
paper
Cited
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- Authors
- Prescott, C A; Aggen, S H; Kendler, K S
- Year
- 1999
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 10443978
- DOI
- 10.1111/j.1530-0277.1999.tb04270.x
BACKGROUND: There are substantial sex differences in all levels of alcohol involvement among U.S. adults. The goal of this study was to test whether the magnitude and sources of genetic and environmental influences on liability for alcohol abuse and dependence differ for men and women. METHODS: Structured personal interviews were used to assess DSM-III-R- and DSM-IV-defined alcohol abuse and dependence among 5091 male and 4168 female twins (including 1546 identical, 1128 same-sex fraternal, and 1423 opposite-sex pairs) born in Virginia between 1934 and 1974. Twin correlations were analyzed using structural equation modeling. RESULTS: The magnitude of twin-pair resemblance was similar across several definitions of alcoholism and was substantially higher among identical than fraternal pairs. The proportion of population variation in liability attributed to genetic factors was substantial among both women (55-66%) and men (51-56%), and we found little evidence of a role of environmental factors shared by family members. In all definitions studied, we could reject a model that the genetic sources of liability in the two sexes overlap completely. CONCLUSION: In this first population-based study of alcoholism among male and female twins from the U.S., we found that genetic factors play a major role in the development of alcoholism in both sexes, that the magnitudes of genetic influence were equally high for men and women, and that the genetic sources of vulnerability are partially, but not completely, overlapping in men and women.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| FYN Tyrosine Kinase Gene Polymorphisms in Alcohol-Dependent Korean Patients. | Huh SY et al. | β | 2025 | β |
| Genetic and environmental influences on alcohol consumption in middle to late life. | Gustavson DE et al. | β | 2025 | β |
| Weighted Family History Density of Substance Use: Influence on Participant Substance Use Onset, Duration, and Escalation. | Litteral CA et al. | β | 2025 | β |
| Sweet liking predicts liking and familiarity of some alcoholic beverages, but not alcohol intake: A population study using a split-sample approach. | Spinelli S et al. | β | 2024 | β |
| Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach. | Gentry AE et al. | β | 2023 | β |
| Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach | Gentry AE et al. | β | 2022 | β |
| Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals. | Hartwell EE et al. | β | 2022 | β |
| Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder. | Hitzemann R et al. | β | 2022 | β |
| Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of collaborative cross mouse strains and their inbred founders. | Bagley JR et al. | β | 2021 | β |
| Using the tools of genetic epidemiology to understand sex differences in neuropsychiatric disorders. | Merikangas AK et al. | β | 2020 | β |
| Altered brain cortical maturation is found in adolescents with a family history of alcoholism. | Holla B et al. | β | 2019 | β |
| Genetic Epidemiology of Liability for Alcohol-Induced Blacking and Passing Out. | Davis CN et al. | β | 2019 | β |
| Amphetamine primes enhanced motivation toward uncertain choices in rats with genetic alcohol preference. | Oinio V et al. | β | 2018 | β |
| Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction. | Reginsson GW et al. | β | 2018 | β |
| The role of parent and offspring sex on risk for externalizing psychopathology in offspring with parental alcohol use disorder: a national Swedish study. | Long EC et al. | β | 2018 | β |
| Transmission of alcohol use disorder across three generations: a Swedish National Study. | Kendler KS et al. | β | 2018 | β |
| Developmental Etiologies of Alcohol Use and Their Relations to Parent and Peer Influences Over Adolescence and Young Adulthood: A Genetically Informed Approach. | Deutsch AR et al. | β | 2017 | β |
| Familial association of abstinent remission from alcohol use disorder in first-degree relatives of alcohol-dependent treatment-seeking probands. | McCutcheon VV et al. | β | 2017 | β |
