Heritable features of the auditory oddball event-related potential: peaks, latencies, morphology and topography.
paper
Cited
Public
Unavailable
- Authors
- O'Connor, S; Morzorati, S; Christian, J C; Li, T K
- Year
- 1994
- Journal
- Electroencephalography and clinical neurophysiology
- PMID
- 7511509
- DOI
- 10.1016/0168-5597(94)90052-3
Baseline auditory ERP data from a larger study of the genetic determinants of the response to alcohol were collected from 59 monozygotic (MZ) twin pairs and from 39 same-sex dizygotic (DZ) twin pairs who drank socially. Three methods for measuring genetic influence on the ERPs were applied. First, based on maximum-likelihood estimates, the heritability of conventional peak amplitude and latency of N1 and P3 components was computed for each of 16 lead locations using tests of the significance of heritability based on intraclass correlations. P3 amplitude provided the strongest results, distributed symmetrically over caudal leads, and implied gene dominance as the mode of genetic transmission for the P3 component. A substantial genetic influence on N1 latency suggested a mixture of additive and dominance effects in the left fronto-temporal regions. N1 amplitude measures trended towards significant heritability, but none was observed for P3 latency. The second method used the maximum of the cross-correlation function to compare wave form shape in a lead-by-lead analysis of data from cotwins. Genetic influence was apparent in both target and non-target ERP responses, with a fronto-central topography of significant results. The third method reduced all spatial and temporal ERP differences from a pair of twins to a single scalar number for each response. Distributions of this global measure revealed significant genetic influence on both non-target and target ERPs. A post hoc analysis of the effect of gender on the heritability of N1 or P3 peaks and latencies revealed no statistically significant observations in this sample of young adult twins.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Toward precision EEG: assessing the reliability of individual-level ERPs across EEG systems. | Korisky A et al. | — | 2026 | → |
| Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. | Brislin SJ et al. | — | 2024 | → |
| P300 in schizophrenia: Then and now. | Hamilton HK et al. | — | 2024 | → |
| Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome. | Hill SY et al. | — | 2022 | → |
| Neurophysiology in psychosis: The quest for disease biomarkers. | Wang B et al. | — | 2022 | → |
| Density and Dichotomous Family History Measures of Alcohol Use Disorder as Predictors of Behavioral and Neural Phenotypes: A Comparative Study Across Gender and Race/Ethnicity. | Pandey G et al. | — | 2020 | → |
| Electrophysiological Endophenotypes for Schizophrenia. | Owens EM et al. | — | 2016 | → |
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | Bell RL et al. | — | 2016 | → |
| Genetic effects on source level evoked and induced oscillatory brain responses in a visual oddball task. | Antonakakis M et al. | — | 2016 | → |
| The utility of P300 as a schizophrenia endophenotype and predictive biomarker: clinical and socio-demographic modulators in COGS-2. | Turetsky BI et al. | — | 2015 | → |
| Biological impact of auditory expertise across the life span: musicians as a model of auditory learning. | Strait DL et al. | — | 2014 | → |
| Biomarkers of bipolar disorder: specific or shared with schizophrenia? | Bellivier F et al. | — | 2013 | → |
| Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. | Hill SY et al. | — | 2013 | → |
| Genetic influences on composite neural activations supporting visual target identification. | Ethridge LE et al. | — | 2013 | → |
| Genetic association study of the P300 endophenotype in schizophrenia. | Decoster J et al. | — | 2012 | → |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | — | 2012 | → |
| A longitudinal twin study of effects of adolescent alcohol abuse on the neurophysiology of attention and orienting. | Koskinen SM et al. | — | 2011 | → |
