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Chunk #2 — 1. Introduction

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Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300.
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Additionally, P300 obtained at one point in time has been used to predict substance use disorders at a later time (Carlson et al., 2007; Habeych et al., 2005; Hill et al., 2009). These studies have assessed P300 and determined substance use disorder outcome at 3, 7 and 11 years post assessment, respectively, finding those with lower P300 were more likely to develop a substance use disorder at follow-up. The conclusion of a recent meta-analysis is that P300 does index risk for SUD (Euser et al 2012).