| Genes, Environments, and Sex Differences in Alcohol Research. | Salvatore JE et al. | β | 2017 | β |
| The association between personality disorders with alcohol use and misuse: A population-based twin study. | Long EC et al. | β | 2017 | β |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | β | 2017 | β |
| A National Swedish Twin-Sibling Study of Alcohol Use Disorders. | Kendler KS et al. | β | 2016 | β |
| Overview of the Genetics of Alcohol Use Disorder. | Tawa EA et al. | β | 2016 | β |
| ACN9 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. | Hill SY et al. | β | 2015 | β |
| Alcohol preferring (P) rats as a model for examining sex differences in alcohol use disorder and its treatment. | Moore CF et al. | β | 2015 | β |
| Commentary: sex differences in the pathways to symptoms of alcohol use disorder: a study of opposite-sex twin pairs. | Kapoor M et al. | β | 2015 | β |
| Sex differences in the effects of adolescent social deprivation on alcohol consumption in ΞΌ-opioid receptor knockout mice. | Moriya Y et al. | β | 2015 | β |
| The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores. | Mbarek H et al. | β | 2015 | β |
| The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. | Suchankova P et al. | β | 2015 | β |
| The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies. | Verhulst B et al. | β | 2015 | β |
| Early age of alcohol initiation is not the cause of alcohol use disorders in adulthood, but is a major indicator of genetic risk. A population-based twin study. | Ystrom E et al. | β | 2014 | β |
| Genetic and environmental factors underlying comorbid bulimic behaviours and alcohol use disorders: a moderating role for the dysregulated personality cluster? | Slane JD et al. | β | 2014 | β |
| Genetic and environmental influences on the ages of drinking and gambling initiation: evidence for distinct aetiologies and sex differences. | Richmond-Rakerd LS et al. | β | 2014 | β |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | β | 2014 | β |
| Assessment of a modified DSM-5 diagnosis of alcohol use disorder in a genetically informative population. | Edwards AC et al. | β | 2013 | β |
| Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families. | Hill SY et al. | β | 2013 | β |
| Neural correlates of impulsivity in healthy males and females with family histories of alcoholism. | DeVito EE et al. | β | 2013 | β |
| ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. | Hill SY et al. | β | 2012 | β |
| Bulimic behaviors and alcohol use: shared genetic influences. | Slane JD et al. | β | 2012 | β |
| Environmental influences predominate in remission from alcohol use disorder in young adult twins. | McCutcheon VV et al. | β | 2012 | β |
| Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence. | Kendler KS et al. | β | 2012 | β |
| Global DNA promoter methylation in frontal cortex of alcoholics and controls. | Manzardo AM et al. | β | 2012 | β |
| Twin study of the relationship between adolescent attention-deficit/hyperactivity disorder and adult alcohol dependence. | Edwards AC et al. | β | 2012 | β |
| Two-part random effects growth modeling to identify risks associated with alcohol and cannabis initiation, initial average use and changes in drug consumption in a sample of adult, male twins. | Gillespie NA et al. | β | 2012 | β |
| A candidate gene association study of alcohol consumption in young women. | Agrawal A et al. | β | 2011 | β |
| Alcohol dependence in men: reliability and heritability. | Ystrom E et al. | β | 2011 | β |
| ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students. | Luczak SE et al. | β | 2011 | β |
| Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women. | Sartor CE et al. | β | 2011 | β |
| Disordered gambling as defined by the Diagnostic and Statistical Manual of Mental Disorders and the South Oaks Gambling Screen: evidence for a common etiologic structure. | Slutske WS et al. | β | 2011 | β |
| Genetic liability to disability pension in women and men: a prospective population-based twin study. | Narusyte J et al. | β | 2011 | β |
| Heritability of serum osteoprotegerin. | Kwan JS et al. | β | 2011 | β |
| Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence. | Kertes DA et al. | β | 2011 | β |
| Sex differences in the genetic and environmental influences on childhood conduct disorder and adult antisocial behavior. | Meier MH et al. | β | 2011 | β |