| Auditory P300 and N100 components as intermediate phenotypes for psychotic disorder: familial liability and reliability. | Simons CJ et al. | — | 2011 | → |
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | Zlojutro M et al. | — | 2011 | → |
| Characteristics of the athletes' brain: evidence from neurophysiology and neuroimaging. | Nakata H et al. | — | 2010 | → |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | — | 2010 | → |
| Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. | Chen AC et al. | — | 2009 | → |
| Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families: a prospective study. | Hill SY et al. | — | 2009 | → |
| Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. | Duncan CC et al. | — | 2009 | → |
| Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. | Roopesh BN et al. | — | 2009 | → |
| The P300 as a possible endophenotype for schizophrenia and bipolar disorder: Evidence from twin and patient studies. | Bestelmeyer PE et al. | — | 2009 | → |
| Auditory P300 in individuals clinically at risk for psychosis. | Frommann I et al. | — | 2008 | → |
| Neurobiological processes in adolescent addictive disorders. | Schepis TS et al. | — | 2008 | → |
| Neurophysiological endophenotypes across bipolar and schizophrenia psychosis. | Thaker GK | — | 2008 | → |
| Genetic contribution to the P3 in young and middle-aged adults. | Smit DJ et al. | — | 2007 | → |
| Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. | Turetsky BI et al. | — | 2007 | → |
| Updating P300: an integrative theory of P3a and P3b. | Polich J | — | 2007 | → |
| A cholinergic receptor gene (CHRM2) affects event-related oscillations. | Jones KA et al. | — | 2006 | → |
| Heritability and reliability of P300, P50 and duration mismatch negativity. | Hall MH et al. | — | 2006 | → |
| Heritability of P300 amplitude development from adolescence to adulthood. | Carlson SR et al. | — | 2006 | → |
| P300 amplitude as an indicator of externalizing in adolescent males. | Patrick CJ et al. | — | 2006 | → |
| S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism. | Jones KA et al. | — | 2006 | → |
| Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse. | Yoon HH et al. | — | 2006 | → |
| Association study of a functional MAOA-uVNTR gene polymorphism and cognitive function in healthy females. | Yu YW et al. | — | 2005 | → |
| Effects of chronic alcohol consumption in a visual attention task and an auditory oddball task: an event-related potential study. | Bijl S et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Association analysis for MAOA gene polymorphism with long-latency auditory evoked potentials in healthy females. | Yu YW et al. | — | 2004 | → |
| Association analysis for the C-1019G promoter variant of the 5-HT1A receptor gene with auditory evoked potentials in major depression. | Chen TJ et al. | — | 2004 | → |
| Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. | Jones KA et al. | — | 2004 | → |
| Auditory P3 in female alcoholics. | Suresh S et al. | — | 2003 | → |
| Genetics of human prefrontal function. | Winterer G et al. | — | 2003 | → |
| Genetic factors and neurocognitive traits. | Bates JA et al. | — | 2002 | → |
| Genetic sources of covariation among P3(00) and online performance variables in a delayed-response working memory task. | Wright MJ et al. | — | 2002 | → |
| Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes. | Porjesz B et al. | — | 2002 | → |
| P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders. | Carlson SR et al. | — | 2002 | → |
| Twin and family studies of the human electroencephalogram: a review and a meta-analysis. | van Beijsterveldt CE et al. | — | 2002 | → |
| Alcohol use disorders and anxiety disorders: relation to the P300 event-related potential. | Enoch MA et al. | — | 2001 | → |
| Auditory P3a deficits in male subjects at high risk for alcoholism. | Hada M et al. | — | 2001 | → |
| Discrepant target detection and action monitoring in obsessive-compulsive disorder. | Johannes S et al. | — | 2001 | → |
| Frontal cortex reactivity differentiates between schizophrenic subtypes: auditory ERP-evidence. | Sweden BV et al. | — | 2001 | → |
