Developmental delay in P300 production in children at high risk for developing alcohol-related disorders.
paper
Cited
Public
Unavailable
- Authors
- Hill, S Y; Shen, S; Locke, J; Steinhauer, S R; Konicky, C; Lowers, L; Connolly, J
- Year
- 1999
- Journal
- Biological psychiatry
- PMID
- 10509180
- DOI
- 10.1016/s0006-3223(99)00032-3
BACKGROUND: Reduction of P300 amplitude in children and adolescents at high risk for developing alcoholism has frequently been reported. It has been hypothesized that this reduction represents a developmental delay in reaching age-appropriate levels in P300 amplitude. Using latent growth analysis of longitudinal data obtained at yearly intervals, this study seeks to define normal growth, and determine if the pattern seen in high-risk children differs from that obtained in normal low-risk controls. METHODS: A total of 156 children from either high or low-risk families have been assessed multiple times (two-thirds more than 4 times) using both a clinical assessment (K-SADS) and ERP evaluation performed on the same day. A total of 635 separate assessments were available for modeling. RESULTS: Quadratic growth curves revealed a slower rate of change in P300 amplitude in high-risk than low-risk males. High-risk girls showed reduced visual P300 amplitude only when the presence of a K-SADS diagnosis was considered. No differences were seen for P300 latency. CONCLUSIONS: This study confirms the hypothesis that when reduction of P300 amplitude is seen in males at high risk for developing alcoholism, it is due to a developmental delay.
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| Event-related Oscillations to Emotional Faces are Related to a History of Internalizing Disorders. | Ehlers CL et al. | — | 2023 | → |
| Influences of age and pubertal development on P300 amplitude trajectory across two years in female adolescents. | Santopetro NJ et al. | — | 2023 | → |
| Longitudinal stability and change in time-frequency measures from an oddball task during adolescence and early adulthood. | Malone SM et al. | — | 2023 | → |
| Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome. | Hill SY et al. | — | 2022 | → |
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| Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk. | Ehlers CL et al. | — | 2020 | → |
| Phase locking of event-related oscillations is decreased in both young adult humans and rats with a history of adolescent alcohol exposure. | Ehlers CL et al. | — | 2020 | → |
| Altered brain cortical maturation is found in adolescents with a family history of alcoholism. | Holla B et al. | — | 2019 | → |
| Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence. | Vaidya JG et al. | — | 2019 | → |
| CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms. | Ehlers CL et al. | — | 2019 | → |
| Decision- and feedback-related brain potentials reveal risk processing mechanisms in patients with alcohol use disorder. | Sehrig S et al. | — | 2019 | → |
| Why cognitive event-related potentials (ERPs) should have a role in the management of alcohol disorders. | Campanella S et al. | — | 2019 | → |
| Cortical Thickness in Adolescents with a Family History of Alcohol Use Disorder. | Henderson KE et al. | — | 2018 | → |
| Disrupted resting brain graph measures in individuals at high risk for alcoholism. | Holla B et al. | — | 2017 | → |
| Endophenotype best practices. | Iacono WG et al. | — | 2017 | → |
| Genetic correlates of the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | — | 2017 | → |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | — | 2016 | → |
| One-year developmental stability and covariance among oddball, novelty, go/no-go, and flanker event-related potentials in adolescence: A monozygotic twin study. | Burwell SJ et al. | — | 2016 | → |
| Volumetric Differences in Cerebellar Lobes in Individuals from Multiplex Alcohol Dependence Families and Controls: Their Relationship to Externalizing and Internalizing Disorders and Working Memory. | Hill SY et al. | — | 2016 | → |
| Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. | Kamarajan C et al. | — | 2015 | → |
| Gender modulates the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | — | 2015 | → |
| Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology. | Yoon HH et al. | — | 2015 | → |
| Psychological and Neurobiological Precursors of Alcohol Use Disorders in High Risk Youth. | Hill SY et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| The development of prospective memory across adolescence: an event-related potential analysis. | Bowman C et al. | — | 2015 | → |
| The P300 component wave reveals differences in subclinical anxious-depressive states during bimodal oddball tasks: An effect of stimulus congruence. | Delle-Vigne D et al. | — | 2015 | → |
| Genetic psychophysiology: advances, problems, and future directions. | Anokhin AP | — | 2014 | → |
| Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence. | Cuzen NL et al. | — | 2013 | → |
| Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults. | Yoon HH et al. | — | 2013 | → |
| Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders. | Euser AS et al. | — | 2013 | → |
| Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. | Hill SY et al. | — | 2013 | → |
| Experimental and clinical usefulness of crossmodal paradigms in psychiatry: an illustration from emotional processing in alcohol-dependence. | Maurage P et al. | — | 2013 | → |
| Family history of alcohol use disorders and neuromaturation: a functional connectivity study with adolescents. | Spadoni AD et al. | — | 2013 | → |
| Parental rearing behavior prospectively predicts adolescents' risky decision-making and feedback-related electrical brain activity. | Euser AS et al. | — | 2013 | → |
| White matter microstructure, alcohol exposure, and familial risk for alcohol dependence. | Hill SY et al. | — | 2013 | → |
| Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism. | Wetherill RR et al. | — | 2012 | → |
| Greater sensitivity of the P300 component to bimodal stimulation in an event-related potentials oddball task. | Campanella S et al. | — | 2012 | → |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | — | 2012 | → |
| Developmental Endophenotypes: Indexing Genetic Risk for Substance Abuse with the P300 Brain Event-Related Potential. | Iacono WG et al. | — | 2011 | → |
