Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence.

paper Cited Public

Authors: Cuzen, Natalie L; Andrew, Colin; Thomas, Kevin G F; Stein, Dan J; Fein, George
Year: 2013
Journal: Alcoholism, clinical and experimental research
PMID: 22676302
DOI: 10.1111/j.1530-0277.2012.01837.x
PMCID: PMC3491103

#	Section	Preview
0	Introduction	Reduced amplitude of the P3b event-related potential (ERP) is a robust finding in individuals with…
1	Introduction	Most research on the P3b reduction in AUDs has focused on clinical populations of treated…
2	Introduction	Regarding the P3b reduction specifically, we have shown that treatment-naïve actively drinking…
3	Introduction	There is a paucity of data examining possible P3b reductions in treatment-naïve AUD adolescents…
4	Introduction	We have been studying such a ‘pure’ sample (without substance or psychiatric comorbidity) of…
5	Introduction	Although alcoholism research consistently finds a reduction in P3b amplitude, evidence for P3a…
6	Materials and Methods — Participants	We recruited English- and Afrikaans-speaking adolescents (13–18 years) of low socioeconomic status…
7	Materials and Methods — Measures — History of alcohol use	We used a revised version of the Timeline Followback (TLFB) procedure (Sobell and Sobell, 1992) to…
8	Materials and Methods — Measures — History of alcohol use	Group membership was determined thus: Participants in the TNAD group were required to have a…
9	Materials and Methods — Measures — Psychopathology	Current and past psychiatric symptoms were ascertained during administration of the K-SADS-PL.…
10	Materials and Methods — Measures — Family history density of alcohol problems	We asked participants whether they were currently cohabiting with, or had ever cohabited with, a…
11	Materials and Methods — Measures — Experimental paradigm	We administered a standard three-condition visual target detection task, programmed using E-Prime…
12	Materials and Methods — Procedures	The study protocol adhered strictly to the guidelines contained in the Declaration of Helsinki…
13	Materials and Methods — Procedures	EEGs were recorded for each participant during performance of the visual target detection task. EEG…
14	Materials and Methods — EEG and Statistical Analysis	We used the BrainVision Analyzer package (BVA; Brain Products, 2008) for ERP processing. Eye…
15	Materials and Methods — EEG and Statistical Analysis	ERP waveforms were extracted by averaging across trials for each condition. In addition to the ERP…
16	Materials and Methods — EEG and Statistical Analysis	P3b amplitude for each subject for the target and P3a amplitude for the rare non-target conditions…
17	Materials and Methods — EEG and Statistical Analysis	We used SPSS software (SPSS Inc., 2008) for data analyses. The main analyses consisted of 2 (group)…
18	Materials and Methods — EEG and Statistical Analysis	despite the fact that we calculated multiple sets of correlations. We took this position because…
19	Results — Sample Characteristics	Table 1 shows the demographic, alcohol-use (individual and family), and psychiatric symptom count…