| Genetic correlation between the P300 event-related brain potential and the EEG power spectrum. | Anokhin AP et al. | — | 2001 | → |
| Genetic influence on the variance in P3 amplitude and latency. | Wright MJ et al. | — | 2001 | → |
| Mismatch negativity in subjects at high risk for alcoholism. | Zhang XL et al. | — | 2001 | → |
| A twin MRI study of size variations in human brain. | Pennington BF et al. | — | 2000 | → |
| Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders: Part 1. | Hill SY | — | 2000 | → |
| Slow cortical potentials in migraine families. | Siniatchkin M et al. | — | 2000 | → |
| A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism. | Ramchandani VA et al. | — | 1999 | → |
| A twin study of genetic influences on the acute adaptation of the EEG to alcohol. | O'Connor S et al. | — | 1999 | → |
| Description of the Genetic Analysis Workshop 11 Collaborative Study on the Genetics of Alcoholism. | Begleiter H et al. | — | 1999 | → |
| Developmental delay in P300 production in children at high risk for developing alcohol-related disorders. | Hill SY et al. | — | 1999 | → |
| Genetic influence on auditory information processing in schizophrenia: P300 in monozygotic twins. | Weisbrod M et al. | — | 1999 | → |
| Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. | Williams JT et al. | — | 1999 | → |
| Path analysis of P300 amplitude of individuals from families at high and low risk for developing alcoholism. | Hill SY et al. | — | 1999 | → |
| Visual P3a in male alcoholics and controls. | Rodriguez Holguin S et al. | — | 1999 | → |
| Visual P3a in male subjects at high risk for alcoholism. | Rodríguez Holguín S et al. | — | 1999 | → |
| Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA Project. Collaborative Study on the Genetics of Alcoholism. | Porjesz B et al. | — | 1998 | → |
| Effects of ethanol on temporal recovery of auditory-evoked potentials in individuals at risk for alcoholism. | Cohen HL et al. | — | 1998 | → |
| Event-related potentials during visual selective attention in children of alcoholics. | van der Stelt O et al. | — | 1998 | → |
| Gender differences in electrophysiological responses to facial stimuli. | Orozco S et al. | — | 1998 | → |
| Genetic association between reduced P300 amplitude and the DRD2 dopamine receptor A1 allele in children at high risk for alcoholism. | Hill SY et al. | — | 1998 | → |
| Genetic basis of event-related potentials and their relationship to alcoholism and alcohol use. | Porjesz B et al. | — | 1998 | → |
| Individual differences in P300 amplitude: a genetic study in adolescent twins. | van Beijsterveldt CE et al. | — | 1998 | → |
| Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. | Begleiter H et al. | — | 1998 | → |
| Alcohol, auditory functioning and deafness. | Crawford A | — | 1997 | → |
| Neuroelectric correlates of response production and inhibition in individuals at risk to develop alcoholism. | Cohen HL et al. | — | 1997 | → |
| P300 event-related potential heritability in monozygotic and dizygotic twins. | Katsanis J et al. | — | 1997 | → |
| A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA). | Reich T | — | 1996 | → |
| Alcohol effects on the heritability of EEG spectral power. | Sorbel J et al. | — | 1996 | → |
| Genetic analysis of the resting electroencephalographic power spectrum in human twins. | Christian JC et al. | — | 1996 | → |
| NIAAA 25th anniversary: advances in the neuroscience of alcohol. | Gordis E | — | 1996 | → |
| Auditory P300 in young alcoholics: regional response characteristics. | Cohen HL et al. | — | 1995 | → |
| Event-Related Potentials. | Hill SY | — | 1995 | → |
| Event-Related Potentials and Cognitive Function in Alcoholism. | Porjesz B et al. | — | 1995 | → |
| Measuring Electrical Activity of the Brain: ERP Mapping in Alcohol Research. | Chorlian DB et al. | — | 1995 | → |
| The Collaborative Study on the Genetics of Alcoholism. | — | — | 1995 | → |
| Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review. | van Beijsterveldt CE et al. | — | 1994 | → |
| Visual P300: an interlaboratory consistency study. | Cohen HL et al. | — | 1994 | → |