Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism.
- Authors
- Almasy, L; Porjesz, B; Blangero, J; Goate, A; Edenberg, H J; Chorlian, D B; Kuperman, S; O'Connor, S J; Rohrbaugh, J; Bauer, L O; Foroud, T; Rice, J P; Reich, T; Begleiter, H
- Year
- 2001
- Journal
- American journal of human genetics
- PMID
- 11102287
- DOI
- 10.1086/316936
- PMCID
- PMC1234905
Event-related brain potentials (ERPs) are altered in patients with a variety of psychiatric disorders and may represent quantitative correlates of disease liability that are more amenable to genetic analysis than disease status itself. Results of a genomewide linkage screen are presented for amplitude of the N4 and P3 components of the ERP, measured at 19 scalp locations in response to a semantic priming task for 604 individuals in 100 pedigrees ascertained as part of the Collaborative Study on the Genetics of Alcoholism. N4 and P3 amplitudes in response to three stimuli (nonwords, primed words [i.e., antonyms], and unprimed words) all showed significant heritabilities, the highest being.54. Both N4 and P3 showed significant genetic correlations across stimulus type at a given lead and across leads within a stimulus, indicating shared genetic influences among the traits. There were also substantial genetic correlations between the N4 and P3 amplitudes for a given lead, even across stimulus type. N4 amplitudes showed suggestive evidence of linkage in several chromosomal regions, and P3 amplitudes showed significant evidence of linkage to chromosome 5 and suggestive evidence of linkage to chromosome 4.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Spatio-temporal processing of words and nonwords: hemispheric laterality and acute alcohol intoxication. | Marinkovic K et al. | — | 2014 | → |
| The genetics of alcohol dependence: advancing towards systems-based approaches. | Palmer RH et al. | — | 2012 | → |
| Genetics of alcohol dependence. | Kimura M et al. | — | 2011 | → |
| N4 component responses to pre-pulse startle stimuli in young adults: relationship to alcohol dependence. | Ehlers CL et al. | — | 2011 | → |
| Neurogenetic effects on cognition in aging brains: a window of opportunity for intervention? | Reinvang I et al. | — | 2010 | → |
| Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm. | Roopesh BN et al. | — | 2010 | → |
| The reliability and validity of the family history method for assessing pathological gambling and gambling involvement. | Ellingson JM et al. | — | 2010 | → |
| Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. | Roopesh BN et al. | — | 2009 | → |
| A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. | Ghosh S et al. | — | 2008 | → |
| QTLs identified for P3 amplitude in a non-clinical sample: importance of neurodevelopmental and neurotransmitter genes. | Wright MJ et al. | — | 2008 | → |
| Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens. | Potenza MN et al. | — | 2008 | → |
| Application of electroencephalography to the study of cognitive and brain functions in schizophrenia. | van der Stelt O et al. | — | 2007 | → |
| A cholinergic receptor gene (CHRM2) affects event-related oscillations. | Jones KA et al. | — | 2006 | → |
| Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. | Dick DM et al. | — | 2006 | → |
| Heritability of P300 amplitude development from adolescence to adulthood. | Carlson SR et al. | — | 2006 | → |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | — | 2006 | → |
| Alcohol and gene interactions. | Whitfield JB | — | 2005 | → |
| Characterization of N200 and P300: selected studies of the Event-Related Potential. | Patel SH et al. | — | 2005 | → |
| Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14. | Edenberg HJ et al. | — | 2005 | → |
| N400 as an index of semantic expectancies: differential effects of alcohol and cocaine dependence. | Ceballos NA et al. | — | 2005 | → |
| Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association. | Rosenberger A et al. | — | 2005 | → |
| The role of parametric linkage methods in complex trait analyses using microsatellites. | Badzioch MD et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| A genome wide search for alcoholism susceptibility genes. | Hill SY et al. | — | 2004 | → |
| Exploring positional candidate genes: linkage conditional on measured genotype. | Almasy L et al. | — | 2004 | → |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | — | 2004 | → |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | — | 2004 | → |
| Genetics and genomics of behavioral and psychiatric disorders. | Inoue K et al. | — | 2003 | → |
| Genetics of human prefrontal function. | Winterer G et al. | — | 2003 | → |
| Linkage mapping of beta 2 EEG waves via non-parametric regression. | Ghosh S et al. | — | 2003 | → |
| The search for genes related to a low-level response to alcohol determined by alcohol challenges. | Wilhelmsen KC et al. | — | 2003 | → |
| Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism. | Bierut LJ et al. | — | 2002 | → |
| Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes. | Porjesz B et al. | — | 2002 | → |
| P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders. | Carlson SR et al. | — | 2002 | → |
| Twin and family studies of the human electroencephalogram: a review and a meta-analysis. | van Beijsterveldt CE et al. | — | 2002 | → |
| Genetic influence on the variance in P3 amplitude and latency. | Wright MJ et al. | — | 2001 | → |
| Genetics of brain function and cognition. | de Geus EJ et al. | — | 2001 | → |
| Stability of genetic and environmental influences on P300 amplitude: a longitudinal study in adolescent twins. | van Beijsterveldt CE et al. | — | 2001 | → |