Name	Type
accuracy	phenotype
Accuracy for rare non-target condition local	phenotype
Accuracy for target condition local	phenotype
Actively drinking adolescents local	cohort
ADHD symptoms	phenotype
adolescents	cohort
adolescent sample	cohort
adolescent TNAD males local	cohort
adults	cohort
adult sample	cohort
Adult treated samples local	cohort
alcohol	phenotype
alcohol abuse	phenotype
Alcohol consumption quantity local	phenotype
alcohol dependence	phenotype
Alcohol-dependent adolescents local	phenotype
Alcohol Exposure	phenotype
alcoholism	phenotype
alcohol lifetime dose local	phenotype
Alcohol Use	phenotype
Alcohol Use Disorder	phenotype
Alcohol-use problem local	phenotype
anxiety	phenotype
attention deficit hyperactivity disorder	phenotype
AUD	phenotype
average monthly drinking quantity local	phenotype
beer	drug
binge drinking	phenotype
brain	anatomy
brain development	phenotype
cannabis use	phenotype
Cape Town region local	cohort
centro-parietal region	anatomy
Childhood externalizing diagnoses local	phenotype
children	cohort
chronic alcoholism	phenotype
cognition	phenotype
Collaborative Study on the Genetics of Alcoholism (COGA)	cohort
community-dwelling individuals with AUDs local	cohort
comorbidity	phenotype
conduct disorder	phenotype
consumption quantity local	phenotype
Consumption quantity local	phenotype
corpus callosum	anatomy
CPz	anatomy
current sample	cohort
Cz	anatomy
depression	phenotype
DSM criteria for dependence local	phenotype
Duration of regular alcohol use local	phenotype
Earlier onset of alcohol use local	phenotype
electrophysiological abnormalities local	phenotype
epilepsy	phenotype
ERP	phenotype
ERP difference waveform (rare non-target vs standard) local	phenotype
ERP difference waveform (target vs standard) local	phenotype
ERP waveform local	phenotype
externalizing disorders	phenotype
family history of alcoholism	phenotype
fetal alcohol syndrome	phenotype
First-degree relative local	cohort
frequency of alcohol use	phenotype
genetic vulnerability to alcoholism local	phenotype
Genetic vulnerability to alcoholism local	phenotype
Genetic vulnerability to AUDs local	phenotype
hazardous drinking local	drug
high family history density of alcohol problems local	phenotype
HIV infection	phenotype
human alcoholics	phenotype
internalizing disorders	phenotype
Internalizing psychiatric comorbidity local	phenotype
internalizing symptom counts local	phenotype
Later onset of alcohol use local	phenotype
lifetime alcohol exposure local	phenotype
liquor	drug
low family history density of alcohol problems local	phenotype
Medical history local	phenotype
Meningitis local	phenotype
methamphetamine	drug
midline electrode local	anatomy
midline electrode site local	anatomy
mixed drink	drug
non-clinical sample local	cohort
Non-clinical sample local	cohort
Non-substance-abusing local	phenotype
Non-substance-abusing controls local	cohort
NSAC local	cohort
NSAC participants local	cohort
oppositional defiant disorder	phenotype
P300 amplitude	phenotype
P300 component	phenotype
P300 measures	phenotype
P3a amplitude	phenotype
P3a latency local	phenotype
P3b amplitude	phenotype
P3b event-related potential (ERP) local	phenotype
P3b latency	phenotype
P3b reduction local	phenotype
P3b reductions local	phenotype
parietal cortex	anatomy
participants	cohort
Polygenic risk score for alcohol dependence	phenotype
Polysubstance comorbidity local	phenotype
posttraumatic stress disorder	phenotype
POz local	anatomy
Previous intoxication local	phenotype
psychiatric disorders	phenotype
psychiatric history	phenotype
Psychiatric symptom count local	phenotype
psychiatric symptom counts local	phenotype
Psychiatric symptom counts local	phenotype
psychotropic medication	drug
Pz	anatomy
rare non-target condition local	phenotype
Rare non-target condition local	phenotype
reaction time	phenotype
Reaction time to target stimuli local	phenotype
sedatives	drug
sex	phenotype
sex steroids local	drug
South Africa	cohort
Standard condition local	phenotype
Structural impairment local	phenotype
Subdiagnostic psychopathology local	phenotype
subjects	cohort
substance	phenotype
substance use	phenotype
Subthreshold externalizing psychopathology local	phenotype
Subthreshold internalizing psychopathology local	phenotype
symptom count	phenotype
target condition local	phenotype
Target condition local	phenotype
TNAD local	cohort
TNAD group local	cohort
TNAD participants local	cohort
TNAD sample local	cohort
Topographical map local	phenotype
Treated alcoholics local	cohort
Treated individuals with alcohol dependence local	cohort
Treated samples local	cohort
Treatment-naïve actively drinking alcohol-dependent adults local	cohort
Treatment‑naïve adolescent AUD cohort local	cohort
Treatment-naïve adolescents local	cohort
Treatment-naïve alcohol-dependent adolescents local	cohort
Treatment-naïve alcohol-dependent individuals local	cohort
Treatment-naïve AUD cohort local	cohort
Treatment-naïve AUD samples local	cohort
Treatment-naïve individuals local	cohort
Treatment-seeking cohort local	cohort
treatment-seeking individuals	cohort
treatment-seeking members of densely affected families local	cohort
Treatment-seeking populations local	cohort
Treatment-seeking samples local	cohort
visual target detection task local	cohort
wine	drug
wine cooler	drug

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Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence.

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