Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300.

paper Cited Public

Authors: Hill, Shirley Y; Jones, Bobby L; Holmes, Brian; Steinhauer, Stuart R; Zezza, Nicholas; Stiffler, Scott
Year: 2013
Journal: Psychiatry research
PMID: 23747232
DOI: 10.1016/j.psychres.2013.04.027
PMCID: PMC3796118

#	Section	Preview
0	1. Introduction	The P300 component of the event-related potential (ERP) was first identified by Sutton et al (1965).…
1	1. Introduction	Many early cross-sectional studies have shown that P300 is reduced in children from alcoholic…
2	1. Introduction	Additionally, P300 obtained at one point in time has been used to predict substance use disorders at…
3	1. Introduction	Studies using a pre/post design are not technically considered trajectory studies because trajectory…
4	1. Introduction	A large scale follow-up using repeated ERP assessments of child and adolescent offspring from…
5	1. Introduction	Although long-term longitudinal studies are in agreement that P300 amplitude is associated with…
6	1. Introduction	These studies also found that childhood psychopathology whether externalizing or internalizing is…
7	1. Introduction	Overall, the internalizing dimension has received less attention in studies of children and…
8	1. Introduction	The usefulness of P300 amplitude as an endophenotype for AD risk is strengthened by observations…
9	1. Introduction	The CHRM2 gene shows particular promise because both association and linkage analyses point to a…
10	1. Introduction	Because developmental trajectories of P300 have been shown to differ by familial risk group status…
11	2. Methods — 2.1. Description of Family Studies	The high and low-risk (control) children/adolescents are participants in one of two ongoing family…
12	2. Methods — 2.2. Inclusion Criteria for High-Risk Families	Probands and their families were selected if a pair of same-sexed adult siblings with an alcohol…
13	2. Methods — 2.3. Exclusion Criteria for High-Risk Families	The DIS was administered to all available relatives (adult probands, their siblings and parents…
14	2. Methods — 2.4. Selection of Control Families	Selection of control families was based on availability of a pair of same sex adult siblings.…
15	2. Methods — 2.5. Participants	The minor offspring of HR proband pairs and their adult siblings along with control offspring are…
16	2. Methods — 2.5. Participants	Young adult subjects in the study gave written consent after the nature and purpose of the study was…
17	2. Methods — 2.6. Auditory Event-Related Potential Recordings and analysis of ERP	Each subject performed two blocks (80 trials) of a Choice Reaction auditory task using high (1500…
18	2. Methods — 2.6. Auditory Event-Related Potential Recordings and analysis of ERP	To provide exactly the same recording conditions throughout the longitudinal study, a PDP-11/23 has…
19	2. Methods — 2.6. Auditory Event-Related Potential Recordings and analysis of ERP	A computer algorithm was used to search for the maximum peak amplitude for each component within…

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In this knowledge base

Title	Year	PMID
Genetic correlates of the development of theta event related oscillations in adolescents and young adults.	2017	27847216
Advances in Electrophysiological Research.	2015	26259089
Gender modulates the development of theta event related oscillations in adolescents and young adults.	2015	26102560
Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study.	2014	25387705

External

Title	Authors	Journal	Year	Link
The collaborative study on the genetics of alcoholism: Brain function.	Meyers JL et al.	—	2023	→
Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome.	Hill SY et al.	—	2022	→
Cognitive Control Deficits in Alcohol Dependence Are a Trait- and State-Dependent Biomarker: An ERP Study.	Liu X et al.	—	2020	→
CHRM2 Genotype Affects Inhibitory Control Mechanisms During Cognitive Flexibility.	Zink N et al.	—	2019	→
Genetic correlates of the development of theta event related oscillations in adolescents and young adults.	Chorlian DB et al.	—	2017	→
Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments.	Sakata K et al.	—	2017	→
Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families.	Hill SY et al.	—	2016	→
Advances in Electrophysiological Research.	Kamarajan C et al.	—	2015	→
Gender modulates the development of theta event related oscillations in adolescents and young adults.	Chorlian DB et al.	—	2015	→
Psychological and Neurobiological Precursors of Alcohol Use Disorders in High Risk Youth.	Hill SY et al.	—	2015	→
Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes.	Lichenstein SD et al.	—	2014	→
Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study.	Malone SM et al.	—	2014	→
Who gains? Genetic and neurophysiological correlates of BMI gain upon college entry in women.	Bauer LO	—	2014	→