| Neural activation during inhibition predicts initiation of substance use in adolescence. | Norman AL et al. | — | 2011 | → |
| Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects? | Ehlers CL et al. | — | 2010 | → |
| Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats. | Criado JR et al. | — | 2010 | → |
| Electrophysiological changes during adolescence: a review. | Segalowitz SJ et al. | — | 2010 | → |
| Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations. | Campanella S et al. | — | 2010 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Neural plasticity, human genetics, and risk for alcohol dependence. | Hill SY | — | 2010 | → |
| Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families: a prospective study. | Hill SY et al. | — | 2009 | → |
| Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families. | Hill SY et al. | — | 2009 | → |
| Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. | Duncan CC et al. | — | 2009 | → |
| The P300 event-related potential and its possible role as an endophenotype for studying substance use disorders: a review. | Singh SM et al. | — | 2009 | → |
| Brain activation, response inhibition, and increased risk for substance use disorder. | McNamee RL et al. | — | 2008 | → |
| Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology. | Carlson SR et al. | — | 2008 | → |
| P3 components of the event-related potential and marijuana dependence in Southwest California Indians. | Ehlers CL et al. | — | 2008 | → |
| Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: a prospective study during childhood and adolescence. | Hill SY et al. | — | 2008 | → |
| The role of selected factors in the development and consequences of alcohol dependence. | Gilbertson R et al. | — | 2008 | → |
| Auditory event-related potentials and cognitive function of preterm children at five years of age. | Mikkola K et al. | — | 2007 | → |
| Cerebellar volume in offspring from multiplex alcohol dependence families. | Hill SY et al. | — | 2007 | → |
| Cognitive deficits in children of alcoholics: At risk before the first sip! | Silva MC et al. | — | 2007 | → |
| Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. | Rangaswamy M et al. | — | 2007 | → |
| Electrophysiological responses to affective stimuli in Mexican Americans: Relationship to alcohol dependence and personality traits. | Criado JR et al. | — | 2007 | → |
| Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence. | Benegal V et al. | — | 2007 | → |
| P3 components and adolescent binge drinking in Southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| Updating P300: an integrative theory of P3a and P3b. | Polich J | — | 2007 | → |
| Association between P3 event-related brain potential amplitude and adolescent problem behavior. | Iacono WG et al. | — | 2006 | → |
| Heritability of P300 amplitude development from adolescence to adulthood. | Carlson SR et al. | — | 2006 | → |
| P300 amplitude as an indicator of externalizing in adolescent males. | Patrick CJ et al. | — | 2006 | → |
| P300 development during adolescence: effects of DRD2 genotype. | Berman SM et al. | — | 2006 | → |
| Alcoholism: the dissection for endophenotypes. | Hines LM et al. | — | 2005 | → |
| Borderline personality disorder features in adolescent girls: P300 evidence of altered brain maturation. | Houston RJ et al. | — | 2005 | → |
| The P3 in 'ecstasy' polydrug users during response inhibition and execution. | Gamma A et al. | — | 2005 | → |
| A genome wide search for alcoholism susceptibility genes. | Hill SY et al. | — | 2004 | → |
| Alcoholism risk, tobacco smoking, and P300 event-related potential. | Polich J et al. | — | 2004 | → |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | — | 2004 | → |
| Trajectories of alcohol use and electrophysiological and morphological indices of brain development: distinguishing causes from consequences. | Hill SY | — | 2004 | → |
| Alcoholism risk and the P300 event-related brain potential: modality, task, and gender effects. | Reese C et al. | — | 2003 | → |
| Brain maturation and subtypes of conduct disorder: interactive effects on p300 amplitude and topography in male adolescents. | Bauer LO et al. | — | 2003 | → |
| Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics. | Berman SM et al. | — | 2003 | → |
| Executive-cognitive functioning in the development of antisocial personality disorder. | Stevens MC et al. | — | 2003 | → |
| Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. | Tarter RE et al. | — | 2003 | → |
| P300 (latency) event-related potential: an accurate predictor of memory impairment. | Braverman ER et al. | — | 2003 | → |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | — | 2003 | → |
| Assessing cerebral dysfunction with probe-evoked potentials in a CNV task -- a study in alcoholics. | Olbrich HM et al. | — | 2002 | → |
| Attention dysfunction predicts substance involvement in community youths. | Tapert SF et al. | — | 2002 | → |
| Etiology of adolescent substance abuse: a developmental perspective. | Tarter RE | — | 2002 | → |
| Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis. | Hill SY et al. | — | 2002 | → |
| P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders. | Carlson SR et al. | — | 2002 | → |
| A comparison of correlates of DSM-IV alcohol abuse or dependence among more than 400 sons of alcoholics and controls. | Schuckit MA et al. | — | 2001 | → |
| Contingent negative variation in subjects at risk for migraine without aura. | Siniatchkin M et al. | — | 2001 | → |
| Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. | Hill SY et al. | — | 2001 | → |
| Visual P3 findings in Mission Indian youth: relationship to family history of alcohol dependence and behavioral problems. | Ehlers CL et al. | — | 2001 | → |
| Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders: Part 1. | Hill SY | — | 2000 | → |
| Developmental changes in postural sway in children at high and low risk for developing alcohol-related disorders. | Hill SY et al. | — | 2000 | → |
| Factors predicting the onset of adolescent drinking in families at high risk for developing alcoholism. | Hill SY et al. | — | 2000 | → |
| Genetics of the risk for alcoholism. | Schuckit MA | — | 2000 | → |
| Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. | Blum K et al. | — | 2000 | → |
| Absence of visual and auditory P300 reduction in nondepressed male and female alcoholics. | Hill SY et al. | — | 1999 | → |