| The Serotonin Transporter Polymorphism (5-HTTLPR) and Alcohol Problems in Heavy Drinkers: Moderation by Depressive Symptoms. | Tartter MA et al. | β | 2011 | β |
| Variation in the ADH1B proximal promoter affects expression. | Pochareddy S et al. | β | 2011 | β |
| Addictions and their familiality in Iceland. | Tyrfingsson T et al. | β | 2010 | β |
| Age at regular drinking, clinical course, and heritability of alcohol dependence in the San Francisco family study: a gender analysis. | Ehlers CL et al. | β | 2010 | β |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | β | 2010 | β |
| Early onset alcohol dependence with high density of family history is not "male limited". | Magnusson A et al. | β | 2010 | β |
| Eating disorder symptomatology and substance use disorders: prevalence and shared risk in a population based twin sample. | Baker JH et al. | β | 2010 | β |
| Nature and nurture in neuropsychiatric genetics: where do we stand? | Dick DM et al. | β | 2010 | β |
| Neural plasticity, human genetics, and risk for alcohol dependence. | Hill SY | β | 2010 | β |
| [Neurobiology and genetics of addiction]. | Kiefer F | β | 2010 | β |
| The 10 most important things known about addiction. | Sellman D | β | 2010 | β |
| The relationship between genetic influences on alcohol dependence and on patterns of alcohol consumption. | Kendler KS et al. | β | 2010 | β |
| Using expression genetics to study the neurobiology of ethanol and alcoholism. | Farris SP et al. | β | 2010 | β |
| An assay for evoked locomotor behavior in Drosophila reveals a role for integrins in ethanol sensitivity and rapid ethanol tolerance. | Bhandari P et al. | β | 2009 | β |
| Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms. | Agrawal A et al. | β | 2009 | β |
| Gender differences in factors influencing alcohol use and drinking progression among adolescents. | Schulte MT et al. | β | 2009 | β |
| Gender effect on association between DRD2 polymorphism and substance dependence in a Spanish sample. | LΓ³pez-CastromΓ‘n J et al. | β | 2009 | β |
| [Genetic factors of alcohol-dependence]. | Pinto E et al. | β | 2009 | β |
| Mental health in a gendered context: Gendered community effect on depression and problem drinking. | van Praag L et al. | β | 2009 | β |
| Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. | Roopesh BN et al. | β | 2009 | β |
| The TaqI A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease? | Pinto E et al. | β | 2009 | β |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | β | 2009 | β |
| Disentangling the complex association between childhood sexual abuse and alcohol-related problems: a review of methodological issues and approaches. | Sartor CE et al. | β | 2008 | β |
| Evidence for a closing gender gap in alcohol use, abuse, and dependence in the United States population. | Keyes KM et al. | β | 2008 | β |
| Genetic and environmental influences on the rate of progression to alcohol dependence in young women. | Sartor CE et al. | β | 2008 | β |
| Searching for an environmental effect of parental alcoholism on offspring alcohol use disorder: a genetically informed study of children of alcoholics. | Slutske WS et al. | β | 2008 | β |
| The development of children's intentions to use alcohol: direct and indirect effects of parent alcohol use and parenting behaviors. | Tildesley EA et al. | β | 2008 | β |
| The performance of elements of a 'level of response to alcohol'-based model of drinking behaviors in 13-year-olds. | Schuckit MA et al. | β | 2008 | β |
| The short allele of the serotonin transporter promoter polymorphism influences relapse in alcohol dependence. | Pinto E et al. | β | 2008 | β |
| Association between broadly defined bulimia nervosa and drug use disorders: common genetic and environmental influences. | Baker JH et al. | β | 2007 | β |
| Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults. | Haberstick BC et al. | β | 2007 | β |
| Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism. | Connor JP et al. | β | 2007 | β |
| How gene-stress-behavior interactions can promote adolescent alcohol use: the roles of predrinking allostatic load and childhood behavior disorders. | Zimmermann US et al. | β | 2007 | β |
| Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects? | Grant JD et al. | β | 2007 | β |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | β | 2006 | β |
| Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. | Enoch MA et al. | β | 2006 | β |
| Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. | Prescott CA et al. | β | 2006 | β |
| Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry. | Lessov-Schlaggar CN et al. | β | 2006 | β |
| Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. | Enoch MA et al. | β | 2006 | β |
| Comorbid alcohol and nicotine dependence: from the biomolecular basis to clinical consequences. | Ait-Daoud N et al. | β | 2005 | β |
| Co-occurring DSM-IV drug abuse in DSM-IV drug dependence: results from the National Epidemiologic Survey on Alcohol and Related Conditions. | Hasin DS et al. | β | 2005 | β |
| Genes, stress, and depression. | Wurtman RJ | β | 2005 | β |
| Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students. | Wall TL et al. | β | 2005 | β |
| Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. | Phillips TJ et al. | β | 2005 | β |
| Neuroimaging of gender differences in alcohol dependence: are women more vulnerable? | Mann K et al. | β | 2005 | β |
| The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history. | Prescott CA et al. | β | 2005 | β |
| The level of response to alcohol in daughters of alcoholics and controls. | Eng MY et al. | β | 2005 | β |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | β | 2005 | β |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | β | 2004 | β |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | β | 2004 | β |
| Is risk for alcoholism mediated by individual differences in drinking motivations? | Prescott CA et al. | β | 2004 | β |
| Resting EEG in offspring of male alcoholics: beta frequencies. | Rangaswamy M et al. | β | 2004 | β |
| Sweet liking, novelty seeking, and gender predict alcoholic status. | Kampov-Polevoy AB et al. | β | 2004 | β |
| Trajectories of alcohol use and electrophysiological and morphological indices of brain development: distinguishing causes from consequences. | Hill SY | β | 2004 | β |
| Using the Mplus computer program to estimate models for continuous and categorical data from twins. | Prescott CA | β | 2004 | β |
| D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. | Noble EP | β | 2003 | β |
| Family history of alcoholism and response to sweets. | Kampov-Polevoy AB et al. | β | 2003 | β |
| Pharmacogenomics of alcohol response and addiction. | Enoch MA | β | 2003 | β |
| Association study of alcoholism subtypes with a functional promoter polymorphism in the serotonin transporter protein gene. | Kranzler H et al. | β | 2002 | β |
| D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence. | Connor JP et al. | β | 2002 | β |
| Neurodevelopmental liabilities in alcohol dependence: central serotonin and dopamine dysfunction. | Naranjo CA et al. | β | 2002 | β |
| Sex differences in the genetic risk for alcoholism. | Prescott CA | β | 2002 | β |
| Shared genetic vulnerability in alcohol and cigarette use and dependence. | Madden PA et al. | β | 2002 | β |
| Alcohol abuse as a risk factor for and consequence of child abuse. | Widom CS et al. | β | 2001 | β |
| Detecting and addressing alcohol abuse in women. | Becker KL et al. | β | 2001 | β |
| Knowing the risk: relationships between risk behaviour and health knowledge. | Cook PA et al. | β | 2001 | β |
| P300 event-related potential amplitude as an endophenotype of alcoholism--evidence from the collaborative study on the genetics of alcoholism. | Hesselbrock V et al. | β | 2001 | β |
| The genetics of alcoholism and alcohol abuse. | Enoch MA et al. | β | 2001 | β |
| Visual p3 in female alcoholics. | Prabhu VR et al. | β | 2001 | β |
| Influence of ascertainment strategy on finding sex differences in genetic estimates from twin studies of alcoholism. | Prescott CA et al. | β | 2000 | β |
| Psychopathology: biological and psychological correlates. | Stone MH | β | 2000 | β |
| Segregation analysis of drinking problem in elderly men and their first-degree relatives from the Western Collaborative Group Study. | Cheng LS et al. | β | 2000 | β |
| Smoking and the genetic contribution to alcohol-dependence risk. | Madden PA et al. | β | 2000 | β |
| The DRD2 gene in psychiatric and neurological disorders and its phenotypes. | Noble EP | β | 2000 | β |